Experimental studies on antipyretic,analgesic and antibacterial effects of GK 001,a poly-prescription of traditional chinese medicine

作     者：JIANG Su-yun,ZhANG Ting-ting,DING Hong-yu(Dalian Institute for Drug Control,Dalian 116021,China) 

出 版 物：《沈阳药科大学学报》 (Journal of Shenyang Pharmaceutical University)

年 卷 期：2008年第25卷第S1期

页      面：105-105页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：GK001 antipyretic analgesic bacteriostasis 

摘      要：Objective To study the anti-inflammatory effect of a poly-prescription of traditional Chinese medicine *** *** effect on pain in mice:The pain was induced by i.p.0.2 ml of 0.6% HAc per mouse 1 h post dosing *** writhing numbers of mice were recorded in 10 minutes and the inhibitory rate of pain was calculated compared with the control *** effect In single dose experiment 15 healthy rabbits weighing 1.7-2.8 kg with body temperature(BT)measured in the experiment day meeting to the requirements were selected for the experiment and divided into 5 groups(3 in each group),which were dosed orally with GK001 and 1 h later followed by *** of 40 EU bacterial endotoxin standard·***,the BT of rabbits was measured every 30 min during 1-3 h after *** difference between the highest BT post-dose and the average BT pre-dose was *** multi-dose experiment rabbits were selected and grouped as well as received *** in the same way as above,but were administered with GK001 for consecutive 5 *** *** antibacterial activities of GK001 on Bacillus Pumilus,Bacillus Subtilis and Micrococcus Luteus were measured in vitro at concentrations of 0.125-1.0 g·*** *** GK001 showed a significant and dose-dependent pain-suppressant effect,with inhibitory rate being 45.2%,31.2% and 20.8% at high,medium and low dose,respectively(P0.05).*** single and multiple administration of GK001 had no effect on rabbit pyrogen response caused by ***001 had bacteriostatic effects on the aforementioned 3 bacteria significantly and in dose-dependent *** GK001 has analgesic and in vitro antibacterial but no antipyretic effects.