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Hourglass-like constriction of the anterior interosseous nerve in the left forearm:A case report

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World Journal of Clinical Cases 2023年第17期11卷 4194-4201页

作者： Rong He Jian-Long Yu Hai-Long Jin Liqi Ng Jin-Chao Wang Xin Li ting-ting gai Yu Zhou Da-Peng Li Bone and Hand Microsurgery Yantai Hospital of Shandong Wendeng Osteopathic&TraumatologyYantai 264009Shandong ProvinceChina Bone and Hand Microsurgery Shandong Wendeng Osteopathic HospitalWeihai 264400Shandong ProvinceChina Institute of Orthopaedic and Musculoskeletal Science University College LondonLondon HA74LPUnited Kingdom Foot and Ankle Surgery Chongqing Orthopedic Hospital of Traditional Chinese MedicineChongqing 400012China

BACKGROUND Hourglass-like constriction neuropathy is a rare neurological *** main clinical manifestation is peripheral nerve injury with no apparent cause,and the pathomorphological change is an unexplained narrowing of the diseased *** diagnosis and treatment of the disease are challenging and there is no accepted diagnostic or therapeutic *** SUMMARY This report describes a rare hourglass constriction of the anterior interosseous nerve in the left forearm in a 47-year-old healthy male who was treated surgically and gradually recovered function over a 6-mo follow-up *** Hourglass-like constriction neuropathy is a rare *** the development of medical technology,more examinations are now available for *** case aims to highlight the rare manifestations of Hourglass-like constriction neuropathy and provides a reference for enriching the clinical diagnosis and treatment experience.

关键词： Hourglass-like constriction neuropathy Anterior interosseous nerve of the forearm Nerve Surgery Literature review Case report

Molecular basis of the silkworm mutant re^(l) causing red egg color and embryonic death

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Insect Science 2021年第5期28卷 1290-1299页

作者： Jiang-Wen Luo Er-Xia An Ya-Ru Lu Ling Yang ting-ting gai Song-Zhen He Song-Yuan Wu Hai Hu Chun-Lin Li Cheng Lu Xiao-Ling Tong Fang-Yin Dai State Key Laboratory of Silkworm Genome Biology Key Laboratory of Sericultural Biology and Genetic BreedingCollege of BiotechnologySouthwest UniversityChongqing400715 China

The coloration and hatchability of insect eggs can affect individual and population ***,few genetic loci have been documented to affect both traits,and the genes involved in regulating these two traits are *** silkworm recessive mutant re^(l)shows both red egg color and embryo *** studied the molecular basis of the re^(l)phenotype *** genetic analysis,gene screening and sequencing,we found that two closely linked genes,BGIBMGA003497(Bmre)and BGIBMG4003697(Bm-Semala),control egg color and embryo mortality,*** base pairs of the Bm-re gene are deleted in its open reading frame,and BmSemala is expressed at abnormally low levels in mutant re^(l).BmSemala gene function verification was performed using RNA interference and clustered randomly interspersed palindromic repeats(CRISPR)/CRISPR-associate protein *** of the BmSemala gene can cause the death of silkworm *** study revealed the molecular basis of silkworm re^(l)mutant formation and indicated that the Semala gene is essential for insect embryo development.

关键词： BmSemala CRISPR/Cas9 embryonic mortality red egg silkworm

Myeloid sarcoma with ulnar nerve entrapment:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10227-10235页

作者： Da-Peng Li Chao-Zong Liu Mortimer Jeremy Xin Li Jin-Chao Wang Swastina Nath Varma ting-ting gai Wei-Qi Tian Qi Zou Yan-Mian Wei Hao-Yu Wang Chang-Jiang Long Yu Zhou Yantai Hospital of Shandong Wendeng Osteopathic&Traumatology Hand and Foot MicrosurgeryYantai 264009Shandong ProvinceChina University College London Royal National Orthopaedic HospitalLondon HA74LPUnited Kingdom Jilin Ginseng Academy Changchun University of Chinese MedicineChangchun 130000Jilin ProvinceChina Yantai Hospital of Shandong Wendeng Osteopathic&Traumatology Hand and Foot MicrosurgeryYantai 264009China Qinhai University Medical InstituteXining 810000Qinhai ProvinceChina College of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchun 130000Jilin ProvinceChina

BACKGROUND Myeloid sarcoma(MS) is relatively rare,occurring mainly in the skin and lymph nodes,and MS invasion of the ulnar nerve is particularly *** main aim of this article is to present a case of MS invading the brachial plexus,causing ulnar nerve entrapment syndrome,and to further clinical understanding of the possibility of MS invasion of peripheral *** SUMMARY We present the case of a 46-year-old man with a 13-year history of well-treated acute nonlymphocytic leukaemia who was admitted to the hospital after presenting with numbness and pain in his left little *** initial diagnosis was considered a simple case of nerve entrapment disease,with magnetic resonance imaging showing slightly abnormal left brachial plexus nerve alignment with local thickening,entrapment,and high signal on compression lipid *** to the severity of the ulnar nerve compression,we surgically investigated and cleared the entrapment and nerve tissue hyperplasia;however,subsequent pathological biopsy results revealed evidence of *** patient had significant relief from his neurological symptoms,with no postoperative complications,and was referred to the haemato-oncology department for further consultation about the primary *** is the first report of safe treatment of ulnar nerve entrapment from *** is intended to inform hand surgeons that nerve entrapment may be associated with extramedullary MS,as a rare presenting feature of the *** MS invasion of the brachial plexus and surrounding tissues of the upper arm,resulting in ulnar nerve entrapment and degeneration with significant neurological pain and numbness in the little finger,is *** treatment significantly relieved the patient’s nerve entrapment symptoms and prevented further neurological *** case is reported to highlight the rare presenting features of MS.

关键词： Myeloid sarcoma Ulnar nerve entrapment syndrome Acute nonlymphocytic leukaemia Sarcoma Upper limb surgery Case report

Molecular mapping and characterization of the silkworm apodal mutant

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Molecular mapping and characterization of the silkworm apoda...

Mutation of a Cuticular Protein, BmorCPR2, Alters Larval Body Shape and Adaptability in Silkworm, Bombyx mori

中国蚕学会第九届青年学术研讨会

作者： Peng Chen Xiao-Ling Tong Ming-Yue Fu Hai Hu Jiang-Bo Song Song-Zhen He ting-ting gai Fang-Yin Dai Cheng Lu State Key Laboratory of Silkworm Genome Biology Southwest University Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural Ministry Southwest University

The morphological diversity of insects is important for their survival;in essence,it results from the differential expression of genes during development of the insect *** silkworm apodal（ap） mutant has degraded thoracic legs making crawling and eating difficult and the female is sterile,which is an ideal subject for studying the molecular mechanisms of ***,we confirmed that the infertility of ap female moths is a result of the degradation of the bursa *** cloning of ap locus and expression analyses reveal that the Bombyx mori sister of odd and bowl（Bmsob） gene is a strong candidate for the ap *** expression of Bmsob is down-regulated,while the corresponding Hox genes are up-regulated in the ap mutant compared to the wild *** with the dual luciferase assay present a declined activity of the Bmsob promoter in the ap ***,we demonstrate that Bmsob can inhibit Hox gene expression directly and by suppressing the expression of other genes,including the Bm Dsp *** results of this study are an important contribution to our understanding of the diversification of insect body plan.

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Mutation of a Cuticular Protein, BmorCPR2, Alters Larval Bod...

The genetic basis and improvement of photosynthesis in tomato

第十二届家（柞）蚕遗传育种暨良种繁育学术研讨会

作者： Liang Qiao Gao Xiong Ri-xin Wang Song-zhen He Jie Chen Xiao-ling Tong Hai Hu Chun-lin Li ting-ting gai Ya-qun Xin Xiao-fan Liu Bin Chen Zhong-huai Xiang Cheng Lu Fang-yin Dai State Key Laboratory of Silkworm Genome Biology Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural Ministry Southwest University Institute of Entomology and Molecular Biology College of Life Sciences Chongqing Normal University

Cuticular proteins（CPs） are crucial components of the insect cuticle. Although numerous genes encoding cuticular proteins have been identified in known insect genomes to date, their functions in maintaining insect body shape and adaptability remain largely unknown. In the current study, positional cloning led to the identification of a gene encoding an RR1-type cuticular protein, Bmor CPR2, highly expressed in larval chitin-rich tissues and at the mulberry leaf-eating stages, which is responsible for the silkworm stony mutant. In the Dazao-stony strain, the Bmor CPR2 allele is a deletion mutation with significantly lower expression, compared to the wild-type Dazao strain. Dysfunctional Bmor CPR2 in the stony mutant lost chitin binding ability, leading to reduced chitin content in larval cuticle, limitation of cuticle extension, abatement of cuticle tensile properties, and aberrant ratio between internodes and intersegmental folds. These variations induce a significant decrease in cuticle capacity to hold the growing internal organs in the larval development process, resulting in whole-body stiffness, tightness, and hardness, bulging intersegmental folds, and serious defects in larval adaptability. To our knowledge, this is the first study to report the corresponding phenotype of stony in insects caused by mutation of RR1-type cuticular protein. Our findings collectively shed light on the specific role of cuticular proteins in maintaining normal larval body shape and will aid in the development of pest control strategies for the management of Lepidoptera.

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Horticultural Plant Journal 2025年第1期11卷 69-84页

作者： Haiqiang Dong Fangman Li Xiaoxiao Xuan John Kojo Ahiakpa Jinbao Tao Xingyu Zhang Pingfei Ge Yaru Wang Wenxian gai Yuyang Zhang National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops Huazhong Agricultural UniversityWuhan 430070 China Hubei Hongshan Laboratory Wuhan 430070China Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityWuhan 430070China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministryof AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China

Photosynthesis is one the most important chemical reaction in plants,and it is the ultimate energy source of any living *** light and dark reactions are two essential phases of *** reaction harvests light energy to synthesize ATP and NADPH through an electron transport chain,and as well as giving out O_(2);dark reaction fixes CO_(2) into six carbon sugars by utilizing NADPH and energy from ***,plants convert optical energy into chemical energy for maintaining growth and development through absorbing light ***,firstly,we highlighted the biological importance of photosynthesis,and hormones and metabolites,photosynthetic and regulating enzymes,and signaling components that collectively regulate photosynthesis in ***,we reviewed the advances in tomato photosynthesis,including two aspects of genetic basis and genetic *** genes regulating tomato photosynthesis are gradually uncovered,and the interaction network among those genes remains to be ***,the photosynthesis occurring in fruit of tomato and the relationship between photosynthesis in leaf and fruit were *** and fruits are photosynthate sources and sinks of tomato respectively,and interaction between photosynthesis in leaf and fruit ***,future perspectives that needs to be addressed on tomato photosynthesis were proposed.

关键词： Photosynthesis Tomato Genetics Improvement Leaf Fruit

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang Liu tingting Li Chengcheng gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

Literature study on traditional Chinese medicine syndromes after renal transplantation

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World Journal of Transplantation 2025年第1期15卷 150-155页

作者： Yun-Peng Guo Ling-Xue Bao Yu-Yang Wang Quan Wen gai Hang Bo Chen Tongliao Clinical Medical College Inner Mongolia Medical UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Department of Urology Tongliao People's HospitalTongliao 028000Inner Mongolia Autonomous RegionChina

BACKGROUND Kidney transplantation is the most effective means to treat patients with renal failure,but its postoperative problems such as rejection reactions,immunosuppressant poisoning,chronic transplant kidney nephropathy,*** have not been effectively *** study searched for literature on traditional Chinese medicine(TCM)syndromes after kidney transplantation in China,conducted statistical analysis of the results,and sought to identify the underlying *** To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical *** The literature pertaining to TCM syndromes in renal transplantation,published in the China National Knowledge Infrastructure,Wanfang database,and WIP database from 1970 to 2021,was meticulously searched and comprehensively and statistically *** Following the established inclusion and exclusion criteria,13 studies were selected for ***-renal transplantation,no significant discrepancy was noted among the groups based on the location of TCM ***,when categorized according to TCM pathogenic factors,the groups with spleen and kidney yang deficiency,as well as liver and kidney yin deficiency,exhibited a statistically significant difference in the *** Currently,the research on TCM syndromes pertaining to renal transplantation is in its nascent *** is imperative to conduct a multicentric,large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.

关键词： Kidney transplantation Syndrome Literature analysis Traditional Chinese medicine Systematic review

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跨媒介艺术视角下喜剧电影的剧场性考察

当代电影 2025年第2期 121-128页

作者：盖琪广州大学人文学院

从跨媒介艺术的视角来看,喜剧电影在很大程度上保留了源于19世纪末20世纪初现代戏剧场域的剧场性,并将之转化为喜剧电影自身的核心特质之一。20世纪20年代后,随着商业电影场域对封闭故事世界和沉浸式观影幻觉的偏好,喜剧电影的剧场性自... 详细信息

从跨媒介艺术的视角来看,喜剧电影在很大程度上保留了源于19世纪末20世纪初现代戏剧场域的剧场性,并将之转化为喜剧电影自身的核心特质之一。20世纪20年代后,随着商业电影场域对封闭故事世界和沉浸式观影幻觉的偏好,喜剧电影的剧场性自觉无论在创作中还是在研究中都受到了抑制。进入21世纪以来,随着媒介形态的飞速发展和喜剧文化逻辑的内在变革,喜剧电影的剧场性自觉大幅上升,情境性剧场性和表演性剧场性等典型策略/表征日益凸显,由此也召唤着我们对之做出更为深入的学理考察。

关键词：跨媒介艺术喜剧电影剧场性受众