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Transmissive-detected laser speckle contrast imaging for blood flow monitoring in thick tissue: from Monte Carlo simulation to experimental demonstration

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Light(Science & Applications) 2021年第12期10卷 2492-2506页

作者： Dong-yu Li Qing Xia ting-ting yu Jing-Tan Zhu Dan Zhu Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology430074 WuhanHubeiChina MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology430074 WuhanHubeiChina

Laser speckle contrast imaging(LSCI)is a powerful tool to monitor blood flow distribution and has been widely used in studies of microcirculation,both for animal and clinical ***,LSCI usually works on reflectivedetected ***,it could provide promising temporal and spatial resolution for in vivo applications only with the assistance of various tissue windows,otherwise,the overlarge superficial static speckle would extremely limit its contrast and ***,we systematically investigated the capability of transmissive-detected LSCI(TR-LSCI)for blood flow monitoring in thick *** Monte Carlo simulation,we theoretically compared the performance of transmissive and reflective *** was found that the reflective-detected mode was better when the target layer was at the very surface,but the imaging quality would rapidly decrease with imaging depth,while the transmissivedetected mode could obtain a much stronger signal-to-background ratio(SBR)for thick *** further proved by tissue phantom,animal,and human experiments that in a certain thickness of tissue,TR-LSCI showed remarkably better performance for thick-tissue imaging,and the imaging quality would be further improved if the use of longer wavelengths of near-infrared ***,both theoretical and experimental results demonstrate that TR-LSCI is capable of obtaining thick-tissue blood flow information and holds great potential in the field of microcirculation research.

关键词： reflective thick speckle

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淫羊藿苷预处理增强人牙周膜干细胞对M1型巨噬细胞的影响

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中国组织工程研究 2025年第7期29卷 1328-1335页

作者：喻婷吕冬梅邓浩孙涛程钎西南医科大学口颌面修复重建和再生泸州市重点实验室四川省泸州市646000 西南医科大学口腔医学研究所四川省泸州市646000 西南医科大学附属口腔医院正畸科四川省泸州市646000 西南医科大学口腔医学院四川省泸州市646000

背景:人牙周膜干细胞对M1型巨噬细胞促炎功能有一定抑制作用,具有抗炎等药理活性的淫羊藿苷是否能增强人牙周膜干细胞对M1型巨噬细胞的抑制作用尚不明确。目的:探究淫羊藿苷预处理人牙周膜干细胞后对M1型巨噬细胞的影响。方法:分离培养... 详细信息

背景:人牙周膜干细胞对M1型巨噬细胞促炎功能有一定抑制作用,具有抗炎等药理活性的淫羊藿苷是否能增强人牙周膜干细胞对M1型巨噬细胞的抑制作用尚不明确。目的:探究淫羊藿苷预处理人牙周膜干细胞后对M1型巨噬细胞的影响。方法:分离培养原代人牙周膜干细胞,并进行鉴定。对THP-1细胞进行诱导,采用免疫荧光染色及PCR进行M1型巨噬细胞鉴定。用含浓度10^(-7),10^(-6),10^(-5),10^(-4)mol/L淫羊藿苷的α-MEM完全培养基培养人牙周膜干细胞1,3,5,7 d,采用CCK-8法筛选合适的淫羊藿苷浓度进行实验。将α-MEM完全培养基、未处理的人牙周膜干细胞α-MEM条件培养基及淫羊藿苷预处理24 h的人牙周膜干细胞α-MEM条件培养基与RPMI-1640完全培养基以1∶1的比例对M1型巨噬细胞进行条件培养,分别为对照组、未处理组及预处理组,24 h后RT-PCR法检测M1型巨噬细胞炎症因子的mRNA表达情况;ELISA法检测M1型巨噬细胞炎症因子的蛋白表达情况;Western blot检测M1/M2型巨噬细胞表面标记物及核转录因子κB通路相关蛋白的表达。结果与结论:(1)CCK-8检测结果显示,10^(-7),10^(-6),10^(-5),10^(-4)mol/L淫羊藿苷对人牙周膜干细胞均无细胞毒性,且从第5天起,各浓度都提高了细胞活力,促进细胞增殖,选择10^(-4)mol/L淫羊藿苷进行后续实验。(2)RT-PCR法及ELISA检测结果显示,与对照组相比,未处理组及预处理组均降低了M1型巨噬细胞白细胞介素1β、白细胞介素6及肿瘤坏死因子α的表达与分泌(P<0.05),且预处理组低于未处理组(P<0.05)。(3)Western blot检测结果显示,与未处理组相比,预处理组CD86的表达明显降低(P<0.05);与对照组相比,未处理组和预处理组M2型巨噬细胞表面标志物CD206的表达均升高(P<0.01),且预处理组明显高于未处理组(P<0.01);M1型巨噬细胞经24 h条件培养后,与对照组相比,核转录因子κB/P65的表达在未处理组和预处理组均有降低(P<0.01),p-IκBα的表达仅在预处理组降低(P<0.01);与未处理组相比,预处理组核转录因子κB/P65和p-IκBα的表达均显著降低(P<0.05),而IκBα在3组中的表达差异无显著性意义。(4)上述结果证实,淫羊藿苷增强了人牙周膜干细胞对M1型巨噬细胞的抑制作用,此作用可能与抑制了巨噬细胞的核转录因子κB信号通路相关。

关键词：人牙周膜干细胞淫羊藿苷巨噬细胞条件培养基共培养表面标志物炎症因子抗炎核转录因子κB信号通路

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Phase Behavior of Amphiphiles at Liquid Crystals/Water Interface: A Coarse-grained Molecular Dynamics Study

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Chinese Journal of Polymer Science 2014年第10期32卷 1298-1310页

作者： yu-ting Ouyang 郭洪霞 Beijing National Laboratory for Molecular Sciences (BNLMS) State Key Laboratory for Polymer Physics and ChemistryInstitute of Chemistry Chinese Academy of Sciences

We present a coarse-grained molecular dynamics simulation study of phase behavior of amphiphilic monolayers at the liquid crystal （LC）/water interface. The results revealed that LCs at interface can influence the lateral ordering of amphiphiles. Particularly, the amphiphile tails along with perpendicularly penetrated LCs between tails undergo a two-dimension phase transition from liquid-expanded into a liquid-condensed phase as their area density at interface reaches 0.93. While, the liquid-condensed phase of the monolayer never appears at oil/water interface with isotropic shape oil particles. These findings reveal the penetration of anisotropic LC can promote ordered lateral organization of amphiphiles. Moreover, we find the phase transition point is shifted to lower surface coverage of amphiphiles when the LCs have larger affinity to the amphiphile tails.

关键词： Phase behavior Amphiphilic monolayer Lateral ordering Molecular simulation Liquid crystal.

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Movement behavior and separation of Al_(2)O_(3)from Al melt under rotating magnetic field

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China Foundry 2024年第6期21卷 625-633页

作者： Shan-hao Du yu-ting Shen yu-bo Zhang Shao-jun yu De-hua Liu ting-ju Li Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024LiaoningChina Ningbo Institute of Dalian University of Technology Ningbo 315016ZhejiangChina School of Mechanics Dalian University of TechnologyDalian 116024LiaoningChina

The effect of a rotating magnetic field(RMF)on the distribution of Al_(2)O_(3)particles with an Al melt was studied by means of simulation and *** results show that Al_(2)O_(3)particles(diameter of 1-10μm,1wt.%)are significantly agglomerated at the top of ingots when subjected to an RMF,and their distribution is influenced by both the intensity and the duration of RMF *** optimal separation efficiency is achieved with the magnetic intensity of 12 mT for 120 *** number of the particles at the bottom and the middle decreases by 64.5%and 69.7%,respectively,while that at the top increases by 242.5%compared to the condition without an ***,if further increase the intensity or the duration of RMF,it can induce turbulent flows that draw some of the separated Al_(2)O_(3)particles back into the melt,reducing separation *** calculation results show that as the magnetic intensity increases from 6 mT to 18 mT,the velocity difference between the particles and the Al melt flow quadruples,increasing from 0.013 m·s^(-1)to 0.066 m·s^(-1).Driven by this velocity difference,centrifugal motion,and secondary circulation,Al_(2)O_(3)particles tend to migrate upwards within the melt,facilitating the separation of impurity particles and enhancing the purity of the melt.

关键词： Al_(2)O_(3)particles rotating magnetic field numerical simulation electromagnetic purification

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The Gleason's problem on normal weight general function spaces in the unit ball of C^(n)

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Applied Mathematics(A Journal of Chinese Universities) 2023年第4期38卷 604-613页

作者： GUO yu-ting ZHANG Xue-jun College of Mathematics and Statistics Hunan Normal UniversityChangsha 410006China

In this paper,we first discuss the boundedness of certain integral operator T_(t) on the normal weight general function space F(p,μ,s)in the unit ball Bnof C^(n).As an application of this operator,we prove that the G... 详细信息

关键词： Gleason's problem solvability F(p,μ,s)space integral operator

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Effects of Neuregulins on Invasion and Metastasis of Non-overexpression ErbB2 Breast Cancer Cells

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Chinese Journal of Cancer Research 2009年第2期21卷 115-121页

作者： Ya-mei Zhang ting-ting Zhao Hua-yu Deng Laboratory of Stem Cell and Tissue Engineering Chongqing Medical University Chongqing 400016 China

Objective： To explore the effects of neuregulins on ErbB2 receptor signal transduction pathway activation, and invasion and metastasis of non-overexpression ErbB2 breast cancer cell MDA-MB-231. Methods： The expressions of neuregulin were detected by immunocytochemistry and Western blot. MDA-MB-231 cells were treated with ErbB2 kinase inhibitor AG825. Proliferations were measured with MTT assay. Invasion and metastasis of MDA-ME-231 cells were evaluated with transwell chamber. The enzyme activities of MMP-2 and MMP-9 were detected by gelatin zymography. The expressions of MMP-2 and HIF-1α were detected by Western blot. Results： MDA-MB-231 cells expressed a relatively higher level of neuregulin. In Western blot, the positive reaction band was found at 44KD which coincides with the molecular weight of NRG. When MDA-MB-231 cells were treated with AG825, the proliferation was inhibited in a time-dose-dependent manner （P〈0.01）, invasion and metastasis were also depressed （P〈0.05）. The enzyme activities of MMP-2 and MMP-9 were lower （P〈0.05）. The expression levels of MMP-2 and HIF-lct were decreased （P〈0.05）. Conclusion： Our study indicates that neuregulins are synthesized in MDA-MB-231 cells as transmembrane proteins, neuregulins could activate ErbB2 receptor signal transduction pathway by autocrine or paracrine secretion, and induce invasion and metastasis of MDA-MB-231 cells.

关键词： Non-overexpression ErbB2 breast cancer Neuregulins Invasion Metastasis

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THEORETICAL INVESTIGATION ON THE DYNAMIC PERFORMANCE OF CMUT FOR DESIGN OPTIMIZATION

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Acta Mechanica Solida Sinica 2013年第1期26卷 99-110页

作者： ting yu Wenchao Zhou Peng Xu Fengqi yu Qin Qian Department of Integrated Electronics Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences The Chinese University of Hong Kong School of Civil Engineering and Mechanics Huazhong University of Sciences and Technology

Although many modeling approaches exist for analyzing the behavior of capacitive micro-machined ultrasonic transducers （CMUTs）, the relation equation between the design pa- rameters with input and output is still lacking. What there is can only be used to analyze the dynamic performance of CMUT indirectly and qualitatively, such as stiffness and sound pressure. A lumped-parameter theoretical model based on the dynamic theory is proposed in this paper. The relation equations between the design parameters with inputs and outputs are given. The results obtained by the proposed model agree well with those by finite element method （FEM） simulation. The dynamic and static behavior of CMUT can be clearly depicted, which is helpful for design and optimization iterations. This shows that the proposed model makes it easier to optimize the parameters of a CMUT with respect to output and bandwidth directly and to better understand the influence of each parameter.

关键词： CMUT dynamic theory finite element method

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Simulation procedure of unconfined seepage with an inner seepage face in a heterogeneous field

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Science China(Physics,Mechanics & Astronomy) 2013年第6期56卷 1139-1147页

作者： WU MengXi YANG LianZhi yu ting Institute of Mechanics Chinese Academy of Sciences Hydrochina Chengdu Engineering Corporation

An inner seepage face phenomenon is given and a numerical simulation procedure has been *** may appear at the interface of two materials when an unconfined seepage flows from a porous media to a coarser porous media with a higher *** and divergent problems may arise both in a saturated-only and in a variably saturated analysis while an inner seepage face is not simulated with a special *** position of the seepage face is determined during the nonlinear iteration process and the flux of the inner seepage face nodes is transferred to the downstream side *** and efficiency of the procedure are illustrated by the simulation of two dimensional steady state seepage examples of heterogeneous zoned dams which is usually used to validate *** analysis of a three-dimensional earth core rockfill dam is also presented *** procedure can also be applied to general transient seepage problems.

关键词： unconfined seepage inner seepage face finite element method free surface

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Low-Brightness Object Recognition Based on Deep Learning

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Computers, Materials & Continua 2024年第5期79卷 1757-1773页

作者： Shu-Yin Chiang ting-yu Lin Department of Information and Telecommunications Engineering Ming Chuan UniversityTaoyuan City333Taiwan

This research focuses on addressing the challenges associated with image detection in low-light environments,particularly by applying artificial intelligence techniques to machine vision and object recognition *** primary goal is to tackle issues related to recognizing objects with low brightness *** this study,the Intel RealSense Lidar Camera L515 is used to simultaneously capture color information and 16-bit depth information *** detection scenarios are categorized into normal brightness and low brightness *** the system determines a normal brightness environment,normal brightness images are recognized using deep learning *** low-brightness situations,three methods are proposed for *** first method is the SegmentationwithDepth image(SD)methodwhich involves segmenting the depth image,creating amask from the segmented depth image,mapping the obtained mask onto the true color(RGB)image to obtain a backgroundreduced RGB image,and recognizing the segmented *** second method is theHDVmethod(hue,depth,value)which combines RGB images converted to HSV images(hue,saturation,value)with depth images D to form HDV images for *** third method is the HSD(hue,saturation,depth)method which similarly combines RGB images converted to HSV images with depth images D to form HSD images for *** experimental results,in normal brightness environments,the average recognition rate obtained using image recognition methods is 91%.For low-brightness environments,using the SD method with original images for training and segmented images for recognition achieves an average recognition rate of over 82%.TheHDVmethod achieves an average recognition rate of over 70%,while the HSD method achieves an average recognition rate of over 84%.The HSD method allows for a quick and convenient low-light object recognition *** research outcome can be applied to nighttime surveillance systems or nighttime road safety systems

关键词： Low-brightness depth image image segmentation image recognition HDV HSD

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Facile Synthesis of Bi2MoO6 Nanosheets@Nitrogen and Sulfur Codoped Graphene Composites for Sodium-ion Batteries

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Chemical Research in Chinese Universities 2020年第1期36卷 115-119页

作者： XU Xin LI Mingyan yu ting Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University637371Singapore School of Electrical Engineering Xi'an Jiaotong UniversityXi'an 710049P.R.China

Recently,sodium-ion batteries gradually become the promising alternative to lithium-ion batteries because of cost *** this work,a kind of Bi2MoO6 nanosheets@N,S codoped graphene composite is designed and fabricated for sodium storage *** characterizations are employed to investigate its morphology,structure and chemical *** evaluated as an anode material for sodium-ion batteries,the as-prepared composite is able to display a specific capacity of 254 mA·h/g after 50 cycles at a current density of 0.2 A/g,and 186 mA·h/g at 1.6 A/g during the rate capability *** a result,the further morphology and structure optimization is still required for high performance sodium-ion batteries.

关键词： Bi2MoO6 Nanosheet Codoped graphene Composite Sodium-ion battery

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