检索结果-南通市图书馆

energy & environmental Materials 2024年第3期7卷 72-83页

作者： Sheng Liu chaozhu Shu Yu Yan Dayue Du Longfei Ren ting Zeng Xiaojuan Wen Haoyang Xu Xinxiang Wang Guilei Tian Ying Zeng college of Materials and chemistry&chemical engineering Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China Institute of Fundamental and Frontier Sc.ences University of Electronic Science and Technology of ChinaChengdu 611731China State Key Laboratory of Polymer Materials engineering Polymer Research InstituteSichuan UniversityChengdu 610065China

The interfacial chemistry of solid electrolyte interphases(SEI)on lithium(Li)electrode is directly determined by the structural chemistry of the electric double layer(EDL)at the ***,a strategy for regulating the structural chemistry of EDL via the introduction of intermolecular hydrogen bonds has been proposed(p-hydroxybenzoic acid(pHA)is selected as proof-of-concept).According to the molecular dynamics(MD)simulation and density functional theory(DFT)calculation results,the existence of hydrogen bonds realizes the anion structural rearrangement in the EDL,reduces the lowest unoccupied molecular orbital(LUMO)energy level of anions in the EDL,and the number of free solvent molecules,which promotes the formation of inorganic species-enriched SEI and eventually achieves the dendrite-free Li *** on this strategy,Li‖cu cells can stably run over 185 cycles with an accumulated active Li loss of only 2.27 mAh cm^(-2),and the long-term cycle stability of Li‖Li cells is increased to 1200 *** addition,the full cell pairing with the commercial LiFePO_(4)(LFP)cathodes exhibits stable cycling performance at 1c,with a capacity retention close to 90%after 200 cycles.

关键词： electric double layer electrolyte additives intermolecular hydrogen bonds Li metal batteries p-Hydroxybenzoic acid

Genetic Analysis of Two Novel GPI Variants Disrupting H Bonds and Localization characteristics of 55 Gene Variants Associated with Glucose-6-phosphate Isomerase Defic.ency

在线全文

学校读者我要写书评

暂无评论

current Medical Sc.ence 2024年第2期44卷 426-434页

作者： Bi-xin XI Si-ying LIU Yu-ting XU De-dong ZHANG Qun HU Ai-guo LIU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Glucose-6-phosphate isomerase(GPI)defic.ency is a rare hereditary nonspherocytic hemolytic anemia caused by GPI gene *** disorder exhibits wide heterogeneity in its clinical manifestations and molecular characteristics,often posing challenges for precise diagnoses using conventional *** this end,this study aimed to identify the novel variants responsible for GPI defic.ency in a chinese ***:The clinical manifestations of the patient were summarized and analyzed for GPI defic.ency phenotype *** compound heterozygous variants of the GPI gene,c.174c>A(***58Lys)and c.1538G>T(***513Leu),were identified using whole-exome and Sanger *** AlphaFold program and chimera software were used to analyze the effects of compound heterozygous variants on GPI ***:By characterizing 53 GPI missense/nonsense variants from previous literature and two novel missense variants identified in this study,we found that most variants were located in exons 3,4,12,and 18,with a few localized in exons 8,9,and *** study identified novel compound heterozygous variants associated with GPI *** pathogenic variants disrupt hydrogen bonds formed by highly conserved GPI amino ***:Early family-based sequencing analyses,especially for patients with congenital anemia,can help increase diagnostic accuracy for GPI defic.ency,improve child healthcare,and enable genetic counseling.

关键词： glucose-6-phosphate isomerase defic.ency whole-exome sequencing compound heterozygous variants genetic characterization hydrogen bond

Sous le voile blanc Au coeur de la saison froide,floraison des sports d'hiver au Xinjiang

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国与非洲（法文版） 2024年第3期16卷 22-23页

作者： LIU ting 不详

Malgre des temperatures descendantes jusqu'a moins 20 degres celsius en decembre,la station de ski du mont Jiangjun a Altay,situee au Xinjiang,attire une foule de skieurs aux telesieges.

关键词： des Xinjiang les

Relationship between Phenotypic changes of Dendritic cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with cHB

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and environmental Sc.ences 2024年第3期37卷 303-314页

作者： YANG Liu WANG Shi Yu JIANG ting ting DenG Wen cHANG Min WU Shu Ling cAO Wei Hua LU Yao SHen Ge LIU Ru Yu GAO Yuan Jiao XU Meng Jiao HU Lei Ping ZHANG Lu XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China center for Infectious Diseases Second Affiliated Hospital of Air Force Medical UniversityXi'an 710038ShaanxiChina Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China

Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules cD40,cD80,cD83,and *** This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow *** In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that cD141/cD1c double negative myeloid dendritic cell(DNmDc)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and cD86 mean fluorescence intensity of DNmDcs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P allced DNmDcs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.

关键词： cHB Dendritic cells Intermittent Interferon Therapy Plateau Phase

Recent advances in Fe-N-c-and co-N-c-based materials as bifunctional electrocatalysts for oxygen reduction and oxygen evolution

在线全文

学校读者我要写书评

暂无评论

Sc.ence china chemistry 2024年第4期67卷 1137-1160页

作者： Hui-Min Xu Hong-Rui Zhu c.en-Jin Huang Zhi-Jie Zhang ting-Yu Shuai Qi-Ni Zhan Gao-Ren Li college of Materials Sc.ence and engineering Sichuan UniversityChengdu 610065China

Fe-nitrogen-carbon(Fe-N-c)-and co-nitrogen-carbon(co-N-c)-based electrocatalysts have been widely concerned because of their high OER/ORR activity,low metal cost,and simple *** exploration of Fe-N-c and co-N-c single atombased catalysts with high activity and stability to overcome the slow kinetics of oxygen reduction and oxygen evolution reactions is also the key to the development of effic.ent electrolytic water,fuel cells,and rechargeable metal-air ***-N-c and co-N-c single atom-based electrocatalysts have the advantages of a high utilization rate of metal atoms and high electrocatalytic activity,and are ideal catalysts for promoting electrochemical energy conversion and *** general principles of designing Fe-N-c and co-N-c single atom-based electrocatalysts are reviewed in this ***,the strategies to improve the bifunctional catalytic activity and stability are ***,the challenges and prospects of Fe-N-c and co-N-c single atom-based catalysts are well *** review will provide a reference for the directed optimization of Fe-N-c and co-N-c single atom-based catalysts.

关键词： Fe-N-c co-N-c single atom bifunctional oxygen electrocatalysts

constructing a nomogram to predict overall survival of colon cancer based on computed tomography characteristics and clinicopathological factors

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第10期16卷 4104-4114页

作者： Zhe-Xing Hu Yin Li Xuan Yang Yu-Xia Li Yao-Yao He Xiao-Hui Niu ting-ting Nie Xiao-Fang Guo Zi-Long Yuan Department of Radiology Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079Hubei ProvinceChina Department of Radiology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina college of Informatics Huazhong Agriculture UniversityWuhan 430070Hubei ProvinceChina

BAcKGROUND The colon cancer prognosis is influenced by multiple factors,including clinical,pathological,and non-biological ***,only a few studies have focused on computed tomography(cT)imaging ***,this study aims to predict the prognosis of patients with colon cancer by combining cT imaging features with clinical and pathological characteristics,and establishes a nomogram to provide critical guidance for the individualized *** To establish and validate a nomogram to predict the overall survival(OS)of patients with colon *** A retrospective analysis was conducted on the survival data of 249 patients with colon cancer confirmed by surgical pathology between January 2017 and December *** patients were randomly divided into training and testing groups at a 1:1 *** and multivariate logistic regression analyses were performed to identify the independent risk factors associated with OS,and a nomogram model was constructed for the training *** curves were calculated using the Kaplan–Meier *** concordance index(c-index)and calibration curve were used to evaluate the nomogram model in the training and testing *** Multivariate logistic regression analysis revealed that lymph node metastasis on cT,perineural invasion,and tumor classification were independent prognostic factors.A nomogram incorporating these variables was constructed,and the c-index of the training and testing groups was 0.804 and 0.692,*** calibration curves demonstrated good consistency between the actual values and predicted probabilities of *** A nomogram combining cT imaging characteristics and clinicopathological factors exhibited good discrimination and *** can aid clinicians in risk stratification and postoperative monitoring and provide important guidance for the individualized treatment of patients with colon cancer.

关键词： colon cancer Nomogram Prognosis Overall survival computed tomography clinicopathology

Management of locally advanced non-small cell lung cancer: State of the art and future directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

cancer communications 2024年第1期44卷 23-46页

作者： Da Miao Jing Zhao Ying Han Jiaqi Zhou Xiuzhen Li ting Zhang Wen Li Yang Xia Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory and Critical Care MedicineSecond Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangP.R.China Department of Oncology Shaoxing Second HospitalShaoxingZhejiangP.R.China Department of Medical Oncology Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangP.R.China Department of chemoradiotherapy The Affiliated People’s Hospital of Ningbo UniversityNingboZhejiangP.R.China Key Discipline of Jiaxing Respiratory Medicine construction Project Jiaxing Key Laboratory of Precision Treatment for Lung CancerAffiliated Hospital of Jiaxing UniversityJiaxingZhejiangP.R.China Department of Pathology Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangP.R.China Department of Radiation Oncology Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangP.R.China cancer center Zhejiang UniversityHangzhouZhejiangP.R.China

Lung cancer is the second most common and the deadliest type of cancer ***,non-small cell lung cancer(NScLc)is the most com-mon pathological type of lung cancer;approximately one-third of affected patients have locally advanced NScLc(LA-NScLc,stage III NScLc)at *** of its heterogeneity,LA-NScLc often requires multidisciplinary ***,the prognosis of affected patients is much below satisfac-tion,and the efficacy of traditional therapeutic strategies has reached a *** the emergence of targeted therapies and immunotherapies,as well as the continuous development of novel radiotherapies,we have entered an era of novel treatment paradigm for ***,we reviewed the landscape of relevant therapeutic modalities,including adjuvant,neoadjuvant,and periop-erative targeted and immune strategies in patients with resectable LA-NScLc with/without oncogenic alterations;as well as novel combinations of chemora-diation and immunotherapy/targeted therapy in unresectable *** addressed the unresolved challenges that remain in the field,and examined future directions to optimize clinical management and increase the cure rate of LA-NScLc.

关键词： locally advanced non-small cell lung cancer neoadjuvant therapy adjuvant therapy immunotherapy targeted therapy

Therapeutic efficacy of methylprednisolone sodium succinate via diverse administration routes for mid-to high-frequency sudden sensorineural hearing loss

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of clinical cases 2024年第18期12卷 3321-3331页

作者： Xiang-Da Meng ting-ting Li Li-Min Deng Department of Otolaryngology The First Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161041Heilongjiang ProvinceChina Department of Otolaryngology Head and Neck Surgery Harbin Medical University Affiliated Fourth Hospital UniversityHarbin 150001Heilongjiang ProvinceChina Department of Facial Ward The First Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161041Heilongjiang ProvinceChina

BAcKGROUND Sudden sensorineural hearing loss(SSNHL),characterized by a rapid and unexplained loss of hearing,particularly at moderate to high frequencies,presents a significant clinical *** therapeutic use of methylprednisolone sodium succinate(MPSS)via different administration routes,in combination with conventional medications,remains a topic of *** To compare the therapeutic efficacy of MPSS administered via different routes in combination with conventional drugs for the treatment of mid-to high-frequency *** The medical records of 109 patients with mid-to high-frequency SSNHL were *** patients were divided into three groups based on the route of administration:Group A[intratympanic(IT)injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection],Group B(intravenous injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection),and Group c(single IT injection of MPSS).The intervention effects were compared and *** The posttreatment auditory thresholds in Group A(21.23±3.34)were significantly lower than those in Groups B(28.52±3.36)and c(30.23±4.21;Pcantly greater speech recognition rate(92.23±5.34)than Groups B and *** disappearance time of tinnitus,time to hearing recovery,and disappearance time of vertigo in Group A were significantly shorter than those in Groups B and c(Pctive rate in Group A(97.56%)was significantly greater than that in Groups B and c(77.14%and 78.79%,χ^(2)=7.898,P=0.019).Moreover,the incidence of adverse reactions in Groups A and c was significantly lower than that in Group B(4.88%,3.03%vs 2.57%,χ^(2)=11.443,P=0.003),and the recurrence rate in Group A was significantly lower than that in Groups B and c(2.44%vs 20.00%vs 21.21%,χ^(2)=7.120,P=0.028).cONcLUSION IT injection of MPSS combined with conventional treatment demonstrates superior efficacy and safety compared to systemic administ

关键词： Sudden loss of hearing at middle-and high-frequency of the descending type Methylprednisolone sodium succinate Intratympanic injection Intravenous injection

Facile construction of Mxene-supported niobium hydride nanoparticles toward reversible hydrogen storage in magnesium borohydride

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4387-4400页

作者： Ao Xia Jia-Guang Zheng Qing-Bo Zhang Yu-Gang Shu c.eng-Guo Yan Liu-ting Zhang Zhan-Liang Tao Li-Xin c.en School of energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Key Laboratory of Advanced energy Materials chemistry(Ministry of Education) Nankai UniversityTianjin 300071China State Key Laboratory of Silicon and Advanced Semiconductor Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

The facile construction of nanoscale NbH_(x)supported by Ti_(3)c_(2)(NbH_(x)@Ti_(3)c_(2))was achieved using facile ball milling strategy to improve the hydrogen desorption kinetics and reversibility of magnesium borohydride(Mg(BH_(4))_(2)).The doping of 30 wt%NbH_(x)@Ti_(3)c_(2)catalyst reduced the onset dehydrogenation temperature of Mg(BH_(4))_(2)to 71.2℃.Additionally,the Mg(BH_(4))_(2)+30NbH_(x)@Ti_(3)c_(2)composite achieved remarkable hydrogen release of over 9.2 wt%at a temperature as low as 230℃,indicating unexpected dehydrogenation ***,the reversibility of NbH_(x)@Ti_(3)c_(2)doped Mg(BH_(4))_(2)was retained to more than 4.2 wt%after four cycles,which was increased by 68%compared to that of undoped Mg(BH_(4))_(2).The strong catalysis of NbH_(x)@Ti_(3)c_(2)catalyst could be attributed to the synergistic effect of NbH_(x)and Ti_(3)c_(2)in hydrogen spillover and ***_(x)acted as a"hydrogen pump"for effective hydrogen spillover,while Ti_(3)c_(2)created numerous diffusion channels for hydrogen dissolution and provided the active catalytic site to facilitate the re/dehydrogenation of Mg(BH_(4))_(2).

关键词： Hydrogen storage Magnesium borohydride catalysts Mxene

Pre-operative enhanced magnetic resonance imaging combined with clinical features predict early recurrence of hepatocellular carcinoma after radical resection

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1192-1203页

作者： Jian-Ping c.en Ri-Hui Yang Tian-Hui Zhang Li-An Liao Yu-ting Guan Hai-Yang Dai Department of Intervention Meizhou People’s HospitalMeizhou 514031Guangdong ProvinceChina Department of Medical Imaging Meizhou People’s HospitalMeizhou 514031Guangdong ProvinceChina Department of Medical Imaging Huizhou Municipal Central HospitalHuizhou 516001Guangdong ProvinceChina

BAcKGROUND Indentifying predictive factors for postoperative recurrence of hepatocellular carcinoma(Hcc)has great significance for patient *** To explore the value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced magnetic resonance imaging(MRI)combined with clinical features in predicting early recurrence of Hcc after *** A total of 161 patients with pathologically confirmed Hcc were *** patients were divided into early recurrence and non-early recurrence group based on the follow-up *** clinical,laboratory,pathological results and Gd-EOB-DTPA enhanced MRI imaging features were *** Of 161 patients,73 had early recurrence and 88 were had non-early *** analysis showed that patient age,gender,serum alpha-fetoprotein level,the Barcelona clinic Liver cancer stage,china liver cancer(cNLc)stage,microvascular invasion(MVI),pathological satellite focus,tumor size,tumor number,tumor boundary,tumor capsule,intratumoral necrosis,portal vein tumor thrombus,large vessel invasion,nonperipheral washout,peritumoral enhancement,hepatobiliary phase(HBP)/tumor signal intensity(SI)/peritumoral SI,HBP peritumoral low signal and peritumoral delay enhancement were significantly associated with early recurrence of Hcc after *** logistic regression analysis showed that patient age,MVI,cNLc stage,tumor boundary and large vessel invasion were independent predictive *** data validation indicated that the area under the curve of the combined predictors was 0.861,suggesting that multivariate logistic regression was a reasonable predictive model for early recurrence of *** Gd-EOB-DTPA enhanced MRI combined with clinical features would help predicting the early recurrence of Hcc after operation.

关键词： Hepatocellular carcinoma enhanced magnetic resonance imaging Microvascular invasion Hepatobiliary phase Recurrence