Therapeutic efficacy of methylprednisolone sodium succinate via diverse administration routes for mid-to high-frequency sudden sensorineural hearing loss
作者机构：Department of OtolaryngologyThe First Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161041Heilongjiang ProvinceChina Department of Otolaryngology Head and Neck SurgeryHarbin Medical University Affiliated Fourth Hospital UniversityHarbin 150001Heilongjiang ProvinceChina Department of Facial WardThe First Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161041Heilongjiang ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2024年第12卷第18期
页 面：3321-3331页
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
主 题：Sudden loss of hearing at middle-and high-frequency of the descending type Methylprednisolone sodium succinate Intratympanic injection Intravenous injection
摘 要：BACKGROUND Sudden sensorineural hearing loss(SSNHL),characterized by a rapid and unexplained loss of hearing,particularly at moderate to high frequencies,presents a significant clinical *** therapeutic use of methylprednisolone sodium succinate(MPSS)via different administration routes,in combination with conventional medications,remains a topic of *** To compare the therapeutic efficacy of MPSS administered via different routes in combination with conventional drugs for the treatment of mid-to high-frequency *** The medical records of 109 patients with mid-to high-frequency SSNHL were *** patients were divided into three groups based on the route of administration:Group A[intratympanic(IT)injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection],Group B(intravenous injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection),and Group C(single IT injection of MPSS).The intervention effects were compared and *** The posttreatment auditory thresholds in Group A(21.23±3.34)were significantly lower than those in Groups B(28.52±3.36)and C(30.23±4.21;P0.05).Group A also exhibited a significantly greater speech recognition rate(92.23±5.34)than Groups B and *** disappearance time of tinnitus,time to hearing recovery,and disappearance time of vertigo in Group A were significantly shorter than those in Groups B and C(P0.05).The total effective rate in Group A(97.56%)was significantly greater than that in Groups B and C(77.14%and 78.79%,χ^(2)=7.898,P=0.019).Moreover,the incidence of adverse reactions in Groups A and C was significantly lower than that in Group B(4.88%,3.03%vs 2.57%,χ^(2)=11.443,P=0.003),and the recurrence rate in Group A was significantly lower than that in Groups B and C(2.44%vs 20.00%vs 21.21%,χ^(2)=7.120,P=0.028).CONCLUSION IT injection of MPSS combined with conventional treatment demonstrates superior efficacy and safety compared to systemic administ
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