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Acoustic signal dominance in the multimodal communication of a nocturnal mammal

Current Zoology 2022年第5期68卷 592-599页

作者： Chun-Mian Zhang Cong-Nan Sun Jeffrey R Lucas Jiang Feng ting-lei Jiang Jilin Provincial Key Laboratory of Animal Resource Conservation and Utilization Northeast Normal University2555 Jingyue StreetChangchun 130117China Key Laboratory of Vegetation Ecology of Education Ministry Institute of Grassland ScienceNortheast Normal University2555 Jingyue StreetChangchun 130117China Department of Biological Sciences Purdue UniversityWest LafayetteIN 47907USA College of Life Science Jilin Agricultural University2888 Xincheng StreetChangchun 130118China

Multimodal communication in animals is common,and is particularly well studied in signals that include both visual and auditory *** signals that combine acoustic and olfactory components are less well *** communication plays a crucial role in agonistic interactions in many mammals,but relatively little is known about this type of communication in nocturnal ***,we used male Great Himalayan leaf-nosed bats Hipposideros armiger to investigate multimodal signal function in acoustic and olfactory aggressive *** monitored the physiological responses(heart rate[HR])when *** was presented with 1 of 3 stimuli:territorial calls,forehead gland odors,and bimodal signals(calls+odors).Results showed that *** rapidly increased their HR when exposed to any of the 3 ***,the duration of elevated HR and magnitude of change in HR increased significantly more when acoustic stimuli were presented alone compared with the presentation of olfactory stimuli *** contrast,the duration of elevated HR and magnitude of change in HR were significantly higher with bimodal stimuli than with olfactory stimuli alone,but no significant differences were found between the HR response to acoustic and bimodal *** previous work showed that acoustic and chemical signals provided different types of information;here we describe experiments investigating the responses to those *** results suggest that olfactory and acoustic signals are non-redundant signal components,and that the acoustic component is the dominant modality in male ***,at least as it related to *** study provides the first evidence that acoustic signals dominate over olfactory signals during agonistic interactions in a nocturnal mammal.

关键词： acoustic agonistic interactions heart rate Hipposideros armiger multimodal communication olfaction

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Fabrication, bacteriostasis and osteointegration properties researches of the additively-manufactured porous tantalum scaffolds loading vancomycin

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Bioactive Materials 2023年第6期24卷 450-462页

作者： Hu Qian ting lei Long Hua Yu Zhang Dongyu Wang Jiangyu Nan Wenbin Liu Yan Sun Yihe Hu Pengfei lei Department of Orthopedic Surgery Xiangya Hospital Central South UniversityChangsha410008China Department of Orthopedic Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityChina Department of Orthopaedic Surgery Affiliated Hospital of Zunyi Medical UniversityZunyiChina Xiangya School of Medicine Central South UniversityChangsha410008China

Infected bone defects(IBDs)remains a challenging problem for ***,routine management for IBDs has two stages:debridement and systematic antibiotics administration to control infection,and secondary grafting to repair bone *** the efficacy is not satisfactory,because the overuse of antibiotics may lead to systemic toxicity,and the emergence of drug-resistant bacteria,as well as the secondary surgery would cause additional trauma and economic burden to the ***,it is imperative to develop a novel scaffold for one-stage repair of *** this study,vancomycin(Van)was encapsulated into poly(lactic co-glycolic acid)(PLGA)microspheres through the double emulsion method,which were then loaded into the additively-manufactured porous tantalum(AM-Ta)through gelatin methacryloyl(GelMA)hydrogel to produce the composite Ta/GelMA hydrogel(Gel)/PLGA/vancomycin(Van)scaffolds for repairing *** characterization of the newly-developed scaffold indicated that the releasing duration of Van was over 2 *** experiments indicated good biocompatibility of the composite scaffold,as well as bacteriostasis and osteointegration properties,which showed great potential for clinical *** construction of this novel scaffold would provide new sight into the development of orthopaedic implants,shedding a novel light on the treatment of IBDs.

关键词： Infected bone defects Porous tantalum PLGA microspheres Vancomycin

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RNA表观遗传修饰与免疫细胞功能调控

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生命的化学 2024年第8期44卷 1458-1466页

作者：雷婷李云晖周烨郏凯威侯晋海军军医大学免疫与炎症全国重点实验室上海200433

RNA的表观遗传修饰是一种发生在RNA分子的化学修饰,在不改变DNA序列的情况下,它能够导致基因表达发生可遗传的改变。在天然免疫应答和适应性免疫应答中,RNA的表观遗传修饰通过影响RNA的稳定性、剪接、折叠、输出、运输和蛋白质翻译效率... 详细信息

RNA的表观遗传修饰是一种发生在RNA分子的化学修饰,在不改变DNA序列的情况下,它能够导致基因表达发生可遗传的改变。在天然免疫应答和适应性免疫应答中,RNA的表观遗传修饰通过影响RNA的稳定性、剪接、折叠、输出、运输和蛋白质翻译效率进而调控基因的表达,最终在免疫细胞的分化、成熟、应答反应方面发挥重要作用。本文就几种常见的RNA表观遗传修饰类型的生物学调控过程及其在多种免疫细胞中的功能和机制的研究进展作一综述。

关键词：表观遗传修饰 RNA 基因表达免疫细胞功能

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基于数据挖掘分析含天花粉成方制剂的组方规律

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医学信息 2024年第8期37卷 10-16页

作者：陈燕红张继州蒋畅雷婷韩静福建中医药大学药学院福建省中医药科学院

目的基于中医传承计算平台（TCMICS）分析《中华人民共和国卫生部药品标准中药成方制剂》（简称《中药成方制剂》）含天花粉方剂组方规律，为临床应用及新药研发提供参考。方法运用中医传承计算平台（V3.0）软件，收集《中药成方制剂... 详细信息

目的基于中医传承计算平台（TCMICS）分析《中华人民共和国卫生部药品标准中药成方制剂》（简称《中药成方制剂》）含天花粉方剂组方规律，为临床应用及新药研发提供参考。方法运用中医传承计算平台（V3.0）软件，收集《中药成方制剂》中含天花粉方剂，整理后采用频次统计、关联规则等数据挖掘方法，对主治疾病、常用药对及组方规律进行分析，并对高频疾病和高频药对进行分析。结果共获得含天花粉方剂143首，涉及中药352味，主治疾病80种。其中，与天花粉合用药物多为清热解毒、化痰止咳平喘药如甘草、桔梗、黄芩、玄参等。高频主治疾病为咳嗽、感冒、喉痹、消渴等，且用于治疗的高频药物组合与疾病的临床治则基本一致。结论《中药成方制剂》中含天花粉方剂多具有清热生津、化痰止咳之功效。

关键词：天花粉中药成方制剂中医传承计算平台组方规律

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Static Recrystallization Behavior of Inconel 718 Alloy during Thermal Deformation

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Journal of Wuhan University of Technology(Materials Science) 2014年第2期29卷 379-383页

作者：魏先平 ZHENG Wenjie SONG Zhigang lei ting YONG Qilong XIE Qingcheng Faculty of Metallurgical and Energy Engineering Kunming University of Science and Technology Central Iron and Steel Research Institute No.704 Institute of China Shipbuilding Industry Corporation

The softening behavior of Inconel 718 alloy at different temperatures was studied using two- stage interrupted compression method on Gleeblel500D thermal stimulator, and the 2% offset method was applied to analyze the experimental dates. Finally, the static reerystallizafion fraction was obtained, At the same times, optical microscope （OM） and transmission electron microscopy （TEM） were employed to investigate the microstructure characteristic. The experimental results showed that the recrystallization was more sensitive to temperature than holding time. The reerystaUization process finished quickly above 1 050℃, and significantly prolonged below 1 025℃. Additionally, the dynamical model of static recrystallization follows the Avrami equation. The nucleating mechanism was characterized by bulging at grain boundary and merging of sub-grain.

关键词： Inconel 718 ahoy static recrystallization nucleating mechanism

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基于知信行干预理论的药学服务模式在肿瘤患者中的应用

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现代医药卫生 2024年第7期40卷 1188-1192页

作者：高攀谢颖天六李婷婷雷婷大理大学药学院云南大理671000 西双版纳傣族自治州人民医院药学部云南景洪666100

目的探讨基于知信行(KAP)干预理论的药学服务模式,在肿瘤患者的全程化管理中的应用效果。方法收集2022年10月至2023年4月西双版纳傣族自治州人民医院就诊的肿瘤患者60例临床资料,采用随机数字表法将其分为干预组和对照组,各30例。对照... 详细信息

目的探讨基于知信行(KAP)干预理论的药学服务模式,在肿瘤患者的全程化管理中的应用效果。方法收集2022年10月至2023年4月西双版纳傣族自治州人民医院就诊的肿瘤患者60例临床资料,采用随机数字表法将其分为干预组和对照组,各30例。对照组由医生和护士进行常规的诊疗指导,干预组的患者在常规诊疗的基础上,给予肿瘤专业药师基于知信行干预理论的全程化药学服务。在干预2个周期后,比较两组患者存在的未解决的药物相关问题、KAP得分水平、情绪情况及满意度等指标,并分析临床药师提供药学服务的情况。结果干预2个周期后,与对照组比较,干预组患者药物相关问题的发生率及人均存在数量均显著降低,差异均有统计学意义(P<0.01);而满意度显著提高,差异有统计学意义(P<0.01);干预组KAP各维度除行为维度外得分均高于对照组,差异均有统计学意义(P<0.05);相对于干预前,干预组患者焦虑与抑郁情绪评分也明显降低,差异有统计学意义(P<0.05)。结论基于KAP干预理论的全程化药学服务模式,能够减少肿瘤患者在治疗过程中可能出现的药物相关问题,缓解就诊过程中的紧张、焦虑情绪,从而提高患者依从性及满意度。

关键词：药学服务知信行药物相关问题满意度全程管理效果评价

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Spatiotemporal Evolution Characteristics Study on the Precipitation Infiltration Recharge over the Past 50 Years in the North China Plain

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Journal of Earth Science 2015年第3期26卷 416-424页

作者： Suhua Meng Jin Liu Zhaoji Zhang ting lei Yong Qian Yasong Li Yuhong Fei Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological Sciences

The spatiotemporal evolution characteristics of precipitation infiltration recharge during the past 50 years are discussed in this paper. This research is significant for groundwater resource rational utilization. The distribution of precipitation infiltration recharge coefficients in the 1960 s, 1980 s, and 2000 s can be obtained using unsaturated zone lithology and depth to water table at different times. The amount of precipitation infiltration recharge in the 1960 s, 1980 s, and 2000 s can be calculated using precipitation infiltration recharge coefficients and precipitation data from the Ministry of Water Resources of China. Results show that the change in the precipitation infiltration recharge coefficient is closely related to the water table decrease. From the 1960 s to the 1980 s, the precipitation infiltration recharge coefficient clearly increased in all units. From the 1980 s to the 2000 s, the value slightly increased in the ancient Yellow River alluvial-proluvial and eastern alluvial-marine plains and slightly decreased in the piedmont alluvial-proluvial and central alluvial-lacustrine plains. The piedmont alluvial-proluvial and ancient Yellow River alluvial-proluvial plains exhibited a large precipitation infiltration recharge coefficient for the coarse lithology. The amounts of precipitation infiltration recharges were 16.23×109（1960s）, 19.11×109（1980s）, and 19.42×109 m3/a（2000s）. The amount of precipitation infiltration recharge increased from the 1960 s to the 1980 s then decreased from the 1980 s to the 2000 s in the piedmont alluvial-proluvial and the central alluvial-lacustrine plains. However, this value increased from the 1960 s to the 2000 s in the ancient Yellow River alluvial-proluvial and eastern alluvial-marine plains.

关键词： North China Plain precipitation infiltration recharge evolution characteristics water table

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基于六水铝酸三钙的双电层调控从铝酸钠溶液中短流程脱除有机物

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Transactions of Nonferrous Metals Society of China 2024年第7期34卷 2354-2366页

作者：符振江刘桂华齐天贵申雷霆彭志宏周秋生王一霖房辉王永林中南大学冶金与环境学院长沙410083 龙口东海氧化铝有限公司龙口265713

从铝酸钠溶液中经济地脱除有机物是长期以来的研究重点。基于叶滤环节将六水铝酸三钙(TCA)作为助滤剂的工艺,提出一种短流程同时滤除杂质颗粒和吸附脱除有机物的新方法。在浓缩铝酸钠溶液中制备结晶度低、TCA含量高、表面能高、晶格畸... 详细信息

从铝酸钠溶液中经济地脱除有机物是长期以来的研究重点。基于叶滤环节将六水铝酸三钙(TCA)作为助滤剂的工艺,提出一种短流程同时滤除杂质颗粒和吸附脱除有机物的新方法。在浓缩铝酸钠溶液中制备结晶度低、TCA含量高、表面能高、晶格畸变大的超细TCA样品。同时,TCA样品在碱性溶液中的Zeta电位线性依赖于TCA含量,揭示二元混合物Zeta电位的可加性。描述在碱性溶液中TCA二元混合物双电层的演化规律。此外,超细TCA样品对长烷基链及高相对分子质量有机物具有较高的吸附容量,对腐殖酸钠的吸附容量可达69.69mg/g(以有机碳计),而高温溶出过程会显著降低TCA的吸附容量。

关键词：有机物脱除六水铝酸三钙铝酸钠溶液 Zeta电位双电层

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Celastrol Induces Apoptosis and Autophagy via the AKT/mTOR Signaling Pathway in the Pituitary ACTH-secreting Adenoma Cells

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Current Medical Science 2022年第2期42卷 387-396页

作者： Zhi CAI Bin QIAN Jing PANG Zhou-bin TAN Kai ZHAO ting lei Sino-German Neuro-Oncology Molecular Laboratory Department of NeurosurgeryTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Human Functional Genomics of Jiangsu Province Biochemistry and Molecular BiologyNanjing Medical UniversityNanjing211100China Department of Biochemistry and Molecular Cell Biology Shanghai Jiao Tong University School of MedicineShanghai200240China

Objective Pituitary adrenocorticotropic hormone(ACTH)-secreting adenoma is a relatively intractable endocrine adenoma that can cause a range of severe metabolic disorders and pathological changes involving multiple *** studies have shown that celastrol has antitumor effects on a variety of tumor cells via the AKT/mTOR ***,whether celastrol has pronounced antitumor effects on pituitary ACTH-secreting adenoma is *** study aimed to identify a new effective therapeutic drug for pituitary ACTH-secreting *** Mouse pituitary ACTH-secreting adenoma cells(AtT20 cells)were used as an experimental model in vitro and to establish a xenograft tumor model in *** and animals were administered doses of celastrol at various *** effects of celastrol on cell viability,migration,apoptosis and autophagy were then ***,the potential involvement of AKT/mTOR signaling in celastrol’s mechanism was *** Celastrol inhibited the proliferation and migration of pituitary adenoma cells in a time-and concentration-dependent *** blocked AtT20 cells in the G0/G1 phase,and induced apoptosis and autophagy by downregulating the AKT/mTOR signaling *** results were obtained in *** Celastrol exerts potent antitumor effects on ACTH-secreting adenoma by downregulating the AKT/mTOR signaling in vitro and in vivo.

关键词： pituitary adenoma celastrol autophagy apoptosis AKT/mTOR signaling pathway

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N-doped MoS_(2) via assembly transfer on an elastomeric substrate for high-photoresponsivity,air-stable and stretchable photodetector

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Nano Research 2022年第11期15卷 9866-9874页

作者： Shuyan Qi Weifeng Zhang Xiaoli Wang Yifan Ding Yan Zhang Jiakang Qiu ting lei Run Long Nan Liu Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing 100875China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter of Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 100871China

As a direct-bandgap semiconductor,single-layer MoS_(2) has gained great attention in optoelectronics,especially wearable ***,MoS_(2) exhibits poor photoresponsivity on a stretchable substrate due to intrinsic low carrier density and a large number of scattering centers on polymer *** air-stable yet strong dopants on MoS_(2) has been *** addition,the roughness,hydrophobicity and susceptibility to organic solvents of polymer surface are critical roadblocks in the development of stretchable high-performance MoS_(2) ***,we realize a stretchable and stable photodetector with high photoresponsivity by combining n-type dopant((4-(1,3-dimethyl-2,3-dihydro-1H-benzoimidazol-2-yl)phenyl)dimethylamine,N-DMBI)with MoS_(2) and assembly transfer *** is found electron tends to transfer from N-DMBI to MoS_(2) and the effect is maintained after the integrable photodetector transferred directly by elastic substrate styrene-ethylene-butylene-styrene(SEBS),even after being exposed to the air for 20 days,which benifits greatly from the encapsulation of *** increased carrier density greatly promotes carrier injection efficiency and photogenerated electron–hole separation efficiency at the metal–semiconductor interface,thus offering a significantly improved photoresponsivity in MoS_(2) ***,such photodetector shows great durability to stretch,which can remain functional after stretched 100 cycles within its stretch *** strategy opens a new avenue to fabricate high-photoresponsivity stretchable electronics or optoelectronics of two-dimensional(2D)materials.

关键词： transition metal dichalcogenides charge transfer stretchable photodetectors organic molecules

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