Celastrol Induces Apoptosis and Autophagy via the AKT/mTOR Signaling Pathway in the Pituitary ACTH-secreting Adenoma Cells
作者机构：Sino-German Neuro-Oncology Molecular LaboratoryDepartment of NeurosurgeryTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Human Functional Genomics of Jiangsu ProvinceBiochemistry and Molecular BiologyNanjing Medical UniversityNanjing211100China Department of Biochemistry and Molecular Cell BiologyShanghai Jiao Tong University School of MedicineShanghai200240China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2022年第42卷第2期
页 面：387-396页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the National Natural Science Youth Foundation of China(No.81602204)
主 题：pituitary adenoma celastrol autophagy apoptosis AKT/mTOR signaling pathway
摘 要：Objective Pituitary adrenocorticotropic hormone(ACTH)-secreting adenoma is a relatively intractable endocrine adenoma that can cause a range of severe metabolic disorders and pathological changes involving multiple *** studies have shown that celastrol has antitumor effects on a variety of tumor cells via the AKT/mTOR ***,whether celastrol has pronounced antitumor effects on pituitary ACTH-secreting adenoma is *** study aimed to identify a new effective therapeutic drug for pituitary ACTH-secreting *** Mouse pituitary ACTH-secreting adenoma cells(AtT20 cells)were used as an experimental model in vitro and to establish a xenograft tumor model in *** and animals were administered doses of celastrol at various *** effects of celastrol on cell viability,migration,apoptosis and autophagy were then ***,the potential involvement of AKT/mTOR signaling in celastrol’s mechanism was *** Celastrol inhibited the proliferation and migration of pituitary adenoma cells in a time-and concentration-dependent *** blocked AtT20 cells in the G0/G1 phase,and induced apoptosis and autophagy by downregulating the AKT/mTOR signaling *** results were obtained in *** Celastrol exerts potent antitumor effects on ACTH-secreting adenoma by downregulating the AKT/mTOR signaling in vitro and in vivo.
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