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Improvement of hepatic fibrosis after tenofovir disoproxil fumarate switching to tenofovir alafenamide for three years

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World Journal of hepatology 2024年第7期16卷 1009-1017页

作者： Tung huynh Delana MyAn Bui tina Xiwen Zhou Ke-Qin hu Department of Pharmacy University of California Irvine Medical CenterOrangeCA 92868United States University of houston HoustonTX 77204United States Chicago Medical School at Rosalind Franklin University North ChicagoIL 60064United States Division of Gastroenterology and hepatology University of California IrvineSchool of MedicineOrangeCA 92868United States

BACKGROUND Both tenofovir alafenamide(TAF)and tenofovir disoproxil fumarate(TDF)are the first-line treatments for chronic hepatitis B(ChB).We have showed switching from TDF to TAF for 96 weeks resulted in further alanine aminotransferase(AlT)improvement,but data remain lacking on the long-term benefits of TDF switching to TAF on hepatic *** To assess the benefits of TDF switching to TAF for 3 years on AlT,aspartate aminotransferase(AST),and hepatic fibrosis improvement in patients with *** A single center retrospective study on 53 patients with ChB who were initially treated with TDF,then switched to TAF to determine dynamic patterns of AlT,AST,AST to platelet ratio index(APRI),fibrosis-4(FIB-4)scores,and shear wave elastography(SWE)reading improvement at switching week 144,and the associated *** The mean age was 55(28-80);45.3%,males;15.1%,clinical cirrhosis;mean baseline AlT,24.8;AST,25.7 U/l;APRI,0.37;and FIB-4,*** 144 weeks TDF switching to TAF,mean AlT and AST were reduced to 19.7 and 21,*** baseline to switching week 144,the rates of AlT and ASTle)/25(female)andle)/19(female)were persistently increased;hepatic fibrosis was also improved by APRIly;mean APRI was reduced to 0.27;FIB-4,to 1.38;and mean SWE reading,from 7.05 to 6.30 kPa after a mean of 109 weeks *** renal function was stable and the frequency of patients with glomerular filtration rate>60 ml/min was increased from 86.5%at baseline to 88.2%at switching week *** Our data confirmed that switching from TDF to TAF for 3 years results in not only persistent AlT/AST improvement,but also hepatic fibrosis improvement by APRI,FIB-4 scores,as well as SWE reading,the important clinical benefits of long-term hepatitis B virus antiviral treatment with TAF.

关键词： Tenofovir alafenamide Tenofovir disoproxil fumarate Switching hepatic fibrosis improvement Aspartate aminotransferase to platelet ratio index Fibrosis-4 Shear wave elastography

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Exercise training improves long-term memory in obese mice

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life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey l.Egan tina l.Robinson Nimna Perera heidy K.latchman lauren V.Terry Emma D.Mclennan Carolina Chavez Emma l.Burrows John W.Scott Robyn M.Murphy henriette van Praag Martin Whitham Mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia la Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and Mental health University of MelbourneMelbourneVictoria3052Australia Department of Biomedical Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of life and Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(hFD)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(BDNF)could be mitigated by voluntary exercise training in male C57Bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

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“新”爱之选怦然心动

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中国宝石 2024年第1期 150-153页

作者： tina 不详

新一季珠宝,哪件打动了你?请随China Gems一睹为快。18K金意式风格吊坠钻之韵钻之韵18K金全新意式风格吊坠,打破K金传统配色,以蓝、绿、紫三种明亮色泽,展示与众不同的魅力,出彩更出色。工艺上,采用意大利工艺,并以CNC立体精雕细节,融... 详细信息

新一季珠宝,哪件打动了你?请随China Gems一睹为快。18K金意式风格吊坠钻之韵钻之韵18K金全新意式风格吊坠,打破K金传统配色,以蓝、绿、紫三种明亮色泽,展示与众不同的魅力,出彩更出色。工艺上,采用意大利工艺,并以CNC立体精雕细节,融入流苏元素,打造高级轻奢时尚感。

关键词：时尚感 18K金配色

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德国高校教学数字化的变革潜力

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应用型高等教育研究 2024年第1期9卷 69-73页

作者： Johanna leifeld tina Basner tina Classen 陈颖高等教育发展中心德国居特斯洛33332 国际管理学院德国多特蒙德44227 不详

为了明确何为高质量的数字化辅助教学及其先决条件,一项调查研究对20位德国高校数字化教学奖获得者进行了定性访谈。在此调查研究的基础上,文章阐释了实施高质量数字化教学理念的具体策略和关键成功因素。调查结果揭示了促进教学创新的... 详细信息

为了明确何为高质量的数字化辅助教学及其先决条件,一项调查研究对20位德国高校数字化教学奖获得者进行了定性访谈。在此调查研究的基础上,文章阐释了实施高质量数字化教学理念的具体策略和关键成功因素。调查结果揭示了促进教学创新的必要条件,强调了线上和线下教学方式均衡结合的重要性。这些发现为高校教师提供了实践指导,并有助于推进具有前瞻性的高等教育发展。

关键词：数字化最佳实践范例高校教学教学创新

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luteolin， a common flavone in vegetables， acts as a hormetin possessing neurotrophic function: signaling mediated by inducing mitochondrial stress

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Food Science and human Wellness 2024年

作者： Alex Xiong Gao Tracy Chenxi Xia Maggie Suisui Guo Gary Kawing Yuen Kevin Qiyun Wu tina Tingxia Dong Karl Wah-Keung Tsim Shenzhen Key laboratory of Edible and Medicinal Bioresources， hKUST Shenzhen Research Institute Division of life Science and Center for Chinese Medicine， The hong Kong University of Science and Technology

This study aims to uncover the hormetic process of luteolin， a common dietary flavone， in neuronal cells through its role in inducing mitochondrial stress. In rat pheochromocytoma PC12 cells， luteolin at low concentrations caused a mild and reversible loss of mitochondrial membrane potential (MMP)， while high concentrations of luteolin triggered intense and sustained depolarization of MMP. The MMP disturbance was shown to have a close association with the trophic and/or toxic effects triggered by luteolin; because the common mitochondrial uncouplers shared similar bi-phase dose-response on cell viability， as that of luteolin. Along with the induced MMP pertubation， luteolin triggered the development of autophagy and mitophagy， as determined by mCherry-GFP-lC3B tandem protein， and by the co-localization of mitochondrial/lysosomal staining. Subsequent application of autophagy inhibitors in the cultures blocked the luteolin-induced neurotrophic activities and sensitized the cells to be less resistant to luteolin-mediated cytotoxicity. Other flavonoids also displayed similar properties in the cultures， indicating that these compounds act as hormetic pharmacological inducers that stimulate cells to become more resilient and adapt to threats. This study provides a unifying mechanistic explanation for the neuro-beneficial effects of luteolin and other flavonoids.

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黄明昊青春蒙太奇

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大众电影 2024年第7期 66-75,2,3页

作者：李拾齐 tina Tsai(摄影) 不详

上海国际电影节开幕式当晚,夜上海灯火阑珊,群星云集,又是一年盛夏,又有一个个新故事联袂登场。酒店中,我们与黄明昊相见,他刚刚从开幕式现场返回,一身黑西服,英气逼人。采访之前,我们先进行了平面拍摄,记者不小心碰到了手机的音乐播放... 详细信息

上海国际电影节开幕式当晚,夜上海灯火阑珊,群星云集,又是一年盛夏,又有一个个新故事联袂登场。酒店中,我们与黄明昊相见,他刚刚从开幕式现场返回,一身黑西服,英气逼人。采访之前,我们先进行了平面拍摄,记者不小心碰到了手机的音乐播放键,一首韦礼安的《慢慢等》响起,正在拍摄的黄明昊在椅子上忽然抬起手:“这也是我歌单里的歌!”

关键词：上海国际电影节音乐播放蒙太奇相见开幕式

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重组大肠杆菌合成聚(3-巯基丙酸)和聚(3-羟基丁酸-3-巯基丙酸)的研究(英文)

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生物工程学报 2003年第2期19卷 195-199页

作者：刘双江 tina l.tke-eversl.h Alexander Steinbüchel 中国科学院微生物研究所北京100080 Institute of Microbiology

利用Clostridiumacetobutylicum的丁酸激酶基因 (buk)和磷酸转丁酰基酶基因 (ptb) ,以及Thiocapsapfennigii的PhA合成酶基因 ,设计了一条能够合成多种聚羟基烷酸的代谢途径 ,用构建的质粒转化大肠杆菌 ,获得了重组大肠杆菌菌株。前期的... 详细信息

利用Clostridiumacetobutylicum的丁酸激酶基因 (buk)和磷酸转丁酰基酶基因 (ptb) ,以及Thiocapsapfennigii的PhA合成酶基因 ,设计了一条能够合成多种聚羟基烷酸的代谢途径 ,用构建的质粒转化大肠杆菌 ,获得了重组大肠杆菌菌株。前期的研究表明 ,在合适的前体物条件下 ,该重组大肠杆菌能够合成包括聚羟基丁酸、聚 (羟基丁酸戊酸 )等多种生物聚酯 [liuandSteinb櫣ｃｈｅｌ,*** .Microbiol.6 6 :739 743]。利用该重组大肠杆菌 ,通过生物催化作用合成了 3 巯基丙酸的同型共聚酯 ,同时利用该重组大肠杆菌还获得了含 3 巯基丙酸单体的多种异型共聚物。实验首先研究了 3 巯基丙酸对大肠杆菌生长的影响 ,在此基础上优化了培养过程中添加 3 巯基丙酸的时机和浓度 ,结果表明 ,在实验的条件下 ,细胞合成聚 (3 巯基丙酸 )可达 6 7% (占细胞干重 ) ,合成聚 (3 羟基丁酸— 3 巯基丙酸 ) (分子中 3 巯基丙酸 :3 羟基丁酸 =3:1)可达 2 4 3%。实验进一步研究了同时或分别表达以上 3个基因的重组大肠杆菌合成聚合物的能力 ,结果表明只有当 3个基因同时表达时才能合成聚合物 ,说明 3个基因对合成过程是必须的 ,从而表明了合成途径是按照设计的路线进行的。还通过GC MS、GPC、IR等手段对合成的化合物进行了定性?

关键词：重组大肠杆菌聚3—巯基丙酸聚3—羟基丁酸—3—巯基丙酸生物合成聚羟基烷酸生物多聚物

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Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang liu Junya Fujimoto lingzhi hong Alexandre Reuben Susan Varghese Carmen Behrens tina McDowell luisa Solis Soto Cara haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning le Natalie I Vokes Chao Cheng John V.heymach Don l.Gibbons P.Andrew Futreal Ignacio IWistuba humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSClC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune high(IM-h)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-h tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

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Children are not little adults:blood transfusion in children with burn injury

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Burns & Trauma 2017年第3期5卷 158-163页

作者： tina l. Palmieri Shriners hospital for Children Northern California and the University of California Davis 2425 Stockton Blvd Suite 718 Sacramento CA 95817 USA

Blood transfusion in burns larger than 20%total body surface area (TBSA) are frequent due to operative procedures, blood sampling, and physiologic response to burn injury. Optimizing the use of blood transfusions requires an understanding of the physiology of burn injury, the risks and benefits of blood transfusion, and the indications for transfusion. Age also plays a role in determining blood transfusion requirements. Children in particular have a different physiology than adults, which needs to be considered prior to transfusing blood and blood products. This article describes the physiologic differences between children and adults in general and after burn injury and describes how these differences impact blood transfusion practices in children.

关键词： Blood transfusion Pediatric Burn injury

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Obstetric Emergencies at the Kara University hospital Maternity Ward: Sociodemographic, Etiological and Prognostic Aspects

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 69-76页

作者： logbo-Akey Kossi Edem Bassowa Akila Ketevi tina Kambote Yendoubé Patchidi Kibandou Amewouho Kofi Ajavon Dédé Régina Aboubakari Abdoul-Samadou Service de Gynécologie-Obstétrique CHU Kara Université de Kara Kara Togo Service de Gynécologie-Obstétrique CHU Campus Université de Lomé Lomé Togo Service de Gynécologie-Obstétrique CHU Sylvanus Olympio Université de Lomé Togo Faculté des sciences de la santé Université de Lomé Lomé Togo Service de Gynécologie-Obstétrique CHR Tomdé Université de Kara Togo

Introduction: Obstetric emergencies are common throughout the world and more particularly in developing countries where they are responsible for high maternal-fetal mortality and morbidity. Objective: Study obstetric emergencies in the maternity ward of Kara University hospital. Method: Retrospective and descriptive study from April 1, 2022 to March 30, 2023, carried out in the Obstetrics and Gynecology Department of Kara University hospital. Results: Eight hundred and thirty-five (835) obstetric emergencies were recorded out of 2215 admissions, i.e. a frequency of 37.7%. The average age of the patients was 26.7 with a range of 14 and 45 years. They were primigravidas (36.7%) and nulliparous (38.7%), referred (84.7%) and came from rural areas (72%). Emergencies occurred in the 3rd trimester in 74.1% and in parturients (54.1%). Preeclampsia (27%), cessation of progression of labor due to feto-pelvic disproportion (12.4%), postpartum hemorrhage (7.5%) constituted the main obstetric emergencies. In 44.8%, the delivery was carried out vaginally. Magnesium sulfate was the most used drug, i.e. 30.1%;followed by antihypertensive medications in 28.1%. Blood transfusion was performed in 24.3%. The evolution was simple in 90.9%. The maternal fatality rate was 1.6%. The perinatal case fatality rate was 12.3%. Conclusion: Obstetric emergencies are common, dominated by preeclampsia, stopping progress of labor and postpartum hemorrhages. They are responsible for high morbidity and mortality.

关键词： Obstetric Emergency Kara University hospital

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