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Impact of conditioning regimen on peripheral blood hematopoietic cell transplant

World Journal of Clinical Oncology 2019年第2期10卷 86-97页

作者： Michael burns Anurag K Singh Carrie C Hoefer Yali Zhang Paul K Wallace George L Chen Alexis Platek timothy b winslow Austin J Iovoli Christopher Choi Maureen Ross Philip L McCarthy Theresa Hahn Department of Medicine Roswell Park Comprehensive Cancer Center Department of Radiation Medicine Roswell Park Comprehensive Cancer Center Department of Flow Cytometry Roswell Park Comprehensive Cancer Center Center for Immunotherapy Roswell Park Comprehensive Cancer Center

AIM To investigate infused hematopoietic cell doses and their interaction with conditioning regimen intensity +/-total body irradiation(TbI) on outcomes after peripheral blood hematopoietic cell transplant(PbHCT).METHODS Our retrospective cohort included 247 patients receiving a first, T-replete, human leukocyte antigen-matched allogeneic PbHCT and treated between 2001 and2012. Correlations were calculated using the Pearson product-moment correlation coefficient. Overall survival and progression free survival curves were generated using the Kaplan-Meier method and compared using the log-rank *** Neutrophil engraftment was significantly faster after reduced intensity TbI based conditioning [reduced intensity conditioning(RIC) + TbI] and > 4 × 10~6 CD34+cells/kg infused. A higher total nucleated cell dose led to a higher incidence of grade II-IV acute graft-versus-host disease in the myeloablative + TbI regimen group(P = 0.03), but no significant difference in grade III-IV graft-versus-host disease. A higher total nucleated cell dose was also associated with increased incidence of moderate/severe chronic graft-versus-host disease, regardless ofconditioning regimen. Overall and progression-free survival were significantly better in patients with a RIC + TbI regimen and total nucleated cell dose > 8 ×10~8/kg(3 years, overall survival: 70% vs 38%, P = 0.02, 3 years, progression free survival: 64% vs 38%, P = 0.02).CONCLUSION TbI and conditioning intensity may alter the relationship between infused cell doses and outcomes after PbHCT. Immune cell subsets may predict improved survival after unmanipulated PbHCT.

关键词： Total body radiation Peripheral blood hematopoietic cell transplant Total nucleated dose Neutrophil engraftment Graft-versus-host-disease

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Active bleb formation is abated in Lytechinus variegatus red spherule coelomocytes after disruption of acto-myosin contractility

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Integrative Zoology 2008年第2期3卷 115-122页

作者： Lisanne D’ANDREA-winslow Amy K.NOVITSKI Department of biology Northwestern CollegeSt.PaulMinnesotaUSA

Red spherule coelomocytes are immune cells in the sea urchin Lytechinus variegatus that have been characterizedas motile O2 transport cells. Video microscopy of living red spherule coelomocytes reveals a constitutive, dynamicarray of cellular morphologies and movements. Cells continuously send out and retract membrane blebs all over thecell surface as part of their normal cellular physiology. Disruption of microtubules by perfusion with either nocodazoleor taxol had no effect on bleb formation or motility. Perfusion with cytochalasin b abated bleb formation andrevealed cells that exhibited multiple small spheres attached by short membrane extensions. Attenuation of blebbingand intracellular organelle motility were restored by washing out with cytochalasin b. Treatment with phalloidinalso abated bleb formation and revealed a smooth, spherical cellular morphology. The effects of phalloidin werecompletely reversible after washout. Red spherule coelomocytes treated with blebbistatin rounded up with anirreversible retraction of blebs into surface blebs that were greatly reduced in size, number and motility. Normal cellsurface bleb formation and intracellular organelle motility were not restored after washout of the drug. These resultsindicate that the acto-myosin contractile mechanism contributes to the dynamics of constitutive cell surface membraneblebbing in invertebrate immune cells.

关键词： sea urchin invertebrate immunology coelomocyte cell motility cell movement microfilament dynamics

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2019年

作者： (美)艾米莉·温斯洛(Emily winslow)

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bME 2.0: Engineering the Future of Medicine

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biomedical Engineering Frontiers 2023年第1期4卷 217-227页

作者： Michael I.Miller Andrew O.brightman Frederick H.Epstein KJane Grande-Allen Jordan J.Green Eileen Haase Cato T.Laurencin Elizabeth Logsdon Feilim Mac Gabhann brenda Ogle Chun Wang George R.Wodicka Raimond L.winslow Department of biomedical Engineering Johns Hopkins UniversityBaltimoreMDUSA Weldon School of biomedical Engineering Purdue UniversityWest LafayetteINUSA biomedical Engineering University of VirginiaCharlottesvilleVAUSA Department of bioengineering Rice UniversityHoustonTXUSA Department of biomolecular Engineering and Department of Orthopaedic Surgery University of ConnecticuttStorrsCTUSA Department of biomedical Engineering University of Minnesota-Twin CitiesMinneapolisMNUSA

If the 20th century was the age of mapping and controlling the external world,the 21st century is the biomedical age of mapping and controlling the biological internal *** biomedical age is bringing new technological breakthroughs for sensing and controlling human biomolecules,cells,tissues,and organs,which underpin new frontiers in the biomedical discovery,data,biomanufacturing,and translational *** article reviews what we believe will be the next wave of biomedical engineering(bME)education in support of the biomedical age,what we have termed bME *** 2.0 was announced on October 122017 at bMES 49(https://***/news-events/news/miller-opens-2017-bmes-annual-meeting-with-vision-for-new-bme-era/).We present several principles upon which we believe the bME 2.0 curriculum should be constructed,and from these principles,we describe what view as the foundations that form the next generations of curricula in support of the bME *** core principles of bME 2.0 education are(a)educate students bilingually,from day 1,in the languages of modern molecular biology and the analytical modeling of complex biological systems;(b)prepare every student to be a biomedical data scientist;(c)build a unique bME community for discovery and innovation via a vertically integrated and convergent learning environment spanning the university and hospital systems;(d)champion an educational culture of inclusive excellence;and(e)codify in the curriculum ongoing discoveries at the frontiers of the discipline,thus ensuring bME 2.0 as a launchpad for training the future leaders of the biotechnology *** envision that the bME 2.0 education is the path for providing every student with the training to lead in this new era of engineering the future of medicine in the 21st century.

关键词： organs education frontier

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拟交感神经药物诱发的“万花筒样”视幻觉与胼胝体压部的可逆性损伤相关

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 23-23页

作者： winslow H. Mickey b. Frohman E.M. 王孝文 Department of Neurology University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Blvd Dallas TX 75235 United States.Dr

background: Sympathomimetic-induced metabolic derangements within the central nervous system can result in conspicuous changes in neurological functioning and corresponding radiographic abnormalities that can be reversible. Objective: To describe a patient with a “ kaleidoscopic" visual illusion who was found by magnetic resonance imaging to have a transient lesion in the splenium of the corpus callosum. Design: Case report. Setting: The University of Texas Southwestern Medical Center, Dallas. Patient: A 17-year-old adolescent girl who developed an episode of kaleidoscopic vision while using sympathomimetic-containing diet pills that was associated with a reversible lesion of the splenium of the corpus callosum. Her brother has a history of migraine and experienced a similar episode while using illicit stimulant agents. Intervention: Withdrawal of the medication resulted in the cessation of the episodes and normalization of the magnetic resonance image. Main Outcome Measures: Clinical and radiographic improvement. Results: Sympathomimetic-ind-uced metabolic derangements can be associated with reversible lesions within the brain. Conclusions: We hypothesize that the visual fragmentation was a manifestation of a migraine triggered by sympathomimetic-containing diet pills, and that the transient lesion in the corpus callosum was a manifestation of a reversible metabolic derangement. both the visual fragmentation and the lesion in the corpus callosum resolved once the patient stopped receiving diet pills.

关键词：胼胝体压部拟交感神经药可逆性视幻觉

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生长激素不足青少年芳香化酶抑制剂治疗后的精液分析:与正常对照的比较性研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 35-35页

作者： Mauras N. bell J. Snow b.G. winslow K.L. 李跃萍 Nemours Children' s Clinic 807 Children' s Way Jacksonville FL 32207 United States Dr

We performed two semen analyses in each of a small cohort of 11 GH- deficient (GHD) adolescents (mean age 18.1 ± 0.6 yrs), previously treated (mean 29 months prior) with either GH alone or GH and an aromatase inhibitor (anastrozole) for 12 months and compared their data with those of 10 healthy controls (mean age 18.7 ± 1.8 yrs). Although some adolescents had lower sperm parameters as compared to adult reference values, mean sperm concentrations, motility, and morphology were comparable among the 3 groups, suggestive that this small group of GHD adolescents previously treated with anastrozole has descriptively similar sperm parameters as other GHD and GH- sufficient adolescent controls.

关键词：芳香化酶抑制剂比较性研究精液分析精子形态学精子活力参考值阿纳托唑

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梨的砧木的现状与展望

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北方果树 1983年第4期 53-55页

作者： M.N.Westwood b.hombard 蒲富慎

引言西方早期梨的砧木研究集中在抗火疫病(Erwinia amylovora(bur)winslow,etal)的研究上。F.C 赖默曾经收集了欧洲原产的古屋和法明德尔以及亚洲的许多原始种作抗性砧木。五十年代随着新病害“梨衰退病”的出现,西部各州又重新对梨的... 详细信息

引言西方早期梨的砧木研究集中在抗火疫病(Erwinia amylovora(bur)winslow,etal)的研究上。F.C 赖默曾经收集了欧洲原产的古屋和法明德尔以及亚洲的许多原始种作抗性砧木。五十年代随着新病害“梨衰退病”的出现,西部各州又重新对梨的砧木进行了研究。已经查明梨的衰退病是梨木虱在蛀食梨叶过程中将可能是类菌体的病原带给植株所引起的。

关键词：砧木火疫病古屋营养系德尔台木嫁接材料花萎病杜梨实生苗梨衰退病仁果类豆梨

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