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To bridge or not to bridge:summary of the new evidence in endovascular stroke treatment

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Stroke & Vascular Neurology 2022年第3期7卷 179-181页

作者： Anna Podlasek Permesh Singh Dhillon Waleed Butt Iris q Grunwald timothy J England Tayside Innovation MedTech Ecosystem(TIME) University of DundeeDundeeUK NIHR Nottingham Biomedical Research Centre University of NottinghamNottinghamUK Interventional Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Interventional Neuroradiology University Hospitals Birmingham NHS TrustBirminghamUK Stroke Division of Mental Health and Clinical NeurosciencesSchool of MedicineUniversity of NottinghamNottinghamUK Stroke University Hospitals of Derby and Burton NHS Foundation TrustDerbyUK

WHAT IS ALREADY KNOWN Recently published summaries and meta-analyses of four randomised controlled trials(RCTs)1-5 comparing direct mechan-ical thrombectomy(dMT)and bridging therapy with intravenous(IV)thrombolytics(alteplase)suggested that dMT is non-inferior to bridging therapy to achieve good functional outcome 3 months after stroke(modified Rankin Score 0-2)with the non-inferiority margin(NIM)<−5%.

关键词： intravenous bridging treatment

A brief report on MRI investigation of experimental traumatic brain injury

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Neural Regeneration Research 2016年第1期11卷 15-17页

作者： timothy q.Duong Lora T.Watts Research Imaging Institute Departments of Cellular and Structure Biology and Ophthalmology University of Texas Health Science Center South Texas Veterans Health Care System

Traumatic brain injury is a major cause of death and disability. This is a brief report based on a symposium presentation to the 2014 Chinese Neurotrauma Association Meeting in San Francisco, USA. It covers the work from our laboratory in applying multimodal MRI to study experimental traumatic brain injury in rats with comparisons made to behavioral tests and histology. MRI protocols include structural, perfusion, manganese-enhanced, diffusion-tensor MRI, and MRI of blood-brain barrier integrity and cerebrovascular reactivity.

关键词： MRI traumatic brain injury magnetic resonance imaging diffusion tensor imaging cerebral blood flow

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SMT无卤工艺的焊接挑战

现代表面贴装资讯 2010年第2期9卷 14-17页

作者： timothy Jensen Ronald Ronald Lasky Amanda hartnett 沈新海（编译）不详湖州生力电子有限公司

由于卤素材料对环境存在巨大的破坏作用，电子工业生产进行无卤转换是不可避免的趋势。本文详细描述了卤素材料的测定方法和SMT无卤工艺面临的三个焊接挑战及应对办法，今编译出来与大家分享。

关键词：无卤焊料焊接助焊剂

Controllable vortex lasing arrays in a geometrically frustrated exciton-polariton lattice at room temperature

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National Science Review 2023年第1期10卷 196-204页

作者： Jun Wang Yutian Peng Huawen Xu Jiangang Feng Yuqing Huang Jinqi Wu timothy C.H.Liew qihua Xiong Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Department of Optical Science and Engineering and Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Fudan University State Key Laboratory of Low-Dimensional quantum Physics and Department of Physics Tsinghua University Beijing Academy of quantum Information Sciences

quantized vortices appearing in topological excitations of quantum phase transition play a pivotal role in strongly correlated physics involving the underlying confluence of superfluids,Bose-Einstein condensates and superconductors.Exciton polaritons as bosonic quasiparticles have enabled studies of non-e quilibrium quantum gases and superfluidity.Exciton-polariton condensates in artificial lattices intuitively emulate energy-band structures and quantum many-body effects of condensed matter,underpinning constructing vortex lattices and controlling quantum fluidic circuits.Here,we harness exciton-polariton quantum fluids of light in a frustrated kagome lattice based on robust metal-halide perovskite microcavities,to demonstrate vortex lasing arrays and modulate their configurations at room temperature.Tomographic energy-momentum spectra unambiguously reveal massless Dirac bands and quenched kinetic-energy flat bands coexisting in kagome lattices,where polariton condensates exhibit prototypical honeycomb and kagome spatial patterns.Spatial coherence investigations illustrate two types of phase textures of polariton condensates carrying ordered quantized-vortex arrays and π-phase shifts,which could be selected when needed using lasing emission energy.Our findings offer a promising platform on which it is possible to study quantum-fluid correlations in complex polaritonic lattices and highlight feasible applications of structured light.

关键词： vortex lasing exciton–polariton lattice Bose–Einstein condensation the orbital angular momentum of light geometric frustration perovskite semiconductor

On the Role of Dual Active Margin Collision for Exhuming the World's Largest Ultrahigh Pressure Metamorphic Belt

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Journal of Earth Science 2012年第6期23卷 802-812页

作者：王璐 timothy M Kusky M Santosh State Key Laboratory for Geological Processes and Mineral Resources China University of Geosciences Three Gorges Geo-hazard Research Center of Ministry of Education China University of Geosciences China University of Geosciences

ABSTRACT： A wide variety of tectonic models have been invoked to explain the exhumation of the world＇s largest ultrahigh pressure （UHP） orogenic belt, the qinling Dabieshan Sulu belt in China, and its correlatives in Korea. Most of these models assume that the orogen contains one main collisional suture between the North and South China cratons that collided in the Mesozoic. New field data reveal that this model is too simplistic, and that the collision involved an additional mi- croplate, which initially rifted off the Yangtze craton. This continental microplate was partially sub- ducted beneath an active margin on the North China craton, and subsequently an additional active Andean-style margin developed on the southern margin of the qinling microplate after collision, leav- ing the near-vertical microplate wedged between the two thickened and thermally softened margins. The thermo-mechanical environment of collision thus left a cold, thick, and buoyant microplate wedged between two easily deformed margins, which acted as power-law creep channels, accommodating rapid buoyancy-driven rise of a 2 000 km long wedge of the subducted microplate, which became intimately involved with the collisional process. An addi- tional segment of the northern Yangtze craton was subducted to ~100 kin, and formed a separate wedge that rose alongside the thermally softened margin of the qinling mieroeontinent, and was bordered on the south by the recently thermally- softened rift zone where the qinling mieroeonti- nent broke off the Yangtze eraton between Late Devonian and Permian times. Recognizing the dual active margins in qinling-Dabieshan-Sulu orogen and the thermally-softened power-law creep channels sheds new light on understanding exhumation of the world＇s largest ultrahigh pressure belt. We propose that this model is generally applicable to other UHP belts worldwide.

关键词： ultrahigh-pressure metamorphic belt plate tectonics subduction collision exhumation,qinling-Dabieshan-Sulu belt.

Supramolecular Self-assembly Formed from Cucurbit[8]uril and p-Hydroxybenzoic Acid

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Chemical Research in Chinese Universities 2023年第6期39卷 1058-1063页

作者： WANG Chenghui YU Zhichao BAI qinghong PAN Dingwu PRIOR timothy J TAO Zhu REDSHAW Carl XIAO Xin Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Guizhou UniversityGuiyang 550025P.R.China Chemistry School of Natural SciencesUniversity of HullHull HU67RXUK

The binding behavior of cucurbit[8]uril(q[8])and p-hydroxybenzoic acid(p-HBA)has been investigated using ^(1)H NMR titration experiments,UV-Vis absorption,isothermal titration calorimetry(ITC),and X-ray crystallography.Results revealed that the q[8]can accommodate two p-HBA molecules to form a 1:2 host-guest inclusion complex in solution,namely(p-HBA)2@q[8].From a poorly scattering crystal,we were able to identify two symmetry unique q[8]rings,but with different p-HBA fillings.The structure can be represented as q[8]+1.5 p-HBA,which gives q[8]@(p-HBA)2∙q[8]@p-HBA as the structural formula.This supramolecular structure was screened for its ability to capture iodine.The experimental results showed that the adsorption efficiency of the supramolecular organic framework material for iodine capture was 43.8%,with an equilibrium adsorption capacity of 223.3 mg/g.

关键词： Supramolecular self-assembly Cucurbituril p-Hydroxybenzoic acid

Spontaneously coherent orbital coupling of counterrotating exciton polaritons in annular perovskite microcavities

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Light(Science & Applications) 2021年第3期10卷 401-408页

作者： Jun Wang Huawen Xu Rui Su Yutian Peng Jinqi Wu timothy C.H.Liew qihua Xiong Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingaporeSingapore State Key Laboratory of Low-Dimensional quantum Physics and Department of Physics Tsinghua UniversityBeijingChina MajuLab International Joint Research Unit UMI 3654CNRSUniversite Cote d'AzurSorbonne UniversiteNational University of SingaporeNanyang Technological UniversitySingaporeSingapore Beijinq Academy of quantum Information Sciences Beiiinq 100193P.R.China

Exciton-polariton condensation is regarded as a spontaneous macroscopic quantum phenomenon with phase ordering and collective coherence.By engineering artificial annular potential landscapes in halide perovskite semiconductor microcavities,we experimentally and theoretically demonstrate the room-temperature spontaneous formation of a coherent superposition of exciton-polariton orbital states with symmetric petal-shaped patterns in real space,resulting from symmetry breaking due to the anisotropic effective potential of the birefringent perovskite crystals.The lobe numbers of such petal-shaped polariton condensates can be precisely controlled by tuning the annular potential geometry.These petal-shaped condensates form in multiple orbital states,carrying locked alternating nphase shifts and vortex-anti vortex superposition cores,arising from the coupling of counterrotating exciton-polaritons in the confined circular waveguide.Our geometrically patterned microcavity exhibits promise for realizing room-temperature topological polaritonic devices and optical polaritonic switches based on periodic annular potentials.

关键词： tuning annular coherent

Left ventricular pseudoaneurysm

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Journal of Geriatric Cardiology 2017年第1期14卷 78-80页

作者： Hee Hwa Ho Dasdo Antonius Sinaga Evelyn Lee timothy James Watson Jimmy Kim Fatt Hon Department of Cardiology Tan Tock Hospital Singapore Department of Cardiothoracic Surgery National University Heart Centre Singapore

A 72-year-old elderly male smoker with a known history of hypertension presented with a six day history of chest pain. His blood pressure at presentation was 110/70mmHg and there was no audible murmur. ECG showed q wa... 详细信息

关键词：动脉瘤左心室假性毫米汞柱蛋白水平高血压吸烟者心电图

Closed-loop superconducting materials discovery

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npj Computational Materials 2023年第1期9卷 471-478页

作者： Elizabeth A.Pogue Alexander New Kyle McElroy Nam q.Le Michael J.Pekala Ian McCue Eddie Gienger Janna Domenico Elizabeth Hedrick Tyrel M.Mcqueen Brandon Wilfong Christine D.Piatko Christopher R.Ratto Andrew Lennon Christine Chung timothy Montalbano Gregory Bassen Christopher D.Stiles Research and Exploratory Development Department Johns Hopkins University Applied Physics Laboratory11100 Johns Hopkins RoadLaurel 20723 MDUSA Department of Materials Science and Engineering Northwestern University2220 Campus DriveEvanston 60208 ILUSA Department of Materials Science and Engineering Johns Hopkins University3400 N.Charles StreetBaltimore 21218 MDUSA Department of Chemistry Johns Hopkins University3400 N.Charles StreetBaltimore 21218 MDUSA Institute for quantum Matter William H.Miller III Department of Physics and AstronomyJohns Hopkins University3400 N.Charles StreetBaltimore 21218 MDUSA

Discovery of novel materials is slow but necessary for societal progress.Here,we demonstrate a closed-loop machine learning(ML)approach to rapidly explore a large materials search space,accelerating the intentional discovery of superconducting compounds.By experimentally validating the results of the ML-generated superconductivity predictions and feeding those data back into the ML model to refine,we demonstrate that success rates for superconductor discovery can be more than doubled.Through four closed-loop cycles,we report discovery of a superconductor in the Zr-In-Ni system,re-discovery of five superconductors unknown in the training datasets,and identification of two additional phase diagrams of interest for new superconducting materials.Our work demonstrates the critical role experimental feedback provides in ML-driven discovery,and provides a blueprint for how to accelerate materials progress.

关键词： discovery materials loop