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Brain reward circuitry:The overlapping neurobiology of trauma and substance use disorders

World Journal of Psychiatry 2021年第6期11卷 222-231页

作者： timothy i michaels Emily Stone Sonali Singal Vladan Novakovic Robert L Barkin Stacy Barkin Department of Psychiatry The Zucker Hillside HospitalNorthwell HealthGlen OaksNY 11004United States Department of Psychiatry The Donald and Barbara Zucker School of MedicineHofstra/NorthwellGlen OaksNY 11004United States Department of Anesthesiology Rush University Medical CollegeChicagoIL 60612United States Private Practice ScottsdaleAZ 85250United States

Mental health symptoms secondary to trauma exposure and substance use disorders(SUDs)co-occur frequently in both clinical and community *** possibility of a shared aetiology remains an important question in translational *** in genetics,basic science,and neuroimaging have led to an improved understanding of the neural basis of these disorders,their frequent comorbidity and high rates of relapse remain a clinical *** project aimed to conduct a review of the field’s current understanding regarding the neural circuitry underlying posttraumatic stress disorder and SUD.A comprehensive review was conducted of available published literature regarding the shared neurobiology of these disorders,and is summarized in detail,including evidence from both animal and clinical *** summarizing the relevant literature,this review puts forth a hypothesis related to their shared neurobiology within the context of fear processing and reward *** provides an overview of brain reward circuitry and its relation to the neurobiology,symptomology,and phenomenology of trauma and substance *** review provides clinical insights and implications of the proposed theory,including the potential development of novel pharmacological and therapeutic treatments to address this shared *** and extensions of this theory are discussed to provide future directions and insights for this shared phenomena.

关键词： Posttraumatic stress disorder Substance abuse Reward circuitry Mesolimbic Neurobiology

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THE CAYUGA MEDiCAL CENTER A Case Study in Landscape Master Planning and Sustainability

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Journal of Green Building 2011年第2期6卷 17-28页

作者： Kimberly michaels RLA LEED APand Catherine Callahan Trowbridge&Wolf LLP

iNTRODUCTiON Long-term planning is essential for larger institutions to achieve sustainable goals and *** be truly sustainable,individual projects must fit within a larger scope of campus *** and site systems such as parking,transportation,pedestrian connectivity,storm water treatment,and human health and well-being must be considered and coordinated.

关键词： restorative gardens sustainable landscape planning master planning health care design LEED

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Thymic carcinoma:review and update

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 476-487页

作者： Kirill Karlin Phillip D.michaels Department of Pathology Beth Israel Deaconess Medical CenterBostonMA 02115USA

Thymic carcinoma(TC)is a rare thymic epithelial neoplasm with an aggressive clinical *** are many recognized histologic subtypes as described by the fifth edition of the World Health Organization(WHO)Classification of Thoracic Tumors;however,given the rarity of this tumor group,diagnosis remains a challenge,especially on limited tissue ***,rare variants of TC are continuing to be established,particularly in the era of molecular ***,histologic subtypes are described as the rare subtypes of TC in the context of their immunoprofile,cytogenetic or molecular features,clinical presentation,and ensuing challenges.

关键词： Thymic carcinoma NUT carcinoma thymus KiT thymoma

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Christmas at Timberwoods

Christmas at Timberwoods

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作者： Fern michaels.

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is it time for elective left main percutaneous coronary intervention to become 'main stream'?

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Journal of Geriatric Cardiology 2006年第1期3卷 57-58页

作者： Joshua Cohen Andrew D.michaels Division of Cardiology University of California San Francisco San Francisco CA 94143-0124 USA

　　Left main (LM) stenting is considered by many to be one of the last frontiers of interventional cardiology. Beginning with the VA cooperative study published in 1976 demonstrating a mortality benefit for patients undergoing coronary artery bypass grafting (CABG), i the standard of care for treatment of left main coronary artery disease has been *** most recent 2005 update of the ACC/AHA/SCAi Practice Guidelines on PCi 2 again notes that "CABG using iMA grafting is the 'gold standard' for treatment of unprotected left main disease and has proven benefit on long-term outcomes."……

关键词： left iVUS is it time for elective left main percutaneous coronary intervention to become main stream time

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Acute hemodynamic effects of enhanced external counterpulsation

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Journal of Geriatric Cardiology 2010年第2期7卷 67-73页

作者： Bhavananda T.Reddy Andrew D.michaels Department of Medicine Division of CardiologyUniversity of UtahSalt Lake CityUtahUnited States

introduction in the United States, there are about 17.6 million patients suffer from symptomatic coronary artery disease （CAD）, affecting 7.9% of adults ≥ 20 years of age.1 An estimated 10.2 million patients have angina, and 500,000 patients will develop new angina pectoris each year. 1 A subset of angina patients are categorized as refractory when symptoms continue despite optimal medical therapy and *** daily activities become impossible without experiencing chest pain in this patient population.2

关键词： Enhanced external counterpulsation diastolic augmentation hemodynamics angina heart failure.

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Endoscopic ultrasonography guided celiac plexus neurolysis and celiac plexus block in the management of pain due to pancreatic cancer and chronic pancreatitis

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World Journal of Gastroenterology 2007年第26期13卷 3575-3580页

作者： Anthony J michaels Peter V Draganov University of Florida Department of GastroenterologyHepatology and NutritionUnited States

Pain is a common symptom of pancreatic disease and is frequently difficult to manage. Pain relief provided by narcotics is often suboptimal and is associated with significant side effects. An alternative approach to pain management in pancreatic disease is the use of celiac plexus block (CPB) or neurolysis (CPN). Originally performed by anesthesiologists and radiologists via a posterior approach,recent advances in endoscopic ultrasonography (EUS) have made this technique an attractive alternative. EUS guided celiac plexus block/ neurolysis is simple to perform and avoids serious complications such as paraplegia or pneumothorax that are associated with the posterior approach. EUS guided CPN should be considered first line therapy in patients with pain due to pancreatic cancer. it provides superior pain control compared to traditional management with narcotics. A trend for improved survival in pancreatic cancer patients treated with CPN has been reported,but larger studies are needed to confirm this finding. At this time,the use of EUS guided CPB cannot be recommended as routine therapy for pain in chronic pancreatitis since only one-half of the patients experience pain reduction and the beneficial effect tends to be short lived. EUS guided CPB and CPN should be used as part of a multidisciplinary team approach for pain management.

关键词： Celiac plexus Celiac plexus neurolysis Celiacplexus block Endoscopic ultrasound Pain management

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Open and Closed： The Roles of Linker Histones in Plants and Animals

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Molecular Plant 2014年第3期7卷 481-491页

作者： Ryan S. Over Scott D. michaels Departments of Biology/Molecular and Cellular Biochemistry Indiana University 915 E. Third Street Bloomington IN 47405 USA

Histones package DNA in all eukaryotes and play key roles in regulating gene expression. Approximately 150 base pairs of DNA wraps around an octamer of core histones to form the nucleosome, the basic unit of chromatin. Linker histones compact chromatin further by binding to and neutralizing the charge of the DNA between nucleosomes. it is well established that chromatin packing is regulated by a complex pattern of posttranslational modifications （PTMs） to core histones, but linker histone function is less well understood. in this review, we describe the current understand- ing of the many roles that linker histones play in cellular processes, including gene regulation, cell division, and devel- opment, while putting the linker histone in the context of other nuclear proteins. Although intriguing roles for plant linker histones are beginning to emerge, much of our current understanding comes from work in animal systems. Many unanswered questions remain and additional work is required to fully elucidate the complex processes mediated by linker histones in plants.

关键词： linker histone histone H1 chromatin gene regulation development differentiation imprinting posttrans-lational modifications DNA methylation high mobility group proteins.

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英语戏剧表演综合教程

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丛书名：新起航大学英语

2017年

作者：孙琦（美）Anna michaels编

《英语戏剧表演综合教程》1.课程的创新性。在英语语言教学中引进艺术设计、戏剧表演与创作，是对传统语言教学的创新性的改革。2.学生的参与性。强调在戏剧创作实践训练中提高英语语言的感悟力和表现力，提高学生的艺术素养和参与实践... 详细信息

ISBN: (纸本)9787313158758

《英语戏剧表演综合教程》1.课程的创新性。在英语语言教学中引进艺术设计、戏剧表演与创作，是对传统语言教学的创新性的改革。2.学生的参与性。强调在戏剧创作实践训练中提高英语语言的感悟力和表现力，提高学生的艺术素养和参与实践，以“在做中学，在学中做”的原则让学生做课堂的主角。教师进行有效的组织和适当的指导，是课堂上的旁观者和评论人。3.培养的综合性。项目课程是包括范本阅读、戏剧表演、舞台艺术设计，以及剧场呈现等各种戏剧元素在内的综合性通识实践课程。4.艺术的审美性。在戏剧艺术实践中提高戏剧感悟力和艺术审美能力，全面提升体验戏剧的审美素养，陶冶和塑造积极的人生态度，形成健康的人格素质。5.选材的丰富性。课程安排受到美国戏剧教育家谢克纳（RichardSchechner）的“RASABox”理论的启发，将课文按照人类的七情六欲为选材主题，分十个单元组织课文、练习和训练内容。所选剧本片段充分地体现了各个单元的主题，涵盖了自16世纪戏剧至今的英语戏剧优秀作品选段。6.利用网络信息的时代性。《英语戏剧表演综合教程》鼓励该教程使用者，尤其是学生，合理使用网络资源，课外进行信息的搜寻、知识空缺的填补以及知识的扩展和利用。因此，教材主体剧本仅提供极其简要的剧情梗概和必要引导，原则上不提供网络上可获得的资源，留出空白给学生自学完成。7.教学大纲的灵活性。本课程作为一学期选修通识课，使用《英语戏剧表演综合教程》的教师可根据学生的情况和教学条件，灵活选用书中十个单元中的若干单元。选材难度略有差异，但是基本可以任意选用，顺序亦可按照需求随意选用。8.考核的实践性。一个学期的期末考核建议由学生分组排演本教程中的剧本选段，可以由学生自选，也可由教师指定。按照表演效果、创作新意等进行考核。

关键词：英语戏剧表演教材

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环境样品中杀菌剂的多残留分析

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环境化学 2005年第3期24卷 355-356页

作者： michaels Young Kevin M Jenkins Waters Corporation Waters Corporation

苯并咪唑类化合物(benzimidazoles)如涕必灵(thiabendazole)常作为杀菌剂普遍用在瓜果及农作物上.用液相色谱法分析这些物质比较困难:例如涕必灵,在硅胶基质的色谱柱上会发生严重的拖尾现象,酸性条件下尤为明显.涕必灵和多菌灵(carbenda... 详细信息

苯并咪唑类化合物(benzimidazoles)如涕必灵(thiabendazole)常作为杀菌剂普遍用在瓜果及农作物上.用液相色谱法分析这些物质比较困难:例如涕必灵,在硅胶基质的色谱柱上会发生严重的拖尾现象,酸性条件下尤为明显.涕必灵和多菌灵(carbendazim)在pH10的情况下使用XTerra MS C18色谱柱会得到较好的峰形,但在较高的pH值下,其它类型杀菌剂或杀虫剂可能不稳定,故难以用适合这些碱性杀菌剂的高pH值条件进行同时分析.……

关键词：杀菌剂多残留分析环境样品苯并咪唑类化合物色谱柱

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