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Spatial distribution and network morphology of epicardial,endocardial,interstitial,and Purkinje cell-associated elastin fibers in porcine left ventricle

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Bioactive Materials 2023年第1期19卷 348-359页

作者： Xiaodan Shi Song Zhang Yue Liu Bryn Brazile Jim Cooley J.Ryan Butler Sara R.McMahan Karla L.Perez Jiazhu Xu timothy eastep Kytai T.Nguyen Pietro Bajona Matthias Peltz Huajian Gao Yi Hong Jun Liao Department of Bioengineering University of Texas at ArlingtonArlingtonTX76010USA College of Engineering and College of Veterinary Medicine Mississippi State UniversityMississippi StateMS39762USA School of Engineering Brown UniversityProvidenceRI02912USA College of Engineering Nanyang Technical University308232Singapore Department of Cardiovascular and Thoracic Surgery University of Texas Southwestern Medical CenterDallasTX75390USA Allegheny Health Network-Drexel University College of Medicine PittsburghPA15212USA

Cardiac extracellular matrices(ECM)play crucial functional roles in cardiac *** studies have mainly focused on collagen,the major structural ECM in heart *** role of elastin in cardiac mechanics,however,is poorly *** this study,we investigated the spatial distribution and microstructural morphologies of cardiac elastin in porcine left *** demonstrated that the epicardial elastin network had location-and depth-dependency,and the overall epicardial elastin fiber mapping showed certain correlation with the helical heart muscle fiber *** compared to the epicardial layer,the endocardial layer was thicker and has a higher elastin-collagen ratio and a denser elastin fiber network;moreover,the endocardial elastin fibers were finer and more wavy than the epicardial elastin fibers,all suggesting various interface *** myocardial interstitial elastin fibers co-exist with the perimysial collagen to bind the cardiomyocyte bundles;some of the interstitial elastin fibers showed a locally aligned,hinge-like structure to connect the adjacent cardiomyocyte *** collagen-elastin combination reflects an optimal design in which the collagen provides mechanical strength and elastin fibers facilitate recoiling during ***,cardiac elastin fibers,along with collagen network,closely associated with the Purkinje cells,indicating that this ECM association could be essential in organizing cardiac Purkinje cells into“fibrous”and“branching”morphologies and serving as a protective feature when Purkinje fibers experience large deformations in *** short,our observations provide a structural basis for future in-depth biomechanical investigations and biomimicking of this long-overlooked cardiac ECM component.

关键词： Heart ECM Epicardial elastin Endocardial elastin Interstitial elastin Purkinje-cell associated elastin

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