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Extracellular matrices, artificial neural scaffolds and the promise of neural regeneration

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Neural Regeneration Research 2014年第17期9卷 1573-1577页

作者： Christian B.Ricks Samuel S.Shin Christopher becker Ramesh Grandhi Department of Neurological Surgery University of Pittsburgh Medical CenterPittsburghPAUSA University of Pittsburgh School of Medicine PittsburghPAUSA

Over last 20 years, extracellular matrices have been shown to be useful in promoting tissue regeneration. Recently, they have been used and have had success in achieving neurogenesis. Recent developments in extracellular matrix design have allowed their successful in vivo incorporation to engender an environment favorable for neural regeneration in animal models. Promising treatments under investigation include manipulation of the intrinsic extracellular matrix and incorporation of engineered naometer-sized scaffolds through which inhibition of molecules serving as barriers to neuroregeneration and delivery of neurotrophic factors and/or cells for successful tissue regeneration can be achieved. Further understanding of the changes incurred within the extracellular matrix following central nervous system injury will undoubtedly help design a clinically efficacious extracellular matrix scaffold that can mitigate or reverse neural degeneration in the clinical setting.

关键词： extraceUular matrix neurogenesis scaffolds neural stem cells

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西欧晚泥盆世法门期早期石燕贝类腕足动物

古生物学报 2023年第3期62卷 350-375页

作者：王艺凝马学平 Volker Ebbighausen R.Thomas becker 北京大学地球与空间科学学院造山带与地壳演化教育部重点实验室北京100871 Geologisch-Palaontologisches Institut und Museum Westfalische Wilhelms-Universitat MunsterD-48149 MunsterGermany

比利时新基尔里斯(Senzeilles)地区是西欧晚泥盆世地层研究的一个经典地区,也是法门期石燕贝类腕足动物的重要比产区。然而针对本区弓石燕类的现代研究却较为匮乏,此外,早期的分类工作已难以满足现代专题性的课题资料要求(即层位清楚、... 详细信息

比利时新基尔里斯(Senzeilles)地区是西欧晚泥盆世地层研究的一个经典地区,也是法门期石燕贝类腕足动物的重要比产区。然而针对本区弓石燕类的现代研究却较为匮乏,此外,早期的分类工作已难以满足现代专题性的课题资料要求(即层位清楚、鉴定准确的系统分类工作),因此对比利时地区法门期的“弓石燕属”足动物进行系统古生物学研究及对比具有重要意义。当前研究在华南现有成果的基础上,通过对壳面特征(贝体大小、基面特征、微细纹饰特征、中槽壳褶发生方式)及内部构造(齿板特征、内窗板特征等)的系统研究及对比,拓展了Plicapustula属的定义,即:褶上和褶间均发育微瘤纹饰。欧洲的Plicapustula属分子褶间均发育放射状细瘤微细纹饰,而华南的该属分子褶间均缺失微瘤纹饰。由于该特征存在明显的地域性,因此当前研究以此为依据建立了Paraplicapustula亚属,并将欧洲的标本归入该亚属。此外,本文还首次识别并描述了欧洲的Sinospirifer属。大部分西欧Sinospirifer属和Plicapustula属与华南地区相比,在种级组成上存在明显的差异,包括标本大小、齿板是否增厚、壳褶数目及分枝情况、微细纹饰类型等。本文共描述了上述2属的5种,包括1新亚属、3新种[Plicapustula(Paraplicapustula) eleganta subgen. et sp. nov. Ma and Wang, Plicapustula(Paraplicapustula) magna subgen. et ***. Ma and Wang, Sinospirifer transversus sp. nov. Ma and Wang, Plicapustula(Paraplicapustula) sp.及Sinospirifer subextensus(Martelli, 1902)]。

关键词：中国石燕褶瘤石燕副褶瘤石燕华南西欧晚泥盆世腕足动物

Special Topic:Propulsion Systems with Low Emission and Low Noise

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Chinese Journal of Aeronautics 2023年第5期36卷 I0001-I0001页

作者： Dan ZHAO Sid becker Master Engineering Studies in the Faculty of Engineering at the University of Canterbury the Faculty of Engineering at the University of Canterbury

With the emergence of global warming and various extreme climates,governance has become one of the focus of attention in the current development process of the international *** reducing the emission of carbon dioxide,nitrogen oxides and particles,we can save energy,reduce the damage to the environment,and simultaneously create a more comfortable human living *** the past decades,much more advanced thermodynamics,heat transfer and clean combustion technologies have been developed,such as chemical looping combustion,alkaline combustion technology,porous medium combustion and collaborative control based on fuel characteristics(Oxy-fuel,Ammonia/Hydrogen)and combustion conditions(high pressure or high Mach number).

关键词： thermodynamics dioxide extreme

H_(∞)control in the frequency domain for a semi-active floor isolation system

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Frontiers of Structural and Civil Engineering 2013年第3期7卷 264-275页

作者： Yundong SHI Tracy C becker Masahiro KURATA Masayoshi NAKASHIMA Graduate School of Engineering Kyoto UniversityKyoto 611-0011Japan Disaster Prevention Research Institute Kyoto UniversityKyoto 611-0011Japan

A floor isolation system installed in a single floor or room in a fixed base structure is designed to protect *** this configuration,the input motions to the floor isolation from the ground motions are filtered by the structure,leaving the majority of the frequency content of the input motion lower than the predominant frequency of the *** floor isolation system should minimize the acceleration to protect equipment;however,displacement must also be limited to save floor space,especially with long period ***-active control with an H_(∞)control was adopted for the floor isolation system and a new input shaping filter was developed to account for the input motion characteristics and enhance the effectiveness of the H_(∞)control.A series of shake table tests for a semi-active floor isolation system using rolling pendulum isolators and a magnetic-rheological damper were performed to validate the H_(∞)*** control using an oil damper was also tested for *** test results show that the H_(∞)control effectively reduced acceleration for short period motions with frequencies close to the predominant frequency of the structure,as well as effectively reduced displacement for long period motions with frequencies close to the natural frequency of the floor isolation *** H_(∞)control algorithm proved to be more advantageous than passive control because of its capacity to adjust control strategies according to the different motion frequency characteristics.

关键词： semi-active floor isolation H1 control MR damper shaping filter shaking table test

Human papilloma virus and esophageal carcinoma in a Latin-American region

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World Journal of Gastroenterology 2009年第25期15卷 3142-3147页

作者： Roberto Herrera-Goepfert Marcela Lizano Suminori Akiba Adela Carrillo-García Mauricio becker-D'Acosta Department of Pathology National Cancer Institute Unit of Biomedical Research in Cancer National Cancer Institute and Biomedical Research InstituteNational Autonomous University of Mexico Department of Epidemiology and Preventive Medicine Kagoshima University Graduate School of Medical and Dental Sciences

AIM:To investigate the presence of high-risk human papilloma virus (HPV) in esophageal squamous cell carcinomas (ESCCs) in a non-selected Mexican ***: Cases with a pathological diagnosis of squamous cell carcinoma of the esophagus were obtained from Department of Pathology files, at the National Cancer Institute in Mexico City during the period between 2000 and 2008. Slides from each case were reviewed and cases with sufficient neoplastic tissue were selected for molecular analysis. DNA was extracted from paraffin-embedded tissue samples for polymerase chain reaction analysis to detect HPV DNA sequences. Demographic and clinical data of each patient were retrieved from corresponding clinical ***: HPV was detected in 15 (25%) of ESCCs. HPV-16 was the most frequently observed genotype, followed by HPV-18; HPV-59 was also detected in one case. Unfortunately, HPV genotype could not be established in three cases due to lack of material for direct sequencing, although universal primers detected the presence of HPV generic sequences. No low-risk HPV genotypes were found nor was HPV-16/18 co-infection. HPV presence in ESCC was not significantly associated with gender, age, alcohol consumption, smoking, anatomic location, or histologic grade. All patients belonged to low and very low socioeconomic strata, and were diagnosed at advanced disease stage. Male patients were most commonly affected and the male:female ratio in HPV-positive ESCC increased two- fold in comparison with HPV-negative cases (6.5:1 vs 3.1:1).CONCLUSION: High prevalence of high-risk HPV in ESCC in Mexico does not support the hypothesis that HPV-associated ESCC is more common in areas with higher ESCC incidence rates.

关键词：乳头状瘤病毒拉丁美洲食管癌人类

Liver sinusoidal endothelial and biliary cell repopulation following irradiation and partial hepatectomy

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World Journal of Gastroenterology 2010年第31期16卷 3928-3935页

作者： Petra Krause Margret Rave-Frank Hendrik Andreas Wolff Heinz becker Hans Christiansen Sarah Koenig Department of General Surgery University Medical Centre Goettingen Department of Radiotherapy University Medical Cen-tre Goettingen

AIM: To investigate whether irradiation (IR) and partial hepatectomy (PH) may prepare the host liver for nonparenchymal cell (NPC) ***: Livers of dipeptidyl peptidase(DPP)-deficient rats were pre-conditioned with external beam IR (25 Gy) delivered to two-thirds of the right liver lobules followed by a one-third PH of the untreated lob-ule. DPP-positive liver cells (NPC preparations enriched for liver sinusoidal endothelial cells (LSECs) and hepatocytes) were transplanted via the spleen into the recipient livers. The extent and quality of donor cell engraftment and growth was studied over a long-term interval of 16 wk after ***: Host liver staining demonstrated 3 different repopulation types. Well def ined clusters of donor-derived hepatocytes with canalicular expression of DPP were detectable either adjacent to or in between large areas of donor cells (covering up to 90% of the section plane) co-expressing the endothelial marker platelet endothelial cell adhesion molecule. The third type consisted of formations of DPP-positive duct-like structures which co-localized with biliary epithelial ***: Liver IR and PH as a preconditioning stimulus enables multiple cell liver repopulation by donor hepatocytes, LSECs, and bile duct cells.

关键词： Cell transplants Dipeptidyl peptidase protein Endothelial cells Liver cell transplantation Liver irradiation Liver repopulation

Effects of Resistant Starch on Symptoms,Fecal Markers,and Gut Microbiota in Parkinson’s Disease—The RESISTA-PD Trial

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Genomics, Proteomics & Bioinformatics 2022年第2期20卷 274-287页

作者： Anouck becker Georges Pierre Schmartz Laura Groger Nadja Grammes Valentina Galata Hannah Philippeit Jacqueline Weiland Nicole Ludwig Eckart Meese Sascha Tierling Jorn Walter Andreas Schwiertz Jorg Spiegel Gudrun Wagenpfeil Klaus Faßbender Andreas Keller Marcus M.Unger Department of Neurology Saarland UniversityD-66421 HomburgGermany Chair for Clinical Bioinformatics Saarland UniversityD-66123 SaarbruckenGermany Department of Human Genetics Saarland UniversityD-66421 HomburgGermany Department of Genetics/Epigenetics Saarland UniversityD-66123 SaarbruckenGermany Institute of Microecology D-35745 HerbornGermany Institute of Medical Biometry Epidemiology and Medical InformaticsSaarland UniversityD-66421 HomburgGermany Department of Neurology Stanford UniversityPalo AltoCA 94305USA

The composition of the gut microbiota is linked to multiple diseases,including Parkinson’s disease(PD).Abundance of bacteria producing short-chain fatty acids(SCFAs)and fecal SCFA concentrations are reduced in *** exert various beneficial functions in *** the interventional,monocentric,open-label clinical trial “Effects of Resistant Starch on Bowel Habits,Short Chain Fatty Acids and Gut Microbiota in Parkinson’s Disease”(RESISTA-PD;ID:NCT02784145),we aimed at altering fecal SCFAs by an 8-week prebiotic intervention with resistant starch(RS).We enrolled 87 subjects in three study-arms:32 PD patients received RS(PD+RS),30 control subjects received RS,and 25 PD patients received solely dietary *** performed paired-end 100 bp length metagenomic sequencing of fecal samples using the BGISEQ platform at an average of 9.9 *** was *** the PD+RS group,fecal butyrate concentrations increased significantly,and fecal calprotectin concentrations dropped significantly after 8 weeks of RS ***,we observed a reduction in non-motor symptom load in the PD+RS *** reference-based analysis of metagenomes highlighted stable alpha-diversity and beta-diversity across the three groups,including bacteria producing ***-free analysis suggested punctual,yet pronounced differences in the metagenomic signature in the PD+RS ***-PD highlights that a prebiotic treatment with RS is safe and well-tolerated in *** stable alpha-diversity and beta-diversity alongside altered fecal butyrate and calprotectin concentrations call for long-term studies,also investigating whether RS is able to modify the clinical course of PD.

关键词： Parkinson’s disease Short-chain fatty acid Microbiota Metagenomics Intestinal inflammation

Fast fluorescence lifetime imaging techniques:A review on challenge and development

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Journal of Innovative Optical Health Sciences 2019年第5期12卷 3-29页

作者： Xiongbo Liu Danying Lin Wolfgang becker Jingjing Niu Bin Yu Liwei Liu Junle Qu Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060 P.R.China becker&Hickl GmbH Nunsdorfer Ring 7-9 Berlin 12277Germany

Fluorescence lifetime imaging microscopy(FLIM)is increasingly used in biomedicine,material science,chemistry,and other related research fields,because of its advantages of high specificity and sensitivity in monitoring cellular microenvironments,studying interaction between proteins,metabolic state,screening drugs and analyzing their efficacy,characterizing novel materials,and diagnosing early ***,there is a large interest in obtaining FLIM data within an acquisition time as short as ***,there is currently a technology that advances towards faster and faster FLIM ***,the maximum speed of a recording technique is only part of the *** acquisition time of a FLIM image is a complex function of many *** include the photon rate that can be obtained from the sample,the amount of information a technique extracts from the decay functions,the fficiency at which it determines fluorescence decay parameters from the recorded photons,the demands for the accuracy of these parameters,the number of pixels,and the lateral and axial resolutions that are obtained in biological *** from a discussion of the parameters which determine the acquisition time,this review will describe existing and emerging FLIM techniques and data analysis algo-rithms,and analyze their performance and recording speed in biological and biomedical applications.

关键词： Fluorescence lifetime imaging microscopy(FLIM) acquisitin time imaging speed dead time photon fficiency time domain frequency domain scanning wide-field imaging time-correlated single photon counting(TCSPC) gated detection gated image intensifer modulated inage intensifier SPAD array detector

The dichotomy of p53 regulation by noncoding RNAs

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Journal of Molecular Cell Biology 2014年第3期8卷 198-205页

作者： Qipan Deng Lindsey becker Xiaodong Ma Xiaoming Zhong Ken Young Kenneth Ramos and Yong Li Department of Biochemistry and Molecular Biology School of Medicine University of Louisville 319 Abraham Flexner Way Louisville KY 40202 USA Department of Cardiology Huaihe Hospital of Henan University Kaifeng 475000 China Department of Hematopathology The University of Texas MD AndersonCancer Center Houston TX 77030 USA School of Life Science and Technology ShanghaiTech University Shanghai 200031 Cl~ina

p53 肿瘤 suppressor 基因是在癌症的最经常变异的基因。重要进步被取得了在协调细胞的回答到 DNA 损坏， oncogene 激活，和另外的压力认出 importanceof p53。没有被翻译成蛋白质， Noncoding RNA 是 RNA moleculesfunctioning。在这... 详细信息

p53 肿瘤 suppressor 基因是在癌症的最经常变异的基因。重要进步被取得了在协调细胞的回答到 DNA 损坏， oncogene 激活，和另外的压力认出 importanceof p53。没有被翻译成蛋白质， Noncoding RNA 是 RNA moleculesfunctioning。在这个工作，我们与四个异乎寻常的问题由 noncodingRNAs 讨论 p53 规定的两分。首先， microRNAs 的 overexpression 为在 absenceof p53 变化的 p53 inactivation 负责吗？第二，在 p53 基因的 noncoding 区域有体的变化吗？第三，在预先安排的 p53 基因的 noncoding 区域有 germline 异种搬运人到癌症？第四，罐头 p53 激活由 noncoding RNA 变化原因癌症调停了？Thiswork 在 p53 dysregulation 和 tumorigenesis 加亮 noncoding RNA 的突起。

关键词： p53基因突变非编码RNA 基因调控二分法 microRNA 肿瘤抑制基因体细胞突变基因激活