Extracellular matrices, artificial neural scaffolds and the promise of neural regeneration

作     者：Christian B.Ricks Samuel S.Shin Christopher Becker Ramesh Grandhi 

作者机构：Department of Neurological SurgeryUniversity of Pittsburgh Medical CenterPittsburghPAUSA University of Pittsburgh School of MedicinePittsburghPAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2014年第9卷第17期

页      面：1573-1577页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：NINDS NIH HHS [F30 NS067731] Funding Source: Medline 

主　　题：extraceUular matrix neurogenesis scaffolds neural stem cells 

摘      要：Over last 20 years, extracellular matrices have been shown to be useful in promoting tissue regeneration. Recently, they have been used and have had success in achieving neurogenesis. Recent developments in extracellular matrix design have allowed their successful in vivo incorporation to engender an environment favorable for neural regeneration in animal models. Promising treatments under investigation include manipulation of the intrinsic extracellular matrix and incorporation of engineered naometer-sized scaffolds through which inhibition of molecules serving as barriers to neuroregeneration and delivery of neurotrophic factors and/or cells for successful tissue regeneration can be achieved. Further understanding of the changes incurred within the extracellular matrix following central nervous system injury will undoubtedly help design a clinically efficacious extracellular matrix scaffold that can mitigate or reverse neural degeneration in the clinical setting.