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A Transcriptome Atlas of Physcomitrella patens Provides Insights into the Evolution and Development of Land Plants

Molecular Plant 2016年第2期9卷 205-220页

作者： Carlos Ortiz-Ramirez Marcela Hernandez-Coronado Anna Thamm Bruno Catarino Mingyi Wang Liam Dolan Jose A.Feijo Jorg D. becker Instituto Gulbenklan de Ciencia Rua da Quinta Grande 6 2780-156 Oeiras Portugal Department of Plant Sciences University of Oxford South Parks Road Oxford OX1 3RB UK Division of Plant Biology The Samuel Roberts Noble Foundation Ardmore OK 73401 USA Department of Cell Biology and Molecular Genetics University of Maryland 0118 BioSclence Research Building College Park MD 20742-5815 USA These authors contributed equally to this article

Identifying the genetic mechanisms that underpin the evolution of new organ and tissue systems is an aim of evolutionary developmental biology. Comparative functional genetic studies between angiosperms and bryophytes can define those genetic changes that were responsible for developmental innovations. Here, we report the generation of a transcriptome atlas covering most phases in the life cycle of the model bryo- phyte Physcomitrella patens, including detailed sporophyte developmental progression. We identified a comprehensive set of sporophyte-specific transcription factors, and found that many of these genes have homologs in angiosperms that function in developmental processes such as flowering and shoot branching. Deletion of the PpTCP5 transcription factor results in development of supernumerary sporangia attached to a single seta, suggesting that it negatively regulates branching in the moss sporophyte. Given that TCP genes repress branching in angiosperms, we suggest that this activity is ancient. Finally, compar- ison of P. patens and Arabidopsis thaliana transcriptomes led us to the identification of a conserved core of transcription factors expressed in tip-growing cells. We identified modifications in the expression patterns of these genes that could account for developmental differences between P. patens tip-growing cells and A. thaliana pollen tubes and root hairs.

关键词： land plant evolution Physcomitrella patens transcriptome atlas TCP branching tip growth

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Comparison of survival outcomes between laparoscopic versus open radical nephroureterectomy in upper tract urothelial cancer patients:Experiences of a tertiary care single center

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Current Urology 2023年第4期17卷 292-298页

作者： Benedikt Hoeh Marina Kosiba Mike Wenzel Nicola Meister Felix Preisser Shahrokh F.Shariat Jan Lukas Hohenhorst Andreas becker Philipp Mandel Severine Banek Frederik Roos Pierre I.Karakiewicz Felix K.H.Chun Luis A.Kluth Department of Urology University Hospital FrankfurtGoethe University Frankfurt am MainFrankfurt am Main60590Germany Cancer Prognostics and Health Outcomes Unit Division of UrologyUniversity of Montreal Health CenterMontrealQuebecCanada Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive Health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan Martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany

Objectives:To test for differences in overall and recurrence-free survival between laparoscopic and open surgical approaches in patients undergoing radical nephroureterectomy(RNU)for upper tract urothelial carcinoma(UTUC).Materials and methods:We retrospectively identified patients treated for UTUC from 2010 to 2020 from our institutional *** undergoing laparoscopic or open RNU with no suspicion of metastasis(cM0)were for the current study *** with suspected metastases at diagnosis(cM1)or those undergoing other surgical treatments were *** was performed according to the laparoscopic versus open surgical ***-Meier plots were used to test for differences in overall and recurrence-free survival with regard to the surgical ***,separate Kaplan-Meier plots were used to test the effect of preoperative ureterorenoscopy on overall and recurrence-free survival within the overall study ***:Of the 59 patients who underwent nephroureterectomy,29%(n=17)underwent laparoscopic nephroureterectomy,whereas 71%(n=42)underwent open *** and tumor characteristics were comparable between groups(p≥0.2).The median overall survival was 93 and 73 months in the laparoscopic nephroureterectomy group compared to the open nephroureterectomy group(p=0.5),*** median recurrence-free survival did not differ between open and laparoscopic nephroureterectomies(73 months for both groups;p=0.9).Furthermore,the median overall and recurrence-free survival rates did not differ between patients treated with and without preoperative ***:The results of this retrospective,single-center institution showed that overall and recurrence-free survival rates did not differ between patients with UTUC treated with laparoscopic and open ***,preoperative ureterorenoscopy before RNU was not associated with higher overall or recurrence-free survival rates.

关键词： Upper tract urothelial carcinoma Laparoscopic radical nephroureterectomy Open radical nephroureterectomy Overall survival

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Salt Stress Triggers Phosphorylation of the Arabidopsis Vacuolar K＋ Channel TPK1 by Calcium-Dependent Protein Kinases （CDPKs）

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Molecular Plant 2013年第4期6卷 1274-1289页

作者： Andreas Latz Norbert Mehlmer Simone Zapf Thomas D. Mueller Bernhard Wurzinger Barbara Pfister Edina Csaszar Rainer Hedrich Markus Teige Dirk becker Department of Molecular Plant Physiology and Biophysics Julius-von-Sachs-lnstitute University of Wurzburg Julius-von-Sachs-Platz 2 D-97082 Wurzburg Germany Department of Biochemistry and Cell Biology Max F. Perutz Laboratories University of Vienna Dr. Bohrgasse 9 A-1030 Vienna Austria Present address: Department of Biology I Botany Munich Center for Integrated Protein Science CiPSM Ludwig-Maximilians-Universitat Munchen D-82152 Planegg-Martinsried Germany College of Science King Saud University Riyadh 11451 Saudi Arabia

14-3-3 proteins play an important role in the regulation of many cellular processes. The Arabidopsis vacuolar two-pore K＋ channel 1 （TPK1） interacts with the 14-3-3 protein GRF6 （GF14-λ）. Upon phosphorylation of the putative binding motif in the N-terminus of TPK1, GRF6 binds to TPK1 and activates the potassium channel. In order to gain a deeper understanding of this 14-3-3-mediated signal transduction, we set out to identify the respective kinases, which regulate the phosphorylation status of the 14-3-3 binding motif in TPK1. Here, we report that the calcium-dependent protein kinases （CDPKs） can phosphorylate and thereby activate the 14-3-3 binding motif in TPK1. Focusing on the stress-activated kinase CPK3, we visualized direct and specific interaction of TPK1 with the kinase at the tonoplast in vivo. In line with its proposed role in K＋ homeostasis, TPK1 phosphorylation was found to be induced by salt stress in planta, and both cpk3 and tpkl mutants displayed salt-sensitive phenotypes. Molecular modeling of the TPK1-CPK3 interaction domain provided mechanistic insights into TPK1 stress-regulated phosphorylation responses and pinpointed two arginine residues in the N-terminal 14-3-3 binding motif in TPK1 critical for kinase interaction. Taken together, our studies provide evidence for an essential role of the vacuolar potassium channel TPK1 in salt-stress adaptation as a target of calcium-regulated stress signaling pathways involving Ca2＋, Ca2＋-dependent kinases, and 14-3-3 proteins.

关键词： potassium channel vacuole calcium calcium-dependent kinase 14-3-3 protein salt stress.

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Towards an integrated modeling of the plasma-solid interface

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 201-237页

作者： Michael Bonitz Alexey Filinov Jan-Willem Abraham Karsten Balzer Hanno Kahlert Eckhard Pehlke Franz X.Bronold Matthias Pamperin Markus becker Dettlef Loffhagen Holger Fehske Institute for Theoretical Physics and Astrophysics Kiel University24098 KielGermany Leibniz Institute for Plasma Research (INP) D-17489 GreifswaldGermany Joint Institute for High Temperatures RAS 125412 MoscowRussia Computing Center of Kiel University D-24118 KielGermany Institute of Physics Greifswald UniversityD-17489 GreifswaldGermany

Solids facing a plasma are a common situation in many astrophysical systems and laboratory ***,many plasma technology applications rely on the control of the plasma-surface interaction,i.e.,of the particle,momentum and energy fluxes across the plasma-solid ***,presently often a fundamental understanding of them is missing,so most technological applications are being developed via trial and *** reason is that the physical processes at the interface of a low-temperature plasma and a solid are extremely complex,involving a large number of elementary processes in the plasma,in the solid as well as fluxes across the *** accurate theoretical treatment of these processes is very difficult due to the vastly different system properties on both sides of the interface:Quantum versus classical behavior of electrons in the solid and plasma,respectively;as well as the dramatically differing electron densities,length and time ***,often the system is far from *** the majority of plasma simulations surface processes are either neglected or treated via phenomenological parameters such as sticking coefficients,sputter rates or secondary electron emission ***,those parameters are known only in some cases and with very limited ***,while surface physics simulations have often studied the impact of single ions or neutrals,so far,the influence of a plasma medium and correlations between successive impacts have not been taken into *** an approach,necessarily neglects the mutual influences between plasma and solid surface and cannot have predictive *** this paper we discuss in some detail the physical processes of the plasma-solid interface which brings us to the necessity of coupled plasma-solid *** briefly summarize relevant theoretical methods from solid state and surface physics that are suitable to contribute to such an approach and identify four *** first are

关键词： plasma physics surface science plasmasurface modeling DFT nonequilibrium Green functions

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验证LTE基带接收机

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电子技术应用 2009年第10期35卷 4-5页

作者： Randy becker 安捷伦科技公司

在传统意义上的无线通信系统中，射频领域的模拟信号可使用模拟技术解调为同相（I）和正交（Q）分量。但在当今软件定义的无线技术时代，中频信号经过变频处理后通常会使用模数转换器（ADC）进行数字化处理，然后再将数字信号馈入基带... 详细信息

在传统意义上的无线通信系统中，射频领域的模拟信号可使用模拟技术解调为同相（I）和正交（Q）分量。但在当今软件定义的无线技术时代，中频信号经过变频处理后通常会使用模数转换器（ADC）进行数字化处理，然后再将数字信号馈入基带进行解调和解码。现在，通过将信号发生器的输出频率设为目标中频来生成恰当的中频（IF）信号，可以在射频领域以外测试基带接收机。

关键词：接收机基带 LTE 验证无线通信系统中频信号模拟信号数字化处理

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In-Game Ads Put Brands in Play——How disappearing demographics can be recovered through their video game consoles

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成功营销 2008年第8期 46-48页

作者： Grant Jenman Stephanie becker

Your audience will continue to ***'s that ***'ve already lost young men to digital *** demographics disappear from traditional media every *** the problem gets worse:Married women are spending more time playing online... 详细信息

关键词：营销策略广告企业管理品牌

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通过利用高科技测试设备确保食品和营养安全(英文)

通过利用高科技测试设备确保食品和营养安全(英文)

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第四届中国营养产业高层论坛

作者： Mario becker 赛多利斯集团

＜正＞～～

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Identifying bereaved grievers with greatest medical or social service needs in Japan

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Family Medicine and Community Health 2022年第1期10卷 1-9页

作者： Carl becker Yozo Taniyama Megumi Kondo-Arita Noriko Sasaki Shinya Yamada Kayoko Yamamoto Policy Science Unit School of MedicineKyoto UniversityKyotoJapan Department of Religious Studies Tohoku UniversitySendaiJapan Nakayama International Center Osaka Medical CollegeTakatsukiJapan Department of Healthcare Economics and Quality Management Graduate School of MedicineKyoto UniversityKyotoJapan Department of Ethnology National Museum of Japanese HistorySakuraJapan Department of Nursing Tenri Health Care UniversityTenriJapan

Objective Severe grief adversely affects the health of bereaved families,potentially burdening medical and community health *** for effective community health maintenance must identify the people likely to face severe effects of *** present study identified characteristics of mourners who experience severe grief within a year of bereavement to confirm whether this grief increased their reliance on Japanese medical and social *** We conducted a nationwide postal survey of Japanese bereaved within the previous year,to compare those reporting daily or overwhelming‘heavy’grief to those with less heavy grief,in terms of demographic and socioeconomic details,daily work and non-work activity,frequency of medical and social service ***/participants In 2019,with the support of the Ministry of Education and the All Japan Funeral Co-Operation,we distributed approximately 5500 questionnaires to Japanese who had presided at funerals within the past year for anonymous *** January of 2020,we received 1078 complete voluntary responses from bereaved *** Half of the‘heavy grief’group(n=143)reported adverse effects on health and daily life,including needs for pharmacological,medical or welfare *** of husbands or children were particularly connected to severe grief;‘unexpected’death from cancer caused the greatest ***(even part-time)buffered against severe grief;grief was greater for the unemployed and substantially worse for those who lost significant income at the same time as they lost loved *** These findings suggest that prior counselling should reduce the shock of bereavement and economic loss,which increases subsequent medical *** professionals and community health workers can use the above factors to target in advance the family members in greatest danger of heavy grief,to intervene lest grief adversely affect their physical and psychological health after ber

关键词： service sided return

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Is computed tomography cystography indicated in children with pelvic fractures?

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Chinese Journal of Traumatology 2020年第3期23卷 181-184页

作者： Alexander becker Ori Yaslowitz Joseph Dubose Kobi Peleg Yaakov Daskal Adi Givon Israel Trauma Group Boris Kessel Department of Surgery Emek Medical Center.AfulaIsrael The Rappoport School of Medicine TechnionHaifaIsrael Department of Surgery A Meir Medical CenterKfar-SabaIsrael R Adams Cowley Shock Trauma Center University of Maryland Medical SystemBaltimoreMDUSA National Center for Trauma and Emergency Medicine Research Gertner Institute for Epidemiology and Health Policy ResearchTel HashomerIsrael Emergency and Disaster Management Department Faculty of Medicine.School of Public Health.Tel-Aviv UniversityIsrael Trauma Unit Hillel Yaffe Medical CenterHaderaIsrael

Purpose: Pelvic fracture evaluation with abdominopelvic computed tomography (CT) and formal CT cystography for rule out of urine bladder injury have been commonly employed in pediatric trauma patients. The additional delayed imaging required to obtain optimal CT cystography is, however, associated with increased doses of ionizing radiation to pelvic organs and represent a significant risk in the pediatric population for future carcinogenic risk. We hypothesized that avoidance of routine CT cystography among pediatric pelvic fracture victims would not result in an appreciable rate of missed bladder injuries and would aid in mitigating the radiation exposure risk associated with these additional ***: A retrospective cohort study involving blunt trauma pelvic fractures among pediatric trauma patients (age<14) between the years 1997 and 2016 was conducted utilizing the Israeli National Trauma Registry. Statistical analysis was performed using SAS statistical software version 9.4 via the tests of Chisquare test and two-sided Fisher’s exact test. Ap value of less than 0.05 was considered statistically ***: A total of 1072 children were identified from the registry for inclusion. Mean age of patients was 7.7 years (range 0-14) and 713 (66.5%) were male. Overall mortality in this population was 4.1% (44/1072). Only 2.1% (23) of pediatric patients with pelvic fractures had bladder injury identified, with just 9 children having intraperitoneal bladder rupture (0.8% of all the patients).Conclusion: The vast majority of blunt pediatric trauma victims with pelvic fractures do not have urine bladder injuries. Based on our study results we do not recommend the routine utilization of CT cystography in this unique population.

关键词： Tomography,X-ray computed Cystography Bladder injury Child Pelvic fracture

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Micro-Structured Fiber Interferometer as Sensitive Temperature Sensor

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Photonic Sensors 2013年第3期3卷 208-213页

作者： F. C. FAVERO M. becker, R. SPITTEL M. ROTHHARDT J. KOBELKE H. BARTELT Institute of Photonic Technology (IPHT) Albert-Einstein-Strafle-9 07745 Jena Germany

We report on a fast and sensitive temperature sensor using a micro-structured or photonic crystal fiber interferometer with a high germanium doped fiber core. The wavelength sensitivity for temperature variation was as high as Δλ/ΔT= 78 pm/°C up to 500 °C, which was 6 times more sensitive than the fiber Bragg grating temperature sensitivity of Δλ/ΔT= 13 pm/°C at 1550 nm. The sensor device was investigated concerning the sensitivity characteristics and response time.

关键词：温度传感器温度敏感性光纤干涉仪微结构波长灵敏度光纤布喇格光栅光子晶体温度变化

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