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COVID-19 induced renal injury differs from that in other viral-infections

Emergency and Critical Care Medicine 2022年第1期2卷 23-31页

作者： Rachel S.Parise Manoj Govindarajulu Sindhu Ramesh Tony Thomas timothy moore Muralikrishnan Dhanasekaran Department of Drug Discovery and Development Auburn University Harrison School of PharmacyWalker BuildingAuburnAlabamaUSA Department of Mechanical Engineering Auburn UniversityAuburnAlabamaUSA

Background:Kidney injuries caused by several viral diseases have been reported worldwide among all age groups,races,and *** particular importance is coronavirus disease 2019(COVID-19),and its prevalence in communities infecting all patient populations with symptoms ranging from asymptomatic to severe,including complications and ***:Data were acquired from PubMed,Scopus,Google Scholar,Centers for Disease Prevention and Control(CDC),and Lexi-Comp using the following search terms:“COVID-19 and renal pathology,”“COVID-19 induced kidney disease,”“Viral infection induced kidney disease,”and“Viral infection induced renal damage.”Titles and abstracts were manually analyzed as per the exclusion and inclusion criteria of relevant articles;relevance of articles included studies on the pathology of a specific viral infection and the impact of the virus on the adult renal ***:The mechanisms for renal disease due to COVID-19 include direct renal tubular injury,cytokine storm,inflammation,thrombosis *** tubular necrosis,thrombotic events,and direct renal *** some mechanisms behind renal dysfunction among the studied viral infections are similar,the prevalence rates of kidney injury or damage *** might be described by recommended prophylactic and therapeutic approaches that can alter the viral infection characteristics and possibly the impact a particular organ ***:The patient population at risk was old in age and had a high body mass *** mechanisms associated with renal dysfunction are similar,including direct renal injury through angiotensin converting enzyme 2(ACE2)entry,inflammation,and *** renal pathology of coronaviruses that differs from that of other prevalent viral infections is the activation of cytokine storm,which causes elevations of a greater number and different kinds of cytokines than other viral infections.

关键词： COVID-19 Kidney damage Renal damage Renal pathology

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A scientific perspective of how and why Omicron is less severe than SARS-CoV-2

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Emergency and Critical Care Medicine 2023年第3期3卷 115-121页

作者： Rachel Parise Sindhu Ramesh Jun Ren Manoj Y.Govindarajulu Rishi M.Nadar Suhrud Pathak timothy moore Muralikrishnana Dhanasekaran Department of Drug Discovery and Development Harrison College of PharmacyAuburn UniversityAuburnALUSA Department of Cardiology Zhongshan Hospital Fudan UniversityShanghaiChina Department of Laboratory Medicine and Pathology University of WashingtonSeattleWAUSA

Omicron is currently the dominant variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the coronavirus responsible for the coronavirus disease 2019(COVID-19)*** is associated with mild symptoms,although it can cause harmful effects in high-risk patient *** and COVID-19 affect multiple organ systems,including the respiratory system,gastrointestinal tract,cardiovascular system,central nervous system,ophthalmic system,genitourinary tract,and musculoskeletal ***-19 infects additional organ systems,including the hematological system,hepatobiliary system,renal system,and dermatologic *** viral-induced complications were compared to discuss the effects of Omicron versus the authentic SARS-CoV-2 virus,revealing less detrimental outcomes for ***,COVID-19 is more likely to infect older adults,males,and obesity with mild to severe *** causes mild symptoms in younger populations and overweight *** were acquired using PubMed,Centers for Disease Prevention and Control,and the World Health ***-19 and Omicron mechanisms causing organ system-related complications are likely because of the natural immune response to the active infection,the uncontrollable release of cytokines causing cytokine release syndrome,and direct viral damage through angiotensin-converting enzyme 2/transmembrane serine protease 2 receptor binding and entrance to the host cell for infection.

关键词： Complications Infection Inflammation Omicron SARS-CoV-2

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A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57BL/6J mice

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Liver Research 2021年第4期5卷 239-242页

作者： Satyanarayana R Pondugula Julia M Salamat Kodye L Abbott Patrick C Flannery Mohammed Majrashi Mohammed Almaghrabi Manoj Govindarajulu Sindhu Ramesh Maninder Sandey Suneel K Onterue Chen-Che J Huang Yoshimi Iwaki Kristina Gill Natasha Narayanan Edwin McElroy Darshini Desai Rishi Nadar timothy moore Muralikrishnan Dhanasekaran Department of Anatomy Physiology and PharmacologyCollege of Veterinary MedicineAuburn UniversityAuburnALUSA Department of Pharmacology Faculty of MedicineUniversity of JeddahJeddahSaudi Arabia Department of Drug Discovery and Development Harrison School of PharmacyAuburn UniversityAuburnALUSA Department of Pathobiology College of Veterinary MedicineAuburn UniversityAuburnALUSA Animal Biochemistry Division National Dairy Research InstituteICAR-National Dairy Research InstituteKarnalHaryanaIndia Department of Clinical Science College of Veterinary MedicineAuburn UniversityAuburnALUSA

Background and aims:Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity.A combination chemotherapy regimen of doxorubicin(DOX)and cyclophos-phamide(CPS)is employed in treatment of several cancers such as leukemia,lymphoma,and breast *** is not well understood whether a combination therapy with DOX and CPS can induce *** therefore sought to determine whether co-administration of DOX and CPS at their clini-cally relevant doses and frequency results in ***:Male C57BL/6J mice received one intraperitoneal injection of saline or DOX-2 mg/kg and CPS-50 mg/kg once a week for 4 *** the treatment period,liver histology and various serum bio-markers of hepatotoxicity were ***:Co-treatment with DOX and CPS did not alter the serum levels of alanine aminotransferase(ALT),alkaline phosphatase(ALP),bilirubin,albumin,globulin,or total ***,co-administration of DOX and CPS did not result in a noticeable change in liver ***,it was notable that the concomitant treatment with DOX and CPS resulted in a significant increase in serum levels of aspartate aminotransferase(AST).Elevated serum AST levels were also associated with increased serum creatinine kinase(CK)levels,suggesting that the elevated serum AST levels are likely due to muscle injury following the co-administration of DOX and ***:Taken together,our results,for the first time,suggest that co-administration of DOX and CPS,at their clinically relevant doses and frequency does not induce a significant hepatotoxicity in the mice.

关键词： Cyclophosphamide(CPS) Doxorubicin(DOX) Hepatotoxicity Liver injury Muscle injury

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音乐集市

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现代装饰 2022年第2期 146-151页

作者： Amelia Borg Nick Braun Jane Caught Qianyi Lim timothy moore Rafid Hai John Tanner Lauren Crockett Peter Bennetts(摄影) 郭映琴(译) 不详

本案位于澳大利亚墨尔本,集工作、学习、表演、合作于一体,是澳大利亚当代音乐的新型文化社交空间。为了促进音乐与商业的融合,本中心汇聚了多家澳大利亚顶尖的音乐机构,包括:维多利亚音乐、维多利亚音乐发展办公室以及The Push音乐慈... 详细信息

本案位于澳大利亚墨尔本,集工作、学习、表演、合作于一体,是澳大利亚当代音乐的新型文化社交空间。为了促进音乐与商业的融合,本中心汇聚了多家澳大利亚顶尖的音乐机构,包括:维多利亚音乐、维多利亚音乐发展办公室以及The Push音乐慈善机构,同时也容纳了一系列共享办公、教育以及表演空间。项目坐落于科林伍德院新区的两栋19世纪学校建筑内,是音乐与创业的结合体。落成后的项目与周边的建筑、附近的住户以及号称“墨尔本岩石之家”的Tote酒店形成了良好的互动关系,有效地鼓励了当地社区创意型产业的融合。室内涵盖了多种功能空间,包括作曲室、教育空间、走廊、会议室以及社交空间,其能够为不同类型的活动及表演提供场所,接纳人们随时迸发的表演灵感,而可移动的墙壁与窗帘则进一步增强了空间的灵活性。多功能空间体现了空间项目与使用者的融合,大门与吧台闪烁的灯光吸引着人们。与大多数文化社交中心相同,室内的照明系统在使用和空间配置上都非常灵活:设有可移动隔断的会议空间在日程结束后可变身为激动人心的演出现场。

关键词：科林伍德演出现场功能空间空间配置照明系统澳大利亚慈善机构当代音乐

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库拉索芦荟:伤口复原和口腔疾病控制的潜在应用

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中国农村科技 2006年第8期 37-37页

作者： timothy E.moore D.D.S/M.S P.C.

库拉索芦荟已经显示出了很强的防御能力,它有多种成分可以帮助抵抗牙齿周围的疾病和保护口腔其它环境.一个牙周病医师已持续了14年,以各种浓度的库拉索芦荟应用于病人,其案例超过了6000宗.我已经观察到它有非凡的复原能力,可消去浮肿,... 详细信息

库拉索芦荟已经显示出了很强的防御能力,它有多种成分可以帮助抵抗牙齿周围的疾病和保护口腔其它环境.一个牙周病医师已持续了14年,以各种浓度的库拉索芦荟应用于病人,其案例超过了6000宗.我已经观察到它有非凡的复原能力,可消去浮肿,减轻患者疼痛.

关键词：库拉索芦荟疾病控制应用口腔复原伤口防御能力牙周病

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Neuromuscular electrical stimulation and testosterone did not influence heterotopic ossification size after spinal cord injury: A case series

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World Journal of Clinical Cases 2016年第7期4卷 172-176页

作者： Pamela D moore Ashraf S Gorgey Rodney C Wade Refka E Khalil timothy D Lavis Rehan Khan Robert A Adler Spinal Cord Injury Service and Disorders Hunter Holmes Mc Guire VA Medical Center Physical Medicine and Rehabilitation Virginia Commonwealth University Radiology Service Hunter Holmes McG uire VA Medical Center Endocrinology Service Hunter Holmes Mc Guire VA Medical Center Endocrine Division Virginia Commonwealth University School of Medicine

Neuromuscular electrical stimulation(NMES) and testosterone replacement therapy(TRT) are effective rehabilitation strategies to attenuate muscle atrophy and evoke hypertrophy in persons with spinal cord injury(SCI). However both interventions might increase heterotopic ossification(HO) size in SCI patients. We present the results of two men with chronic traumatic motor complete SCI who also had pre-existing HO and participated in a study investigating the effects of TRT or TRT plus NMES resistance training(RT) on body composition. The 49-year-old male, Subject A, has unilateral HO in his right thigh. The 31-year-old male, Subject B, has bilateral HO in both thighs. Both participants wore transdermal testosterone patches(4-6 mg/d) daily for 16 wk. Subject A also underwent progressive NMES-RT twice weekly for 16 wk. Magnetic resonance imaging scans were acquired prior to and post intervention. Cross-sectional areas(CSA) of thewhole thigh and knee extensor skeletal muscles, femoral bone, and HO were measured. In Subject A(NMES-RT + TRT), the whole thigh skeletal muscle CSA increased by 10%, the knee extensor CSA increased by 17%, and the HO + femoral bone CSA did not change. In Subject B(TRT), the whole thigh skeletal muscle CSA increased by 13% in the right thigh and 6% in the left thigh. The knee extensor CSA increased by 7% in the right thigh and did not change in the left thigh. The femoral bone and HO CSAs in both thighs did not change. Both the TRT and NMES-RT + TRT protocols evoked muscle hypertrophy without stimulating the growth of preexisting HO.

关键词： Heterotopic ossification Neuromuscular electrical stimulation Testosterone Resistance training Spinal cord injury

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Brain metastasis in advanced colorectal cancer： results from the South Australian metastatic colorectal cancer (SAmCRC) registry

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Cancer Biology & Medicine 2017年第4期14卷 371-376页

作者： Gonzalo Tapia Rico timothy J. Price Christos Karapetis Cynthia Piantadosi Rob Padbury Amitesh Roy Guy Maddern James moore Scott Carruthers David Roder Amanda R. Townsend Department of Medical Oncology The Queen Elizabeth Hospital and University of Adelaide Adelaide SA 5011 Australia Department of Medical Oncology Flinders Medical Center and Flinders University Adelaide SA 5042 Australia Department of Surgery Flinders Medical Center Bedford Park SA 5042 Australia Department of Surgery The Queen Elizabeth Hospital Adelaide SA 5011 Australia Department of Surgery University of South Australia Adelaide SA 5005 Australia Department of Surgery Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Radiation Oncology Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Epidemiology University of South Australia Adelaide SA 5005 Australia

Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the *** reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(SAmCRC)was analyzed to assess the number of patients presenting with brain metastasis during their *** to small numbers,a descriptive analysis is ***:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were *** the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain *** median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).Patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the SAmCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 ***:Brain metastasis is a rare outcome in advanced *** within the registry tended to be female,young in age,and harbored with higher rates of KRAS *** routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease.

关键词： Brain metastasis colorectal cancer survival surveillance

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碳酸氢钠预防造影剂肾病——一项随机对照研究

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美国医学会杂志（中文版） 2005年第6期24卷 339-345页

作者： Gregory J. Merten, MD W. Patrick Burgess, MD,PhD 1 Lee V. Gray,MD Jeremiah H. Holleman, MD timothy S. Roush, MD Gien J. Kowalchuk, MD Robert M. Bersin, MD Arl Van moore,MD Charles A. Simonton Ⅲ, MD Robert A. Rittase, PharmD H. James Norton,PhD Thomas P. Kennedy, MD, MPH 罗洋（译）谌贻璞（校） Departments of Internal Medi- cine Carolinas Medical Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Departments of Internal Radiology Carolinas Medical Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Departments of Internal Clinical Pharmacy Carolinas Medical Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Departments of Internal Biostatistics Carolinas Medical Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Departments of Internal Sanger Cardiology Carolinas Medical Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Departments of Internal Sanger Cardio- vascular Surgery Carolinas Medical Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Departments of Internal Metrolina Nephrology Carolinas Medical Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. 不详

背景：造影剂肾病仍是放射影像学检查的一种常见并发症。在动物急性缺血性肾衰竭模型中，预先使用碳酸氢钠比氯化钠的肾脏保护作用更佳。缺血和造影剂引发的急性肾衰竭均被认为是自由基损伤所致。但是，在人或动物至今尚无评价碳酸氢钠... 详细信息

背景：造影剂肾病仍是放射影像学检查的一种常见并发症。在动物急性缺血性肾衰竭模型中，预先使用碳酸氢钠比氯化钠的肾脏保护作用更佳。缺血和造影剂引发的急性肾衰竭均被认为是自由基损伤所致。但是，在人或动物至今尚无评价碳酸氢钠预防造影剂肾病有效性的研究。目的：在使用放射性造影剂前后用碳酸氢钠或氯化钠进行预防性水化，比较二者的有效性。设计、地点和病人：一项于2002年9月16日至2003年6月17日进行的前瞻性、单中心、随机试验。119例血清肌酐稳定在≥1．1mg／dL（t≥97．2μmol／L）水平的病人，在应用碘帕醇（370mg碘／mL）造影前后，随机接受了氯化钠静脉滴注（n=59）或碳酸氢钠静脉滴注（n=60），剂量均为154mEq／L。在造影前及造影后第1、2天进行了血清肌酐检测。干预：病人接受154mEq／L的氯化钠或碳酸氢钠，造影前以每小时3mL／kg的速度静脉滴注1小时，造影后以每小时1mL／kg的速度滴注上述药物6小时。主要观察指标：造影剂肾病，其定义为在造影后2天内血清肌酐升高tμ25％。结果：两组病人在年龄、性别、糖尿病发生、种族以及造影剂用量方面无显著差异。碳酸氢钠治疗组病人基线血清肌酐水平稍高于氯化钠治疗组，但亦无显著差异（氯化钠组均值[sD]为1．71[0．42]mg／dL[151．2{37．1}μmol／L]，碳酸氢钠组为1．89[0．69]mg／dL[167．1{61．0}μmol／L]；P=0．09）。氯化钠组8例（13．6％），发生造影剂肾病一级终点，而碳酸氢钠组仅1例（1．7％）（均值差别，11．9％；95％可信区间[CI]，2．6％～21．2％；P=0．02）。随后，又对191例符合研究纳入标准的病人给予了碳酸氢钠治疗并进行随访登记，结果有3例出现了造影剂肾病（1．6％；95％CI，0％～3．4％）。结论：对于造影剂引发的肾衰竭，在造影前采用碳酸氢钠进行水化治疗比采用氯化钠水化治疗更为有效。

关键词：造影剂肾病随机对照研究碳酸氢钠预防性急性缺血性肾衰竭放射影像学检查水化治疗血清肌酐静脉滴注肾脏保护作用

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Principles for managing marine ecosystems prone to tipping points

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Ecosystem Health and Sustainability 2015年第5期1卷 15-32页

作者： Kimberly A.Selkoe Thorsten Blenckner Margaret R.Caldwell Larry B.Crowder Ashley L.Erickson timothy E.Essington James A.Estes Rod M.Fujita Benjamin S.Halpern Mary E.Hunsicker Carrie V.Kappel Ryan P.Kelly John N.Kittinger Phillip S.Levin John M.Lynham Megan E.Mach Rebecca G.Martone Lindley A.Mease Anne KSalomon Jameal F.Samhouri Courtney Scarborough Adrian C.Stier Crow White Joy Zedler National Center for Ecological Analysis and Synthesis 735 State StreetSuite 300Santa BarbaraCalifornia 93101 USA Hawaii Institute of Marine Biology University of HawaiiKaneoheHawaii 96744 USA Stockholm Resilience Centre Stockholm UniversityKra¨ftriket 2B10691 StockholmSweden Center for Ocean Solutions Stanford Woods Institute for the EnvironmentStanford University473 Via Ortega Room 193StanfordCalifornia 94305 USA School of Aquatic and Fishery Sciences University of WashingtonSeattleWashington 98195 USA Department of Ecology and Evolutionary Biology 100 Shaffer RoadUniversity of CaliforniaSanta CruzCalifornia 95060 USA Environmental Defense Fund 123 Mission Street28th FloorSan FranciscoCalifornia 94105 USA Bren School of Environmental Science and Management University of CaliforniaSanta BarbaraCalifornia 93106 USA Imperial College London Silwood Park CampusBuckhurst RoadAscot SL57PY United Kingdom School of Marine and Environmental Affairs University of Washington3707 Brooklyn Avenue NESeattleWashington 98105-6715 USA Conservation International Betty and Gordon Moore Center for Science and Oceans7192 Kalaniana‘ole HighwaySuite G230HonoluluHawaii 96825 USA Conservation Biology Division Northwest Fisheries Science CenterNational Marine Fisheries ServiceNational Oceanic and Atmospheric Administration2725 Montlake Boulevard EastSeattleWashington 98112 USA Department of Economics University of Hawaii at ManoaHonoluluHawaii 96822 USA School of Resource and Environmental Management Simon Fraser UniversityBurnabyBritish Columbia V5A1S6 Canada Department of Biological Sciences California Polytechnic State UniversitySan Luis ObispoCalifornia 93407 USA Botany Department University of WisconsinMadisonWisconsin 53706 USA

As climatic changes and human uses intensify,resource managers and other decision makers are taking actions to either avoid or respond to ecosystem tipping points,or dramatic shifts in structure and function that are often costly and hard to *** indicates that explicitly addressing tipping points leads to improved management *** on theory and examples from marine systems,we distill a set of seven principles to guide effective management in ecosystems with tipping points,derived from the best available *** principles are based on observations that tipping points(1)are possible everywhere,(2)are associated with intense and/or multifaceted human use,(3)may be preceded by changes in earlywarning indicators,(4)may redistribute benefits among stakeholders,(5)affect the relative costs of action and inaction,(6)suggest biologically informed management targets,and(7)often require an adaptive response to *** suggest that early action to preserve system resilience is likely more practical,affordable,and effective than late action to halt or reverse a tipping *** articulate a conceptual approach to management focused on linking management targets to thresholds,tracking early-warning signals of ecosystem instability,and stepping up investment in monitoring and mitigation as the likelihood of dramatic ecosystem change *** approach can simplify and economize management by allowing decision makers to capitalize on the increasing value of precise information about threshold relationships when a system is closer to tipping or by ensuring that restoration effort is sufficient to tip a system into the desired regime.

关键词： critical transition ecosystem-based management marine spatial planning nonlinear relationships restoration ecology stakeholder engagement

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新研究确定了与肝病和脂肪代谢有关的肝细胞突变

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中西医结合肝病杂志 2021年第11期31卷 1011-1011页

作者： Stanley W. K. Ng Foad J. Rouhani Simon F. Brunner Natalia Brzozowska Federico Abascal Luiza moore Lia Chappell Daniel Leongamornlert Aleksandra Ivovic Philip Robinson timothy Butler Mathijs A. Sanders Nicholas Williams Tim H. H. Coorens Jon Teague Keiran Raine Adam P. Butler Yvette Hooks Beverley Wilson Natalie Birtchnell Michael R. Stratton Iñigo Martincorena Raheleh Rahbari Peter J. Campbell Huw Naylor Sarah J. Aitken Matthew Hoare Susan E. Davies Ming Yang Efterpi Nikitopoulou Christian Frezza Cancer Genome Project Wellcome Sanger Institute Hinxton UK Department of Surgery Addenbrooke’s Hospital Cambridge UK Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands Stem Cell Institute University of Cambridge Cambridge UK CRUK Cambridge Institute Cambridge UK Department of Pathology Addenbrooke’s Hospital Cambridge UK MRC Toxicology Unit University of Cambridge Cambridge UK Department of Medicine University of Cambridge Addenbrooke’s Hospital Cambridge UK MRC Cancer Unit University of Cambridge Cambridge UK

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GP... 详细信息

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GPAM 五个基因在肝病患者的肝细胞中发生了突变,过程如图a所示。而其中的FOXO1、CIDEB、GPAM三个基因是对肝细胞如何代谢脂肪和对胰岛素作出反应有直接影响的基因。

关键词： FOXO1 肝病患者细胞突变肝细胞脂肪代谢胰岛素 GPA 剑桥大学

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