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Predicting potential invasion risks of Leucaena leucocephala(Lam.)de Wit in the arid area of Saudi Arabia

Journal of Arid Land 2024年第7期16卷 983-999页

作者： haq S MARIFATUL Darwish MOhAMMED Waheed MUhAMMAD Kumar MANOJ Siddiqui h MANZER Bussmann W rainer Department of Ethnobotany Institute of BotanyIlia State UniversityTbilisi 0162Georgia The Centre of Excellence on Sustainable Land Management(CoE-SLM) Indian Council of Forestry Research and EducationDehradun 248006India Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Botany State Museum for Natural HistoryKarlsruhe 76133Germany

The presence of invasive plant species poses a substantial ecological impact,thus comprehensive evaluation of their potential range and risk under the influence of climate change is *** study uses maximum entropy(MaxEnt)modeling to forecast the likelihood of Leucaena leucocephala(Lam.)de Wit invasion in Saudi Arabia under present and future climate change *** the MaxEnt modeling,we integrated climatic and soil data to predict habitat suitability for the invasive *** conducted a detailed analysis of the distribution patterns of the species,using climate variables and ecological *** focused on the important influence of temperature seasonality,temperature annual range,and precipitation *** distribution modeling used robust measures of area under the curve(AUC)and receiver-operator characteristic(ROC)curves,to map the invasion extent,which has a high level of accuracy in identifying appropriate *** complex interaction that influenced the invasion of *** was highlighted by the environmental parameters using Jackknife ***,the actual geographic area where *** was found in Saudi Arabia was considerably smaller than the theoretical maximum range,suggesting that it had the capacity to expand *** MaxEnt model exhibited excellent prediction accuracy and produced reliable results based on the data from the ROC *** and temperature were the primary factors influencing the potential distribution of ***,an estimated area of 216,342 km^(2)in Saudi Arabia was at a high probability of invasion by *** investigated the potential for increased invasion hazards in the future due to climate change scenarios(Shared Socioeconomic Pathways(SSPs)245 and 585).The analysis of key climatic variables,including temperature seasonality and annual range,along with soil properties such as clay composition and nitrogen content,unveiled their substanti

关键词： area under the curve invasive species invasion risks climate change MaxEnt model

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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric ho Yin Lau Carrie Yuen Ting Ip ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik hon Tsui timoth. h.dson rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METhODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

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Viscoelasticity and shear resistance at the aggregate scale of structured and organic carbon-free Chernozems

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Pedosphere 2023年第5期33卷 754-764页

作者： Christoph hAAS rainer hORN Philipp SAGGAU rainer DUTTMANN Institute for Plant Nutrition and Soil Science University of KielKiel 24118Germany Department of Geography Division of Landscape Ecology and Geoinformation SciencesUniversity of KielKiel 24118Germany

Soil rheology characterises the flow behaviour of soils at the particle-particle to aggregate *** sweep tests(ASTs)are often the method of choice for parameterizing soil flow properties,such as the shear strain values at the end of the linear viscoelastic range(i.e.,the deformation is mainly elastic)and at the yield point(i.e.,elastic equals plastic deformation).Samples from seven soil profiles and five soil depths of Chernozems,collected in the Maidanetske study area,close to Uman City of Ukraine,were analysed to evaluate the effect of soil organic carbon(SOC)on the parameters related to soil microstructural stability derived from *** organic carbon was removed with h_(2)O_(2)to determine the soil texture-dependent values of soil rheological properties,which were compared to the values determined for samples with intact water-stable *** shear resistance-related parameters increased for aggregated soil samples compared to SOC-free soil samples,indicating an increase in soil stability due to *** contrast,the values of the overall viscoelasticity and the shear strain were reduced for aggregated soil samples,indicating decreased soil *** functions were applied to predict the shear strain-dependent loss and storage moduli and shear stress values as a function of SOC *** particles(630–2000μm)and volumetric water content improved the *** conclude that increased SOC content,through the gluing and cementing effects of SOC and altered aggregate shapes compared to SOC-free soil materials,contributes to higher microstructural ***,the increased water content in the SOC-containing soil samples reversed soil strengthening *** was due to the fact that a more rapid increase in positive water pressure under shear stress weakened the samples and the spherical aggregates began to rotate more easily,thus loosing energy,when compared to platy particles of the SOC-free soil materials.

关键词： aggregation rheology shear strain shear stress soil organic carbon depletion soil stability

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high Responsivity and Ultra-Low Detection Limits in Nonlinear a-Si:h p-i-n Photodiodes Enabled by Photogating

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Photonic Sensors 2023年第4期13卷 27-38页

作者： Andreas BABLICh Maurice MÜLLER rainer BORNEMANN Andreas NAChTIGAL Peter hARING BOLÍVAR Institute of Graphene-Based Nanotechnology University of SiegenHölderlinstr.357076 SiegenGermany Institute of high Frequency and Quantum Electronics University of SiegenHölderlinstr.357076 SiegenGermany

Photodetectors operating at the wavelength in the visible spectrum are key components in high-performance optoelectronic *** this work,massive nonlinearities in amorphous silicon p-i-n photodiodes enabled by the photogating are presented,resulting in responsivities up to 744 mA/W at blue *** detectors exhibit significant responsivity gains at optical modulation frequencies exceeding Mhz and a more than 60-fold enhanced spectral response compared to the non-gated *** detection limits down to 10.4 nW/mm^(2) and mean signal-to-noise ratio enhancements of 8.5dB are demonstrated by illuminating the sensor with an additional 6.6μW/mm^(2) red ***-optical simulations verify photocarrier modulation due to defect-induced field screening to be the origin of such high responsivity *** experimental results validate the theory and enable the development of commercially viable and complementary metal oxide semiconductor(CMOS)compatible high responsivity photodetectors operating in the visible range for low-light level imaging and detection.

关键词： Photogating amorphous silicon a-Si:h nonlinearity photodetector responsivity gain

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Multimodal 4-arylchromene derivatives with microtubule-destabilizing,anti-angiogenic,and MYB-inhibitory activities

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Cancer Drug Resistance 2023年第1期6卷 59-77页

作者： Leonhard h.F.Kohler Sebastian Reich Maria Yusenko Karl-heinz Klempnauer Gerrit Begemann rainer Schobert Bernhard Biersack Organic Chemistry Laboratory University of BayreuthBayreuth 95440Germany Institute for Biochemistry Westfalische-Wilhelms-UniversitatMunster 48149Germany Developmental Biology University of BayreuthBayreuth 95440Germany

Aim:Efficient and readily available anticancer drugs are sought as treatment *** this reason,chromene derivatives were prepared using the one-pot reaction and tested for their anticancer and anti-angiogenic ***:2-Amino-3-cyano-4-(aryl)-7-methoxy-4h-chromene compounds(2A-R)were repurposed or newly synthesized via a three-component reaction of 3-methoxyphenol,various aryl aldehydes,and *** performed assays to study the inhibition of tumor cell growth[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromid(MTT)assay],effects on microtubules(immunofluorescence),cell cycle(flow-activated cell sorting analysis),angiogenesis(zebrafish model),and MYB activity(luciferase reporter assay).Fluorescence microscopy was applied for localization studies via copper-catalyzed azide-alkyne click reaction of an alkyne-tagged drug ***:Compounds 2A-C and 2F exhibited robust antiproliferative activities against several human cancer cell lines(50%inhibitory concentrations in the low nanomolar range)and showed potent MYB *** alkyne derivative 3 was localized in the cytoplasm after only 10 min of *** microtubule disruption and G2/M cell-cycle arrest were observed,where compound 2F stood out as a promising microtubule-disrupting *** study of anti-angiogenic properties showed that 2A was the only candidate with a high potential to inhibit blood vessel formation in ***:The close interplay of various mechanisms,including cell-cycle arrest,MYB inhibition,and anti-angiogenic activity,led to identifying promising multimodal anticancer drug candidates.

关键词： Chromene pyran anticancer drugs microtubule angiogenesis MYB inhibition

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Molecular Mechanism of Electroacupuncture Regulating Cerebral Arterial Contractile Protein in Rats with Cerebral Infarction Based on MLCK Pathway

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Chinese Journal of Integrative Medicine 2023年第1期29卷 61-68页

作者： LI Jing ZhANG Min hE Ying DU Yuan-hao ZhANG Xue-zhu rainer Georgi Bernhard Kolberg Xu Yan-long Institute of Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin300193China Max Planck Institute for Medical Research Heidelberg69120Germany Uniklinik Mannheim Mannheim68167Germany Department of Acupuncture and Moxibustion Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou730050China

Objective To explore the effect of electroacupuncture(EA)intervention on the vasoconstriction of cerebral artery smooth muscle cells after cerebral *** Male Wistar rats were randomly divided into 3 groups by a random number table:the model group(n=24),the EA group(n=24),and the normal group(n=6).The model and the EA groups were divided into different time subgroups at 0.5,1,3,and 6 h after middle cerebral artery occlusion(MCAO),with 6 rats in each *** model was established using intraluminal suture occlusion *** EA group was given EA treatment at acupoint Shuigou(GV 26)instantly after MCAO for 20 *** contents of cerebrovascular smooth muscle MLCK,the 3 subunits of myosin light chain phosphatase(MLCP)MYPT1,PP1c-δand M20,as well as myosin-ATPase activity were detected using immunohistochemistry and Western *** The overall expression level of the MYPT1 and PP1c-δin the model group was significantly higher(Phe 0.5 h group expression level was close to that of the normal group(P>0.05),and the other subgroups were still significantly higher than the normal group(Phe expression level of each subgroup was significantly lower than the corresponding model *** was a significant difference between the 0.5 and 1 h subgroups(Phile a difference was also observed between the 3 and 6 h subgroups(Phe dynamic change rule gradually increased with the prolongation of infarction time within 6 h after *** EA intervention can inhibit contraction of cerebral vascular smooth muscle cells and regulate smooth muscle relaxation by regulating MLCK pathway.

关键词： infarction vasomotor MLCK pathway Shuigou(GV 26) electroacupuncture

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Effect of land-use management systems on coupled physical and mechanical,chemical and biological soil processes:how can we maintain and predict soil properties and functions?

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Frontiers of Agricultural Science and Engineering 2020年第3期7卷 243-245页

作者： rainer hORN Winfried E.h.BLUM Institute of Plant Nutrition and Soil Science 24118 KielGermany Institute of Soil Research University of Natural Resources and Life Sciences(BOKU)1190 ViennaAustria

Soil is one of the most critical life-supporting components of the biosphere. Soil provides many ecosystem services,such as a habitat for biodiversity, water and nutrients, food, feed, fiber and energy, but also serves as archaeologicalrepositories. In addition to natural changes in pedological properties and functions over the course of time (soilgenesis), their properties also undergo intense and irreversible changes due to a non-site adjusted landmanagement and improper application of machinery, sealing and techniques as well as chemical impacts includingacidity from acid rain, heavy metals pollution and salinity.

关键词： soil maintain sealing

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Isolation of Microcystins from the Cyanobacterium Planktothrix rubescens Strain No80

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Natural Products and Bioprospecting 2014年第1期4卷 37-45页

作者： Timo h.J.Niedermeyer Peter Schmieder rainer Kurmayer Cyano Biotech Gmbh Magnusstr.1112489 BerlinGermany Interfaculty Institute for Microbiology and Infection Medicine Tubingen Eberhard Karls University TubingenAuf der Morgenstelle 2872076 TubingenGermany Leibniz Institut fur Molekulare Pharmakologie Robert-Rossle-Str.1013125 BerlinGermany Research Institute for Limnology University of InnsbruckMondseestrasse 95310 MondseeAustria

Three minor microcystins have been isolated from a Planktothrix rubescens *** structures have been elucidated by one-and two-dimensional NMR spectroscopy and high-resolution tandem mass spectrometry as the compounds[Asp^(3),(E)-Dhb^(7)]MC-LY(1),[Asp^(3),(E)-Dhb^(7)]MC-htyW(2),and[Asp^(3),(E)-Dhb^(7)]MC-LW(3).The amino acids found at the variable positions 2 and 4 of the microcystin core structure are in accordance with the predicted amino acid substrate activation selectivities of the non-ribosomal peptide synthetases McyA and McyB described earlier for this *** structural microcystin variants produced by this strain were shown to inhibit protein phosphatase 1 in the nanomolar range.

关键词： Planktothrix Cyanobacteria Microcystins Protein phosphatase inhibition

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Effect of Electro-acupuncture on Vasomotor Symptoms in Rats with Acute Cerebral Infarction Based on Phosphatidylinositol System

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Chinese Journal of Integrative Medicine 2022年第2期28卷 145-152页

作者： LI Jing hE Ying DU Yuan-hao ZhANG Min rainer Georgi Bernhard Kolberg SUN Dong-wei MA Kun LI Yong-feng ZhANG Xue-zhu Key Laboratory of Acupuncture of Tianjin First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin(300381)China Department of Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin(300381)China Department of Chemical Biology Max Planck Institute for Medical ResearchHeidelberg(69120)Germany Department of Internal Medicine Mannheim Medical School of Heidelberg UniversityMannheim(68167)Germany Department of Chinese Medicine Rehabilitation Shenzhen Baoan District Hospital of Traditional Chinese MedicineShenzhenGuangdong Province(518000)China Department of Preventive Treatment of Disease Binhai New Area Hospital of Traditional Chinese MedicineFourth Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin(300193)China Institute of Acupuncture and Moxibustion Shaanxi University of Chinese MedicineXi'an(712046)China

Objective:To investigate the effect of electro-acupuncture(EA)on vasomotor symptoms in rats with acute cerebral infarction,by observing the changes in the expression of factors related to the phosphatidylinositol(PI)***:Forty-two Wistar rats were randomly divided into 3 groups by a random number table:the control group(n=6),the model group(n=18)and the EA group(n=18).The EA group was given EA treatment at Shuigou(GV 26)instantly after modeling with middle cerebral artery occlusion(MCAO)method,while the model and control groups were not given any *** degrees of neurological deficiency were evaluated using neurological severity scores(NSS)and the brain blood flow was evaluated by a laser scanning confocal *** blot analysis was conducted to detect the expression levels of G-protein subtype(Gq)and calmodulin(CaM).Competition for protein binding was conducted to detect the expression level of inositol triphosphate(IP3).Thin layer quantitative analysis was conducted to detect the expression level of diacylglycerol(DAG).The expression level of intracellular concentration of free calcium ion([Ca^(2+)]i)was detected by flow ***:The NSS of the model group was significantly higher than the control group at 3 and 6 h after MCAO(Phile the EA group was significantly lower than the model group at 6 h(Phe cerebral blood flow in the model group was significantly lower than the control group at 1,3 and 6 h after MCAO(Phile for the EA group it was remarkably higher than the model group at the same time points(Phe expressions of Gq,CaM,IP3,DAG and[Ca^(2+)]i in the model group were significantly higher than the control group(Phose in the EA group were significantly lower than the model group at the same time points(Phe over-expression of related factors of PI system in rats with acute cerebral infarction,impro

关键词： cerebral infarction phosphatidylinositol system vasomotion Shuigou(GV 26) electro-acupuncture Chinese medicine

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The enhanced element enrichment in the supercritical states of granite–pegmatite systems

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Acta Geochimica 2019年第3期38卷 335-349页

作者： rainer Thomas Paul Davidson Karen Appel Section 3.6.Chemistry and Physics of Earth Materials Helmholtz-Centre Potsdam German Research Centre for Geoscience – GFZ CODES Centre for Ore Deposit and Earth Sciences School of Natural Sciences University of Tasmania high Energy Density scientific instrument European X-Ray Free-Electron Laser Facility GmbH

In this paper, we show that supercritical fluids have a greater significance in the generation of pegmatites,and for ore-forming processes related to granites than is usually assumed. We show that the supercritical melt or fluid is a silicate phase in which volatiles; principally h_2O are completely miscible in all proportions at magmatic temperatures and pressures. This phase evolves from felsic melts and changes into hydrothermal fluids, and its unique properties are particularly important in sequestering and concentrating low abundance elements, such as metals. In our past research, we have focused on processes observed at upper crustal levels, however extensive work by us and other researchers have demonstrated that supercritical melt/fluids should be abundant in melting zones at deep-crustal levels too. We propose that these fluids may provide a connecting link between lower and upper crustal magmas,and a highly efficient transport mechanism for usually melt incompatible elements. In this paper, we explore the unique features of this fluid which allow the partitioning of variouselements and compounds, potentially up to extreme levels,and may explain various features both of mineralization and the magmas that produced them.

关键词： Granites Pegmatites Supercritical state Extreme element enrichment

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