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Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy:Contribution of neurochemical markers to early diagnosis

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Infectious Medicine 2022年第2期1卷 140-142页

作者： Souheil Zayet Hajer Zahra Nabil Belfeki timothée klopfenstein Beate Hagenkötter Infectious Diseases Department Nord Franche-ComtéHospitalFrance Diabetology Department Nord Franche-ComtéHospitalFrance Internal Medicine Department Groupe Hospitalier Sud Ile de FranceMelunFrance Neurology Department Nord Franche-ComtéHospitalFrance

Background:The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in late *** recently,there have been sporadic case reports on devel-opment of Miller-Fisher Syndrome,a rare variant of Guillain-BarréSyndrome in COVID-19 *** report:We reported herein the case of a French young women presenting with ophtalmoplegia,cerebellar ataxia,and universal areflexia following a bariatric surgery(sleeve gastrectomy).A concomitant COVID-19 diagnosis was retained based on microbiological *** patient was successfully treated after high-dose intravenous thiamine,but areflexia *** COVID-19 related Miller-Fisher Syndrome was established on physical examination and confirmed by pathologic neurophysiological findings and elevated level of phosphorylated neurofilament heavy chain protein in cerebrospinal fluid ***:Guillain-BarréSyndrome and its variants after SARS-CoV-2 infection are extremely *** mea-surement of phosphorylated neurofilament heavy chain protein should be considered as an easy tool to detect an early affection of the peripheral nervous system.

关键词： COVID-19 Miller-fisher syndrome Wernicke encephalopathy Bariatric surgery Phosphorylated neurofilament heavy chain Protein

Clinical spectrum of ocular manifestations in COVID-19:a case series

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Infectious Medicine

Infectious Medicine 2023年第2期2卷 148-152页

作者： Souheil Zayet Ayoub Mihoubi Marion Chatain Nour Sreiri Malek Bouzaien Trimech Vincent Gendrin Fatiha Benjelloun timothée klopfenstein Department of Infectious Diseases Nord Franche-Comte Hospital90400 TrevenansFrance Department of Ophthalmology Nord Franche-Comte Hospital90400 TrevenansFrance

In this current case series,all Coronavirus disease 2019 patients had predominant ophthalmological *** one patient sough care for concomitant respiratory *** reported herein 2 cases with cranial oculomotor nerve palsy,one patient with confirmed diagnosis of branch retinal vein occlusion,and the last one patient presenting for acute kareto-conjunctivitis with several recurrences,which was unsuccessfully treated with steroids and requiring *** case series highlights the importance of collecting a careful history of ocular presentation,including exposures to possible infected patients with *** this will lead to an early diagnosis and treatment and to make appropriate infection control measures.

关键词： SARS-CoV-2 COVID-19 Diplopia Ophtalmoplegia Neuro-ophtalmology

Stem cell treatment improves post stroke neurological outcomes:a comparative study in male and female rats

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Stroke & Vascular Neurology 2021年第4期6卷 519-527,I0005-I0010页

作者： Koteswara Rao Nalamolu Bharath Chelluboina Casimir A Fornal Siva Reddy Challa David M Pinson David Z Wang Jeffrey D klopfenstein Krishna Kumar Veeravalli Cancer Biology and Pharmacology College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Pharmaceutical and Biomedical Sciences California Health Sciences UniversityClovisCaliforniaUSA Neurological Surgery University of Wisconsin-MadisonMadisonWisconsinUSA Health Sciences education College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Neurology College of MedicineUniversity of IllinoisPeoriaIllinoisUSA Neurology Barrow Neurological InstitutePhoenixArizonaUSA Neurosurgery College of MedicineUniversity of IllinoisPeoriaIllinoisUSA OSF HealthCare Illinois Neurological Institute PeoriaIllinoisUSA Pediatrics College of MedicineUniversity of IllinoisPeoriaIllinoisUSA

Background and purpose The therapeutic potential of different stem cells for ischaemic stroke treatment is intriguing and somewhat *** results from our laboratory have demonstrated the potential benefits of human umbilical cord blood-derived mesenchymal stem cells(MSC)in a rodent stroke *** hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females,despite any apparent sex differences in post stroke brain *** Transient focal cerebral ischaemia was induced in adult Sprague-Dawley rats by occlusion of the middle cerebral *** the procedure,male and female rats of the untreated group were euthanised 1 day after reperfusion and their brains were used to estimate the resulting infarct volume and tissue *** groups of stroke-induced male and female rats were treated with MSC or vehicle and were subsequently subjected to a battery of standard neurological/neurobehavioral tests(Modified Neurological Severity Score assessment,adhesive tape removal,beam walk and rotarod).The tests were administered at regular intervals(at days 1,3,5,7 and 14)after reperfusion to determine the time course of neurological and functional recovery after *** The infarct volume and extent of swelling of the ischaemic brain were similar in males and *** similar pathological stroke lesions,the clinical manifestations of stroke were more pronounced in males than females,as indicated by the neurological scores and other *** treatment significantly improved the recovery of sensory and motor function in both sexes,and it demonstrated efficacy in both moderate stroke(females)and severe stroke(males).Conclusions Despite sex differences in the severity of post stroke outcomes,MSC treatment promoted the recovery of sensory and motor function in male and female rats,suggesting that it may be a promising treatment for stroke.

关键词： neurological female rats

Post-stroke mRNA expression profile of MMPs:effect of genetic deletion of MMP-12

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Stroke & Vascular Neurology 2018年第3期3卷 153-159页

作者： Koteswara Rao Nalamolu Bharath Chelluboina Ian B Magruder Diane N Fru Adithya Mohandass Ishwarya Venkatesh Jeffrey D klopfenstein David M Pinson Krishna M Boini Krishna Kumar Veeravalli Department of Cancer Biology and Pharmacology University of Illinois College of MedicinePeoriaIllinoisUSA Department of Neurosurgery University of Illinois College of MedicinePeoriaIllinoisUSA Comprehensive Stroke Center Illinois Neurological InstituteOSF HealthCare SystemSaint Francis Medical CenterPeoriaIllinoisUSA Department of Pathology University of Illinois College of MedicinePeoriaIllinoisUSA Department of Pharmacological and Pharmaceutical Sciences College of PharmacyUniversity of HoustonHoustonTexasUSA Department of Neurology University of Illinois College of MedicinePeoriaIllinoisUSA

background and purpose Recent reports from our laboratory demonstrated the post-ischaemic expression profile of various matrix metalloproteinases(MMPs)in rats and the detrimental role of MMP-12 in post-stroke brain *** hypothesise that the post-stroke dysregulation of MMPs is similar across species and that genetic deletion of MMP-12 would not affect the post-stroke expression of other *** tested our hypothesis by determining the pre-ischaemic and post-ischaemic expression profile of MMPs in wild-type and MMP-12 knockout *** Focal cerebral ischaemia was induced in wildtype and MMP-12 knockout mice by middle cerebral artery occlusion procedure by insertion of a monofilament *** hour after ischaemia,reperfusion was initiated by removing the *** day after reperfusion,ischaemic brain tissues from various groups of mice were collected,and total RNA was isolated and subjected to cDNA synthesis followed by PCR *** Although the post-stroke expression profile of MMPs in the ischaemic brain of mice is different from rats,there is a clear species similarity in the expression of MMP-12,which was found to be predominantly upregulated in both ***,the post-stroke induction or inhibition of various MMPs in MMP-12 knockout mice is different from their respective expression profile in wild-type ***,the brain mRNA expression profile of various MMPs in MMP-12 knockout mice under normal conditions is also different to their expression in wild-type *** In the ischaemic brain,MMP-12 upregulates several fold higher than any other *** derived with the genetic deletion of MMP-12 are constitutive and have altered MMP expression profile both under normal and ischaemic conditions.

关键词： MMPs removing hypothesis

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反刍畜能量补充料—大豆皮

饲料广角 1988年第2期 18-21页

作者： T·klopfenstein 李英

大豆皮是大豆加工过程中得到的大豆的种皮,并非大豆荚壳。它占大豆重的8%,美国大豆加工厂每年产大豆皮达240万吨。经十余年研究证明,大豆皮消化率高,可作反刍畜的能量补充料。在大豆加工厂中首先碾压大豆,使大豆皮爆裂并与豆胚分离,后... 详细信息

大豆皮是大豆加工过程中得到的大豆的种皮,并非大豆荚壳。它占大豆重的8%,美国大豆加工厂每年产大豆皮达240万吨。经十余年研究证明,大豆皮消化率高,可作反刍畜的能量补充料。在大豆加工厂中首先碾压大豆,使大豆皮爆裂并与豆胚分离,后者用己烷浸提植物油,大豆皮下不含油,不再浸提处理。大豆皮纤维含量高,细胞可溶物、蛋白质和可溶性碳水化合物含量低(见表1,以风干样计)。因木质素低,故纤维消化率高。试验室测定72小时内可消化95%,但大豆皮不会在瘤胃存留72小时,所以在动物体内达不到上述消化值。消化速度很重要,大豆皮中性洗涤纤维每小时消化7%,而许多饲草为2%～5%,可见反刍畜对大豆皮消化较快。

关键词：大豆皮饲喂精料日粮纤维含量饲养精饲料补充料瘤胃微生物

发酵谷物或玉米补充物添加频率对饲草采食量和消化率的影响

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饲料博览（技术版） 2008年第1期 65-66页

作者： Loy T W MacDonald J C klopfenstein T J erickson G e

试验旨在检测追加能量的形式和频率对饲草干物质采食量和消化率的影响。选用10头24日龄、体重为416kg的小母牛，安装瘤胃插管。试验设5个处理，每个处理两个重复，采用5×4拉丁方设计。5个处理分别为：不追加任何物质（对照），每天添... 详细信息

试验旨在检测追加能量的形式和频率对饲草干物质采食量和消化率的影响。选用10头24日龄、体重为416kg的小母牛，安装瘤胃插管。试验设5个处理，每个处理两个重复，采用5×4拉丁方设计。5个处理分别为：不追加任何物质（对照），每天添加干压玉米（DRC），隔天添加干压玉米（DRC—A），每天添加玉米干酒糟及其可溶物（DDGS），隔天添加玉米干酒糟及其可溶物（DDGS=A）。每天添加组，每次按照体重的0．40％追加补充物；隔天添加组，每次按照体重的0．80％追加补充物。小母牛自由采食粗蛋白含量为8．2％的禾本科干草，记录采食模式。与各试验组小母牛相比，对照组小母牛干草的干物质采食量极显著增加（P〈0．01），分别为体重的1．88％，1．66％；但是对照组总干物质采食量极显著降低（P〈0．01）。

关键词：肉牛消化性能饲草采食量补充物添加频率

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反刍动物过瘤胃蛋白潜力

草食家畜 1988年第5期 41-45页

作者： T.klopfenstein ,孟庆祥

测定饲料中的过瘤胃蛋白质含量,可以通过实验室的分析结果进行估测,也可以利用装有十二指肠瘘管的动物直接测定。虽然实验室的估测值能提供有用的参考数据,但我们仍认为,欲得到饲料中过瘤胃蛋白质含量的准确结果,还是以应用动物生长试... 详细信息

测定饲料中的过瘤胃蛋白质含量,可以通过实验室的分析结果进行估测,也可以利用装有十二指肠瘘管的动物直接测定。虽然实验室的估测值能提供有用的参考数据,但我们仍认为,欲得到饲料中过瘤胃蛋白质含量的准确结果,还是以应用动物生长试验的方法为最好。我们已在美国内布拉斯加州研究了一种新的蛋白质测定体系,认为这一体

关键词：反刍动物肉粉补充料液态过瘤胃蛋白质旁路蛋白质玉米面筋粉大豆饼油饼类饲料羽毛粉血粉

蛋鸡日粮中的预混合饲料—维生素A、核黄素、尼克酸的贮藏稳定性研究

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饲料广角 1987年第4期 34-37页

作者：郭爱民 Carol F·klopfenstein

生产实践证明,在家禽饲料中补充适当的维生素,对保持禽体健康和生长以及获得最大的产蛋率和孵化率是十分重要的。因而全价饲料和预混合饲料中维生素的损失是人们关心的一个问题。一般认为,较高的贮藏温度对全价饲料和预混合饲料中维生... 详细信息

生产实践证明,在家禽饲料中补充适当的维生素,对保持禽体健康和生长以及获得最大的产蛋率和孵化率是十分重要的。因而全价饲料和预混合饲料中维生素的损失是人们关心的一个问题。一般认为,较高的贮藏温度对全价饲料和预混合饲料中维生素的稳定性,会产生不利的影响,但对维生素损失

关键词：预混合饲料全价饲料维生素蛋鸡日粮核黄素维生素B2 贮藏稳定性

Adding Value to Crop Production Systems by Integrating Forage Cover Crop Grazing

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American Journal of Plant Sciences 2024年第3期15卷 180-192页

作者： Robert B. Mitchell Daren D. Redfearn Kenneth P. Vogel Terry J. klopfenstein Galen erickson P. Stephen Baenziger Bruce e. Anderson Mary e. Drewnoski Jay Parsons Steven D. Masterson Marty R. Schmer Virginia L. Jin USDA-ARS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE USA Department of Animal Science University of Nebraska-Lincoln Lincoln NE USA Department of Agricultural economics University of Nebraska-Lincoln Lincoln NE USA USDA-ARS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

In addition to their value as cereal grains, wheat (Triticum aestivum L.) and triticale (× Triticosecale Wittmack) are important cool-season annual forages and cover crops. Yearling steer (Bos taurus) performance was compared in the spring following autumn establishment as for age cover crops after soybean [Glycine max (L.) Merr.] grain harvest. Replicated pastures (0.4 ha) were no-till seeded in three consecutive years into soybean stubble in autumn, fertilized, and grazed the following spring near Ithaca, Ne, USA. each pasture (n = 3) was continuously stocked in spring with four yearling steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectively. In 2005, average daily gain (ADG) for steers grazing triticale exceeded the ADG for wheat by 0.31 kghd-1d-1. In 2006, wheat ADG exceeded that for triticale by 0.12 kghd-1d-1. In 2007, steers grazing wheat lost weight, while steers grazing triticale gained 0.20 kghd-1d-1. Based on the 3-year average animal gains valued at $1.32 kg-1, mean net return ($ ha-1 yr-1) was $62.15 for triticale and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing could be viewed as a mechanism for recovering costs and adds additional value to the system. Based on this 3-year grazing trial, triticale was superior to wheat and likely will provide the most stable beef yearling performance across years with variable weather for the western Cornbelt USA.

关键词： Cover crops Soybean Triticale Wheat