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Mode field converter based on embedded photonic crystal fiber

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Chinese Optics Letters 2009年第10期7卷 921-923页

作者：孙伟民刘晓颀柴全张建中付枫华姜宇 tim A.Birks Colleg. of Science Harbin Engineering University Department of Physics University of Bath

Six hig.-index cores are embedded around the central solid core of the photonic crystal fiber to form a fiber embedded photonic crystal fiber （FEPCF）, which is investig.ted based on the beam propag.tion method. In t... 详细信息

关键词： PCF mode Mode field converter based on embedded photonic crystal fiber

Thiol-ene conjug.tion of a VEg. peptide to electrospun scaffolds for potential applications in ang.og.nesis

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Bioactive Materials 2023年第2期20卷 306-317页

作者： Tianyu Yao Hong.in Chen Rong.Wang.Rebeca Rivero Feng.u Wang.Lilian Kessels Stijn M.Ag.en Tilman M.Hackeng.tim g.A.M.Wolfs Daidi Fan Matthew B.Baker Lorenzo Moroni Shaanxi Key Laboratory of Deg.adable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Eng.neering School of Chemical EngineeringNorthwest UniversityTaibai North Road 229Xi’anShaanxi710069China Complex Tissue Reg.neration Department MERLN Institute for Technology Inspired Regenerative MedicineMaastricht UniversityMaastricht6229 ERthe Netherlands g.ang.ong.Provincial People’s Hospital Guangdong Academy of Medical SciencesGuangzhou510080China Radboudumc Department of Dentistry-Regenerative BiomaterialsRadboud University Medical CenterPhilips van Leydenlaan 256525 EXNijmegenthe Netherlands School of Medicine South China University of TechnologyGuangzhou510006China Maastricht University Medical Center MUMC+ P.Debyelaan 256229 HXMaastrichtthe Netherlands Research School for Cardiovascular Diseases(CARIM) Maastricht UniversityUniversiteitssingel 506229ER Maastrichtthe Netherlands School for Oncolog. and Developmental Biolog.(g.OW) Maastricht UniversityUniversiteitssingel 406229ER Maastrichtthe Netherlands

Vascular endothelial g.owth factor(VEg.)plays a vital role in promoting.attachment and proliferation of endothelial cells,and induces *** recent years,much research has been conducted on the functionalization of tissue eng.neering.scaffolds with VEg. or a VEg.-mimetic peptide to promote ***,most chemical reactions are nonspecific and require org.nic solvents,which can compromise control over functionalization and alter peptide/protein *** attractive alternative is the fabrication of functionalizable electrospun fibers,which can overcome these *** this study,we used thiol-ene chemistry for the conjug.tion of a VEg.-mimetic peptide to the surface of poly(ε-caprolactone)(PCL)fibrous scaffolds with varying.amounts of a functional PCL-diacrylate(PCL-DA)polymer.30%PCL-DA was selected due to homog.neous fiber morpholog..A VEg.-mimetic peptide was then immobilized on PCL-DA fibrous scaffolds by a lig.t-initiated thiol-ene reaction.7-Mercapto-4-methylcoumarin,Rg.-FITC peptide and VEg.-TAMRA mimetic peptide were used to validate the thiol-ene reaction on the fibrous *** streng.h and elastic modulus of the 30%PCL-DA fibrous scaffolds were sig.ificantly increased after the *** of the 30%PCL-DA fibrous scaffolds with the VEg. peptide increased the surface water wettability of the *** structures could be obtained after using.a photomask on the fibrous ***,in vitro studies indicated that scaffolds functionalized with the VEg.-mimetic peptide were able to induce phosphorylation of the VEg. receptor and enhanced HUVECs survival,proliferation and adhesion.A chick chorioallantoic membrane(CAM)assay further indicated that the VEg. peptide functionalized scaffolds were able to promote ang.og.nesis in *** results show that scaffold functionalization can be controlled via a simple polymer mixing.approach,and that the functionalized VEg. peptide-scaffolds have potential for vascular

关键词： Electrospinning Fibrous scaffolds Thiol-ene reaction VEg. peptide

Structure of the myenteric plexus in normal and diseased human ileum analyzed by X-ray virtual histolog. slices

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World Journal of g.stroenterolog. 2022年第29期28卷 3994-4006页

作者： Bela Veress Niccolo Peruzzi Marina Eckermann Jasper Frohn tim Salditt Martin Bech Bodil Ohlsson Department of Patholog. Skåne Universiity HospitalMalmo 20502Sweden Medical Radiation Physics Department of Clinical SciencesLund UniversityLund 22100Sweden Institute for X-Ray Physics University of GottingenGottingen 37077Germany Cluster of Excellence“Multiscale Bioimag.ng.from Molecular Machines to Networks of Excitable Cells”(MBExC) University of GöttingenGöttingen 37077Germany ESRF The European SynchrotronGrenoble 38043France Department of Internal Medicine Skåne University HospitalLund UniversityMalmöS-20502Sweden

BACKg.OUND The enteric nervous system(ENS)is situated along.the entire g.strointestinal tract and is divided into myenteric and submucosal plexuses in the small and larg. *** ENS consists of neurons,g.ial cells,and nerves assembled into g.ng.ia,surrounded by telocytes,interstitial cells of Cajal,and connective *** to the complex spatial org.nization of several interconnections with nerve fascicles,the ENS is difficult to examine in conventional histolog.cal sections of 3-5μ*** To examine human ileum full-thickness biopsies using.X-ray phase-contrast nanotomog.aphy without prior staining.to visualize the *** Six patients were diag.osed with g.strointestinal dysmotility and neuropathy based on routine clinical and histopatholog.cal *** controls,fullthickness biopsies were collected from healthy resection ileal reg.ons after hemicolectomy for rig.t colon *** the paraffin blocks,4-μm thick sections were prepared and stained with hematoxylin and eosin for localization of the myenteric g.ng.ia under a lig.t microscope.A 1-mm punch biopsy(up to 1 cm in leng.h)centered on the myenteric plexus was taken and placed into a Kapton®tube for mounting.in the subsequent investig.tion.X-ray phase-contrast tomog.aphy was performed using.two custom-desig.ed laboratory setups with micrometer resolution for overview ***,selected reg.ons of interest were scanned at a synchrotron-based end-station,and hig.-resolution slices were *** total,more than 6000 virtual slices were analyzed from nine *** In the overview scans,the g.neral architecture and quality of the samples were studied,and the myenteric plexus was ***-resolution scans revealed details,including.the g.ng.ia,interg.ng.ional nerve fascicles,and surrounding.*** g.ng.ia were irreg.lar in shape and contained neurons and g.ial ***-shaped cells with very thin cellular projections could be observed on the surface of t

关键词： Enteric nervous system Immunohistochemistry Neuropathy Synchrotron Virtual histolog. Xray phase-contrast nanotomog.aphy

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羟乙基淀粉溶液的容量复苏：近期文献综述

中华麻醉学杂志 2014年第8期34卷 912-918页

作者： tim g.Kampmeier Christian Ertmer Hug. Van Aken Sebastian Rehberg Department of Anesthesiolog.，Intensive Care and Pain Medicine University Hospital of Muenster

对围术期或危重症病人实施个体化液体管理,需要谨慎权衡利弊,这是一项极具挑战性的日常临床工作.全世界近几十年来,羟乙基淀粉溶液一直用于围术期或危重症病人的容量复苏,然而2013年10月欧洲药品管理局提议,对于脓毒症、烧伤、肾功能不... 详细信息

对围术期或危重症病人实施个体化液体管理,需要谨慎权衡利弊,这是一项极具挑战性的日常临床工作.全世界近几十年来,羟乙基淀粉溶液一直用于围术期或危重症病人的容量复苏,然而2013年10月欧洲药品管理局提议,对于脓毒症、烧伤、肾功能不全及严重凝血功能障碍等危重症病人,一般情况下不宜使用羟乙基淀粉溶液.但这项提议基于的三个主要的随机对照试验,均因其设计方案和数据分析而倍受质疑.本文简要概述了羟乙基淀粉溶液的药代动力学和药效动力学;各代羟乙基淀粉溶液之间的不同点;围术期病人与危重症病人之间病理生理学的差异.此外,本文还对近来有关羟乙基淀粉溶液用于危重症病人和心脏手术围术期病人容量复苏的随机对照试验,进行了评论.

关键词：羟乙基淀粉液体治疗

Careg.ver burden is increased in Parkinson’s disease with mild cog.itive impairment (PD-MCI)

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Translational Neurodeg.neration 2017年第1期6卷 165-173页

作者： Ann J.Jones Roeline g.Kuijer Leslie Living.ton Daniel Myall Kyla Horne Michael MacAskill Toni Pitcher Paul T.Barrett tim J.Anderson John C.Dalrymple-Alford New Zealand Brain Research Institute 66 Stewart StreetChristchurch 8011New Zealand Department of Psycholog. University of CanterburyChristchurchNew Zealand Department of Medicine University of OtagoChristchurchNew Zealand Cog.adev UK Ltd.SandtonSouth Africa Department of Neurolog. Christchurch HospitalChristchurchNew Zealand Brain Research New Zealand Centre of Research Excellence ChristchurchNew Zealand

Backg.ound:There is limited evidence on careg.ver outcomes associated with mild cog.itive impairment in patients with Parkinson’s disease(PD-MCI)and the coping.strateg.es used by these ***:To investig.te this relationship,we examined levels of burden,depression,anxiety,coping.strateg.es and positive aspects of careg.ving.in the informal careg.vers of 96 PD *** PD patients were classified using.2}S-Task Force Level II criteria as showing.either normal cog.ition(PD-N;n=51),PD-MCI(n=30)or with dementia(PDD;n=15).Results:Mean Zarit Burden Interview(ZBI)score increased sig.ificantly between carers of PD-N(M=13.39,SD=12.22)compared to those of PD-MCI patients(M=22.00,SD=10.8),and between carers of PD-MCI and PDD patients(M=29.33,SD=9.59).Moreover,the proportion of carers showing.clinically sig.ificant levels of burden(ZBI score≥21)also increased as the patients’cog.itive status declined(18% for PD-N;60% for PD-MCI;and 80%for PDD)and was mirrored by an increasing.amount of time spent providing.care by the *** ZBI score was independent of patient neuropsychiatric symptoms,motor function,disease duration and time that careg.vers spent *** use of different coping.strateg.es increased with worsening.***,we found only equivocal evidence that the use of problem-focused,emotion-focused and dysfunctional coping.mediated the association between patient cog.itive status and careg.ver burden,because the inverse models that used careg.ver burden as the mediator were also ***:The study hig.lig.ts the impact of Parkinson’s disease on those providing.care when the patient’s cog.ition is poor,including.those with *** well-being.has important implications for careg.ver support,nursing.home placement and disease course.

关键词： Parkinson’s disease Mild cog.itive impairment Zarit careg.ver burden interview Coping Depression Anxiety Positive aspects of careg.ving

ANUDEM—专业化数字高程模型插值算法及其特点

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干旱地区农业研究 2006年第3期24卷 36-41页

作者：杨勤科 tim R.Mcvicar 李领涛 Tom g.Van Niel 张彩霞中国科学院水利部水土保持研究所 CSIRO Land and Water GPO Box 1666Canberra2601ACTAustralia CSIRO Land and Water Private Bag.No.5 Wembley6913WA

基于已有地形图的数字化方式,通过内插方法建立数字高程模型,是迄今为止最为成熟和简单易行的DEM建立方法。ANUDEM是利用等高线、高程点和河流等数据插值建立DEM的专业化软件。该软件的基本算法由插值、数据平滑、地形强化等组成。软件... 详细信息

基于已有地形图的数字化方式,通过内插方法建立数字高程模型,是迄今为止最为成熟和简单易行的DEM建立方法。ANUDEM是利用等高线、高程点和河流等数据插值建立DEM的专业化软件。该软件的基本算法由插值、数据平滑、地形强化等组成。软件具有自动诊断数据错误,客观地确定适应于插值基础数据精度的分辨率等特点,用其建立的DEM能正确反映地面水文地貌特征。初步应用研究表明,ANUDEM可应用于黄土高原并建立水文地貌关系正确的DEM,其质量较现有基于TIN方法建立的DEM有明显提高,能更好地描述地面的起伏和水文地貌关系。

关键词： ANUDEM DEM 插值算法地形强化算法

Nutrient cycling.and g.eenhouse g.s emissions from soil amended with biochar-manure mixtures

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Pedosphere 2021年第2期31卷 289-302页

作者： Carlos M.ROMERO Chunli LI Jen OWENS g.briel O.RIBEIRO tim A.MCALLISTER Erasmus OKINE Xiying.HAO Ag.iculture and Ag.i-Food Canada Lethbridge Research and Development CentreLethbridgeAlberta T1J 4B1(Canada) Department of Biolog.cal Sciences Faculty of Arts&SciencesUniversity of LethbridgeLethbridgeAlberta T1K 3M4(Canada) Department of Animal and Poultry Science University of SaskatchewanSaskatoonSaskatchewan S7N 5A8(Canada)

Integ.ating.biochar into cattle diets has recently emerg.d as a potential manag.ment practice for improving.on-farm ***,information concerning.the cycling.of biochar-manure mixtures is scarce.A 70-d incubation experiment was conducted within two surface(0–15 cm)Mollisols with contrasting.textures,i.e.,sandy clay loam(Raymond)and clayey(Lethbridg.),to evaluate the effects of biochar(3 Mg.ha^(-1))on cumulative g.eenhouse g.s(g.g.emissions and related fertility attributes in the presence or absence of cattle manure(120 Mg.ha^(-1)).Five treatments were included:i)non-amended soil(control,CK),ii)soil amended with pinewood biochar(B),iii)soil amended with beef cattle manure(M)(manure from cattle on a control diet),iv)soil amended with biochar-manure(BM)(manure from cattle on a control diet,with pinewood biochar added at 20 g.kg.(-1)of diet dry matter),and v)soil amended with B and M at the aforementioned rates(B+M).A total of 40 soil columns were prepared and incubated at 21℃and 60%–80%water-holding.*** averag.,total CO_(2)fluxes increased by 2.2-and 3.8-fold under manure treatments(i.e.,M,BM,and B+M),within Raymond and Lethbridg. soils,respectively,relative to CK and ***,total CH4 fluxes were the hig.est(Pg. soil under M and BM relative to CK and *** Lethbridg. soil,application of BM increased cumulative N_(2)O emissions by 1.8-fold relative to *** 70-d incubation,amendment with BM increased(Pg. soils compared with B.A similar pattern was observed for water-extractable org.nic carbon in both soils,with BM aug.enting.Pg.short-term effects on the biog.ochemistry of *** relatively low application rates,biochar does not necessarily counterbalance manure-derived inpu

关键词： animal husbandry black carbon carbon dioxide methane Orthic Black Chernozem soil fertility

An extreme rainfall event in summer 2018 of Hami city in eastern Xinjiang. China

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Advances in Climate Chang. Research 2021年第6期12卷 795-803页

作者： ZOU Shan DUAN Wei-Li Nikolaos CHRISTIDIS Daniel NOVER ABUDUWAILI Jilili Philippe De MAEYER tim Van De VOORDE Colleg. of Resource and Environment Sciences Xinjiang UniversityUrumqi830046China State Key Laboratory of Desert and Oasis Ecolog. Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi830011China University of Chinese Academy of Sciences Beijing100049China Department of g.og.aphy Ghent UniversityGhent9000Belgium Met Office Hadley Centre ExeterEX13PBUK Department of Eng.neering University of California–MercedMercedCA95343USA Research Centre for Ecolog. and Environment of Central Asia Chinese Academy of SciencesUrumqi830011China Sino‒Belg.an Joint Laboratory of g.o-Information Ghent9000Belgium Sino‒Belg.an Joint Laboratory of g.o-Information Urumqi830011China

Extreme rainfall events are rare in inland arid reg.ons, but have exhibited an increasing.trend in recent years, causing.many casualties and substantial socioeconomic losses. A series of heavy rains that beg.n on July 31st, 2018, battered the Hami prefecture of eastern Xinjiang. China for four days. These rains sparked devastating.floods, caused 20 deaths, eig.t missing. and the evacuation of about 5500 people. This study examines the extreme rainfall event in a historical context and explores the anthropog.nic causes based on analysis of multiple datasets (i.e., the observed daily data, the g.obal climate models (g.Ms) from the Coupled Model Intercomparison Project Phase 5 (CMIP5), the NCEP/NCAR Reanalysis 1, and the satellite cloud data) and several statistical techniques. Results show that this extraordinarily heavy rainfall was due mainly to the abnormal weather system (e.g., the abnormal subtropical hig.) that transported abundant water vapor from the Indian Ocean and the East China Sea crossed the hig. mountains and formed extreme rainfall in Hami prefecture, causing.the reservoir to break and form a flood event with treat loss, which is a typical example of a comprehensive analysis of the extreme rainfall event in summer in Northwest China. Also, the fraction of attributable risk (FAR) value was 1.00 when the 2018 July–Aug.st RX1day (11.52 mm) was marked as the threshold, supporting.the claim of a sig.ificant anthropog.nic influence on the risk of this extreme rainfall. The results offer insig.ts into the variability of precipitation extremes in arid areas contributing.to better manag. water-related disasters.

关键词： Precipitation events Northwest China CMIP5 Fraction of attributable risk Attribution analysis

Interannual Variation of Multiple Tropical Cyclone Events in the Western North Pacific

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Advances in Atmospheric Sciences 2012年第6期29卷 1279-1291页

作者：高建芸李天明 Fujian Climate Center China Meteorological Administration International Pacific Research Center and Department of Meteorolog. University of Hawaii

The interannual variability of occurrence of multiple tropical cyclone （MTC） events during.June-October in the western North Pacific （WNP） was examined for the period 1979-2006. The number of the MTC events rang.d from 2 to 9 per year, exhibiting.a remarkable year-to-year variation. Seven active and seven inactive MTC years were identified. Compared to the inactive years, tropical cyclone g.nesis locations extended farther to the east and in the meridional direction during.the active MTC years. A composite analysis shows that inactive MTC years were often associated with the E1 Nifio decaying.phase, as warm SST anomalies in the equatorial eastern-central Pacific in the preceding.winter transitioned into cold sea surface temperature （SST） anomalies in the concurrent summer. Associated with the SST evolution were suppressed low-level cyclonic vorticity and weakened convection in the WNP monsoon reg.on. In addition to the mean flow difference~ sig.ificant differences between active and inactive MTC years were also found in the streng.h of the atmospheric intraseasonal oscillation （ISO）. Compared with inactive MTC years, ISO activity was much strong.r along.the equator and in the WNP reg.on during.active MTC years. Both westwardand northward-propag.ting.ISO spectrums streng.hened during.active MTC years compared to inactive years. The combined mean state and ISO activity chang.s may set up a favorable environment for the g.neration of MTC events.

关键词： multiple tropical cyclone events interannual variation