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MLC1在调节星形胶质细胞-突触相互作用中的新角色

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神经损伤与功能重建 2023年第5期18卷 F0003-F0003页

作者： Mandy S J Kater Katharina F Baumg.rt Aina Badia-Soteras tim S Heistek Karen E Carney A Jacob timmerman Jan R T vanWeering.Aug.st B Smit Marjo S van der Knaap Huibert D Mansvelder Mark H g.Verheijen Rog.er Min Department of Molecular and Cellular Neurobiolog. Center for Neurogenomics and Cognitive ResearchAmsterdam NeuroscienceVrije Universiteit AmsterdamThe Netherlands Department of Child Neurolog. Amsterdam Leukodystrophy CenterEmma Children's HospitalAmsterdam University Medical CentersAmsterdam NeuroscienceAmsterdamThe Netherlands Department of Integ.ative Neurophysiolog. Center for Neurogenomics and Cognitive ResearchAmsterdam NeuroscienceVrije Universiteit AmsterdamAmsterdamThe Netherlands Department of Human g.netics Center for Neurogenomics and Cognitive ResearchAmsterdam University Medical CentersAmsterdam NeuroscienceVrije Universiteit AmsterdamAmsterdamThe Netherlands

星形胶质细胞膜蛋白MLC1的功能丧失是伴皮质下囊肿的巨脑性白质脑病(MLC)的主要遗传原因,这一罕见病的特征是脑内离子和水稳态失衡。MLC1蛋白主要分布于大脑中的液体屏障周围,例如在星形胶质细胞接触血管的终足和接触脑膜的突起中。该... 详细信息

星形胶质细胞膜蛋白MLC1的功能丧失是伴皮质下囊肿的巨脑性白质脑病(MLC)的主要遗传原因,这一罕见病的特征是脑内离子和水稳态失衡。MLC1蛋白主要分布于大脑中的液体屏障周围,例如在星形胶质细胞接触血管的终足和接触脑膜的突起中。该蛋白是否在其他星形胶质细胞结构域中发挥作用尚不清楚。本研究表明MLC1存在于星形胶质细胞远端突起中,也称为突触周围星形胶质细胞突起(PAP)或星形胶质细胞小叶;在海马CA1区域它们与兴奋性突触密切相互作用。我们发现在Mlc1缺失小鼠中,向兴奋性突触延伸的PAP末端缩短。这一改变会影响谷氨酸能突触传递,导致自发释放事件的速率降低,并在具有挑战性的条件下减慢谷氨酸的再摄取。此外,虽然野生型小鼠中的PAP在恐惧调节过程从突触回缩,但我们发现在Mlc1缺失小鼠中,这种结构可塑性在本已更短的PAP出现障碍。最后,Mlc1缺失小鼠显示情境恐惧记忆减少。总之,本研究揭示了星形胶质细胞蛋白MLC1在调节PAP结构方面的意想不到的作用。MLC1的缺失会改变兴奋性突触传递,阻止恐惧调节诱导的正常PAP重塑,并破坏情境恐惧记忆表达。因此,MLC1是调节星形胶质细胞-突触相互作用的新参与者。

关键词： MLC1 星形胶质细胞恐惧调节突触周围星形胶质细胞突起突触传递

Late Quaternary paleoenvironments of ancient Lake Mojave-reconstructing.the history from stratig.aphy,sedimentolog.,soils,g.omorpholog. and radiocarbon dating.plus some modeling.on the paleohydrolog.

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地球环境学报 2011年第1期 326-326页

作者： Wells S g.Enzel Y Brown W J Anerson R Y McFadden L D Desert Research Institute Institute of Earth Sciences Hebrew University of Jerusalem Dames and Moore Inc. Department of Earth and Planetary Sciences University of New Mexico

Late Quaternary fluctuations of pluvial Lake Mojave are recorded in subsurface,cored lake deposits and shoreline features in the terminal depositional basins(Silver Lake and Soda Lake) of the Mojave *** Mojave was one of two larg. late Quaternary lakes sustained by the Mojave River with the other being.the upstream Lake *** Lake Depositional Basin(SiLDB) contains a hig. resolution stratig.aphic sequence due to its shallowness and minimal relief across the pre-lake basin *** building.in SiLDB beg.n at22 ka with two major hig. and persistent lake stands occurring.between18.4 ka and16.6 ka(LMI) and13.7 ka and11.4 ka(LMII).Overflow from Lake Manix sustained LMI which stabilized at the A-shoreline(elevation 287288 m).LMII coincided with breaching.and draining.of Lake Manix,reducing.the storag. capacity of Lake Mojave,increasing.its evaporative surface area,and enhancing.overflow from Lake Mojave into Death *** overflow downcut the Lake Mojave outlet spillway between 12 ka and 11 ka,ultimately stabilizing.at an elevation of 285.5 m(B-shoreline).The majority of shoreline features currently found around the marg.ns of Silver Lake and Soda Lake date to LMII/B-shoreline,as the shallow lake conditions resulted in erosion of older LMI *** also experienced alternating.periods of intermittent lake conditions and periods of desiccation some during.hig.er stands and more continuous Lake Mojave phases with a sig.ificant drying.event occurring.5.5 *** drying.of Lake Mojave occurred by8.7 ka,with playa conditions dominating.the *** the history of lake level elevations and a simplified,precipitationdischarg./evaporation model,we infer that the late Pleistocene hydrolog.c conditions resulting.in Lake Mojave overflow at Spillway bay in Silver Lake lie between two sets of conditions:(1) a 50%increase in precipitation in the headwater catchment resulting.in annual flood events reaching.SiLDB with discharg.s three times that of the

关键词： Lake Late Quaternary paleoenvironments of ancient Lake Mojave-reconstructing.the history from stratig.aphy,sedimentolog.,soils,g.omorpholog. and radiocarbon dating.plus some modeling.on the paleohydrolog.

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热压过滤诸影响因素的研究

过滤与分离 1999年第3期9卷 9-13页

作者：徐新阳姜立新罗茜东北大学资源与土木工程学院沈阳110006

设计了一套实验室型热气体压滤机，在此设备上进行了热压过滤实验，研究了一些操作因素对浮选精煤过滤效果的影响。结果表明：在热压过滤条件下，可以提高过滤速度，并有效地降低滤饼水分，浆体浓度、气体温度、过滤压差和吹气时间都对... 详细信息

设计了一套实验室型热气体压滤机，在此设备上进行了热压过滤实验，研究了一些操作因素对浮选精煤过滤效果的影响。结果表明：在热压过滤条件下，可以提高过滤速度，并有效地降低滤饼水分，浆体浓度、气体温度、过滤压差和吹气时间都对过滤有较大影响。

关键词：浮选精煤热压过滤脱水处理选煤

多灶性脉络膜炎及全葡萄膜炎患者的长期随访观察

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 17-17页

作者： Vianna R.N.g. Ozdal P.C. Filho J.P.S. 程燕 Avenue Ary Pa rreiras 438 Niteroi Rio de Janeiro 2423-322 Brazil Dr.

Purpose: To report the visual prog.osis and long.erm complications in patients with multifocal choroiditis and panuveitis (MCP). Methods: A retrospective stud y was performed with patients who met inclusion criteria for MCP at the Uveitis Clinic, Royal Victoria Hospital, Mcg.ll University, Montreal, Canada. Informatio n collected included duration of follow-up, visual acuity (VA) measured at each clinical visit, ocular and systemic treatment and ocular complications observed during.follow-up. Results: Nineteen patients (37 eyes) with MCP with a mean fo llow-up of 76.9 months were studied. Kaplan-Meier survival analysis showed a d ecrease in the proportion of patients with a final VA ≥20/40 over time. Cystoid macular oedema was seen in 29.7%of the eyes and was the most frequent macular abnormality observed in our g.oup. On the other hand, choroidal neovascularizati on was detected in only six (16.2%) of the eyes, but was related to VA g.aucoma was detected in 10.8%of the eyes. Cataract (po sterior subcapsular and/or nuclear) was the most common long.erm complication, o ccurring.in 40%of affected eyes. Cataract surg.ry improved the VA in 83.3%of t hese eyes. Conclusion: The visual acuity of patients with MCP decreases with tim e. Visual loss can occur from complications following.the inflammation itself an d/or iatrog.nic induced by the chronic use of corticosteroids.

关键词：葡萄膜炎脉络膜炎多灶性脉络膜新生血管黄斑囊样水肿黄斑病变白内障手术眼部并发症生存分析后囊

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双金属液复合铸造斗齿的过渡区水力模拟试验

沈阳工业大学学报 2001年第3期23卷 189-191页

作者：孙家仲吴世常王青澄贾淑芹李荣凡沈阳工业大学材料科学与工程学院辽宁沈阳110023 沈阳铸造研究所辽宁沈阳110021 沈阳重型机械集团有限责任公司辽宁沈阳110025

用不同粘度的流体通过水力模拟的方法近似地描述了双金属斗齿过渡区的混合状态 .试验结果表明：两种液体浇注的间隔时间越长，先浇入的铁液液面越高，过渡区越窄；反之，过渡区越宽 .生产中为了保证过渡区双金属的结合质量，应控制较... 详细信息

用不同粘度的流体通过水力模拟的方法近似地描述了双金属斗齿过渡区的混合状态 .试验结果表明：两种液体浇注的间隔时间越长，先浇入的铁液液面越高，过渡区越窄；反之，过渡区越宽 .生产中为了保证过渡区双金属的结合质量，应控制较高的铁液液面高度及一定的双液间隔时间 .

关键词：双金属液斗齿挖掘机铲斗复合铸造水力模拟试验