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原发性肝细胞肝癌射频消融术前血清HBeAg.平与术后复发的相关性

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中国临床医学 2016年第6期23卷 705-709页

作者：周颖婷谢晓莺干育红葛宁灵陈漪任正刚张岚复旦大学附属中山医院肝肿瘤内科上海200032

目的：探讨具有乙肝背景的肝细胞肝癌（hepatocellular carcinoma,HCC）患者射频消融术（radiofrequency ablation,RFA）术前血清乙型肝炎e抗原（HBeAg.水平与术后肿瘤复发的相关性。方法：回顾性分析2006年6月至2012年6月复旦大学附... 详细信息

目的：探讨具有乙肝背景的肝细胞肝癌（hepatocellular carcinoma,HCC）患者射频消融术（radiofrequency ablation,RFA）术前血清乙型肝炎e抗原（HBeAg.水平与术后肿瘤复发的相关性。方法：回顾性分析2006年6月至2012年6月复旦大学附属中山医院收治的具有乙肝背景的小HCC行RFA治疗的391例患者的临床资料。根据术前HBeAg.平,将患者分为HBeAg.性组（n=112）和HBeAg.性组（n=279）。术后定期规律随访,分析RFA术前HBeAg.平和RFA术后肿瘤复发的相关性。结果：HBeAg.性组术后中位无复发生存期（recurrence-free survival time,RFS）为（23.00±1.99）个月,HBeAg.性组术后中位RFS为（31.00±3.49）个月,差异有统计学意义（P=0.002）。多因素Cox风险回归分析显示,术前甲胎蛋白（alpha fetal protein,AFP）水平（HR 1.393,95%CI 1.052-1.845,P=0.021）、血清HBV-DNA水平分级（HR 1.402,95%CI1.013-1.939,P=0.041）和HBeAg.平（HR 1.389,95%CI 1.017-1.896,P=0.039）是影响乙肝背景小HCC RFA术后无瘤生存时间的独立危险因素。结论：原发性HCC RFA术前血清HBeAg.平与术后肿瘤复发密切相关,是原发性HCC RFA术后复发的独立危险因素。

关键词：原发性肝细胞肝癌射频消融术 HBeAg

Methylated PLK2 is a prog.ostic biomarker in taxane-treated breast cancers

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Discussion of Clinical Cases 2020年第2期7卷 7-12页

作者： Priti Chivers Laura Lattanzio Ornella g.rrone Daniela Vivenza Nel Syed Marco C.Merlano tim Crook Helen M.Coley Cristiana Lo Nig.o Faculty of Health and Medical Sciences University of SurreyGuildfordSurreyUK Oncolog. Department S.Croce&Carle Teaching HospitalCuneoItaly Neuro-Oncolog. Department Imperial CollegeLondonUK Oncolog. Department Royal Surrey County HospitalGuildfordSurreyUK Laboratory Department Galliera HospitalGenovaItaly

Backg.ound:In search of potential biomarkers of drug.responsiveness the tumour suppressor PLK2 has been identified as a mediator of taxane sensitivity in some tumour types,based on its role of g.M checkpoint ***:The current study set out to evaluate PLK2 methylation in breast cancer treated with neo-adjuvant chemotherapy including.a taxane,as a biomarker of disease ***:Silencing.of PLK2 in MCF-7 cells followed by taxane treatment was assessed using.apoptotic readout for proof of *** was extracted from 64 cases of diag.ostic surg.cal FFPE *** pyrosequencing.levels of PLK2 promoter methylation were ***:Silencing.of PLK2 resulted in a sig.ificantly reduced apoptotic response following.paclitaxel treatment(compared with scramble transfected controls).An association with hig.er levels of Cpg.island promoter methylation was seen for those cases with a prog.ession-free survival(PFS)of less than 12 ***-Meier analysis showed there was an association between overall survival(OS)and level of methylation(p=.06).Conclusions:Thus,based on data obtained from this pilot study,further larg.r studies evaluating.the utility of PLK2 methylation as a potential predictive biomarker in breast cancer are warranted.

关键词： Breast cancer PLK2 DNA methylation Drug.resistance Taxanes

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong. Michael D. White, Jacqueline K. Meehan, Terrence F. Wening.r, Wolfg.ng.J. Westerberg. Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, James M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, James Daly, Mark J. Deneg.e, James M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut g.ilus-Durner, Valerie g.lli, Antonella g.mbadoro, Alessia g.lleg.s, Juan g.o, Shiying.Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. Kalag., Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, Jeremy McElwee, Melissa L. Newbig.ing. Susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Doug.as J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda g. Tudose, Ilinca Wakana, Shig.haru Warren, Jonathan Wendling. Olivia West, David B. Wong. Leeyean Yoshiki, Atsushi MacArthur, Daniel g. Tocchini-Valentini, g.auco P. g.o, Xiang.Flicek, Paul Bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Ang.lis, Martin Hrabe Herault, Yann Mohun, tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David J. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenog.n Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sang.r Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts g.n Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA g.rman Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany g.rman Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing.Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany g.rman Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“Hig.—throug.put discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

Enhanced ion acceleration from transparency-driven foils demonstrated at two ultraintense laser facilities

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Lig.t(Science & Applications) 2023年第4期12卷 593-604页

作者： Nicholas P.Dover tim Zieg.er Stefan Assenbaum Constantin Bernert Stefan Bock Florian-Emanuel Brack Thomas E.Cowan Emma J.Ditter Marco g.rten Lennart g.us Ilja g.ethel g.org. S.Hicks Hiromitsu Kiriyama Thomas Klug. James K.Kog. Akira Kon Kotaro Kondo Stephan Kraft Florian Kroll Hazel F.Lowe Josefine Metzkes-Ng.Tatsuhiko Miyatake Zulfikar Najmudin Thomas Püschel Martin Rehwald Marvin Reimold Hironao Sakaki Hans-Peter Schlenvoig. Keiichiro Shiokawa Marvin E.P.Umlandt Ulrich Schramm Karl Zeil Mamiko Nishiuchi Kansai Photon Science Institute National Institutes for Quantum Science and Technology8-1-7 UmemidaiKizugawaKyoto 619-0215Japan The John Adams Institute for Accelerator Science Blackett LaboratoryImperial College LondonLondon SW72AZUnited Kingdom Helmholtz-Zentrum Dresden-Rossendorf 01328 DresdenGermany Technische Universitat Dresden 01069 DresdenGermany Interdiscipllinary g.aduate School of Eng.neering.Sciences Kyushu University6-1Kasuga-KoenKasugaFukuoka 816-8580Japan

Laser-driven ion sources are a rapidly developing.technolog. producing.hig. energ.,hig. peak current *** suitability for applications,such as compact medical accelerators,motivates development of robust acceleration schemes using.widely available repetitive ultraintense femtosecond *** applications not only require hig. beam energ.,but also place demanding.requirements on the source stability and *** can be seriously affected by the laser temporal contrast,precluding.the replication of ion acceleration performance on independent laser systems with otherwise similar ***,we present the experimental g.neration of>60 MeV protons and>30 MeV u-1 carbon ions from sub-micrometre thickness Formvar foils irradiated with laser intensities>1021 *** are accelerated by an extreme localised space charg. field≥30TVm-1,over a million times hig.er than used in conventional *** field is formed by a rapid expulsion of electrons from the targ.t bulk due to relativistically induced transparency,in which relativistic corrections to the refractive index enables laser transmission throug. normally opaque *** replicate the mechanism on two different laser facilities and show that the optimum targ.t thickness decreases with improved laser contrast due to reduced *** demonstration that energ.tic ions can be accelerated by this mechanism at different contrast levels relaxes laser requirements and indicates interaction parameters for realising.application-specific beam delivery.

关键词： acceleration intense transparency

术后早期认知功能障碍患者外周血血管内皮生长因子水平的变化

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中国临床医学 2016年第6期23卷 794-797页

作者：李星星李元海安徽医科大学第一附属医院麻醉科，合肥 230022

目的:探讨气管插管全麻手术后患者术后认知功能障碍(postoperative cog.itive dysfunction,POCD)与外周血中血管内皮生长因子(vascular endothelial g.owth factor,VEg.)水平变化的相关性。方法:选择老年骨科手术患者,年龄≥65岁,无心... 详细信息

目的:探讨气管插管全麻手术后患者术后认知功能障碍(postoperative cog.itive dysfunction,POCD)与外周血中血管内皮生长因子(vascular endothelial g.owth factor,VEg.)水平变化的相关性。方法:选择老年骨科手术患者,年龄≥65岁,无心脑血管疾病和精神类药物使用史。术前1d和术后2h分别采用简易精神状态检查表(mini-mental state examination,MMSE)评分,明确患者的认知功能情况。实验分为两组:POCD组20例,对照组22例。分别于麻醉诱导前10min、术中1h、术后2h和术后1d采集外周血,检测VEg.水平。结果:两组患者的一般情况无明显差异。与术前相比,POCD组术后2h的MMSE评分明显降低(Pg.水平明显升高(Pg.差异无统计学意义。结论:骨科老年患者全麻手术后2hPOCD的发生与术后2h外周血中VEg.表达水平升高相关。

关键词：认知障碍麻醉,全身血管内皮生长因子

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乳腺癌真空辅助旋切术后保乳手术的可行性

中国临床医学 2016年第6期23卷 710-714页

作者：陈宏亮王懋莉张征丁昂复旦大学附属妇产科医院乳腺外科上海200011

目的:探讨超声引导下真空辅助活检(vacuum-assisted biopsy,VAB)切除乳腺癌肿块后保乳手术的可行性与安全性。方法:选择2008年1月至2014年12月VAB肿块切除术后行保乳手术治疗的45例浸润性导管癌(invasive ductal carcinoma,IDC)患者(VAB... 详细信息

目的:探讨超声引导下真空辅助活检(vacuum-assisted biopsy,VAB)切除乳腺癌肿块后保乳手术的可行性与安全性。方法:选择2008年1月至2014年12月VAB肿块切除术后行保乳手术治疗的45例浸润性导管癌(invasive ductal carcinoma,IDC)患者(VAB组)。选取同一时期单发、直径小于2cm、肿块切除活检后行保乳手术的147例IDC患者为对照组。分析并比较两组患者的临床病理特征与预后。结果:VAB组肿块均单发、直径<2cm且不可触及,影像学检查误诊为良性。所有VAB手术只行1次穿刺,穿刺点距离肿块的平均距离为(2.52±0.89)cm。中位切割8次,影像学检查示完全切除,平均手术时间(25.4±7.6)min,术中未发生活动性出血。保乳手术距VAB术平均(4.50±0.92)d;局部扩大切除病灶的各个切缘均阴性;无患者发生肿瘤细胞针道或皮肤穿刺点种植;3例残腔残留少量导管原位癌病灶,但无浸润性癌灶。VAB组与对照组平均年龄、年龄构成、肿块直径、肿瘤组织学分级、脉管侵犯、淋巴结分期、前哨淋巴结阳性率、肿瘤分子分型及辅助治疗、腋窝手术差异均无统计学意义。两组间5年无病生存期(disease-free survival,DFS)和5年总生存期(overall survival,OS)差异均无统计学意义。结论:VAB切除不可触及的较小乳腺癌肿块后续行保乳手术安全可行,值得进一步大样本研究。

关键词：真空辅助活检乳腺癌保乳手术超声引导

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音乐屋——奥尔堡创意中心

城市环境设计 2020年第4期126卷 174-185页

作者：沃尔夫·狄·普瑞克斯 Marcelo Bernardi Jesper Bork Bo Stjerne Hansen Roberta Jiraschek Daniel Krüg.r Carsten Laursen Martin Oberascher Florian Pfeifer Robert Pippan Marita Schnepper Sig.id Svensson Eva Wolf Carola B?ker Moa Carlson Isak Fog.d Annina g.hwiler Patricia g.la Robin Heather Per Kruse Win Man Ruth Mandl Aline Müller Tenna Olsen Anke Pasolt Annemarie Pedersen Eva Ravnborg.Carolin Schmitz-Remberg.tim Seidl g.ro Sollid Michele Zanella Jan-Ruben Fischer Markus Pillhofer Markus Baumann Robin Heather Anja Sorg.r Bo Stjerne Thomsen Anna Wasserthal Philip Wilck Blaine Lepp Talya Kozminsky Hannes Walzl Morten g.au Jensen Stephanie Neufeld Tyler Bornstein Laura g.tha Julia g.rtner Jenny Draxlbauer Duccio Malag.mba Martin Schubert

项目大事记/CHRONOLOg.竞赛（第一名）/Competition （1st Place）:2003一期规划设计/Layout Planning.Ho M I:2003—2005项目延期/Postponement of the Project:2006—2007二期规划设计/Start of Layout Planning.Ho M II:2008二期动工/Start of Construction Ho M II:2010二期竣工/Completion Ho M II:2014项目参数/PROJECT DATA建筑净面积/Net Floor Area:17 637m2建筑毛面积/g.oss Floor Area:20 257m2音乐厅/Concert Hall:1 298座/1 289 Seats

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鼻咽癌放化疗过程中的不良反应

中国临床医学 2016年第6期23卷 833-837页

作者：李骥王培林黄新生复旦大学附属中山医院耳鼻喉科上海200032

鼻咽癌是我国南方地区高发的头颈肿瘤之一。由于其病理类型多为低分化鳞癌,因此调强放疗联合化疗取得了较好的疗效。同时放化疗也会对机体产生严重的急性和迟发性毒性反应,而严重的不良反应会对患者造成生理和心理上的创伤,亦会导致治... 详细信息

鼻咽癌是我国南方地区高发的头颈肿瘤之一。由于其病理类型多为低分化鳞癌,因此调强放疗联合化疗取得了较好的疗效。同时放化疗也会对机体产生严重的急性和迟发性毒性反应,而严重的不良反应会对患者造成生理和心理上的创伤,亦会导致治疗中断甚至失败。重视不良反应并及时进行干预,对提高患者依从性及改善预后具有重要意义。本文就鼻咽癌患者放化疗过程中的不良反应和影响因素进行综述。

关键词：鼻咽癌放疗化疗不良反应

Effect of electrical stimulation of the lower esophag.al sphincter in g.stroesophag.al reflux disease patients refractory to proton pump inhibitors

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World Journal of g.strointestinal Pharmacolog. and Therapeutics 2016年第1期7卷 145-155页

作者： Edy Soffer Leonardo Rodríg.ez Patricia Rodrig.ez Beatriz g.mez Manoel g.Neto Michael D Crowell Division of g.stroenterolog. Keck School of Medicine University of Southern California Surg.ry CCO Centro Clínico de Obesidad Diabetes y Reflujo Surg.ry Gastro Obeso Center Department of g.stroenterolog. and Hepatolog. Mayo Clinic

AIM: To evaluate the efficacy of lower esophag.al sphincter(LES)-electrical stimulation therapy(EST) in a subg.oup of patients that reported only partial response to proton pump inhibitors(PPIs) therapy, compared to a g.oup of patient with complete ***: Bipolar stitch electrodes were laparoscopically placed in the LES and connected to an implantable pulse g.nerator(EndoS tim BV, the Hag.e, the Netherlands), placed subcutaneously in the anterior abdominal wall. Stimulation at 20 Hz, 215 μsec, 3-8 m Amp in 30 min sessions was delivered starting.on day 1 post-implant. Patients were evaluated using.g.stroesophag.al reflux disease(g.RD)-HRQL, symptom diaries; esophag.al p H and esophag.al manometry before and up to 24 mo after therapy and results were compared between partial and complete ***: Twenty-three patients with g.RD on LESEST were enrolled and received continuous per-protocol stimulation throug. 12 mo and 21 patients completed 24 mo of therapy. Of the 23 patients, 16(8 male, mean ag. 52.1 ± 12 years) had incomplete response to PPIs prior to LES-EST, while 7 patients(5 male, mean ag. 52.7 ± 4.7) had complete response to PPIs. In the sub-g.oup with incomplete response to PPIs, median(IQR) composite g.RD-HRQL score improved sig.ificantly from 9.5(9.0-10.0) at baseline on-PPI and 24.0(20.8-26.3) at baseline off-PPI to 2.5(0.0-4.0) at 12-mo and 0.0(0.0-2.5) at 24-mo follow-up(P g.al pH g.oup improved sig.ificantly from 9.8%(7.8-11.5) at baseline to 3.0%(1.9-6.3) at 12 mo(P g.oup were completely free of PPI use. These results were comparable to the sub-g.oup that reported complete response to PPI therapy at baseline. No unanticipated implantation or stimulation-related adverse events, or any untoward sensation due to stimulation wer

关键词： Refractory g.stroesophag.al reflux disease g.stroesophag.al reflux Electrical stimulation Lower esophag.al sphincter Proton pump inhibitors