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The effect of laves phases and nano-precipitates on the electrochemical corrosion resistance of Mg-Al-Ca alloys under alkaline conditions

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Journal of Magnesium and Alloys 2024年第6期12卷 2447-2461页

作者： Markus Felten Veronika Chaineux Siyuan Zhang Ali Tehranchi tilmann hick.l Christina Scheu Joshua Spille Marta lipińska-Chwałek Joachim Mayer Benjamin Berkels Marcus Hans Imke Greving Silja Flenner Sandra Sefa Daniela Zander Chair of Corrosion and Corrosion Protection RWTH Aachen UniversityAachen 52072 Germany Max-Planck-Institut für Eisenforschung GmbH Düsseldorf 40237 Germany Central Facility for Electron Microscopy RWTH Aachen UniversityAachen 52074 Germany Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons Forschungszentrum Jülich GmbHJülich 52428Germany Mathematical Image and Signal Processing Aachen Institute for Advanced Study in Computational Engineering ScienceRWTH Aachen UniversityAachen 52062 Germany Materials Chemistry RWTH Aachen UniversityAachen 52074 Germany Institute of Materials Physics Helmholtz-Zentrum HereonGeesthacht 21502 Germany

The electrochemical corrosion mechanisms of Mg alloys were extensively studied in previous investigations of different chemical com-positions,modified surface states and various electrolyte ***,recent research focused on the active state of Mg dissolution,leading to unresolved effects of secondary phases adjacent to a stableα-solid solution passive *** present study investigates the fundamental electrochemical corrosion mechanisms of three different laves phases with varying phase morphologies and phase fractions in the passive state of Mg-Al-Ca *** microstructure was characterized by(transmission-)electron microscopy and synchrotron-based transmission X-ray *** electrochemical corrosion resistance was determined with a standard three-electrode setup and advanced in-situ flow cell measurements.A new electrochemical activity sequence(C15>C36>α-Mg>C14)was obtained,as a result of a stable passive layer formation on theα-solid ***,nm-scale Mg-rich precipitates were identified within the laves phases,which tend to inhibit the corrosion kinetics.

关键词： laves phase STEM Magnesium Corrosion Passive layer

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Introduction to the Special Issue “Bioinformatic tools and approaches for Synthetic Biology of natural products”

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Synthetic and Systems Biotechnology 2016年第2期1卷 67-68页

作者： tilmann Weber The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKogle Alle 62970 H鴕sholmDenmark

Microorganisms are the major source for the identification of novel bioactive natural products,which may serve as future lead molecules for drug development to treat infectious and other ***,the research efforts to find such molecules have been hampered by high re-discovery rates of known biomolecules and a lack of new innovative screening technologies resulting in reduced screening efforts by large parts of the pharmaceutical *** recent advances in whole-genome sequencing technologies,mass spectrometry,cheminformatics and Synthetic Biology,new technologies are now available that could become game-changers in the *** these technologies require strong computational efforts to analyze and mine the large datasets,and/or design and optimize new pathways for Synthetic Biology applications.

关键词： Synthetic innovative advances

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The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production

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Synthetic and Systems Biotechnology 2016年第2期1卷 69-79页

作者： tilmann Weber Hyun Uk Kim The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKogle Alle 62970 HosholmDenmark BioInformatics Research Center Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Natural products are among the most important sources of lead molecules for drug *** the development of affordable whole-genome sequencing technologies and other‘omics tools,the field of natural products research is currently undergoing a shift in ***,for decades,mainly analytical and chemical methods gave access to this group of compounds,nowadays genomics-based methods offer complementary approaches to find,identify and characterize such *** paradigm shift also resulted in a high demand for computational tools to assist researchers in their daily *** this context,this review gives a summary of tools and databases that currently are available to mine,identify and characterize natural product biosynthesis pathways and their producers based on‘omics data.A web portal called Secondary Metabolite Bioinformatics Portal(SMBP at http://***)is introduced to provide a one-stop catalog and links to these bioinformatics *** addition,an outlook is presented how the existing tools and those to be developed will influence synthetic biology approaches in the natural products field.

关键词： Antibiotics Biosynthesis Bioinformatics NRPS PKS Natural product

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Designing sgRNAs for CRISPR-BEST base editing applications with CRISPyweb 2.0

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Synthetic and Systems Biotechnology 2020年第2期5卷 99-102页

作者： Kai Blin Simon Shaw Yaojun Tong tilmann Weber The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKgs.LyngbyDenmark

CRISPR/Cas9 systems are an established tool in genome *** double strand breaks caused by the standard Cas9-based knock-out techniques can be problematic in some organisms,new systems were developed that can efficiently create knock-outs without causing double strand breaks to elegantly sidestep these *** recently published CRISPR-BEST base editor system for actinobacteria is built around a C to T or A to G base *** base editing systems however require additional constraints to be considered for designing the ***,we present an updated version of the interactive CRISPy-web single guide RNA design tool https://***/that was built to support“classical”CRISPR and now also CRISPRBEST workflows.

关键词： CRISPR Base editor sgRNA Webserver CRISPR-BEST Genome editing

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Atomic structures of twin boundaries in hexagonal closepacked metallic crystals with particular focus on Mg

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npj Computational Materials 2017年第1期3卷 435-441页

作者： Zongrui Pei Xie Zhang tilmann hick.l Martin Friak Stefanie Sandlobes Biswanath Dutta Jorg Neugebauer Max-Planck-Institut fur Eisenforschung Dusseldorf D-40237Germany Institute of Physics of Materials Academy of Sciences of the Czech Republicv.v.i.Zizkova 22Brno CZ-61662Czech Republic Institut fur Metallkunde und Metallphysik RWTH Aachen UniversityAachen D-52074Germany Oak Ridge National laboratory Oak RidgeTN 37831USA

We have investigated twin boundaries in double-lattice hexagonal close-packed metallic materials,focusing on their atomic *** accurate ab-initio methods and large-scale atomistic simulations we address the following two fundamental questions:(i)What are the possible intrinsic twin boundary structures in hcp crystals?(ii)Are these structures stable against small distortions?In order to help end a decade-long controversy over the experimental observations of the atomic structures of twin boundaries,we have determined the energetics,spectra,and transition mechanisms of the twin *** results confirm that the mechanical stability controls structures which are observed.

关键词： twin hexagonal metallic

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OPAlINUS硬泥岩热反应的监控与模拟(英文)

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岩石力学与工程学报 2006年第4期25卷 659-669页

作者：张春良 Rothfuchs tilmann Wieczorek Klaus Jockwer Norbert Wileveau Yannick 德国核安全研究中心德国不伦瑞克38122 法国国家放射性废物管理局 bp9法国布列55290

目前,一些国家选择硬泥岩作为核废物地质深部处置的围岩。为深入理解硬泥岩在热–水–力(THM)耦合作用下的变化特征,在瑞士的 Mont Terri 地下岩石实验室对 Opalinus 硬泥岩进行了现场加热试验。该试验是利用一电加热器(直径 = 30 cm,长... 详细信息

目前,一些国家选择硬泥岩作为核废物地质深部处置的围岩。为深入理解硬泥岩在热–水–力(THM)耦合作用下的变化特征,在瑞士的 Mont Terri 地下岩石实验室对 Opalinus 硬泥岩进行了现场加热试验。该试验是利用一电加热器(直径 = 30 cm,长度 = 5.4 m)对硬泥岩进行了 1 a 多的加热,然后降温 0.5 a。加热器表面的最高温度达 100 ℃。在试验过程中,安装了 80 多个测试传感器对硬泥岩中的温度、孔隙水压、气体渗透以及变形进行了监控。通过观察发现围岩受热膨胀且产生明显的孔隙水压升高。距加热器约 1 m 的区域,其孔隙水压从约 1 MPa增高到 4 MPa。最后对试验中观测的硬泥岩受热所产生的热–水–力全过程进行了模拟计算,并介绍了现场测量和数值计算的初步结果。

关键词：核废物处置硬泥岩现场试验加热热-水-力过程监测模拟

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Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study

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World Journal of Gastroenterology 2015年第16期21卷 4925-4932页

作者： tilmann Graeter Franziska Ehing Suemeyra Oeztuerk Richard Andrew Mason Mark Martin Haenle Wolfgang Kratzer Thomas Seufferlein Beate Gruener Department of Interventional and Diagnostic Radiology University Hospital Ulm Department of Internal Medicine I University Hospital Ulm louis Stokes Cleveland Department of Veterans Affairs Medical Center Section of Infectious Diseases and Clinical Immunology Comprehensive Infectious Diseases Center Ulm

AIM:To determine the long-term hepatobiliary complications of alveolar echinococcosis(AE) and treatment options using interventional ***:Included in the study were 35 patients with AE enrolled in the Echinococcus Multilocularis Data Bank of the University Hospital of *** underwent endoscopic intervention for treatment of hepatobiliary complications between 1979 and ***' epidemiologic data, clinical symptoms, and indications for the intervention, the type of intervention and any additional procedures, hepatic laboratory parameters(pre- and post-intervention), medication and surgical treatment(pre- and post-intervention), as well as complications associated with the intervention and patients‘ subsequent clinical courses were *** order to compare patients with AE with and without history of intervention, data from an additional 322 patients with AE who had not experienced hepatobiliary complications and had not undergone endoscopic intervention were retrieved and ***:Included in the study were 22 male and 13 female patients whose average age at first diagnosis was 48.1 years and 52.7 years at the time of *** average time elapsed between first diagnosis and onset of hepatobiliary complications was 3.7 *** most common symptoms were jaundice, abdominal pains, and weight *** of interventions per patient ranged from one to *** retrograde cholangiopancreatography(ERCP)was most frequently performed in combination with stent placement(82.9%),followed by percutaneous transhepatic cholangiodrainage(31.4%)and ERCP without stent placement(22.9%).In 14.3%of cases,magnetic resonance cholangiopancreatography was performed.A total of eight patients received a biliary stent.A comparison of biochemical hepatic function parameters at first diagnosis between patients who had or had not undergone intervention revealed that these were significantly elevated in six patients who had undergone interven

关键词： Alveolar echinococcosis Endoscopic retrograde cholangiopancreatography Hepatobiliary complication Magnetic resonance cholangiopancreatography Percutaneous transhepatic cholangiodrainage Stent placement Treatment

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Pangenome analysis of Enterobacteria reveals richness of secondary metabolite gene clusters and their associated gene sets

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Synthetic and Systems Biotechnology 2022年第3期7卷 900-910页

作者： Omkar S.Mohite Colton J.lloyd Jonathan M.Monk tilmann Weber Bernhard O.Palsson The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKongens Lyngby2800Denmark Department of Bioengineering University of California San DiegoLa JollaCA92093USA

In silico genome mining provides easy access to secondary metabolite biosynthetic gene clusters(BGCs)encoding the biosynthesis of many bioactive compounds,which are the basis for many important drugs used in human ***,the association between BGCs and other functions encoded in the genomes of producers have remained ***,we present a systems biology workflow that integrates genome mining with a detailed pangenome analysis for detecting genes associated with a particular *** analyzed 3,889 enterobacterial genomes and found 13,266 BGCs,represented by 252 distinct BGC families and 347 additional singletons.A pangenome analysis revealed 88 genes putatively associated with a specific BGC coding for the colon cancer-related colibactin that code for diverse metabolic and regulatory *** presented workflow opens up the possibility to discover novel secondary metabolites,better understand their physiological roles,and provides a guide to identify and analyze BGC associated gene sets.

关键词： Pangenome analysis Workflow Secondary metabolites Colibactin Enterobacteria Secretion systems

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Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001

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Synthetic and Systems Biotechnology 2019年第3期4卷 142-149页

作者： Sagarika Devi Heiko T.Kiesewalter Renato Kovacs Jens Christian Frisvad tilmann Weber Thomas Ostenfeld larsen Akos T.Kovacs ling Ding Department of Biotechnology and Biomedicine Technical University of Denmark2800Kgs LyngbyDenmark Department of Medical Microbiology Faculty of MedicineUniversity of Debrecen4032DebrecenHungary Center for Biosustainability Technical University of Denmark2800Kgs LyngbyDenmark

For a safe and sustainable environment,effective microbes as biocontrol agents are in high *** have isolated a new Bacillus velezensis strain DTU001,investigated its antifungal spectrum,sequenced its genome,and uncovered the production of lipopeptides in HPlC-HRMS *** test the antifungal efficacy,extracts of *** DTU001 was tested against a range of twenty human or plant pathogenic *** demonstrate that inhibitory potential of *** DTU001 against selected fungi is superior in comparison to single lipopeptide,either iturin or *** isolate showed analogous biofilm formation to other closely related *** further support the biocontrol properties of the isolate,coculture with Candida albicans demonstrated that *** DTU001 exhibited excellent antiproliferation effect against *** summary,the described isolate is a potential antifungal agent with a broad antifungal spectrum that might assist our aims to avoid hazardous pathogenic fungi and provide alternative to toxicity caused by chemicals.

关键词： Bacillus velezensis Candida albicans Secondary metabolites Biocontrol Biofilm

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Discovery of gargantulides B and C,new 52-membered macrolactones from Amycolatopsis *** absolute stereochemistry of the gargantulide family

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Organic Chemistry Frontiers 2022年第2期9卷 462-470页

作者： Daniel Carretero-Molina Francisco Javier Ortiz-lópez Tetiana Gren Daniel Oves-Costales Jesús Martín Fernando Román-Hurtado Tue Sparholt Jorgensen Mercedes de la Cruz Caridad Díaz Francisca Vicente Kai Blin Fernando Reyes tilmann Weber Olga Genilloud Fundación MEDINA Centro de Excelencia en Investigación de Medicamentos Innovadores en AndalucíaAvda.del Conocimiento 3418016 ArmillaGranadaSpain The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKemitorvetbuilding 2202800 Kgs.LyngbyDenmark

Gargantulides B and C,two new and highly complex 52-membered glycosylated macrolactones,were isolated from Amycolatopsis *** CA-230715 during an antibacterial screening *** structures of these giant macrolides were elucidated by 2D NMR spectroscopy and shown to be related to gargantulide A,although containing additional β-glucopyranose and/orα-arabinofuranose monosaccharides separately attached to their *** sequencing allowed the identification of a strikingly large 216 kbp biosynthetic gene cluster,among the largest type Ⅰ PKS clusters described so far,and the proposal of a previously unreported biosynthetic pathway for gargantulides *** absolute configurations of gargantulides B and C were assigned based on a combination of NMR and bioinformatics analysis of ketoreductase and enoylreductase domains within the multimodular type Ⅰ *** addition,the absolute stereochemistry of gargantulide A has now been revised and *** B and C display potent antibacterial activity against a set of drug-resistant Gram-positive bacteria and moderate activity against the clinically relevant Gram-negative pathogen Acinetobacter baumannii.

关键词： absolute membered backbone

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