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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： j.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke jacqueline Proszynski Braden tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz jonathan foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman jangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor julian C.Schmidt Michael A.Schmidt Kelly Blease juan Moreno Andrew Boddicker junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The feil family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

Global Educational Research in Western Times:The Rise and Plight of Chinese Educational Research

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frontiers of Education in China 2018年第2期13卷 163-192页

作者： Robert j.tierney faculty of Education The University of British ColumbiaVancouverBC V6T 1Z2Canada Advanced Innovation Center for future Education Beijing Normal UniversityBeijing 100875China

The paper offers a critical appraisal of the global knowledge developments in education using China’s contributions in a fashion similar to a case *** paper scrutinizes the complicity of Western educational research to euro-centric biases and discusses the pursuit of a global epistemological *** support this claim,the magnitude of the global knowledge economy,including country-by-country comparisons,is explored together with data pertaining to the success rate of submissions and *** data are used as the basis for arguments that the dominant research practices and developmental work serve Western interests,Western thought and a Western economy tied to standardization rather than eastern epistemological interests.

关键词： Chinese educational research globalization Westernization

分离网络的严格计算——从含酚污水中回收苯酚流程的模拟

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化工学报 1985年第3期1卷 278-288页

作者：许锡恩,j.W.tierney 天津大学化工系美国匹兹堡大学化工系

本文提出了用于液液萃取与精馏塔网络模拟的数学模型和解法.此法采用牛顿-拉夫森迭代技术,结合适当的阻尼因子并用简化模型的解作为此严格计算的初值.模拟中除选用一组基本的设计变量外,还可将迭代变量或(和)非迭代变量与这些基本的设... 详细信息

本文提出了用于液液萃取与精馏塔网络模拟的数学模型和解法.此法采用牛顿-拉夫森迭代技术,结合适当的阻尼因子并用简化模型的解作为此严格计算的初值.模拟中除选用一组基本的设计变量外,还可将迭代变量或(和)非迭代变量与这些基本的设计变量互换,以满足设计要求.以从含酚污水中回收苯酚为实例说明了此严格计算法.结果是满意的.

关键词：校正值含酚污水迭代矩阵数学分析苯酚石炭酸一元酚

EXACT CALCULATION METHODS Of INTERLINKED COLUMN SYSTEM——SIMULATION Of RECOVERY Of PHENOL fROM WASTE WATER CONTAINING PHENOL

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Chinese journal of Chemical Engineering 1986年第1期 95-106页

作者：许恩锡 j.W.tierney Tianjin University University of Pittsburgh

This paper describes a mathematical model and an algorithm which can be used for simulation of in-terlinked column systems consisting of liquid-liquid extraction and *** algorithm is basedupon Newton-Raphson iteration technique using suitable damping factors and solutions of simplified modelas initial values of exact *** the exception of principle specification it is possible to interchangethe iteration variables and/or noniteration variables with design variables to meet requirements of design.A process of recovery of phenol from waste water containing pheonol is illustrated to varify the model *** results are satisfied.

关键词： EXACT CALCULATION METHODS Of INTERLINKED COLUMN SYSTEM SIMULATION Of RECOVERY Of PHENOL fROM WASTE WATER CONTAINING PHENOL

The Changing Nature of Academic freedom in an Age of Globalization

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frontiers of Education in China 2014年第1期9卷 1-3页

作者： William G.tierney Qiang ZHA Pullias Center for Higher Education Rossier School of EducationUniversity of Southern CaliforniaLos AngelesCA90033USA faculty of Education York UniversityTorontoM3J 1P3Canada

In this special issue,we offer three papers:(1)The Question of Academic freedom:Universal Right or Relative Term by William *** and Michael Lanford,(2)Academic freedom:A Global Comparative Approach by Simon Marginson,and(3)The“Beijing Consensus”and the Chinese Model of University Autonomy by Qiang Zha and Ruth *** strength of this special issue is that the authors’arguments are complementary;enriching and adding to each other’s views.

关键词： Academic adding Global

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负载型固体超强酸催化剂上的烷基化反应

环境化学 2000年第2期19卷 103-109页

作者：陈建民 tierneyjW WenderIrving 复旦大学环境科学与工程系上海200433 美国匹兹堡大学化工与石油工程系 pa15601

本文利用Ｐｔ／ＳＯ＾２－４／ＺｒＯ２，Ｐｔ／ＷＯ３／ＺｒＯ２负载于大比表面Ａｌ２Ｏ３固体强酸催化剂，进行异丁烷和丁烯的烷基化反应。

关键词：固体强酸催化剂烷基化反应负载型

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煤粉脱水过程的仿真研究

北京化工大学学报(自然科学版) 1984年第4期 52-60页

作者： j.W.tierney,B.S.Gottfried,赵关旗美国匹兹堡大学美国匹兹堡大学北京化工学院

本文提出了描述用于煤粉脱水的真空过滤器及离心分离器性能的数学方程式。这些方程式是脱水模块的数学模型。在美国能源局的资助下,美国匹兹堡大学新近开发了一个煤粉制备厂的仿真程序。这个模块就是为补充这个仿真器所用的。模块提出... 详细信息

本文提出了描述用于煤粉脱水的真空过滤器及离心分离器性能的数学方程式。这些方程式是脱水模块的数学模型。在美国能源局的资助下,美国匹兹堡大学新近开发了一个煤粉制备厂的仿真程序。这个模块就是为补充这个仿真器所用的。模块提出了在离心分离器中发生的机械粉碎,煤粉在离心分离器及过滤器排出液中的漏损,煤粉颗粒尺寸大小及重度分配的变化,含炭量及含硫量的变化以及脱水后成品中最后的含水量。模块的输入量是要进行脱水的煤的流入量,煤的清洗度的分析以及描述真空过滤器或离心分离器的工作参数。本文附有这个模块工作的典型结果。为了配合具体对象工厂的工作条件及实验结果,如有必要,模块中的一些可调参数可以很方便地进行调整。

关键词：离心分离器仿真程序煤饼离心器总含硫量含灰量模拟程序程序系统空气污染指数真空过滤器尺寸范围煤粉制备煤粉

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俯仰马唐草地放牧肉牛补饲糖浆的效果

草原与草坪 1984年第4期 57-57页

作者： T.j.tierney

试验草地年平均降水1718mm。每5—7星期施硝铵(34%N)50—70公斤/公顷。1972—73,1973—74,1974—75年总施氮量分别为252,300和300公斤/公顷。分三组试验。试验Ⅰ设两个处理:(1)对照(末补饲糖浆),(2)不定量补饲糖浆;试验Ⅱ设五个处理:(1... 详细信息

试验草地年平均降水1718mm。每5—7星期施硝铵(34%N)50—70公斤/公顷。1972—73,1973—74,1974—75年总施氮量分别为252,300和300公斤/公顷。分三组试验。试验Ⅰ设两个处理:(1)对照(末补饲糖浆),(2)不定量补饲糖浆;试验Ⅱ设五个处理:(1)对照,(2)定量补饲糖浆(2.6公斤/天,(3)不补饲糖浆(10—11月);补饲糖浆(1—5月),(4)不定量补饲糖

关键词：补饲肉牛草地糖浆