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Management of acute carbamazepine poisoning:A narrative review

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World Journal of Psychiatry 2023年第11期13卷 816-830页

作者： Luan Wang Yang Wang Ruo-Ying Zhang Yao Wang Wei liang tie-gang li Department of Emergency Medicine Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of General Surgery The 4th Affiliated Hospital of China Medical UniversityShenyang 110032Liaoning ProvinceChina

Standard management protocols are lacking and specific antidotes are unavailable for acute carbamazepine(CBZ)*** objective of this review is to provide currently available information on acute CBZ poisoning,including its management,by describing and summarizing various therapeutic methods for its treatment according to previously published *** treatment methods for CBZ poisoning will be briefly introduced,their advantages and disadvantages will be analyzed and compared,and suggestions for the clinical treatment of CBZ poisoning will be provided.A literature search was performed in various English and Chinese *** addition,the reference lists of identified articles were screened for additional relevant studies,including non-indexed ***-reviewed sources were also *** the present review,154 articles met the inclusion criteria including case reports,case series,descriptive cohorts,pharmacokinetic studies,and in vitro *** on 67 patients,including 4 fatalities,were *** on the summary of cases reported in the included articles,the cure rate of CBZ poisoning after symptomatic treatment was 82%and the efficiency of hemoperfusion was 58.2%.Based on the literature review,CBZ is moderately dialyzable and the recommendation for CBZ poisoning is supportive management and gastric *** severe cases,extracorporeal treatment is recommended,with hemodialysis as the first choice.

关键词： Carbamazepine poisoning Management Activated charcoal therapy Extracorporeal treatment Intravenous lipid emulsion

Feasibility of differentiating defect signals of ultrasonic testing for laser weld based on independent component analysis theory

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Rare Metals 2007年第S1期26卷 56-60页

作者： GUO liwei,gang tie,and li Jinquan State Key Laboratory of Advanced Welding Production Technology,Harbin Institute of Technology,Harbin 150001,China Harbin Inst Technol State Key Lab Adv Welding Prod Technol Harbin 150001 Peoples R China

Separating noise from observed signals was *** the small defect in the T-shape laser welding joint was inspected by ultrasonic testing system adopting independent component analysis(ICA) theory to process the *** principle of automatic ultrasonic testing signals processing and negentropy law of ICA were *** experimental data were processed using relative analysis tools and results showed that the ICA could separate defects signals from noise effectively in laboratory.

关键词： independent component analysis automatic ultrasonic testing signal processing

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui Chen Zuo-Tang liang Yu-gang Ma Xin-li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu liu Michael Chopp Michael Millman Yanfeng li Pasquale Cepparulo Amy Kemper Chao li li Zhang Zheng gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang gang li Xing Cheng Peiqiang Su Yong Wan Xiang li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

Text-Image Feature Fine-Grained Learning for Joint Multimodal Aspect-Based Sentiment Analysis

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Computers, Materials & Continua 2025年第1期82卷 279-305页

作者： Tianzhi Zhang gang Zhou Shuang Zhang Shunhang li Yepeng Sun Qiankun Pi Shuo liu School of Data and Target Engineering Information Engineering UniversityZhengzhou450001China Information Engineering Department Liaoning Provincial College of CommunicationsShenyang110122China School of Computer and Artificial Intelligence Zhengzhou UniversityZhengzhou450000China

Joint Multimodal Aspect-based Sentiment Analysis(JMASA)is a significant task in the research of multimodal fine-grained sentiment analysis,which combines two subtasks:Multimodal Aspect Term Extraction(MATE)and Multimodal Aspect-oriented Sentiment Classification(MASC).Currently,most existing models for JMASA only perform text and image feature encoding from a basic level,but often neglect the in-depth analysis of unimodal intrinsic features,which may lead to the low accuracy of aspect term extraction and the poor ability of sentiment prediction due to the insufficient learning of intra-modal *** this problem,we propose a Text-Image Feature Fine-grained Learning(TIFFL)model for ***,we construct an enhanced adjacency matrix of word dependencies and adopt graph convolutional network to learn the syntactic structure features for text,which addresses the context interference problem of identifying different aspect ***,the adjective-noun pairs extracted from image are introduced to enable the semantic representation of visual features more intuitive,which addresses the ambiguous semantic extraction problem during image feature ***,the model performance of aspect term extraction and sentiment polarity prediction can be further optimized and *** on two Twitter benchmark datasets demonstrate that TIFFL achieves competitive results for JMASA,MATE and MASC,thus validating the effectiveness of our proposed methods.

关键词： Multimodal sentiment analysis aspect-based sentiment analysis feature fine-grained learning graph convolutional network adjective-noun pairs

Modeling pedestrian-vehicle interactions at unsignalized mid-block crosswalk under automated vehicle mixed traffic flow conditions: an agent-based approach

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Journal of Traffic and Transportation Engineering(English Edition) 2025年

作者： Haojie li Binyue Zhao Ziqian Zhang Yingheng Zhang gang Ren School of Transportation， Southeast University Jiangsu Key Laboratory of Urban ITS Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies

The introduction of automated vehicles (AVs) is expected to improve the safety and traffic efficiency of the transportation system. However， the impacts of AVs on pedestrian-vehicle interactions (PVIs) remain unclear， especially under the mixed traffic flow condition with AVs and conventional vehicles (CVs). The objective of this paper is to investigate PVIs under AV mixed traffic flow at unsignalized mid-block crosswalk (UMC) where the right of way competition exists and the traffic conditions are more complex. An agent-based simulation model is proposed to evaluate the safety and traffic efficiency under a diverse range of different scenarios. Some agents’ behavioral parameters are calibrated from trajectory and video data collected at two sites in Nanjing. The proposed model is also validated by comparing Post-Encroachment Time (PET) and pedestrian waiting time outputted from simulation with those extracted from empirical data. The simulation results suggest that the introduction of AVs has limited effect on both safety and efficiency levels at UMC under the low AV penetration rate. Compared to the negotiated yielding strategy of AVs， the conservative yielding strategy performs better in terms of pedestrian safety， but worse in improving traffic efficiency. Moreover， the results reveal that pedestrian and vehicle volumes， the proportion of pedestrians familiar with AVs， and the proportion of risk-prone pedestrians could significantly affect the safety and efficiency levels at UMC. Lastly， we provide some practical recommendations for determining treatments for mid-block crosswalks with AV mixed traffic flow to improve pedestrian safety and traffic efficiency.

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Synthesis of faveolate open-structured Ru-N/C cathode catalyst with high bifunctional activity for rechargeable quasi-solid-state li-O_(2)batteries

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Nano Research 2025年第1期18卷 351-361页

作者： tie liu School of Chemistry and Chemical Engineering Heze UniversityHeze 274015China

The constituents and geometric design of cathodic electrocatalyst to achieve high activity and durability are effective but challenging for the development of high-performance li-O_(2)*** study employs a mild solution precipitation method followed by thermolysis to construct a faveolate open-structured Ru-N/C matrix with a loosely braided network morphology as a bifunctional *** details prove that this hybrid structure is composed of ultrafine Ru globular nanoparticles(ca.2 nm)coated with an N-enriched carbon film and exhibits a valuable beehive through-hole character for rapid mass transport during oxygen redox *** synergistic effect of open-structured and reticular network matrix with metal-N4 coordination induces asymmetric charge distributions with moderate adsorption/desorption behaviour with oxygen ***,this particular Ru-N/C matrix cathode provides a promising li_(2)O_(2)accommodation space and exhibits superior electrochemical performance in terms of a positive discharge plateau and low charge ***,the assembled batteries also present a high discharge capacity and a long cycle life(exceeding 283 cycles).The density functional theory(DFT)calculations also corroborate the assertion that the Ru-N/C catalyst exhibits robust electronic coupling transfer and superior bifunctional *** such,our work demonstrates that this type of open-structured Ru-N/C matrix is promising for fabricating high-performance quasi solid-state li-O_(2)batteries.

关键词： ruthenium nitride nitrogen-doped carbon electrocatalyst li-O_(2)battery

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金属螯合亲和层析纯化金属硫蛋白

生物化学与生物物理进展 1994年第5期21卷 447-450页

作者：铁锋茹刚李令媛刘德富茹炳根北京大学生物系北京大学分校生物系

将二价铜离子螯合在ＣｈｅｌａｔｉｎｇＳｅｐｈａｒｏｓｅＦａｓｔＦｌｏｗ凝胶上制成亲和层析柱，锌诱导兔肝和镉诱导小鼠肝经匀浆、乙醇处理后上柱，用ｐＨ４．０的醋酸盐缓冲液平衡，再用ｐＨ５．２不同浓度的醋酸盐缓冲液分别洗脱... 详细信息

将二价铜离子螯合在ＣｈｅｌａｔｉｎｇＳｅｐｈａｒｏｓｅＦａｓｔＦｌｏｗ凝胶上制成亲和层析柱，锌诱导兔肝和镉诱导小鼠肝经匀浆、乙醇处理后上柱，用ｐＨ４．０的醋酸盐缓冲液平衡，再用ｐＨ５．２不同浓度的醋酸盐缓冲液分别洗脱，可得两个金属硫蛋白（ＭＴ）洗脱峰，经确定先后为ＭＴ－２和ＭＴ－１．分离方法比传统的凝胶过滤－离子交换法简单、省时，适于实验室规模分离纯化．

关键词：金属硫蛋白金属螯合分离提纯