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Journal of Systems Science & Complexity 2022年第4期35卷 1225-1243页

作者： tie lin School of Automation Science and Electrical Engineering Beihang UniversityBeijing100083China

Controllable canonical forms play important roles in the analysis and design of control systems.In this paper,a fundamental class of discrete-time bilinear systems are considered.Such systems are of interest since,on one hand,they have the most complete controllability theory.On the other hand,they can be nearly-controllable even if controllability fails.Firstly,controllability of the systems with positive control inputs is studied and necessary and sufficient algebraic criteria for positive-controllability and positive-near-controllability are derived.Then,controllable canonical forms and nearly-controllable canonical forms of the systems are presented,respectively,where the corresponding transformation matrices are also explicitly constructed.Examples are given to demonstrate the effectiveness of the derived controllability criteria and controllable canonical forms.

关键词： Canonical forms controllability discrete-time bilinear systems near-controllability positive control inputs

Portal vein embolization combined with ex vivo liver resection and autotransplantation: A novel treatment strategy for end-stage and metastatic hepatic alveolar echinococcosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 210-216页

作者： Qiang Guo Mao-lin Wang Kai Zhong Jia-Long Li tie-Min Jiang Hao Wen Tuerganaili Aji Ying-Mei Shao Department of Hepatobiliary and Echinococcosis Surgery Digestive and Vascular Surgery CenterFirst Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054China Clinical Medical Research Center of Echinococcosis and Hepatobiliary Disease of Xinjiang Uygur Autonomous Region Urumqi 830054China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaXinjiang Medical UniversityUrumqi 830054China

Alveolar echinococcosis(AE)is a lethal parasitic disease caused by Echinococcus multilocularis larvae,and more than 90%of pri-mary AE lesions occur in the liver.Most of the affected individ-uals remain asymptomatic and the disease is often diagnosed at an advanced stage.The infection may spread to organs adjacent to the liver or distant locations,eventually causing end-stage multi-ple organ AE.Brain metastasis of AE is the most fatal with an inci-dence rate of 0.2%[1].

关键词： organs echinococcosis metastasis

Isolation and culture of human primary osteoblasts:Comparing the effects of differences in method details on osteoblast characteristics

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Genes & Diseases 2024年第2期11卷 546-549页

作者： Fei Chen Yan Zhang Pai Peng Xiao-Ting Huang Zi-Han Qiu Bao-Cheng Liu tie-lin Yang Bo Yang Yan Guo Key Laboratory of Biomedical Information Engineering of Ministry of Education Biomedical Informatics & Genomics CenterSchool of Life Science and TechnologyXi'an Jiaotong UniversityXi'anShaanxi 710049China Department of Orthopaedics Shannxi Provincial People's Hospital (The Third Affiliated Hospital of Xi'an Jiaotong University)Xi'anShaanxi 710068China

Osteoblasts are essential in the maintenance of human bone homeostasis.1 The abnormal formation and impaired differentiation ability of osteoblasts are pivotal factors leading to bone-related diseases,suggesting that an indepth study of osteoblasts can provide novel treatment strategies for these diseases.2 Human primary osteoblasts are precious experimental models in bone-related research.3 However,the isolation and culture of human primary osteoblasts still have some difficulties and limitations.Here,we refined a method to isolate and culture human primary osteoblasts by taking cancellous bone through a bone tissue sampler and pre-digesting it with pancreatin,which makes the process easier,cheaper,and more efficient.Furthermore,we compared the effects of the subtle changes in isolation and culture methods on the phenotype of human primary osteoblasts and examined the differences in morphology,proliferation,and differentiation between micro-explants cultured osteoblasts(MECOBs)and explants cultured osteoblasts(EC-OBs).

关键词： impaired culture details

Mesenchymal stem cell-derived exosomes as a new drug carrier for the treatment of spinal cord injury:A review

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Chinese Journal of Traumatology 2024年第3期27卷 134-146页

作者： lin-Fei Cheng Chao-Qun You Cheng Peng Jjia-ji Ren Kai Guo tie-Long Liu Medical Collge.Anhui University of Science and Technology Huainan232000Anhui provinceChina Department of Orthopaedic Oncology Changzheng HospitalNavy Medical UniversityShanghai200003China Department of Orthopaedics The Central Hospital of Shanghai Putuo DistrictShanghai200333China

Spinal cord injury(SCI)is a devastating traumatic disease seriously impairing the quality of life in patients.Expectations to allow the hopeless central nervous system to repair itself after injury are unfeasible.Developing new approaches to regenerate the central nervous system is still the priority.Exosomes derived from mesenchymal stem cells(MSC-Exo)have been proven to robustly quench the inflammatory response or oxidative stress and curb neuronal apoptosis and autophagy following SCI,which are the key processes to rescue damaged spinal cord neurons and restore their functions.Nonetheless,MSC-Exo in SCI received scant attention.In this review,we reviewed our previous work and other studies to summarize the roles of MSC-Exo in SCI and its underlying mechanisms.Furthermore,we also focus on the application of exosomes as drug carrier in SCI.In particular,it combs the advantages of exosomes as a drug carrier for SCI,imaging advantages,drug types,loading methods,etc.,which provides the latest progress for exosomes in the treatment of SCI,especially drug carrier.

关键词： Spinal cord injury Mesenchymal stem cell Exosomes Mechanism Drug carrier

ON NEARLY-CONTROLLABLE SUBSPACES OF A CLASS OF DISCRETE-TIME BIlinEAR SYSTEMS

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Journal of Systems Science & Complexity 2013年第4期26卷 512-526页

作者： tie lin School of Automation Science and Electrical Engineering Beihang University

If a linear time-invariant system is uncontrollable,then the state space can be decomposed as a direct sum of a controllable subspace and an uncontrollable subspace.In this paper,for a class of discrete-time bilinear systems which are uncontrollable but can be nearly controllable,by studying the nearly-controllable subspaces and defining the near-controllability index,the controllability properties of the systems are fully characterized.Examples are provided to illustrate the conceptions and results of the paper.

关键词：双线性系统离散时间不可控子空间线性时不变系统直和分解状态空间可控性

Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer:Integrating Bioinformatics Analysis with Experimental Confirmation

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Current Medical Science 2024年第3期44卷 529-544页

作者： Yan-min LIU tie-cheng YANG Xiao-chang FANG Li-jie YANG Li-wen SHI Hua-qiao WANG Ting-ting DOU lin SHU Tian-Liang CHEN Jun HU Xiao-ming YU Xuan-fei LI Department of Gastroenterology the Central Hospital of WuhanKey Laboratory for Molecular Diagnosis of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430014China Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Clinical Medical Research Center of Peritoneal Cancer of Wuhan Wuhan430071China Hubei Provincial Clinical Research Center for Cancer Hubei Key Laboratory of Tumor Biological Behavi Wuhan430071China Department of General Surgery Taihe HospitalHubei University of MedicineShiyan442000China Department of Gastrointestinal Surgery Huangshi Central HospitalAffiliated Hospital of Hubei Polytechnic UniversityWuhan435001China

Objective To uncover the mechanisms underlying the development of colorectal cancer(CRC),we applied bioinformatic analyses to identify key genes and experimentally validated their possible roles in CRC onset and progression.Methods We performed Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis on differentially expressed genes(DEGs),constructed a protein-protein interaction(PPI)network to find the top 10 hub genes,and analyzed their expression in colon adenocarcinoma(COAD)and rectum adenocarcinoma(READ).We also studied the correlation between these genes and immune cell infiltration and prognosis and validated the expression of SLC9A2 in CRC tissues and cell lines using qRT-PCR and Western blotting.Functional experiments were conducted in vitro to investigate the effects of SLC9A2 on tumor growth and metastasis.Results We found 130 DEGs,with 45 up-regulated and 85 down-regulated in CRC.GO analysis indicated that these DEGs were primarily enriched in functions related to the regulation of cellular pH,zymogen granules,and transmembrane transporter activity.KEGG pathway analysis revealed that the DEGs played pivotal roles in pancreatic secretion,rheumatoid arthritis,and the IL-17 signaling pathway.We identified 10 hub genes:CXCL1,SLC26A3,CXCL2,MMP7,MMP1,SLC9A2,SLC4A4,CLCA1,CLCA4,and ZG16.GO enrichment analysis showed that these hub genes were predominantly involved in the positive regulation of transcription.Gene expression analysis revealed that CXCL1,CXCL2,MMP1,and MMP7 were highly expressed in CRC,whereas CLCA1,CLCA4,SLC4A4,SLC9A2,SLC26A3,and ZG16 were expressed at lower levels.Survival analysis revealed that 5 key genes were significantly associated with the prognosis of CRC.Both mRNA and protein expression levels of SLC9A2 were markedly reduced in CRC tissues and cell lines.Importantly,SLC9A2 overexpression in SW480 cells led to a notable inhibition of cell proliferation,migration,and invasion.Western blotting analysis revealed that the expression levels of phosphorylated ERK(p-

关键词： SLC9A2 colorectal cancer bioinformatic analysis biomarkers immune infiltrate

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面向特定车头的人地碰撞损伤防护极简方法

中国公路学报 2024年第1期37卷 255-266页

作者：邹铁方曾冲王丹琦胡林长沙理工大学汽车与机械工程学院湖南长沙410114

针对原制动控制方法对监测设备要求极高的问题,提出了一种具有较强实践潜力的人地碰撞损伤防护方法的提取流程。先建立特定车头的多刚体模型,再选择车辆制动控制方法并穷举、寻优,最后回归获得人体头部首次撞击车体时刻t1与车辆再次完... 详细信息

针对原制动控制方法对监测设备要求极高的问题,提出了一种具有较强实践潜力的人地碰撞损伤防护方法的提取流程。先建立特定车头的多刚体模型,再选择车辆制动控制方法并穷举、寻优,最后回归获得人体头部首次撞击车体时刻t1与车辆再次完全制动时刻t2的关系,以此提出面向特定车头的人地碰撞损伤防护极简方法(SMPG)。以小型行人友好型轿车为例,检验此方法的可行性,分析2 400次仿真结果后,获得适用于小型行人友好型轿车的人地碰撞损伤防护极简方法,再经48次仿真发现,所得方法能显著降低人地碰撞损伤且不会增加人车碰撞损伤,添加车速扰动后的480次仿真显示,所得方法仍能很好地防护人地碰撞损伤且未增加人车碰撞损伤,表明能根据所提流程获得防护人地碰撞损伤的极简方法且方法效果佳。进一步分析发现,落地机制及躯干角度的改变是制动控制能降低人地碰撞损伤的主要原因,且通过流程所得的极简方法中的制动系统协调时间已达最优,无需进一步优化。研究结果将为通过制动控制以防护人地碰撞损伤的相关研究提供支持,推动其实用化。

关键词：汽车工程人地碰撞损伤车辆制动控制车头形状损伤对比研究

宁夏供港蔬菜田土壤重金属分布特征及生态风险评价

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环境科学 2024年第6期45卷 3512-3522页

作者：姬丽马琨谢铁娜陈林李虹贾彪宁夏大学农学院银川750021 宁夏大学生态环境学院银川750021 宁夏大学科学技术研究院银川750021 宁夏回族自治区农业环境保护监测站银川750002

农田土壤重金属污染会影响蔬菜作物的生长发育及产量,同时也会影响蔬菜的品质与口感,长期以来通过食物链传递和富集,最终对人体健康造成一定危害.因此为探明宁夏多年多茬种植供港蔬菜后其土壤重金属分布特征,预测其生态风险,分析其污染... 详细信息

农田土壤重金属污染会影响蔬菜作物的生长发育及产量,同时也会影响蔬菜的品质与口感,长期以来通过食物链传递和富集,最终对人体健康造成一定危害.因此为探明宁夏多年多茬种植供港蔬菜后其土壤重金属分布特征,预测其生态风险,分析其污染形成原因,于2019~2021年连续3 a采集了477个宁夏供港蔬菜田表层土壤样本,分析As、Cd、Cr、Hg、Pb、Cu、Zn和Ni这8种重金属含量和分布特征,采用单因子污染指数法、内梅罗综合污染指数法、地累积指数法和潜在生态风险指数法对宁夏供港蔬菜田土壤重金属污染状况进行评价,利用Pearson相关分析和主成分分析法解析了宁夏供港蔬菜田重金属来源.结果表明,宁夏供港蔬菜田土壤中As、Cd、Cr、Hg、Cu和Zn含量均值高于宁夏土壤背景值,但8种重金属含量均低于国内农用地土壤风险筛选值;在空间分布上,As、Cr和Ni在研究区西北部、中部以及南部出现连片高值区,Pb、Zn、Cd、Hg和Cu在研究区西北部与南部出现高值响应;单因子指数法和内梅罗综合污染指数法表明,宁夏供港蔬菜田土壤整体处于清洁水平;地累积指数法结果显示研究区污染以Hg和Cd污染为主,污染区域主要集中在研究区西北部和南部;潜在生态风险指数显示Hg和Cd为主要风险元素,其中Hg以中等、较强和很强生态风险为主,分别占比44.65%、44.65%和1.26%,Cd以中等、较强为主,占比65.83%和3.56%;综合Pearson相关分析和主成分分析表明,8种重金属污染来源可划分为3类,Ⅰ为自然源:Cu、Zn、Pb、As、Ni和Cr;Ⅱ为农业源:Cd;Ⅲ为工业源和农业源:Hg.综合来看,供港蔬菜田土壤重金属均无超标现象,土壤环境条件良好,宁夏供港蔬菜生产整体处于安全水平.研究结果可为宁夏供港菜田土壤安全利用和供港蔬菜安全生产、合理施肥、农艺运筹以及种植结构调整等提供帮助.

关键词：宁夏供港蔬菜土壤重金属空间分布生态风险评价来源解析

中国特色金融文化融入财经院校通识教育体系的路径探析

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湖南财政经济学院学报 2024年第3期40卷 104-112页

作者：林铁湖南财政经济学院人文与艺术学院湖南长沙410205

中国特色金融文化融入财经院校通识教育体系是培育和弘扬中国特色金融文化的重要路径。财经院校通识教育既要推动中华优秀传统文化在金融领域内创造性转化和发展,又要借鉴现代商业和金融业文明成果,以帮助大学生塑造中国金融事业所需的... 详细信息

中国特色金融文化融入财经院校通识教育体系是培育和弘扬中国特色金融文化的重要路径。财经院校通识教育既要推动中华优秀传统文化在金融领域内创造性转化和发展,又要借鉴现代商业和金融业文明成果,以帮助大学生塑造中国金融事业所需的精神品格与人文情怀。由此,需要从课程体系建设目标、课程建设导向、课程讲授形式和教学管理模式等多个方面综合考虑和推进。

关键词：中国特色金融文化财经院校通识教育路径

大黄酚改善缺血再灌注诱导的急性肾损伤的机制研究

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药学学报 2024年第5期59卷 1295-1305页

作者：杨雪王燕青邓敏铁璐李琳琳新疆医科大学药学院新疆乌鲁木齐830017 北京大学基础医学院北京100191 广州中医药大学基础医学院广东广州510006 新疆天然药物活性组分与释药技术重点实验室新疆乌鲁木齐830017

肾脏缺血再灌注损伤(ischemic reperfusion injury,IRI)是导致急性肾损伤(acute kidney injury,AKI)的主要原因,预后不良且死亡率高。有报道提示大黄酚具有肾脏保护作用,但其对IRI的影响及机制尚不清楚。本研究旨在探索大黄酚对IRI诱导... 详细信息

肾脏缺血再灌注损伤(ischemic reperfusion injury,IRI)是导致急性肾损伤(acute kidney injury,AKI)的主要原因,预后不良且死亡率高。有报道提示大黄酚具有肾脏保护作用,但其对IRI的影响及机制尚不清楚。本研究旨在探索大黄酚对IRI诱导的AKI的影响及其作用机制。通过建立小鼠单侧肾脏IRI模型,观察肾脏组织病理变化,检测血清中肌酐、尿素氮水平及肾组织中细胞凋亡、线粒体自噬相关蛋白的表达;建立肾小管上皮细胞(human kidney-2,HK-2)缺氧复氧(hypoxia/reoxygenation,H/R)模型,测定其线粒体膜电位水平及活性氧含量;筛选大黄酚与AKI的相关作用靶点并进行功能富集分析,对核心靶点、关键通路进行验证。动物实验经北京大学实验动物伦理委员会批准(编号:LA2021503)。结果显示,与假手术组相比,IRI组小鼠血清肌酐、尿素氮水平升高,肾组织结构明显遭到破坏,肾损伤分子(KIM1)、凋亡相关蛋白(cleaved-caspase 3、caspase 3、cytochrome C)、线粒体自噬蛋白(PINK1)表达增加,而大黄酚可呈剂量依赖性地改善上述病理变化,并能够显著提高H/R条件下HK-2细胞线粒体膜电位,抑制活性氧产生;通过网络药理学分析发现HSP90AA1和PIK3R1为关键靶点,主要富集于磷脂酰肌醇3激酶/蛋白激酶B(phosphoinositide 3 kinase/protein kinase B,PI3K/Akt)通路,验证发现大黄酚能够显著降低H/R条件下HK-2细胞HSP90AA1和PIK3R1 mRNA水平,并增加p-PI3K、PI3K、p-Akt和Akt蛋白表达水平。综上,大黄酚可能通过靶向调节HSP90AA1、PIK3R1,并活化PI3K/Akt通路,减少细胞凋亡,调节线粒体自噬,提高线粒体膜电位,抑制活性氧产生,进而改善由IRI诱导的AKI,为急性肾损伤提供了潜在治疗方案。

关键词：大黄酚急性肾损伤缺血再灌注损伤网络药理学线粒体