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Histopathologic and Immunohistochemical Analysis of 66 Cases of Gastrointestinal Stromal Tumor

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Journal of Biosciences and Medicines 2023年第6期11卷 140-147页

作者： tianzhi zhang Chao Liang Danting Su Department of Pathology The Seventh Affiliated Hospital of Sun Yat-sen University Shenzhen China

Background and Objective: To investigate the histopathological characteristics and immunohistochemistry of gastrointestinal stromal tumors (GIST). Immunohistochemistry (IHC) refers to the expression and meaning of CD117, DOG-1, CD34. Methods: Sixty-six gastrointestinal stromal tumor (GIST) samples with complete clinical data and definite clinicopathological diagnosis were collected from the Seventh Affiliated Hospital of Sun Yat-sen University from January 2019 to December 2022. Retrospective analysis was performed on the pathological data of 66 patients with GIST, and the histopathology and IHC were analyzed and summarized. Results: Among the 66 cases, 46, 14, 1, 5 were found in the stomach, small intestine, large intestine, and gastroenteral area. There were 45 cases (97%), 11 cases (79%), 1 case (100%), 5 cases (100%) in order of fusiform cell type. There were 1 case (3%), 2 cases (14%), 0 case, 0 case of upper dermatiform;Mixed type in 0 case, 1 case (7%), 0 case, 0 case;CD117 positive 66 cases (100%), DOG-1 positive 66 cases (100%), CD34 positive 61 cases (92%), CD117 and/or CD34 negative 5 cases (8%);CD34, CD117 and DOG-1 were negative simultaneously in 0 case. 19 cases (28%) were positive for SMA and 7 cases (11%) were positive for S-100. Conclusion: Fusiform cell type is the common type of GIST, followed by epithelioid type and mixed type, but the tumor sites are different, and the comparison cases are not completely the same. CD117, DOG-1 and CD34 are high surface in GIST, and the combination of SMA, S-100 and histomorphology can be used to diagnose most GIST.

关键词： Gastrointestinal Stromal Tumor Immunological Organization CD117 DOG-1 CD34

A macro-mesoscopic constitutive model for porous and cracked rock under true triaxial conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3080-3098页

作者： Li Qian Zuguo Mo Jianhai zhang Xianglin Xing Ru zhang tianzhi Yao Yunpeng Gao State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resources and HydropowerSichuan UniversityChengdu610065China Power China Chengdu Engineering Corporation Limited Chengdu610072China

The complex mechanical and damage mechanisms of rocks are intricately tied to their diverse mineral compositions and the formation of pores and cracks under external *** rock tests reveal a complex interplay between the closure of porous defects and the propagation of induced cracks,presenting challenges in accurately representing their mechanical properties,especially under true triaxial stress *** paper proposes a conceptualization of rock at the mesoscopic level as a two-phase composite,consisting of a bonded medium matrix and frictional medium *** bonded medium is characterized as a mesoscopic elastic material,encompassing various minerals surrounding porous *** mechanical properties are determined using the mixed multi-inclusion *** of the bonded medium into the frictional medium occurs through crack extension,with its elastoplastic properties defined by the DruckerePrager yield criterion,accounting for hardening,softening,and *** and Eshelby’s equivalent inclusion methods are applied to the bonded and frictional media,*** macroscopic mechanical properties of the rock are derived from these mesoscopic ***,a True Triaxial Macro-Mesoscopic(TTMM)constitutive model is *** model effectively captures the competitive effect and accurately describes the stress-deformation characteristics of *** the TTMM model,the strains resulting from porous defect closure and induced crack extension are differentiated,enabling quantitative determination of the associated damage evolution.

关键词： Micromechanics Macroemesoscopic Homogenization Constitutive model Competitive effect

Clinicopathologic Characteristics of Differentiated Thyroid Carcinoma in Children and Adolescents

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Advances in Bioscience and Biotechnology 2023年第4期14卷 143-150页

作者： tianzhi zhang Chao Liang Guangchang Shan Danting Su Department of Pathology The Seventh Affiliated Hospital of Sun Yat-sen University Shenzhen China

Objective: To investigate the clinicopathologic features of differentiated thyroid carcinoma in children and adolescents. Methods: The clinical data of 7 children and adolescents with differentiated thyroid carcinoma were retrospectively analyzed, and the clinicopathologic features of differentiated thyroid carcinoma were analyzed by gender, tumor size and BRAF mutation. Results: There were 7 cases of thyroid papillary carcinoma. The mean age of patients was (18.71 ± 2.75), and the mean tumor diameter was (2.4 ± 1.04) cm. Lymph node metastasis rate was 100% (7/7). In children and adolescents, the lesion volume was larger, membrane invasion and vascular cancer thrombus were more likely to occur, BRAF mutation was less common, and the difference was statistically significant. Conclusion: Children and adolescents with differentiated thyroid carcinoma are more aggressive and prone to membrane invasion and lymph node metastasis;BRAF mutation is less common than in adults.

关键词： Children and Adolescents Thyroid Papillary Carcinoma Clinicopathological Features BRAF Mutation

Tubular Carcinoma of the Breast: A Clinicopathological Analysis of Two Cases

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Advances in Bioscience and Biotechnology 2022年第11期13卷 499-506页

作者： tianzhi zhang Danting Su Chao Liang Jianxian Huang Department of Pathology The Seventh Affiliated Hospital of Sun Yat-sen University Shenzhen China

Tubular Carcinoma (TC) of the breast, also known as tubular carcinoma or well-differentiated adenocarcinoma, is defined as a special type of breast cancer consisting of well-differentiated tubular structures with excellent prognosis by WHO (2019) pathological and genetic classification of breast neoplasms. Two cases of breast tubular carcinoma admitted to our hospital were reported. The relevant literature was reviewed and the clinical features, histological morphology (microscopic features and differential diagnosis), molecular changes and clinical prognosis were summarized.

关键词： TC Clinical Pathology Differential Diagnosis Prognosis

Targeted anti-cancer therapy: Co-delivery of VEGF siRNA and Phenethyl isothiocyanate (PEITC) via cRGD-modified lipid nanoparticles for enhanced anti-angiogenic efficacy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 170-187页

作者： Bao Li Haoran Niu Xiaoyun Zhao Xiaoyu Huang Yu Ding Ke Dang tianzhi Yang Yongfeng Chen Jizhuang Ma Xiaohong Liu Keda zhang Huichao Xie Pingtian Ding School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical University Shenyang 110016 China Department of Basic Pharmaceutical Sciences School of Pharmacy Husson University Bangor ME 04401USA College of Pharmacy Shenzhen Technology UniversityShenzhen 518118China

Anti-tumor angiogenesis therapy, targeting the suppression of blood vessel growth in tumors, presents a potent approach in the battle against cancer. Traditional therapies have primarily concentrated on single-target techniques, with a specific emphasis on targeting the vascular endothelial growth factor, but have not reached ideal therapeutic efficacy. In response to this issue, our study introduced a novel nanoparticle system known as CS-siRNA/PEITC&L-cRGD NPs. These chitosan-based nanoparticles have been recognized for their excellent biocompatibility and ability to deliver genes. To enhance their targeted delivery capability, they were combined with a cyclic RGD peptide (cRGD). Targeted co-delivery of gene and chemotherapeutic agents was achieved through the use of a negatively charged lipid shell and cRGD, which possesses high affinity for integrin αvβ3 overexpressed in tumor cells and neovasculature. In this multifaceted approach, co-delivery of VEGF siRNA and phenethyl isothiocyanate (PEITC) was employed to target both tumor vascular endothelial cells and tumor cells simultaneously. The co-delivery of VEGF siRNA and PEITC could achieve precise silencing of VEGF, inhibit the accumulation of HIF-1α under hypoxic conditions, and induce apoptosis in tumor cells. In summary, we have successfully developed a nanoparticle delivery platform that utilizes a dual mechanism of action of anti-tumor angiogenesis and pro-tumor apoptosis, which provides a robust and potent strategy for the delivery of anti-cancer therapeutics.

关键词： Anti-angiogenesis Tumor apoptosis Nanoparticles VEGF siRNA Hypoxia inducible factor(HIF)-1 protein Phenethyl isothi ocyanate(PEITC)

Luminescence of Unusual Bismuth in Barium Borates (BaB_8O_13:Bi)

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Journal of Materials Science & Technology 1999年第3期15卷 281-282页

作者： Qinghua ZENG tianzhi zhang Zhiwu PEI and Qiang SU(Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China) Laboratory of Rare Earth Chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

The luminescence of unusual divalent bismuth (Bi2+) in BaB8O13 is reported. The emission band with maximum peak at 592 nm corresponds to the 2P3/2→2P1/2 transition of Bi2+ in the matrix and the excitation spectrum with two bands peaked at 470 and 580 nm respectively corresponds to two split crystal-field levels of 2P3/2 state. The small Stokes shift (~350 cm-1) reflects the rigid structure of the host for the Bi2+ ions

关键词： BaB8O13

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弱电网下基于导纳合成相量法的单相并网逆变器鲁棒性提升技术研究

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中国电机工程学报 2024年第8期44卷 3213-3223,I0023页

作者：张惠丽方天治刘昊吴皓张雨南京航空航天大学自动化学院江苏省南京市211106

为保证并网逆变器的并网电流与电网电压同步,通常采用锁相环获取电网电压相位信息。同时,为提高并网电流质量,常考虑在回路中加入电网电压前馈。然而,当逆变器工作在弱电网下时,它们均有可能对系统的稳定性带来负面影响。该文以单相LCL... 详细信息

为保证并网逆变器的并网电流与电网电压同步,通常采用锁相环获取电网电压相位信息。同时,为提高并网电流质量,常考虑在回路中加入电网电压前馈。然而,当逆变器工作在弱电网下时,它们均有可能对系统的稳定性带来负面影响。该文以单相LCL型并网逆变器为例,旨在研究弱电网下锁相环和电网电压前馈造成系统不稳定的原因并进行优化。针对2 个不稳定因素存在的情况,该文提出一种导纳合成相量法来分析多个导纳共同作用时的影响机理。考虑到带通滤波器可以衰减不稳定因素的影响,文中加入带通环节对系统的鲁棒性进行优化。结合上述导纳合成相量法的分析结果,确定带通环节的设计目标,并进一步给出带通环节参数的具体设计过程。结果表明,并网逆变器加入优化设计的带通环节后,即使在电网阻抗变化范围较大的情况下,系统仍能稳定工作。

关键词：并网逆变器锁相环电网电压前馈弱电网

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ArUco辅助的爬壁机器人自主定位方法

机器人 2024年第1期46卷 27-35,44页

作者：张文杨耀鑫黄天帜孙振国清华大学机械工程系北京100084

针对现有的爬壁机器人定位技术在纹理特征不明显、环境相对封闭、存在强磁干扰等特殊环境下的不足,提出利用机载鱼眼相机观测固定于地面的ArUco码的全新定位方案并实现了基于该定位方案的惯性测量单元/编码器/鱼眼相机多传感器融合的自... 详细信息

针对现有的爬壁机器人定位技术在纹理特征不明显、环境相对封闭、存在强磁干扰等特殊环境下的不足,提出利用机载鱼眼相机观测固定于地面的ArUco码的全新定位方案并实现了基于该定位方案的惯性测量单元/编码器/鱼眼相机多传感器融合的自主定位方法A-IEF。该方法首先识别ArUco码,并根据其在鱼眼图像中的位置筛选关键帧;然后,研究了固定于地面的ArUco码的角点在鱼眼图像中的重投影规律,并结合机器人姿态约束进行重定位优化;其次,在关键帧区间内,推导了角点重投影误差关于机器人位置和姿态增量的雅可比矩阵;接着,设计了基于ES-EKF(误差状态扩展卡尔曼滤波)的多信息融合方法,以编码器估计的位移误差及ArUco角点重投影误差作为观测量,实现对机器人航向角和位置的修正;最后,在大型钢制构件上进行测试,试验结果表明,本文方法具有更高的定位精度,其中位置估计精度保持在0.06 m以内,航向角估计精度保持在3.7°以内,相较于ArUco-rectified、航位推测法等定位算法,位置误差降低约47%,航向角误差降低约68%,并能够实现在弱光照环境中的定位。

关键词：多传感器融合误差状态扩展卡尔曼滤波爬壁机器人位姿估计 ArUco码

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弱电网下应对复杂稳定性问题的并网逆变器改进电压前馈通路研究

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电工技术学报 2024年第16期39卷 4955-4967页

作者：刘昊方天治张惠丽朱延涛南京航空航天大学自动化学院南京211106

在并网逆变器中,锁相环和电网电压前馈是提高并网电流质量和输出性能的环节。然而在弱电网下,这两个环节均有可能对并网系统的稳定性产生影响,同时两者的影响范围存在重叠,导致稳定性问题变得更为复杂。该文针对这一复杂稳定性问题展开... 详细信息

在并网逆变器中,锁相环和电网电压前馈是提高并网电流质量和输出性能的环节。然而在弱电网下,这两个环节均有可能对并网系统的稳定性产生影响,同时两者的影响范围存在重叠,导致稳定性问题变得更为复杂。该文针对这一复杂稳定性问题展开研究,分析弱电网下两个环节导致系统不稳定的原因,并进一步提出优化方案。首先考虑加入加权系数,讨论其对于电网电压前馈以及锁相环的影响,兼顾这两种因素,需要对加权系数进行权衡取值;然后考虑在更弱电网下,只加入加权系数对于系统稳定性提升效果是有限的,因此需要增加一条用于改善输出导纳相位的电压前馈通路;最后通过实验证明,加入改进方案后的并网逆变器,在阻抗变化较大的弱电网下依然保持良好的鲁棒性。

关键词：并网逆变器弱电网鲁棒性锁相环电网电压前馈

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