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clusterProfiler 4.0:A universal enrichment tool for interpreting omics data

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The Innovation 2021年第3期2卷 51-61页

作者： tianzhi wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan Dai Tingze Feng Lang Zhou Wenli Tang Li Zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu Department of Bioinformatics School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Biotechnology Beijing Institute of Radiation MedicineBeijing 100850China Guangdong Provincial Key Laboratory of Proteomics School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510515China

Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life *** is crucial for this type of tool to use the latest annotation databases for as many organisms as *** meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler *** package has been enhanced considerably compared with its original version published 9 years *** new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online *** also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and *** new features include gene set enrichment analysis and comparison of enrichment results from multiple gene *** anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms.

关键词： clusterProfiler biological knowledge mining functional analysis enrichment analysis visualization

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磷的d轨道在H_3PO分子中的作用

化学学报 1999年第3期57卷 264-269页

作者：丁涪江吴添智江丽葵张良辅中国科学院成都有机化学研究所成都610041

用分子片轨道在分子环境中发生极化的概念研究d轨道在H_3PO分子中的作用.H_3PO分子被分为两个分子片——H_3P和O.在RHF/6-31G^(?)水平上计算出分子环境中的极化了的分子片轨道(FOM).再剔除d函数为主的FOM,用剩余的FOM为基进行构型优化,... 详细信息

用分子片轨道在分子环境中发生极化的概念研究d轨道在H_3PO分子中的作用.H_3PO分子被分为两个分子片——H_3P和O.在RHF/6-31G^(?)水平上计算出分子环境中的极化了的分子片轨道(FOM).再剔除d函数为主的FOM,用剩余的FOM为基进行构型优化,得到与RHF/6-31G^(?)相近的结果.这一结果说明磷原子的d函数在H_3PO分子中仅仅起一个极化函数的作用,而不是起价轨道作用.

关键词：磷原子膦氧化物 H3PO d轨道化学键极化函数

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有限元数值模拟：两种四边形元的计算比较

科教导刊 2011年第12期 92-93页

作者：吴天智重庆工商大学派斯学院重庆401520

文中综述了单元刚度矩阵和栽荷矩阵的形成，总体刚度矩阵和栽荷矩阵的形成，以及对边界条件的处理。比较了双线性元在两种不同坐标下的计算精度。

关键词：有限元四边形等参元面积坐标双线性形式等参坐标

基于模糊逻辑的黄河流域水安全综合评价方法研究

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水利学报 2022年第3期53卷 369-378页

作者：尚文绣尚弈严登明吴天志彭少明周翔南黄河勘测规划设计研究院有限公司河南郑州450003 华北水利水电大学河南郑州450045 洛阳市水利勘测设计有限责任公司河南洛阳471000

为了对黄河流域及流域内省(区)水安全进行评价与诊断,从资源、经济、生态、环境和防灾五个方面构建了黄河流域水安全评价指标体系,建立考虑评价指标间影响关系的模糊逻辑评价模型,并提出了评价方法敏感性分析与水安全提升方向诊断方法... 详细信息

为了对黄河流域及流域内省(区)水安全进行评价与诊断,从资源、经济、生态、环境和防灾五个方面构建了黄河流域水安全评价指标体系,建立考虑评价指标间影响关系的模糊逻辑评价模型,并提出了评价方法敏感性分析与水安全提升方向诊断方法。结果表明:模糊逻辑可通过指标间的影响关系增大单指标对评价结果的作用,所建立的模糊逻辑评价模型对单指标变化的敏感性是加权求和法的1.69倍;黄河流域水安全处于基本安全状态,流域内青海、甘肃、陕西和河南水安全处于基本安全状态,宁夏、内蒙古、山西和山东水安全处于临界状态;水生态安全是黄河流域水安全的主要制约因素,增加水生态安全是提升黄河流域及青海、甘肃、陕西和河南4省水安全的最优方向。研究成果揭示了模糊逻辑在处理多指标、非线性、复杂性问题上的优越性,可为水安全提升方向诊断提供新的思路。

关键词：模糊逻辑水安全指标影响关系敏感性提升方向诊断黄河流域

维普期刊数据库博看期刊

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基于5G的危重母婴急救转运平台设计及应用

中国数字医学 2022年第7期17卷 92-97页

作者：吴天智陈征铮四川省妇幼保健院信息化部成都610041

目的:依托5G,整合院内院外危重母婴急救诊疗中的所有信息资源,打造一套一体化的危重母婴急救转运的整体解决方案。方法:集成智能救护车、创新型车载医疗设备、院前急救智慧系统、院内数字化业务管理系统等,优化业务流程,实现院前急救、... 详细信息

目的:依托5G,整合院内院外危重母婴急救诊疗中的所有信息资源,打造一套一体化的危重母婴急救转运的整体解决方案。方法:集成智能救护车、创新型车载医疗设备、院前急救智慧系统、院内数字化业务管理系统等,优化业务流程,实现院前急救、院内急诊、多学科会诊、多业务全流程的闭环可追溯管理。结果:通过区域母婴急救转运,实现了下级医院和上级医院转诊、转运、会诊、任务管理、急救车管理等信息共享。结论:基于5G的危重母婴急救转运平台提升了急诊工作效率,可为危重母婴提供差异化服务保障。

关键词： 5G应用母婴急救信息平台车载物联转运平台

Ballistic performances of the hourglass lattice sandwich structures under high-velocity fragments

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Defence Technology（防务技术） 2024年第1期31卷 312-325页

作者： He-xiang wu Jia Qu Lin-zhi wu Key Laboratory of Advanced Ship Materials and Mechanics College of Aerospace and Civil EngineeringHarbin Engineering UniversityHarbin150001China School of Civil Engineering Northeast Forestry UniversityHarbin150040China

In this paper,the numerical simulation method is used to study the ballistic performances of hourglass lattice sandwich structures with the same mass under the vertical incidence of *** is paid to elucidating the influences of rod cross-section dimensions,structure height,structure layer,and rod inclination angle on the deformation mode,ballistic performances,and ability to change the ballistic direction of *** results show that the ballistic performances of hourglass lattice sandwich structures are mainly affected by their structural *** this respect,structural parameters optimization of the hourglass lattice sandwich structures enable one to effectively improve their ballistic limit velocity and,consequently,ballistic performances.

关键词： Hourglass lattice sandwich structures Ballistic performances high-velocity Finite element analysis

Resilience-incorporated seismic risk assessment of precast concrete frames with“dry”connections

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 403-425页

作者： wu Chenhao Tang Yuchuan Cao Xuyang wu Gang Key Laboratory of Concrete and Prestressed Concrete Structures of the Ministry of Education Nanjing 211102China Department of Civil and Environmental Engineering University of CaliforniaLos AngelesCA 90095USA School of Civil Engineering Southeast UniversityNanjing 211102China College of Civil and Transportation Engineering Hohai UniversityNanjing 210024China

A resilience-incorporated risk assessment framework is proposed and demonstrated in this study to manifest the advantageous seismic resilience of precast concrete frame(PCF)structures with“dry”connections in terms of their low damage and rapid *** framework integrates various uncertainties in the seismic hazard,fragility,capacity,demand,loss functions,and post-earthquake *** this study,the PCF structures are distinguished from ordinary reinforced concrete frame(RCF)structures by characterizing multiple limit states for the PCF based on its unique damage ***,probabilistic story-wise pushover analyses are performed to yield story-wise capacities for the predefined limit *** the seismic resilience analysis,a step-wise recovery model is proposed to idealize the functionality recovery process,with separate considerations of the repair and non-repair *** recovery model leverages the economic loss and downtime to delineate the stochastic post-earthquake recovery curves for the resilience loss *** such,contingencies in the probabilistic post-earthquake repairs are incorporated and the empirical judgments on the recovery parameters are largely *** proposed framework is demonstrated through a comparative study between two“dry”connected PCFs and one RCF designed as alternative structural systems for a prototype *** results from the risk quantification indicate that the PCFs show reduced loss hazards and lower expected losses relative to the ***,the PCF equipped with energy dissipation devices at the“dry”connections largely reduces the expected economic loss,downtime,and resilience loss by 29%,56%,and 60%,respectively,compared to the RCF.

关键词： precast concrete frame non-emulative precast system seismic resilience seismic risk functional recovery

New findings on the influence of El Nino events on tropical cyclone formation

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Science China Earth Sciences 2024年第3期67卷 892-893页

作者： Liguang wu Department of Atmospheric and Oceanic Sciences Institute of Atmospheric SciencesFudan UniversityShanghai 200438China

Tropical cyclones typically form over warm tropical and subtropical ocean surfaces, as their formation and intensification rely primarily on the energy provided by the ocean. Pioneering research by Gray (1968) revealed that the formation of tropical cyclones requires the sea surface temperature (SST) to be no less than 26.5℃. Consequently, SST is commonly recognized as a crucial parameter among the environmental factors influencing tropical cyclone formation(Gray, 1979;Emanuel and Nolan, 2004).

关键词： tropical cyclone ocean

Two-dimensional semiconductor heterostructures for photocatalytic CO_(2)conversion

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Science China Chemistry 2024年第8期67卷 2434-2447页

作者： Yang wu Mingyu wu Yongfu Sun Yi Xie Hefei National Research Center for Physical Sciences at Microscale University of Science and Technology of ChinaHefei 230026China

The CO_(2)reduction into carbon-contained fuel via solar energy offers the powerful tools to realize the zero-emission carbon *** to the intriguing features of the two-dimensional(2D)heterostructures,it is susceptible to modulate the electronic structure as well as the surface geometry for optimizing the photocatalytic CO_(2)*** this perspective,we surveyed the fundamental insights of 2D semiconductor heterostructures,involving the fabrication strategies and classification of the 2D semiconductor ***,we have detailly discussed the overview of 2D semiconductor heterostructure for optimizing CO_(2)photocatalytic influenced factors,including the solar energy utilization,photogenerated carriers separation,and redox reaction ***,we showed the significant advantages of 2D heterostructures in elevating CO_(2)photoreduction performance,focusing on activity,selectivity and *** analyzing the limitations and developments,we ended by putting forward insights into the further researches about the CO_(2)photocatalysts and reactor design,even industrial applications.

关键词： two-dimensional semiconductor heterostructures photocatalysis CO_(2)conversion