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土壤空间变异对溶解性有机氮淋失风险影响的模拟研究

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海洋湖沼通报 2024年第1期46卷 98-108页

作者：郝玉洁栾永霞郑西来郑天元能惠中国海洋大学环境科学与工程学院山东青岛266100 青岛市城阳区农业农村局山东青岛266109 中国海洋大学海洋环境与生态教育部重点实验室山东青岛266100

本文应用COMSOL软件对土壤中溶解性有机氮(DON)的迁移转化过程进行了模拟,采用局部敏感性分析和全局敏感性分析两种方法,探究了土壤初始状态和土壤水力学参数的空间变异对土壤水分渗漏和DON淋失的影响。结果表明:土壤累积水分渗漏量与... 详细信息

本文应用COMSOL软件对土壤中溶解性有机氮(DON)的迁移转化过程进行了模拟,采用局部敏感性分析和全局敏感性分析两种方法,探究了土壤初始状态和土壤水力学参数的空间变异对土壤水分渗漏和DON淋失的影响。结果表明:土壤累积水分渗漏量与初始基质势的大小正相关,累积DON淋失量的大小与初始基质势以及DON初始含量的大小正相关。土壤在弱变异条件下,累积水分渗漏量的不确定性主要是由饱和导水率(K_(s))和饱和含水率(θ_(s))的空间变异引起的,累积DON淋失量要受到K_(s)的影响;在中等变异条件下,累积水分渗漏量和累积DON淋失量都对K_(s)的波动更为敏感。对于大尺度地区,土壤在弱变异条件下,大部分区域水分渗漏和DON淋失程度一致,在中等变异条件下,土壤水分渗漏和DON淋失量空间分布不均匀性增大,部分区域会发生大规模的水氮淋失。在水氮管理中考虑土壤空间变异特征,有利于降低土壤水分渗漏和DON淋失量,减轻土壤养分的流失,进而降低DON向地下水的淋失风险。

关键词：土壤空间变异水分渗漏溶解性有机氮淋失敏感性分析

肾康注射液对慢性肾衰竭大鼠肾间质纤维化、内质网应激状态和线粒体氧化损伤的影响

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现代药物与临床 2024年第5期39卷 1107-1114页

作者：李鹏周霖王肖辉郑天元房哲郑州大学第一附属医院康复医学科郑州河南450052 郑州大学第一附属医院药学部郑州河南450052 郑州大学第一附属医院超声科郑州河南450052

目的探索肾康注射液对慢性肾衰竭大鼠肾损伤及肾纤维化的作用机制。方法采用腺嘌呤法建立大鼠慢性肾衰竭模型,采用叔丁基过氧化氢(TBHP)诱导NRK-52E细胞,建立慢性肾衰竭肾损伤细胞模型。采用苏木精–伊红(HE)染色评估肾康注射液对慢性... 详细信息

目的探索肾康注射液对慢性肾衰竭大鼠肾损伤及肾纤维化的作用机制。方法采用腺嘌呤法建立大鼠慢性肾衰竭模型,采用叔丁基过氧化氢(TBHP)诱导NRK-52E细胞,建立慢性肾衰竭肾损伤细胞模型。采用苏木精–伊红(HE)染色评估肾康注射液对慢性肾衰竭大鼠的肾脏病理学损伤,免疫组化法检测模型大鼠肾损伤及纤维化的关键蛋白表达,免疫荧光法检测NRK-52E细胞葡萄糖调节蛋白78(GRP78)蛋白表达,Western blotting法进行肾组织和细胞中的关键蛋白定量,活性氧荧光探针检测NRK-52E细胞中的活性氧(ROS)水平,采用JC-1检测试剂盒检测NRK-52E细胞中线粒体膜电位水平。结果肾康注射液可以显著缓解慢性肾衰竭大鼠的肾间质纤维化状态,减轻病理损伤;显著抑制肾损伤分子1(KIM-1)、GRP78、内质网应激相关蛋白(CHOP)阳性表达表达,从而抑制内质网过度应激状态;可显著抑制I型胶原蛋白(Collagen I)沉积,抑制α-平滑肌肌动蛋白(α-SMA)表达,从而抑制肾间质纤维化形成(P<0.01);肾康注射液能够显著抑制NRK-52E细胞内ROS的水平,减轻NRK-52E线粒体氧化损伤,稳定线粒体膜电位水平(P<0.01)。结论肾康注射液能够减轻肾间质纤维化、缓解肾损伤状态,增强肾功能,其机制可能与抑制肾脏过度的内质网应激,抗氧化损伤以及减少肌成纤维细胞的增殖和减少细胞外基质的沉积实现有关。

关键词：肾康注射液慢性肾衰竭肾间质纤维化内质网应激状态肾损伤分子1 葡萄糖调节蛋白78 内质网应激相关蛋白 Ⅰ型胶原蛋白 α-平滑肌肌动蛋白

Tumor microenvironment of cancer stem cells:Perspectives on cancer stem cell targeting

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Genes & Diseases 2024年第3期11卷 275-302页

作者： Qianqian Guo Yi Zhou tianyuan Xie Yin Yuan Huilong Li Wanjin Shi Lufeng zheng Xiaoman Li Wenzhou Zhang Department of Pharmacy The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450003China Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of PharmacyNanjing University of Chinese MedicineNanjingJiangsu 210023China School of Life Science and Technology Jiangsu Key Laboratory of Carcinogenesis and InterventionChina Pharmaceutical UniversityNanjingJiangsu 211198China

There are few tumor cell subpopulations with stem cell characteristics in tumor tis-sue,defined as cancer stem cells(CSCs)or cancer stem-like cells(CSLCs),which can recon-struct neoplasms with malignant biological behaviors such as invasiveness via self-renewal and unlimited *** microenvironment that CsCs depend on consists of various cellular components and corresponding medium *** these factors existing at a variety of levels and forms,cytokine networks and numerous signal pathways play an important role in signaling *** factors promote or maintain cancer cell stem-ness,and participate in cancer recurrence,metastasis,and *** review aims to summarize the recent molecular data concerning the multilayered relationship between CsCs and CsC-favorable *** also discuss the therapeutic implications of target-ing this synergistic interplay,hoping to give an insight into targeting cancer cell stemness for tumortherapyandprognosis.

关键词： Cancer stem cells Cancerstem-like cells Cellular factors Non-cellularfactors Tumor microenvironment

地下水硝酸盐污染源解析及氮同位素分馏效应研究进展

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现代地质 2022年第2期36卷 563-573页

作者：于璐郑天元郑西来中国海洋大学环境科学与工程学院山东青岛266100 青岛大学威海创新研究院生态环境研发中心山东威海264200 中国海洋大学海洋环境与生态教育部重点实验室山东青岛266100

地下水硝酸盐污染已成为世界范围内最严重的环境地质问题之一。全面并准确识别硝酸盐污染源,对地下水的有效管理及污染防治具有重要的指导意义。从地下水硝酸盐来源、同位素检测方法、污染源同位素特征、定量解析模型构建、硝酸盐主要... 详细信息

地下水硝酸盐污染已成为世界范围内最严重的环境地质问题之一。全面并准确识别硝酸盐污染源,对地下水的有效管理及污染防治具有重要的指导意义。从地下水硝酸盐来源、同位素检测方法、污染源同位素特征、定量解析模型构建、硝酸盐主要转化过程及同位素分馏效应等方面进行总结,比较不同解析方法在硝酸盐溯源中的应用与发展,建议采用多学科、多方法相结合的方式,提高对硝酸盐污染源的全面理解。同位素富集系数是定量解析硝酸盐污染源的重要参数,在源解析过程中探讨硝酸盐转化及同位素分馏机制,能够更好地诠释地下水硝酸盐来源和迁移转化过程,提高源解析的准确性,为地下水硝酸盐污染的准确溯源与有效防治提供参考。

关键词：硝酸盐源解析氮循环同位素同位素分馏

Effects of polyethylenimine on the dispersibility of hollow silica nanoparticles

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Frontiers of Chemical Science and Engineering 2007年第3期1卷 277-282页

作者： WEN Lixiong WANG Qing zheng tianyuan CHEN Jianfeng Key Lab for Nanomaterials Ministry of EducationBeijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China

In this study,two different methods were applied to disperse hollow silica nanoparticles(HSNP);one employed polyethylenimine(PEI)as the dispersant during the synthesis processes for preparing HSNP,while the other added PEI into suspensions of the prepared HSNP and used milling treatment to achieve the desired *** was found that adding PEI during the synthesis process of HSNP had no noticeable improvement in the dispersion,while adding PEI into suspen-sions of the prepared HSNP and utilizing milling treatment resulted in remarkable dispersion ***,the latter was chosen as the method in dispersing HSNP *** adsorption of PEI on the surface of HSNP and the stability of the aqueous suspensions was *** results indicated that the adsorption of PEI on the surface of HSNP would increase the repulsive energy among particles,hence reducing the agglomeration of HSNP and improving the stability of the aqueous *** change of HSNP’s ■ potential after adding PEI and the rela-tionship between the adsorbed amount of PEI and pH were also investigated.

关键词： hollow silica nano-particles(HSNP),disper-sion polyethylenimine(PEI),■potential,adsorption

Enhancing the crystallinity and stability of perovskite solar cells with 4-tert-butylpyridine induction for efficiency exceeding 24%

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Journal of Energy Chemistry 2024年第6期93卷 1-7,I0001页

作者： You Liu Lishuang zheng Kuanxiang Zhang Kun Xu Weicheng Xie Jue Zhang Yulu Tian tianyuan Liu Hanzhong Xu Ruoming Ma Wei Huang Jiahui Chen Jusheng Bao Chen Chen Yongsheng Zhou Xuchun Wang Junming Chen Jungan Wang College of Chemistry and Materials Engineering Anhui Science and Technology UniversityBengbu 233000AnhuiChina Anhui Province Quartz Sand Purification and Photovoltaic Glass Engineering Research Center Chuzhou 233100AnhuiChina Triumph Photovoltaic Materials Co.Ltd BengbuAnhuiChina National Laboratory of Solid State Microstructures School of PhysicsNanjing UniversityNanjing 210009JiangsuChina JinkoSolar Holding Co.Ltd HainingZhejiangChina

Perovskite solar cells(PSCs)have emerged as a promising photovoltaic technology because of their high light absorption coefficient,long carrier diffusion distance,and tunable ***,PSCs face challenges such as hysteresis effects and stability *** this study,we introduced a novel approach to improve film crystallization by leveraging 4-tert-butylpyridine(TBP)molecules,thereby enhancing the performance and stability of *** findings demonstrate the effective removal of PbI_(2)from the perovskite surface through strong coordination with TBP ***,by carefully adjusting the concentration of the TBP solution,we achieved enhanced film crystallinity without disrupting the perovskite *** TBP-treated perovskite films exhibit a low defect density,improved crystallinity,and improved carrier *** a result,the PSCs manufactured with TBP treatment achieve power conversion efficiency(PCE)exceeding 24%.Moreover,we obtained the PCE of 21.39%for the 12.25 cm^(2)module.

关键词： 4-tert-butylpyridine Film crystallization Perovskite solar cells Power conversion efficiency Stability improvement

The influence of slope collapse on water exchange between a pit lake and a heterogeneous aquifer

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Frontiers of Environmental Science & Engineering 2019年第2期13卷 63-71页

作者： Bo Zhang Xilai zheng tianyuan zheng Jia Xin Shuai Sui Di Zhang Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of ChinaQingdao 266100China Key Laboratory of Marine Environmental Science and Ecology (Ministry of Education) College of Environmental Science and EngineeringOcean University of ChinaQingdao 266100China Department of Environmental Informatics Helmholtz Centre for Environmental Research-UFZLeipzig 04318Germany Key Laboratory of Surficial Geochemistry Ministry of EducationDepartment of HydrosciencesSchool of Earth Sciences and EngineeringNanjing UniversityNanjing 210023China College of Engineering Ocean University of ChinaQingdao 266100China

Due to the increase in open pit mining,pit lakes have become common surface water features,posing a potential risk to subsurface *** this study,a pit lake–groundwater interaction model is built based on the general program MODFLOW with the LAK3 *** the first time,the effects of lake-slope collapse and aquifer heterogeneity on pit lake–groundwater interactions are analyzed by dividing the lake into six water exchange zones based on the aquifer lithology and groundwater *** investigation and simulations reveal a total water exchange from groundwater to the lake of 349000 m3/a without collapse of the pit lake slope,while the total net water exchange under slope collapse conditions is 248000 m3/a(i.e.,a reduction of 1.40-fold).The monthly net water exchange per unit width from groundwater to the lake reaches the largest in April,shifting to negative values in zone IV from June to August and in zone V in June and ***,the monthly net water exchange per unit width decreases from north to south,and the direction and magnitude of water exchange are found to depend on the hydraulic gradients between the lake and groundwater and the hydraulic conductivity of the slope collapse.

关键词： Pit lak Slope collapse Groundwater-surface water interactions Numerical simulation

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数字孪生多模态视觉推理的神经-符号系统

计算机集成制造系统 2024年第5期30卷 1571-1586页

作者：郑杭彬刘天元郑汉垚左戴悦鲍劲松王森东华大学机械工程学院上海201620 上海宝信软件股份有限公司上海201900

面对数字孪生在多模态视觉数据融合中的异质性和动态性挑战,提出一种结合深度学习与符号智能的方法。该方法通过深度神经网络对视觉数据进行实时解析,并借助符号系统存储的知识和事件响应规则,实现对复杂推理过程的自主管理。为提高系... 详细信息

面对数字孪生在多模态视觉数据融合中的异质性和动态性挑战,提出一种结合深度学习与符号智能的方法。该方法通过深度神经网络对视觉数据进行实时解析,并借助符号系统存储的知识和事件响应规则,实现对复杂推理过程的自主管理。为提高系统对物理世界变化的适应性,提出一种融合多模态信息和外部知识的增强推理机制,该机制能有效地整合来自传感器的实时数据和历史知识库中的信息,以支持更加准确和合理的决策制定。以退役锂电池拆解过程为案例验证表明,该方法不仅能够在多模态数据环境中实现高准确率的识别和分析,还能够基于推理机制生成合理且逻辑一致的操作建议,有效提升了拆解效率和安全性。

关键词：数字孪生多模态视觉推理神经符号系统锂电池拆解

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截渗墙作用下滨海地下水渗流与排泄特征

中国海洋大学学报（自然科学版） 2022年第4期52卷 111-119页

作者：高明鹏郑西来郑天元常钦鹏方运海张博中国海洋大学环境科学与工程学院山东青岛266100 山东省海洋环境地质工程重点实验室山东青岛266100 中国海洋大学工程学院山东青岛266100

截渗墙的修建是防治滨海含水层中海水入侵的有效手段,然而它对地下水渗流和排泄的影响是被忽略的。本文通过建立场地尺度的数值模型,模拟了海水入侵的动力学过程,以地下水流速和流量为指标定量评价了截渗墙结构对地下水渗流和排泄的影... 详细信息

截渗墙的修建是防治滨海含水层中海水入侵的有效手段,然而它对地下水渗流和排泄的影响是被忽略的。本文通过建立场地尺度的数值模型,模拟了海水入侵的动力学过程,以地下水流速和流量为指标定量评价了截渗墙结构对地下水渗流和排泄的影响。研究结果表明,截渗墙条件下的地下水排泄量呈现先上升后下降的趋势,并在墙体下方形成高流速区域,但地下水平均流速有所降低;随着墙体深度增加,与海洋边界距离减小,地下水排泄量和平均流速减小,特别是当墙体深较大时,地下水排泄量和平均流速对深度变化更加敏感。

关键词：地下水排泄截渗墙滨海含水层数值模拟海水入侵