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Chinese Medical Journal 2022年第19期135卷 2378-2379页

作者： Taotao Lyu Zhifeng Liu tianyuan yu Mengqian Lu Yingqi Zhang Yi Jiao Hourong Wang Yajing Xu Qian Guan School of Acupuncture Moxibustion and TuinaBejing University of Chinese MedicineBeijing 100029China Tuina Research Center of Beijing University of Chinese Medicine Bejing 100029China

To the Editor:Peripheral nerve injury(PNI)refers to the injury of the peripheral nerve plexus,nerve trunk,or its branches undertheaction of externalforces.Skeletal muscle-derived cells servea strong secretory,function while they can differentiate into Schwann cell-like cells or other ceil types,so that it can,effectively promote regeneration'of peripheral nerves.llUsing some specific acupuncture points with mild mechanical stimulation on the surface can have a positive effect on nerve repair.2i Tuina helps relieve symptoms such as muscle spasms and pain caused by nerve damage.There are three points belonging to the Bladder meridian of foot Taiyang(BL)and the Gallbladder meridian of foot Shaoyang(GB),which usually are selected to carry out Tuina.According to the anatomical nerve position,Yinmen(BL37)is on the sciatic nerve trunk,Chengshan(BL57)is on the tibial nerve,and Yanglingquan(GB34)is on the common peroneal nerve;meanwhile,the three points are on the sciatic nerve or its branches.The three points are on the biceps femoris,gastrocnemius,and tibial anterior muscles.

关键词： meridian gastro acupuncture

An investigation of the influence of intestinal flora in external traditional Chinese medicine therapy

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 10-18页

作者： Hourong Wang Zhifeng Liu tianyuan yu Yingqi Zhang Yi Jiao Di Liu Yajing Xu Qian Guan Mengqian Lu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102488China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Dongfang Hospital Beijing University of Chinese MedicineBeijing 100078China

External therapy,which has been used for millennia to treat disease,has now become the newest member of complementary and alternative therapies.A growing number of clinical studies and animal experiments have shown that external therapy exerts a positive effect on the intestinal flora.In this paper,we review the research related to external therapy on various systemic diseases and focus on changes in the intestinal flora.We found that studies on external therapy are dominated by acupuncture and tuina,primarily aimed at the treatment of digestive and neurological diseases.However,the deeper mechanism of regulation of the intestinal flora by external therapy has not yet been experimentally confirmed.

关键词： Traditional Chinese medicine External therapy Intestinal flora Digestive diseases Neurological diseases Acupoint Mechanism

Effect of pediatric tuina on hypothalamic metabolites in young rabbits using liquid chromatography-mass spectrometry

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 188-196页

作者： Zhifeng Liu Yi Jiao tianyuan yu Yingqi Zhang Di Liu Hourong Wang Yajing Xu Qian Guan Taotao Lv Jian Shu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing102488China Department of Acupuncture Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Shu Acupuncture Clinic FayettevilleNY13066USA

Objective: To investigate the changes in the hypothalamic metabolites of lipopolysaccharide(LPS) febrile young rabbits after the treatment with pediatric tuina.Methods: A total of 30 young rabbits were randomly assigned into three groups: the normal group, the model group, and the tuina group. Both the model group and the tuina group were injected intravenously with LPS. “Six antipyretic manipulations”(pushing Tianmen, pushing Kangong, kneading Taiyang,kneading Erhougaogu, clearing Tianheshui, and pushing Jizhu) were administered 1 h after the LPS injection in the tuina group. The rectal temperatures of the young rabbits were monitored during the experiment to explore the antipyretic effect. Three hours after the injection, the content of interleukin-1β(IL-1β), tumor necrosis factor(TNF)-a, and prostaglandin E;(PGE;) in the serum was detected. In addition, liquid chromatography-mass spectrometry(LC-MS) was used for the hypothalamus metabolomics.Results: Compared with the model group, the rectal temperature of the tuina group was decreased at 2 h and 3 h after the LPS injection(P =.04, P =.03, respectively), and the content of IL-1β, TNF-a, and PGE2was decreased(P =.03, P =.003, and P =.008, respectively). The metabolomics results showed that there were 23 potential biomarkers after the tuina intervention, enriching 27 pathways. Lipid metabolites,especially glycerophospholipids, were a majority of the altered metabolites. The primary metabolic pathways affected by tuina included the arachidonic acid metabolism, the GABAergic synapse, D-glutamine and D-glutamate metabolism, and the glutamatergic synapse.Conclusion: Pediatric tuina reduced the temperature of the febrile rabbits and downregulated the expression of IL-1β, TNF-a, and PGE2, and the antipyretic mechanism may be related to changes in metabolites and metabolic pathways in the hypothalamus.

关键词： Fever Pediatric tuina Metabolomics Liquid chromatography coupled with mass spectrometry Hypothalamus Interleukin-1b Tumor necrosis factor-a Prostaglandin E_(2)

Protective mechanisms of Tuina therapy against lipopolysaccharide-induced fever in young rabbits based on untargeted metabolomics analysis

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中医杂志:英文版 2023年第4期43卷 725-733页

作者： LIU Di ZHANG Yingqi yu tianyuan LIU Zhifeng JIAO Yi WANG Hourong XU Yajing GUAN Qian CHEN Lulu HU Hui School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102401China Department of Acupuncture-Moxibustion Beijing Massage HospitalBeijing 100035China Department of Acupuncture-Moxibustion Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China

OBJECTIVE:To investigate the effect of Tuina on the plasma metabolites of lipopolysaccharide-induced febrile in infant rabbits.METHODS:Twenty-four infant New Zealand rabbits were selected and randomly divided into three groups:saline,model,and Tuina.The fever model was established by injecting LPS intravenously through the ear margin vein in the model group and Tuina group,respectively.The modeling was considered successful when the anal temperature increased by 0.5℃or above within 1 h.In the Tuina group,six Tuina techniques(i.e.,opening Tianmen/the heaven gate,pushing Kangong/the superciliary arch,kneading Taiyang and the prominent bone behind the ears,clearing Tianheshui,spine pinching)that alleviate fever were performed on the young rabbits 1 h after the modeling,whereas the model and saline groups were not given Tuina treatment,with the real-time anal temperature monitored during the experiment.The plasma was taken 3 h after the modeling for liquid chromatography-mass spectrometry(LC-MS)untargeted metabolomics study.RESULTS:Our results showed a fever-reducing effects of Tuina therapy on lipopolysaccharide-induced fever in young rabbits,as indicated by a significantly lower anal temperature,maximum rise in body temperature,and body response index at 2 and 3 h after modeling in the Tuina group compared to the model group,with reductions in the PGE2 expression observed in the blood and hypothalamus.The differential metabolites including riboflavin,nicotinamide N-oxide,porphobilinogen,5-hydroxyindoleacetic acid,gamma-aminobutyric acid,and lysoPC(16:1(9Z)/0:0)were found following the Tuina intervention.Tuina primarily involves glycine-serinethreonine,arginine-proline,porphyrin-chlorophyll,pyrimidine,primary bile acid biosynthesis,and cyanoamino acid metabolic pathways.CONCLUSION:Tuina therapy has proven to be effective in reducing body temperature and down-regulating PGE2 expression in LPS-induced febrile young rabbits,with its mechanism of fever-reducing action possibly associated with the changes in plasma metab

关键词： fever pediatrics metabolomics Lipopolysaccharides riboflavin glycine Tuina therapy

于天源教授治疗损伤性髋关节炎粘连状态的临证手法探讨

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中医药学报 2024年第5期52卷 52-56页

作者：刘迪杨震杰于天源萨出拉张英琦陈金平张润龙北京中医药大学针灸推拿学院北京100029 北京中医药大学东方医院北京100078

损伤性髋关节炎粘连状态可引发局部剧烈疼痛,导致受损关节活动受限,进而出现废用性肌萎缩、肌力下降等表现,严重影响患者生活质量,早期治疗能够有效控制病情发展。推拿能够直接作用于病变部位,安全且无副作用,因此探索关节粘连状态的推... 详细信息

损伤性髋关节炎粘连状态可引发局部剧烈疼痛,导致受损关节活动受限,进而出现废用性肌萎缩、肌力下降等表现,严重影响患者生活质量,早期治疗能够有效控制病情发展。推拿能够直接作用于病变部位,安全且无副作用,因此探索关节粘连状态的推拿手法对于解除关节粘连状态、恢复关节功能活动具有重要意义。于天源教授在将中医学经络理论与西医学相结合的基础上,根据多年临床经验总结出“强则松之,塞则通之,瘀则去之,凝则动之,收则散之”的治疗原则,提出以“松筋、通经,祛瘀,助动,宣散”为核心的关节粘连治疗手法。本文通过介绍于天源教授治疗损伤性髋关节炎的手法操作与内涵,推动构建关节粘连状态的推拿特色治疗方案,为学科发展奠定基础。

关键词：损伤性髋关节炎关节粘连推拿名医经验

基于IL-17F/IL-17RC信号通路及M1小胶质细胞探讨“三法三穴”推拿手法即刻镇痛作用的机制

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北京中医药大学学报 2024年第1期47卷 116-123页

作者：陈金平刘志凤于天源王厚融张英琦官乾徐亚静杨震杰萨出拉张润龙张汉钰刘家玥孙佳伟北京中医药大学针灸推拿学院北京100029 北京中医药大学东直门医院北京医院

目的通过观察“三法三穴”推拿手法对轻型慢性压迫性损伤(minor CCI)模型大鼠脊髓背角中白细胞介素-17F(IL-17F)、白细胞介素-17受体C(IL-17RC)、核转录因子-κB激活剂1(Act1)、肿瘤坏死因子受体相关因子6(TRAF6)及M1型小胶质细胞表达... 详细信息

目的通过观察“三法三穴”推拿手法对轻型慢性压迫性损伤(minor CCI)模型大鼠脊髓背角中白细胞介素-17F(IL-17F)、白细胞介素-17受体C(IL-17RC)、核转录因子-κB激活剂1(Act1)、肿瘤坏死因子受体相关因子6(TRAF6)及M1型小胶质细胞表达的影响,探讨推拿对周围神经病理性疼痛的即刻镇痛机制。方法将36只SD大鼠按随机数字表法分为假手术组、模型组、推拿组,12只/组,结扎右侧坐骨神经复制minor CCI模型。推拿组使用按摩推拿手法模拟仪在大鼠患侧殷门、承山、阳陵泉依次进行点法、拨法、揉法,假手术组及模型组仅抓握束缚,干预1次。采用机械痛实验与冷板实验评价即刻干预后大鼠对机械刺激、冷刺激的反应情况;采用蛋白质印迹法检测各组大鼠脊髓背角中IL-17F、TRAF6的蛋白表达情况;采用实时荧光PCR(RT-PCR)法检测各组大鼠脊髓背角中IL-17F、IL-17RC、Act1、TRAF6的mRNA表达情况;采用免疫荧光法检测各组大鼠脊髓背角中M1型小胶质细胞平均荧光强度。结果行为学结果显示,干预前,与假手术组比较,模型组、推拿组大鼠机械缩足反射阈值(PMWT)降低,冷敏阈值升高;推拿手法干预后,与模型组比较,推拿组大鼠PMWT升高,冷敏阈值降低;与干预前比较,干预后推拿组大鼠PMWT升高,冷敏阈值降低(均P<0.05)。RT-PCR结果显示,与假手术组比较,模型组大鼠脊髓背角中IL-17F、IL-17RC、TRAF6、Act1的mRNA表达均升高;与模型组比较,推拿组大鼠上述指标mRNA表达均降低(均P<0.05)。蛋白质印迹法结果显示,与假手术组比较,模型组大鼠脊髓背角中IL-17F、TRAF6蛋白表达升高;与模型组比较,推拿组大鼠IL-17F、TRAF6蛋白表达降低(均P<0.05)。免疫荧光结果显示,与假手术组比较,模型组大鼠脊髓背角分化簇40(CD40)平均荧光强度增强;与模型组比较,推拿组大鼠CD40平均荧光强度减弱(均P<0.05)。结论“三法三穴”推拿手法干预1次,其机制可能是通过抑制脊髓背角中IL-17F、IL-17RC、Act1、TRAF6的表达及M1型小胶质细胞的活化实现的,从而有即刻镇痛的作用。

关键词：推拿小胶质细胞殷门承山阳陵泉大鼠

三法三穴推拿对坐骨神经损伤大鼠的即刻镇痛作用及其机制

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山东医药 2024年第17期64卷 12-15页

作者：张润龙杨震杰于天源萨出拉陈金平刘志凤焦谊北京中医药大学针灸推拿学院北京102401 北京中医药大学东直门医院推拿疼痛科中日友好医院临床医学研究所

目的观察三法三穴推拿对坐骨神经损伤大鼠的即刻镇痛作用并探讨其机制。方法SD大鼠随机分为假手术组、模型组及推拿组,每组6只。模型组及推拿组建立轻型坐骨神经慢性压迫性损伤模型模拟临床神经病理性疼痛,假手术组仅暴露神经并缝合。... 详细信息

目的观察三法三穴推拿对坐骨神经损伤大鼠的即刻镇痛作用并探讨其机制。方法SD大鼠随机分为假手术组、模型组及推拿组,每组6只。模型组及推拿组建立轻型坐骨神经慢性压迫性损伤模型模拟临床神经病理性疼痛,假手术组仅暴露神经并缝合。推拿组在造模后7 d采用按摩推拿手法模拟仪进行三法三穴推拿干预,假手术组及模型组进行等时间的抓握束缚。分别于造模前(T_(1))、造模后推拿前(T_(2))、推拿后(T_(3))采用机械缩足反射阈值及热缩足反射潜伏期评价三法三穴推拿即刻镇痛效果;评价结束后取大鼠腰膨大节段脊髓背角组织,采用Western blotting法检测各组大鼠脊髓背角组织嘌呤能受体P2Y12(P2RY12)、磷酸化p38丝裂原活化蛋白激酶(p-p38 MAPK)及肿瘤坏死因子α(TNF-α)蛋白。结果与假手术组同时点比较,模型组、推拿组在T_(2)及T_(3)时点MWT、TWL均降低(P均0.05)。结论三法三穴推拿在坐骨神经损伤大鼠中具有较好的即刻镇痛效果,其机制可能为抑制小胶质细胞P2RY12/p38 MAPK/TNF-α通路从而缓解神经病理性疼痛。

关键词：推拿坐骨神经损伤神经病理性疼痛痛觉敏感化小胶质细胞

维普期刊数据库博看期刊

早期推拿后大鼠24 h内疼痛变化特点的研究

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长春中医药大学学报 2024年第7期40卷 740-745页

作者：杨震杰萨出拉于天源陈金平张润龙张英琦刘家玥孙佳伟张汉钰北京中医药大学针灸推拿学院北京102446

目的通过机械、温度伤害感受变化评价早期推拿镇痛启动后,慢性压迫性神经损伤(minor CCI)模型大鼠24 h内疼痛变化情况及疗效最优时间点,为推拿镇痛启动疗效提供支撑。方法将49只SD大鼠随机分为7组,即假手术组、模型组、推拿后即刻组、... 详细信息

目的通过机械、温度伤害感受变化评价早期推拿镇痛启动后,慢性压迫性神经损伤(minor CCI)模型大鼠24 h内疼痛变化情况及疗效最优时间点,为推拿镇痛启动疗效提供支撑。方法将49只SD大鼠随机分为7组,即假手术组、模型组、推拿后即刻组、推拿后6 h组、推拿后12 h组、推拿后18 h组与推拿后24 h组。模型组和推拿各亚组建立minor CCI模型。推拿各亚组在造模后7 d进行1次三法三穴干预;模型组与假手术组进行抓握束缚。干预结束后对推拿各亚组、模型组及假手术组先后进行冷敏阈值(CST)、机械缩足反射阈值(PWMT)和热缩足反射潜伏期(TWL)测试不同性质痛觉的变化;取血清进行ELISA测试白介素-10(IL-10)和肿瘤坏死因子(TNF-α)的变化;取造模侧背根神经节(DRG)进行qPCR检测;观察TNF-α、TRPV1和TRPA1基因表达的变化。结果行为学检测显示CST、PWMT、TWL均有不同程度的降低或延长;ELISA检测大鼠血清IL-10、TNF-α显示明显降低;qPCR检测显示TNF-α、TRPV1、TRPA1基因表达均减少,但三种检测方法结果显示指标变化显著时间点均不相同。结论对于CST、PWMT、TWL三种不同伤害性感受阈值,推拿干预后24 h内的镇痛疗效显著时间点不同;推拿可通过降低IL-10、TNF-α、TRPV1和TRPA1的表达发挥即刻镇痛和持续镇痛作用。

关键词：三法三穴周围神经病理性疼痛行为学酶联免疫吸附试验镇痛

Aerodynamic/Stealthy/Structural Multidisciplinary Design Optimization of Unmanned Combat Air Vehicle

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Chinese Journal of Aeronautics 2009年第4期22卷 380-386页

作者： Hu tianyuan,yu Xiongqing Key Laboratory of Fundamental Science for National Defense-Advanced Design Technology of Flight Vehicle,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,China Key Laboratory of Fundamental Science for National Defense-Advanced Design Technology of Flight Vehicle Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

An optimization strategy is proposed to deal with the aerodynamic/stealthy/structural multidisciplinary design optimization （MDO） issue of unmanned combat air vehicle （UCAV）. In applying the strategy, the MDO process is divided into two levels, i.e. system level optimization and subsystem level optimization. The system level optimization is to achieve optimized system objective （or multi-objective） through the adjustment of global external configuration design variables. The subsystem level optimization consists of the aerodynamic/stealthy integrated design and the structural optimization. The aerodynamic/stealthy integrated design aims at achieving the minimum aerodynamic drag coefficient under the constraint of stealthy requirement through the adjustment of local external configuration design variables. The structural optimization is to minimize the structural weight by adjusting the dimefisions of structural components. A flowchart to implement this strategy is presented. The MDO for a flying-wing configuration of UCAV is employed to illustrate the detailed process of the optimization. The results indicate that the overall process of the surrogate-based two-level optimization strategy can be implemented automatically, and quite reasonable results are obtained.

关键词： aircraft design multidisciplinary design optimization aerodynamics radar cross section structure

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推拿干预神经根型颈椎病镇痛机制的研究进展

环球中医药 2024年第4期17卷 752-758页

作者：张汉钰王厚融于天源刘家玥张英琦孙佳伟陈金平张润龙杨震杰萨出拉官乾徐亚静北京中医药大学针灸推拿学院 102488 北京医院

神经根型颈椎病(cervical spondylotic radiculopathy, CSR)是颈椎病最常见的临床证型,严重影响了人们的日常生活。推拿作为临床上治疗颈椎病的常用中医外治法之一,疗效肯定。本文对推拿治疗CSR机制进行综述,发现:(1)通过改善颈部的受... 详细信息

神经根型颈椎病(cervical spondylotic radiculopathy, CSR)是颈椎病最常见的临床证型,严重影响了人们的日常生活。推拿作为临床上治疗颈椎病的常用中医外治法之一,疗效肯定。本文对推拿治疗CSR机制进行综述,发现:(1)通过改善颈部的受力结构缓解颈椎失稳、减轻椎间关节的错位及紊乱从而缓解机械压迫,纠正病变解剖结构改善疼痛;(2)通过降低肿瘤细胞坏死因子-α(tumor necrosis factor-α, TNF-α)、白细胞介素-1α(interleukin-1α, IL-1α)、白细胞介素-6(interleukin-6, IL-6)等促炎因子表达,上调白细胞介素-4(interleukin-4, IL-4)、白细胞介素-10(interleukin-10, IL-10)、转化生长因子(transforming growth factor, TGF)-β1等抗炎因子的表达,缓解炎性浸润产生镇痛作用;(3)通过调节外周及中枢β-EP等神经递质的表达,发挥镇痛效果;(4)恢复胸腺T细胞、分化抗原(cluster of differentiation, CD)4^(+)免疫细胞的平衡,以缓解疼痛反应。可见,推拿可通过“多水平—多途径—多靶点”从而发挥对CSR的镇痛作用。本文通过回顾推拿治疗CSR的相关文献,以期为日后临床应用或实验研究提供参考依据。

关键词：推拿神经根型颈椎病镇痛疼痛炎症神经递质细胞免疫