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基于网络药理学与分子对接探讨六味地黄丸治疗肾阴亏虚型老年性便秘的作用机制

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湖南中医杂志 2024年第2期40卷 173-182页

作者：李双霜谭天颖曾兴琳胡文婷陈小朝贵州中医药大学贵州贵阳550025 成都中医药大学四川成都610075 成都肛肠专科医院四川成都610017

目的:运用网络药理学与分子对接技术探究六味地黄丸治疗肾阴亏虚型老年性便秘的作用机制。方法:通过TCMSP、TCMID、SwissTargetPrediction获取药物的活性成分并筛选,在Genecards、OMIM、TTD、DisGeNET数据库检索与该疾病相关的主要靶点... 详细信息

目的:运用网络药理学与分子对接技术探究六味地黄丸治疗肾阴亏虚型老年性便秘的作用机制。方法:通过TCMSP、TCMID、SwissTargetPrediction获取药物的活性成分并筛选,在Genecards、OMIM、TTD、DisGeNET数据库检索与该疾病相关的主要靶点;运用韦恩图获取六味地黄丸与老年性便秘的交集靶点。将以上数据通过STRING获得交集靶点的蛋白网络,构建药物-活性成分-靶点及蛋白质-蛋白质相互作用(PPI)网络图,进行基因本体(GO)功能和京都基因与基因组百科全书(KEGG)通路富集分析,并对药物有效成分和核心靶点进行分子对接验证。结果:共获得58个有效活性成分和675个对应靶点,主要有效成分有槲皮素、羟基芫花素、泽泻醇B等;药物-疾病交集靶点296个,包括丝氨酸/苏氨酸蛋白激酶1 (AKT1)、肿瘤坏死因子(TNF)、白细胞介素-6(IL-6)等。GO功能富集共有3175个条目,KEGG通路富集得到215条通路,主要有癌症通路、磷脂酰肌醇3-激酶/苏氨酸蛋白激酶信号通路、癌症中的蛋白聚糖、丝裂原活化蛋白激酶信号通路等。分子对接显示该药物主要有效成分和核心靶点蛋白有较好的结合力。结论:该研究在总体上预测了六味地黄丸治疗肾阴亏虚型老年性便秘的活性成分、靶点和信号通路,表明了其多成分-多靶点-多途径的治疗特点。

关键词：老年性便秘肾阴亏虚证六味地黄丸作用机制网络药理学分子对接

Improved Removal Efficiency of Submicron Inclusions in Non-oriented Silicon Steel during RH Process

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Journal of Wuhan University of Technology(Materials Science) 2020年第6期35卷 1122-1127页

作者： CHEN tianying JIN Yan CHENG Zhaoyang YUAN Zexi BI Yunjie LIU Jing The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China

To improve the removal efficiency of such submicron inclusions,we designed an argon blowing method for an RH facility based on mathematical *** effect of the argon blowing on the liquid steel flow and the movement of submicron inclusions was studied using the k-ε flow model coupled with the DPM model for inclusion movement based on fluid computational dynamics in *** was found that a more uniform argon flow can be achieved in the up-leg snorkel with a new nozzle position and inner diameter,which resulted in a favorable up-lifting and mixing *** new design also increased the circulation rate of molten steel in the RH *** increased turbulent kinetic energy and turbulent dispersing rate enhanced the collision probability of submicron inclusions,which results in an improved removal for 0.5-1 μm *** proposed RH facility could increase the removal rate of submicron inclusions from the original 57.1% to 66.4%,which improves the magnetic properties of non-oriented silicon steel.

关键词： RH treatment argon blowing method model optimization submicron inclusions numerical simulation

Room temperature liquid metal:its melting point,dominating mechanism and applications

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Frontiers in Energy 2020年第1期14卷 81-104页

作者： Junheng FU Chenglin ZHANG tianying LIU Jing LIU CAS Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of Sciences Beijing 100190China School of Future Technology University of Chinese Academy of Sciences Beijing 100049China Beijing Key Laboratory of Cryo-Biomedical Engineering Beijing 100190China CAS Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing 100084China

The room temperature liquid metal(LM)is recently emerging as a new class of versatile materials with fascinating characteristics mostly originated from its simultaneous metallic and liquid *** melting point is a typical parameter to describe the peculiarity of LM,and a pivotal factor to consider concerning its practical applications such as phase change materials(PCMs)and advanced thermal ***,the theoretical exploration into the melting point of LM is an essential issue,which can be of special value for the design of new LM materials with desired *** far,some available strategies such as molecular dynamics(MD)simulation and classical thermodynamic theory have been applied to perform correlative *** paper is primarily dedicated to performing a comprehensive overview regarding typical theoretical strategies on analyzing the melting ***,then,presents evaluations on several factors like components,pressure,size and supercooling that may be critical for melting processes of liquid *** that,it discusses applications associated with the characteristic of low melting points of *** is expected that a great many fundamental and practical works are to be conducted in the coming future.

关键词： melting point liquid metal crystal thermodynamics molecular dynamics

AECOPD合并肺部感染病原学特点及其血清miR-127、IL-17及NLR水平检测价值分析

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分子诊断与治疗杂志 2024年第9期16卷 1725-1728,1733页

作者：徐志礼罗田应江胜利王璐钟兴峰湖北省麻城市人民医院呼吸与危重症医学科湖北麻城438300

目的分析急性加重期慢性阻塞性肺疾病(AECOPD)合并肺部感染患者病原学特点,并探讨微小RNA(microRNA,miR)-127、白介素-17(IL-17)及中性粒细胞与淋巴细胞比值(NLR)的预测价值。方法选取2020年5月至2023年5月湖北麻城市人民医院收治的146... 详细信息

目的分析急性加重期慢性阻塞性肺疾病(AECOPD)合并肺部感染患者病原学特点,并探讨微小RNA(microRNA,miR)-127、白介素-17(IL-17)及中性粒细胞与淋巴细胞比值(NLR)的预测价值。方法选取2020年5月至2023年5月湖北麻城市人民医院收治的146例AECOPD患者的病例资料进行分析,根据患者是否合并肺部感染分为感染组(n=43)和未感染组(n=103)。分析感染组患者痰液中病原体的种类分布,采用单因素及多因素Logistic回归分析血清miR-127、IL-17和NLR水平与AECOPD患者肺部感染的关系,并绘制受试者工作特征曲线(ROC)分析上述指标对AECOPD合并肺部感染的检测价值。结果感染组患者中共检出57株病原菌,其中革兰阴性菌42株(73.68%),革兰阳性菌12株(21.05%),真菌3株(5.26%)。与未感染者相比,感染组患者高龄、低蛋白血症、糖皮质激素使用时间>7 d占比较多,差异有统计学意义(χ^(2)=5.092、7.205、14.090,P127、IL-17及NLR水平更高,差异有统计学意义(t=5.171、5.697、4.767,P15)、糖皮质激素使用时间(OR=1.969)、miR-127(OR=2.394)、IL-17(OR=2.524)及NLR(OR=2.784)水平是AECOPD合并肺部感染的独立危险因素(P127、IL-17及NLR单独及联合预测AECOP合并肺部感染曲线下面积(AUC)分别为0.747、0.764、0.732及0.878,联合预测高于单一检测(P127、IL-17及NLR是该类患者的独立危险因素,三者联合对AECOPD合并肺部感染具有较高的预测价值。

关键词：急性加重期慢性阻塞性肺疾病肺部感染病原菌微小RNA-127 白介素-17

基于SrTO法探讨当代中医名家论治出血性中风的学术特点

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中国中医基础医学杂志 2024年第5期30卷 836-843页

作者：赵珮希常天瀛崔英子王文雅王健廖星长春中医药大学长春130117 长春中医药大学附属医院长春130021 中国中医科学院中医临床基础医学研究所北京100700

目的探究当代中医医家论治出血性中风的学术特点,为临床诊治提供思路与方法。方法全面系统检索当代中医名家论治出血性中风相关文献。依据澳大利亚循证方法学组织(Joanna Briggs Institute,JBI)研发的基于文本和专家意见的系统综述(the ... 详细信息

目的探究当代中医医家论治出血性中风的学术特点,为临床诊治提供思路与方法。方法全面系统检索当代中医名家论治出血性中风相关文献。依据澳大利亚循证方法学组织(Joanna Briggs Institute,JBI)研发的基于文本和专家意见的系统综述(the systematic review of text and opinion,SrTO)方法,对中医脑病领域名医名家诊治出血性中风临证经验、学术思想等相关研究进行证据整合,并从理法方药、因机证治多方面分析其学术特点及影响因素。结果共纳入36名中医医家,医家在华南、华东、华北、华中等医疗发达地区分布多,其中北京地区纳入医家数量最多,为7名;纳入医家的20%有中医家传教育背景,69.4%有师承名医学习经历;36名医家总结归纳形成包括脑髓理论、伏邪理论、毒损脑络在内共计11种新理论;创新性地提出包括通腑化痰、破血化瘀、痰瘀同治在内共计23种新治法。结论当代中医名家将传统理论和现代研究相融合,诊治上经典理论与临床实践并重,学术上传承与创新兼备,对出血性中风的研究逐渐深入。

关键词：出血性中风脑出血中医名家学术特色 SrTO方法

臭氧疗法治疗腰椎间盘突出症的疗效与安全性:一项基于随机对照的Meta分析和系统综述

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介入放射学杂志 2024年第7期33卷 745-752页

作者：马飞宏冯周利吉天英宋志靖李洋常睿王建国吴建民甘肃中医药大学附属医院康复骨科甘肃兰州730000 甘肃中医药大学

目的系统评价臭氧注射治疗腰椎间盘突出症(LDH)的疗效与安全性。方法检索Embase、PubMed、Cochrane library、Web of science数据库中有关臭氧疗法治疗LDH的随机对照研究(RCT)文献,检索日期为建库至2023年2月。由两位研究者独立进行... 详细信息

目的系统评价臭氧注射治疗腰椎间盘突出症(LDH)的疗效与安全性。方法检索Embase、PubMed、Cochrane library、Web of science数据库中有关臭氧疗法治疗LDH的随机对照研究(RCT)文献,检索日期为建库至2023年2月。由两位研究者独立进行文献检索、筛选、数据提取,采用Cochrane偏倚风险评价工具评估纳入文献的质量,应用Stata 17.0软件进行Meta分析。结果最终纳入9项RCTs,涉及702例患者。Meta分析结果显示与单纯选择射频热凝、经皮旋切等治疗LDH相比,联合臭氧注射治疗能显著提高Macnab疗效评价的有效率(RR=1.097,95%CI:1.038~1.159,P=0.001)和优良率(RR=1.185,95%CI:1.074~1.309,P=0.001),降低视觉模拟疼痛评分(VAS)(WMD=-0.810~95%CI:-1.205,-0.414,P=0.000)差异具有统计学意义。结论相较于单纯使用射频热凝、经皮旋切等治疗LDH,联合使用臭氧疗法能显著提高Macnab疗效评价的有效率和优良率,降低VAS评分,安全性高。因受限于纳入原始研究的数量和质量,上述结论有待多中心、大样本、高质量研究进一步予以验证。

关键词：臭氧疗法腰椎间盘突出系统综述 Meta分析

静态冷保存序贯低温机械灌注参数对移植肾短期预后影响

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中华器官移植杂志 2024年第8期45卷 543-549页

作者：邢添瑛吴江涛王琦李广萍黄莹欧彤文首都医科大学宣武医院泌尿外科北京100053

目的探讨静态冷保存(SCS)序贯低温机械灌注(HMP)参数对移植肾短期预后的影响。方法回顾性分析2023年2月至2023年10月首都医科大学宣武医院157例(包括后期删失6例)符合条件的成人供肾移植受者相关资料及对应供肾机械灌注数据, 根据灌注... 详细信息

目的探讨静态冷保存(SCS)序贯低温机械灌注(HMP)参数对移植肾短期预后的影响。方法回顾性分析2023年2月至2023年10月首都医科大学宣武医院157例(包括后期删失6例)符合条件的成人供肾移植受者相关资料及对应供肾机械灌注数据, 根据灌注阻力指数及供肾动脉变异情况进行不同层面的观察比较, 主要观察终点为发生移植肾功能延迟(delayed graft function, DGF)及1个月内肌酐是否降至正常, 次要观察终点为1个月内的最低肌酐值、肌酐下降幅度、肌酐降至最低的时间和肌酐降至正常的时间, 使用单因素和多因素回归分析探讨HMP灌注的参数与术后短期预后的关系。结果 157例受者术前平均肌酐(870.0±283.9)μmol/L, 术后1个月内最低肌酐(118.5±63.5)μmol/L。术后16例(10.2%)受者发生DGF, 10例(6.4%)受者肌酐在术后1个月内未降至正常。1个月内肌酐降至最低的时间为(14.5±7.6)d(范围在3~30 d), 肌酐降至正常的时间为(6.4±5.8)d(范围在1~30 d)。多因素回归分析显示HMP的终末阻力指数是发生DGF(P1)、1个月内肌酐是否降至正常(P=0.001)、肌酐下降幅度(P1)、肌酐降至正常所需时间(P=0.024)的独立影响因素。结论在SCS序贯HMP的供肾保存模式下, HMP的参数对判断肾移植术后短期预后具有应用价值。终末阻力指数是多种预后事件的独立影响因素。

关键词：肾移植器官保存低温机械灌注

Development of the peanut precision fertilization control system based on threshold velocity algorithm

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International Journal of Agricultural and Biological Engineering 2022年第5期15卷 116-122页

作者： Yuqi Fan Yan Yu Shuqi Shang tianying Gu Yanrui Hu Linsong Diao Ruchao Ge Xing Zhang College of Mechanical and Electrical Engineering Qingdao Agricultural UniversityQingdao 266109ShandongChina

In view of the fact that the current ground wheel velocimetry of the peanut precision fertilizer control system cannot solve the phenomenon of ground wheel slippage,and signal interference and delay loss cannot be excluded by BeiDou positioning velocimetry,a set of peanut precision fertilizer control system was designed based on the threshold speed *** system used STM32F103ZET6 microcontroller as the main controller,and touch screen for setting the operating parameters such as operating width,fertilizer type,and fertilizer application *** threshold speed algorithm combined with BeiDou and ground wheel velocimetry was adopted to obtain the forward speed of the tractor and adjust the speed of the DC drive motor of the fertilizer applicator in real time to achieve precise fertilizer ***,through the threshold speed algorithm test,the optimal value of the length N of the ground wheel speed measurement queue was determined as 3,and the threshold of the speed variation coefficient was set to 4.6%.Then,the response performance of the threshold speed algorithm was verified by comparative test with different fertilization amounts(40 kg/hm^(2),50 kg/hm^(2),60 kg/hm^(2),70 kg/hm^(2))under two speed acquisition methods of ground wheel speed measurement and threshold speed algorithm(combination of Beidou single-point speed and ground wheel speed measurement)in different operation speeds(3 km/h,4 km/h,5 km/h).The response performance test results showed that the average value of the velocimetry delay distance of the BeiDou single-point positioning velocimetry method was 0.58 m,while the average value of that with the threshold velocity algorithm was 0.27 m,which decreased by 0.31 m and indicated more accurate with the threshold velocity *** field comparison test for fertilizer application performance turned out an over 96.08%accuracy rate of fertilizer discharge by applied with the threshold speed algorithm,which effectively avoided the ina

关键词： peanut precision fertilizer planter BeiDou velocimetry ground wheel velocimetry threshold speed algorithm control system

Microstructure and Mechanical Properties of Ti–Ta Composites Prepared Through Cold Spray Additive Manufacturing

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Acta Metallurgica Sinica(English Letters) 2022年第9期35卷 1465-1476页

作者： Junrong Tang Naeem ul Haq Tariq Zhipo Zhao Mingxiao Guo Hanhui Liu Yupeng Ren Xinyu Cui Yanfang Shen Jiqiang Wang tianying Xiong Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China Department of Metallurgy and Materials Engineering Pakistan Institute of Engineering and Applied SciencesNiloreIslamabadPakistan

In this study, an innovative approach was used to fabricate Ti–Ta composite biomaterials through cold spray additive manufacturing followed by a diff usion treatment. The microstructure and mechanical properties of the composites were investigated in detail using field emission scanning electron microscopy, electron backscatter diff raction, 3D X-ray computed tomography, tensile test, nanohardness test and resonance vibration test. The obtained results indicated that the prepared composites have inhomogeneity in their microstructure and composition. A unique microstructure, composed of Ti-rich, Ta-rich and diff usion regions, was evolved in the composites due to incomplete diff usion between Ti and Ta splats. Further, Kirkendall pores were formed in the composites due to uneven diff usion of the two phases(of Ti and Ta) during high-temperature heat treatment. The prepared composites simultaneously showed low elastic modulus and high tensile strength which is required for a good biomaterial. Low elastic modulus was associated with the residual pores and the alloying eff ect of Ta in Ti, while high tensile strength was related to the solid solution strengthening eff ects. The obtained results indicated that the prepared Ti–Ta composites have a great potential to become a new candidate for biomedical applications.

关键词： Ti–Ta composites Cold spray additive manufacturing(CSAM) Biomaterials Mechanical properties X-ray computed tomography(XCT)