检索结果-南通市图书馆

Journal of Molecular Cell Biology 2016年第6期8卷 477-491页

作者： Fengxia He Mengya Zhou tianyi yu Dan Zhao Jing Zhang Wen Qiu Yanlai Lu yu Liu Lulu Wang Yingwei Wang Department of Immunology Nanjing Medical UniversityNanjing 210029China

The apoptosis of glomerular mesangial cells(GMCs)is considered to be an important contributor to the initiation and development of rat Thy-1 nephritis(Thy-1N)and is accompanied by sublytic C5b-9 ***,the mechanism by which sublytic C5b-9 triggers GMC apoptosis has not been *** this study,functional and histological examinations were performed on GMCs treated with sublytic C5b-9(in vitro)and renal tissues of Thy-1N rats(in vivo).The in vitro studies found that sublytic C5b-9 could trigger GMC apoptosis through upregulating Egr-1,ATF3,and Gadd45 ***-1-mediated post-transcriptional modulation of ATF3,Egr-1/ATF3-enhanced Gadd45 promoter activity,and p300-mediated ATF3 acetylation were all involved in GMC *** importantly,the effective binding elements for Egr-1 and ATF3 to Gadd45β/γpromoters and the ATF3 acetylation site were *** vivo,silencing renal p300,Egr-1,ATF3,and Gadd45β/γsignificantly decreased GMC apoptosis,secondary GMC proliferation,and urinary protein secretion in Thy-1N ***,these findings implicate that sublytic C5b-9-induced activation of Egr-1/p300–ATF3/Gadd45 axis plays a critical role in GMC apoptosis in Thy-1N rats.

关键词： glomerular mesangial cells sublytic C5b-9 Thy-1 nephritis transcription factor acetylation apoptosis

High precision landing site mapping and rover localization for Chang'e-3 mission

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2015年第1期58卷 139-149页

作者： LIU ZhaoQin DI KaiChang PENG Man WAN WenHui LIU Bin LI LiChun yu tianyi WANG BaoFeng ZHOU JianLiang CHEN HongMin State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital Earth (RADI) Chinese Academy of Sciences Beijing Aerospace Control Center (BACC)

This paper presents the comprehensive results of landing site topographic mapping and rover localization in Chang’e-3 ***-precision topographic products of the landing site with extremely high resolutions(up to 0.05 m)were generated from descent images and registered to CE-2 *** DEM and DOM with 0.02 m resolution were produced routinely at each waypoint along the rover *** lander location was determined to be(19.51256°W,44.11884°N,-2615.451 m)using a method of DOM *** order to reduce error accumulation caused by wheel slippage and IMU drift in dead reckoning,cross-site visual localization and DOM matching localization methods were developed to localize the rover at waypoints;the overall traveled distance from the lander is 114.8 m from cross-site visual localization and 111.2 m from DOM matching *** latter is of highest accuracy and has been verified using a LRO NAC image where the rover trajeactory is directly *** CE-3 mission operations,landing site mapping and rover localization products including DEMs and DOMs,traverse maps,vertical traverse profiles were generated timely to support teleoperation tasks such as obstacle avoidance and rover path planning.

关键词： Chang'e-3 yutu rover landing site mapping rover localization descent camera navigation camera

Inhibiting Hyper-O-GlcNAcylation of c-Myc accelerate diabetic wound healing by alleviating keratinocyte dysfunction

在线全文

学校读者我要写书评

暂无评论

Burns & Trauma 2021年第1期9卷 170-183页

作者： Jie Zhang Peilang Yang Dan Liu Min Gao Jizhuang Wang tianyi yu Xiong Zhang Yan Liu Department of Burn Ruijin Hospital Affliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

Background:Diabetic foot ulcers characterized by delayed healing are one of the main complications of *** keratinocyte dysfunction has been found to play a pivotal role in the poor healing ability of diabetic *** this study,we aimed to explore the relationship between c-Myc and its O-linked N-acetylglucosamine(O-GlcNAc)glycosylation(O-GlcNAcylation)modification and keratinocyte dysfunction in diabetic ***:Clinical wound samples were collected and a full-thickness skin defect wound model of diabetic rats was ***-epithelialization of wounds was observed by H&E staining and expressions of proliferating cell nuclear antigen,transglutaminase 1,loricrin,c-Myc and O-GlcNAc were measured by *** functional changes of proliferation,migration and differentiation of human immortalized epidermal cells(HaCaT)cells after overexpression or knockdown of c-Myc were observed.O-GlcNAcylation of c-Myc was confirmed using immunoprecipitation and proximity ligation *** of the c-Myc protein was measured using *** healing was observed after topical application of compounds that inhibited c-Myc or O-GlcNAc on diabetic ***:Keratinocytes at the diabetic wound margin were characterized by active proliferation and division,slow migration and poor *** phenomena were observed in HaCaT cells cultured in 30 mM glucose and keratinocytes at the wound margin of the diabetic *** expression of c-Myc was increased in keratinocytes at the wound margin of diabetic rats,patients,and in HaCaT cells cultured with 30 mM *** expression of c-Myc promoted the proliferation while inhibiting the migration and differentiation of the HaCaT cells,and inhibition of c-Myc promoted diabetic wound *** O-GlcNAcylation of c-Myc with 30mMglucose stabilized the c-Myc *** of O-GlcNAc ameliorated keratinocyte dysfunction and promoted diabetic wound ***

关键词： c-Myc O-GlcNAc diabetes wound healing keratinocyte glucose

Study on the Style of Urban Development as a Center of Kitakyushu Monorail —About the User Actual Situation and the Demographic around the Station

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Civil Engineering 2014年第4期4卷 318-327页

作者： yuanwen Zhang Hiroatsu Fukuda tianyi yu Faculty of Environmental Engineering University of Kitakyushu Kitakyushu Japan School of Architecture and Fine Art Dalian University of Technology Dalian China

The ageing of the population in Japan has become a problem. According to the research of different regions, where the ratio of the ageing population is above 25%, it is found that the Japanese society is gradually turned to hyper-aged society. The population along Kitakyushu monorail is also in such a situation. This study is based on the background, with excessive reliance on their own vehicles and public transport problems arising from the abolition of public transportation in Kitakyushu as the area of this study. Under the full consideration of people who can’t drive, the elderly who had to take buses as well as people who lack of transport ability where population decrease and the aging problem have been worsening, their surrounding environment should be further improved. In addition, it should be taken into consideration to increase the population in the walking distance around the stations.

关键词： Monorail Population Hyper-Aged Society Aging Ratios

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于风振舒适度的高层建筑生命周期费用模型

同济大学学报（自然科学版） 2013年第12期41卷 1793-1798页

作者：赵昕余天意同济大学建筑设计研究院(集团)有限公司上海200092 同济大学土木工程学院上海200092

根据感知结构在风荷载作用下振动的人数所占比例,将超高层建筑舒适度性能水平划分为5个等级,并以结构水平振动加速度作为控制指标,建立了超高层建筑舒适度性能的评价方法.通过虚拟激励法进行频域分析,求得结构在随机风荷载作用下的响应... 详细信息

根据感知结构在风荷载作用下振动的人数所占比例,将超高层建筑舒适度性能水平划分为5个等级,并以结构水平振动加速度作为控制指标,建立了超高层建筑舒适度性能的评价方法.通过虚拟激励法进行频域分析,求得结构在随机风荷载作用下的响应特性,获得1次强风作用下结构各性能水平的可靠度;考虑工程场地可能出现的风荷载水平,得到建筑生命周期内各舒适度性能水平的可靠度;同时,根据投资-收益准则,建立基于舒适度性能的超高层建筑生命周期费用模型;该模型可以考虑不同设计方案下的生命周期费用,并可依据生命周期费用最小原则进行投资决策,是基于性能的抗风设计的具体应用.利用该方法对某超高层建筑调频质量阻尼器(TMD)安装与否进行了投资决策,说明了本方法的适用性.

关键词：超高层建筑基于性能的抗风设计舒适度生命周期费用投资-效益准则

在线全文

学校读者我要写书评

暂无评论

试论中国文化对芥川龙之介创作的影响

学术交流 2009年第12期 215-218页

作者：于天祎山东大学外国语学院山东济南250100

中国一直以自己灿烂的文明影响着历代日本文人。这种影响在近代却变得复杂而微妙。芥川龙之介是日本近代文坛的著名作家,中国对芥川文学的影响颇具代表性。受中国古典文化的熏陶,芥川以古代中国为舞台的作品中饱含了对浪漫中国幻象的向... 详细信息

中国一直以自己灿烂的文明影响着历代日本文人。这种影响在近代却变得复杂而微妙。芥川龙之介是日本近代文坛的著名作家,中国对芥川文学的影响颇具代表性。受中国古典文化的熏陶,芥川以古代中国为舞台的作品中饱含了对浪漫中国幻象的向往,面对现代,他保持了一种文化回归的心态;中国访问使芥川心中的文本幻象被丑陋的真实所取代,他在停止了对古代中国叙事的同时产生了了解真实中国的欲望,他依据中国访问的经验写下了一系列具有反战、反侵略意识的作品。

关键词：芥川龙之介中国影响

Coexistence behavior of asymmetric attractors in hyperbolic-type memristive Hopfield neural network and its application in image encryption

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第3期33卷 302-315页

作者：李晓霞何倩倩余天意才壮徐桂芝 Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province Hebei University of TechnologyTianjin 300130China State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of TechnologyTianjin 300130China School of Life Science & Health Engineering Hebei University of TechnologyTianjin 300130China

The neuron model has been widely employed in neural-morphic computing systems and chaotic *** study aims to develop a novel circuit simulation of a three-neuron Hopfield neural network(HNN)with coupled hyperbolic memristors through the modification of a single coupling connection *** bistable mode of the hyperbolic memristive HNN(mHNN),characterized by the coexistence of asymmetric chaos and periodic attractors,is effectively demonstrated through the utilization of conventional nonlinear analysis *** techniques include bifurcation diagrams,two-parameter maximum Lyapunov exponent plots,local attractor basins,and phase trajectory ***,an encryption technique for color images is devised by leveraging the mHNN model and asymmetric structural *** method demonstrates significant benefits in correlation,information entropy,and resistance to differential attacks,providing strong evidence for its effectiveness in ***,an improved modular circuit design method is employed to create the analog equivalent circuit of the memristive *** correctness of the circuit design is confirmed through Multisim simulations,which align with numerical simulations conducted in Matlab.

关键词： hyperbolic-type memristor Hopfield neural network(HNN) asymmetric attractors image encryption

Effects of electric field on vibrational resonances in Hindmarsh-Rose neuronal systems for signal detection

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2023年第4期32卷 730-741页

作者：李晓霞薛小鹏刘栋杰余天意何倩倩徐桂芝 State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of TechnologyTianjin 300130China School of Health Sciences&Biomedical Engineering Hebei University of TechnologyTianjin 300130China Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province Hebei University of TechnologyTianjin 300130China

Changes in the concentration of charged ions in neurons can generate induced electric fields,which can further modulate cell membrane *** this paper,Fourier coefficients are used to investigate the effect of electric field on vibrational resonance for signal detection in a single neuron model and a bidirectionally coupled neuron model,*** study found that the internal electric field weakens vibrational resonance by changing two factors,membrane potential and phase-locked mode,while the periodic external electric field of an appropriate frequency significantly enhances the vibrational resonance,suggesting that the external electric field may play a constructive role in the detection of weak signals in the brain and neuronal ***,when the coupling of two neurons is considered,the effect of the electric field on the vibrational resonance is similar to that of a single *** paper also illustrates the effect of electric field coupling on vibrational *** study may provide a new theoretical basis for understanding information encoding and transmission in neurons.

关键词： electric field Fourier-coefficient neuronal dynamics vibrational resonance

Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation

在线全文

学校读者我要写书评

暂无评论

Sublytic C5b-9 triggers glomerular mesangial cell apoptosis ...

Physiological Characteristics of Nitrogen Nutrition in Peanut and Efficient Nitrogen Application Technology

第十二届全国免疫学学术大会

作者： He Fengxia Zhou Mengya yu tianyi Zhao Dan Zhang Jing Qiu Wen Lu Yanlai Liu yu Wang Lulu Wang Yingwei Nanjing Medical University

The apoptosis of glomerular mesangial cells(GMCs)is considered to be an important contributor to the initiation and development of rat Thy-1 nephritis(Thy-IN)and is accompanied by sublytic C5b-9 ***,the mechanism by w... 详细信息

关键词： GMC sublytic C5b-9 Thy-1 nephritis transcription factor acetylation apoptosis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Asian Agricultural Research 2022年第7期14卷 47-50页

作者： Chunxiao WANG Changsong JIANG Ke ZHAO Xiaoping ZHANG Zhengfeng WU Yongmei ZHENG tianyi yu Yaping ZHENG Yantai Academy of Agricultural Sciences Yantai 265500China Haiyang City Agricultural Technology Extension Center Haiyang 265100China Sichuan Agricultural University Ya'an 625014China Shandong Peanut Research Institute Qingdao 266100China

Nitrogen plays a very important role in peanut nutrition and *** peanuts,the nitrogen nutrition comes from root nodules,soil and fertilizer,which are separately referred to as root nodule nitrogen,soil nitrogen and fertilizer *** research obtained following findings.(ⅰ)The nitrogen supply ratio of the three nitrogen sources for peanut is about 5∶3∶*** are significant differences in the nitrogen supply capacity of the three nitrogen *** root nodules have the largest variation in nitrogen fixation and have a high potential for *** fixation in root nodules is closely related to carbon metabolism indicators such as photosynthesis in peanut *** application could increase the accumulation of three nitrogen sources,and the increase in nodule nitrogen accumulation is greater than that of soil nitrogen and fertilizer nitrogen.(ⅱ)Nitrogen fertilizer has a significant effect on nitrogen nutrition of *** forms of nitrogen fertilizers,such as amide nitrogen,ammonium nitrogen,nitrate nitrogen and mixed ammonium nitrate nitrogen,have significant effects on nitrogen metabolism and nitrogen accumulation in *** nitrogen fertilizer is beneficial to improving the activity of enzymes related to nitrogen metabolism and nitrogen ***-release fertilizer can significantly increase the content of soluble protein and improve the activities of NRase,GDH,GS,GPT,*** roots and leaves at the pod setting and mature stages of peanuts,which is favorable for delaying the plant senescence and increasing the yield of *** application of common nitrogen fertilizer and slow-release fertilizer can increase the soil nitrate nitrogen level at the later growth stage,which is beneficial to the development of the root system at the later stage of growth,increasing the distribution ratio of nitrogen in the pods,and also favorable for increasing the yield and nitrogen utilization rate.(ⅲ)Increa

关键词： Peanuts Nitrogen Physiological characteristics Efficient fertilization