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Mitochondrial targeting sequence of magnetoreceptor MagR:More than just targeting

Zoological Research 2024年第3期45卷 468-477页

作者： Yanqi zhang Peng zhang Junjun Wang Jing zhang tianyang Tong Xiujuan Zhou Yajie Zhou Mengke Wei Chuanlin Feng Jinqian Li Xin zhang Can Xie Tiantian Cai High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China University of Science and Technology of China HefeiAnhui 230026China Department of Anatomy School of Basic MedicineAnhui Medical UniversityHefeiAnhui 230032China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China Key Laboratory of Tropical Translational Medicine of Ministry of Education NHC Key Laboratory of Tropical Disease ControlSchool of Tropical Medicine and The Second Affiliated HospitalHainan Medical UniversityHaikouHainan 571199China International Magnetobiology Frontier Research Center Science IslandHefeiAnhui 230031China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang 310027China

Iron-sulfur clusters(ISC)are essential cofactors for proteins involved in various biological processes,such as electron transport,biosynthetic reactions,DNA repair,and gene expression regulation.ISC assembly protein IscA1(or MagR)is found within the mitochondria of most eukaryotes.Magnetoreceptor(MagR)is a highly conserved A-type iron and iron-sulfur cluster-binding protein,characterized by two distinct types of iron-sulfur clusters,[2Fe-2S]and[3Fe-4S],each conferring unique magnetic properties.MagR forms a rod-like polymer structure in complex with photoreceptive cryptochrome(Cry)and serves as a putative magnetoreceptor for retrieving geomagnetic information in animal navigation.Although the N-terminal sequences of MagR vary among species,their specific function remains unknown.In the present study,we found that the N-terminal sequences of pigeon MagR,previously thought to serve as a mitochondrial targeting signal(MTS),were not cleaved following mitochondrial entry but instead modulated the efficiency with which iron-sulfur clusters and irons are bound.Moreover,the N-terminal region of MagR was required for the formation of a stable MagR/Cry complex.Thus,the N-terminal sequences in pigeon MagR fulfil more important functional roles than just mitochondrial targeting.These results further extend our understanding of the function of MagR and provide new insights into the origin of magnetoreception from an evolutionary perspective.

关键词： Magnetoreceptor(MagR) N-terminal sequence Mitochondrial targeting signal Iron-sulfur cluster

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Unexpected divergence in magnetoreceptor MagR from robin and pigeon linked to two sequence variations

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Zoological Research 2024年第1期45卷 69-78页

作者： Shun Wang Peng zhang Fan Fei tianyang Tong Xiujuan Zhou Yajie Zhou Jing zhang Mengke Wei Yanqi zhang Lei zhang Yulong Huang Lin zhang Xin zhang Tiantian Cai Can Xie Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Department of Anatomy Anhui Medical UniversityHefeiAnhui 230032China Department of Mechanical and Aerospace Engineering University at BuffaloState University of New YorkBuffaloNY 14260 USA International Magnetobiology Frontier Research Center Science IslandHefeiAnhui 230031China

Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance movement.Bird species also show tremendous diversity in navigation strategies,with considerable differences even within the same taxa and among individuals from the same population.The highly conserved iron and iron-sulfur cluster binding magnetoreceptor(MagR)protein is suggested to enable animals,including birds,to detect the geomagnetic field and navigate accordingly.Notably,MagR is also implicated in other functions,such as electron transfer and biogenesis of iron-sulfur clusters,raising the question of whether variability exists in its biochemical and biophysical features among species,particularly birds.In the current study,we conducted a comparative analysis of MagR from two different bird species,including the migratory European robin(Erithacus rubecula)and the homing pigeon(Columba livia).Sequence alignment revealed an extremely high degree of similarity between the MagRs of these species,with only three sequence variations.Nevertheless,two of these variations underpinned significant differences in metal binding capacity,oligomeric state,and magnetic properties.These findings offer compelling evidence for the marked differences in MagR between the two avian species,potentially explaining how a highly conserved protein can mediate such diverse functions.

关键词： Homing and migration Animal navigation Magnetoreceptor(MagR) Diverse navigation pattern Conserved protein

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Organic heterojunction synaptic device with ultra high recognition rate for neuromorphic computing

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Nano Research 2024年第6期17卷 5614-5620页

作者： Xuemeng Hu Jialin Meng tianyang Feng Tianyu Wang Hao Zhu Qingqing Sun David Wei zhang Lin Chen School of Microelectronics State Key Laboratory of Integrated Chips and SystemsFudan UniversityShanghai 200433China National Integrated Circuit Innovation Center Shanghai 201203China

Traditional computing structures are blocked by the von Neumann bottleneck,and neuromorphic computing devices inspired by the human brain which integrate storage and computation have received more and more attention.Here,a flexible organic device with 2,7-dioctyl[1]benzothieno[3,2-b][1]benzothiophene(C8-BTBT)and 2,9-didecyldinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene(C10-DNTT)heterostructural channel having excellent synaptic behaviors was fabricated on muscovite(MICA)substrate,which has a memory window greater than 20 V.This device shows better electrical characteristics than organic field effect transistors with single organic semiconductor channel.Furthermore,the device simulates organism synaptic behaviors successfully,such as paired-pulse facilitation(PPF),long-term potentiation/depression(LTP/LTD)process,and transition from short-term memory(STM)to long-term memory(LTM)by optical and electrical modulations.Importantly,the neuromorphic computing function was verified using the Modified National Institute of Standards and Technology(MNIST)pattern recognition,with a recognition rate nearly 100%without noise.This research proposes a flexible organic heterojunction with the ultra-high recognition rate in MNIST pattern recognition and provides the possibility for future flexible wearable neuromorphic computing devices.

关键词： organic heterojunction neuromorphic computing synapse behaviors optical modulation Modified National Institute of Standards and Technology(MNIST)pattern recognition

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Field test of high-power microwave-assisted mechanical excavation for deep hard iron ore

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1922-1935页

作者： Feng Lin Xia-Ting Feng Shiping Li Xiao Hai Jiuyu zhang Xiangxin Su tianyang Tong Jianchun Song Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang110819China Benxi Longxin Mining Corporation Limited Benxi117000China

Microwave-assisted mechanical excavation has great application prospects in mines and tunnels,but there are few field experiments on microwave-assisted rock breaking.This paper takes the Sishanling iron mine as the research object and adopts the self-developed high-power microwave-induced fracturing test system for hard rock to conduct field experiments of microwave-induced fracturing of iron ore.The heating and reflection evolution characteristics of ore under different microwave parameters(antenna type,power,and working distance)were studied,and the optimal microwave parameters were obtained.Subsequently,the ore was irradiated with the optimal microwave parameters,and the cracking effect of the ore under the action of the high-power open microwave was analyzed.The results show that the reflection coefficient(standing wave ratio)can be rapidly(<5 s)and automatically adjusted below the preset threshold value(1.6)as microwave irradiation is performed.When using a right-angle horn antenna with a working distance of 5 cm,the effect of automatic reflection adjustment reaches the best among other antenna types and working distances.When the working distance is the same,the average temperature of the irradiation surface and the area of the high-temperature area under the action of the two antennas(right-angled and equal-angled horn antenna)are basically the same and decrease with the increase of working distance.The optimal microwave parameters are:a right-angle horn antenna with a working distance of 5 cm.Subsequently,in further experiments,the optimal parameters were used to irradiate for 20 s and 40 s at a microwave power of 60 kW,respectively.The surface damage extended 38 cm×30 cm and 53 cm×30 cm,respectively,and the damage extended to a depth of about 50 cm.The drilling speed was increased by 56.2%and 66.5%,respectively,compared to the case when microwaves were not used.

关键词： Microwave parameters High power Field experiment Mechanical mining

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A High Spatiotemporal Iontronic Single-Cell Viscometer

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Research 2022年第4期2022卷 239-247页

作者： tianyang zhang Siyuan Yu Bing Wang Yitong Xu Xiaomei Shi Weiwei Zhao Dechen Jiang Hongyuan Chen Jingjuan Xu State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China

Ideal single-cell viscometer has remained unachieved,leaving a gap in current palette of single-cell nanotools.Information of single-cell viscosity could contribute to our knowledge of fundamental biological processes,e.g.,mass diffusion,biochemical interaction,and cellular responses to many diseases and pathologies.Although advances have been made to this end,existing methods generally suffer from limitations,e.g.,low spatiotemporal resolution.Here,we describe a high spatiotemporal iontronic single-cell viscometer that operates upon a patch clamp integrated with double-barreled nanopores separated by a septum of ca.32 nm.The system enables reversible electroosmotic manipulation of the adjacent small fluid bridging two nanopores,the viscous alternation of which could be sensitively monitored by the ionic responses.In practical cellular studies,significantly,our findings reveal not only the less deviated medium viscosities than those of lysosomes and mitochondria but also the highest viscosities in the near-nuclear region than those of mitochondrion-dense and lysosome-dense regions.This work has provided an accessible single-cell viscometer and enriched the armory of single-cell nanotools.

关键词： pores viscosity bridging

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Highly crystalline core dominated the catalytic performance of carbon dot for cyclohexane to adipic acid reaction

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Nano Research 2022年第8期15卷 7662-7669页

作者： Xiao Wang Wenyi Bian tianyang zhang Yajie Zhao Mingwang Shao Haiping Lin Yang Liu Hui Huang Zhenhui Kang Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipa 999078MacaoChina School of Physics and Information Technology Shaanxi Normal UniversityXi’an 710062China

Carbon dots(CDs)have uniquely structural,physicochemical and photochemical properties,suggesting a promising platform for catalysis applications.The in-depth understanding of the structure-activity relationship in the CDs-based catalyst system needs to know the effect of the crystalline core on their catalytic performance.The efficient catalytic oxidation of cyclohexane is an urgent challenge in current chemical industry,in which,adipic acid(AA)plays an important role in industry for synthesis of nylon6 and nylon-66.Here,we fabricated the pristine CDs by electrochemical etching graphite rod method and derived CDs with high crystalline core(CD-600,CD-800,and CD-1100)through a thermal treatment method in tube furnace.Furthermore,these CDs performed an outstanding catalytic performance for one-step synthesis of AA from cyclohexane.With the help of machine learning(ML),the deep correlations between features(structures of CDs,catalytic conditions)and catalytic performances were investigated by XGBoost(XGB)model.Then under the optimization and prediction of XGB,it was found that high crystalline core preceded the other features and CD-1100 could get the best conversion of 30.696%and selectivity to AA of 92.52%at reaction conditions of 130℃,1.5 MPa,and 10 h.This work pioneered the application of ML in industrial issues and demonstrated a comprehensive understanding on CDs as catalyst to realize one-step synthesis of AA.

关键词： adipic acid carbon dots machine learning catalytic performances crystalline core

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Determination of Total Flavonoids in Acanthopanax senticosus(Rupr. et Maxim.) Harms by Enzymolysis and Its Technological Optimization

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Journal of Northeast Agricultural University(English Edition) 2024年第1期31卷 53-60页

作者： Li Xinzhi Wang Yudan Wang Meiliang Liu tianyang Gao Ruihua Qiu Youwen zhang Shunjie College of Life Sciences Northeast Agricultural UniversityHarbin 150030China College of Horticulture and Landscape Architecture Northeast Agricultural UniversityHarbin 150030China Mudanjiang Branch of Heilongjiang Forestry Science College Mudanjiang 157006HeilongjiangChina

In order to optimize the ultrasonic extraction technique for the total flavonoid of leaf yellows plus, the contents of 21 leaf yellows plus total flavonoid from four regions in Heilongjiang Province were comparatively analyzed. The ultrasonic extraction technology was optimized by Box-Behnken response surface method, and the total flavonoid content of 21 kinds of Acanthopanax senticosus(Rupr. et Maxim.) Harms from different producing areas were analyzed by cluster analysis. The optimal process conditions were determined as ultrasonic time 30 min, solid-liquid ratio 1 : 12 and ultrasonic power 250 W, and the average yield of the total flavonoid was 1.453 mg·g^ (-1). By optimizing the ultrasonic-assisted extraction method, the total flavonoid content from different producing areas was compared in the experiment, which provided certain data support for the optimization of the extraction process in the future and laid a certain theoretical foundation for the quality analysis of Chinese medicinal materials.

关键词： Acanthopanax senticosus(Rupr.et Maxim.)Harms total flavonoid Box-Behnken response surface test ultrasonic-assisted extraction

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Research on motor rotation anomaly detection based on improved VMD algorithm

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Railway Sciences 2024年第1期3卷 18-31页

作者： Fuzhao Chen Zhilei Chen Qian Chen tianyang Gao Mingyan Dai Xiang zhang Lin Sun China Academy of Railway Sciences Corporation Limited Locomotive and Car Research InstituteBeijingChina Brake Development Department Beijing Zongheng Electro-Mechanical Technology Co.Ltd.BeijingChina Process Management Department Beijing Zongheng Electro-Mechanical Technology Co.Ltd.BeijingChina

Purpose–The electromechanical brake system is leading the latest development trend in railway braking technology.The tolerance stack-up generated during the assembly and production process catalyzes the slight geometric dimensioning and tolerancing between the motor stator and rotor inside the electromechanical cylinder.The tolerance leads to imprecise brake control,so it is necessary to diagnose the fault of the motor in the fully assembled electromechanical brake system.This paper aims to present improved variational mode decomposition(VMD)algorithm,which endeavors to elucidate and push the boundaries of mechanical synchronicity problems within the realm of the electromechanical brake system.Design/methodology/approach–The VMD algorithm plays a pivotal role in the preliminary phase,employing mode decomposition techniques to decompose the motor speed signals.Afterward,the error energy algorithm precision is utilized to extract abnormal features,leveraging the practical intrinsic mode functions,eliminating extraneous noise and enhancing the signal’s fidelity.This refined signal then becomes the basis for fault analysis.In the analytical step,the cepstrum is employed to calculate the formant and envelope of the reconstructed signal.By scrutinizing the formant and envelope,the fault point within the electromechanical brake system is precisely identified,contributing to a sophisticated and accurate fault diagnosis.Findings–This paper innovatively uses the VMD algorithm for the modal decomposition of electromechanical brake(EMB)motor speed signals and combines it with the error energy algorithm to achieve abnormal feature extraction.The signal is reconstructed according to the effective intrinsic mode functions(IMFS)component of removing noise,and the formant and envelope are calculated by cepstrum to locate the fault point.Experiments show that the empirical mode decomposition(EMD)algorithm can effectively decompose the original speed signal.After feature extraction,signal enhancement and fault identification,the mo

关键词： Electromechanical brake system Railway brake system Motor fault diagnosis Variational mode decomposition Error energy Feature extraction

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气候变化损失损害处理的中国方案探讨

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东岳论丛 2024年第2期45卷 167-176,192页

作者：王灿发张天杨中国政法大学民商经济法学院北京100088

国际法上的气候变化损失损害问题由来已久。随着发达国家与发展中国家针对气候变化损失损害问题讨论的不断深入,该问题已经从对适应机制和减缓机制的依赖中独立出来,成为国际上应对和解决气候变化问题的独立机制。当前,国际上对于气候... 详细信息

国际法上的气候变化损失损害问题由来已久。随着发达国家与发展中国家针对气候变化损失损害问题讨论的不断深入,该问题已经从对适应机制和减缓机制的依赖中独立出来,成为国际上应对和解决气候变化问题的独立机制。当前,国际上对于气候变化损失损害的讨论存在三个层面的争议,我国应当结合自身国情和实际诉求选择相应的立场。一方面,应当从国际、国家、地方及个体多维层面出发,构建整体性的气候变化损失损害预防机制,提升我国应对气候变化的适应能力和预防能力,减少潜在损失损害。另一方面,应当积极构建由保险、基金和临时性援助组成的综合性救济机制,以确保有充足的资金用于救济各类气候变化所导致的经济与非经济类损失损害。预防机制与救济机制彼此辅助、互相支持,共同建构起气候变化损失损害处理的中国方案。

关键词：气候变化损失损害《联合国气候变化框架公约》预防机制救济机制

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Research on evaluation of network discourse power:Taking the Twitter accounts of Chinese diplomats as an example

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Data Science and Informetrics 2023年第1期3卷 13-25页

作者： Rongying Zhao Xiaoyu Wang Ruru Chang tianyang zhang Research Center for Chinese Science Evaluation Wuhan UniversityWuhanChina School of Information Management Wuhan UniversityWuhanChina

[Purpose/Significance]Changes in network technology and the network environment have caused profound changes in the publication,dissemination,and influence of network discourses.The main body of a network discourse demonstrates the characteristics of civilians,which can impact the discourse power status of national discourse institutions.Research on the evaluation of network discourse power is conducive to clarifying the determinants of network discourse power and of considerable importance to the enhancement of the network discourse power of national public opinion institutions and improvement of the network environment.[Method/Process]First,this study explores the connotation of network discourse power and analyzes its generation process.Second,this study establishes a network discourse power evaluation indicator system and evaluation model based on information metrology and evaluation theory.Finally,this study conducts empirical research using the Twitter accounts of Chinese diplomats as the research object.[Result/Conclusion]Results show that the evaluation of network discourse power is a comprehensive evaluation of the network leading power,network communication power,and network influence of the main body of a network discourse.Moreover,the findings reveal that Chinese diplomats have a certain amount of network discourse power in society and demonstrate a trend of continuous improvement.

关键词： Network discourse power Discourse power evaluation Network leading power Network communicationpower Networkinfluence

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