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Genes & Diseases 2023年第1期10卷 51-54页

作者： Nanlan Yu tianxing hu Haichao Yangg Lian Zhang Lin Zhu Xiaofang Zhou Fei Xiang Xichuan Yang Yuhong Li Department of Dermatology Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Cell Biology Army Medical UniversityChongqing 400038China Institute of Burn Research State Key Laboratory of TraumaBurns and Combined InjurySouthwest HospitalArmy Medical UniversityChongqing 400038China

Androgenic alopecia(AGA)is the most common type of clinical alopecia.Androgen receptor(AR)is the most logical candidate gene for regulating the occurrence of AGA.Dermal papilla cells(DPCs)are a special kind of mesenchymal cells,located in the hair bulb of hair follicles.DPCs play a role in maintaining and inducing the periodic cycling of hair follicles,and are considered as a key cell target of androgen in hair follicles.

关键词： clinical hair cycling

Improving the Covertness in the Physical-Layer Authentication

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China Communications 2021年第3期18卷 122-131页

作者： Ning Xie tianxing hu College of Electronics and Information Engineering Shenzhen UniversityShenzhen 518060China Guangdong Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security(Shenzhen University) Shenzhen 518060China

A well-designed Physical-Layer Authentication(PLA)scheme should consider three properties:covertness,robustness,and security.However,the three properties always cause some dilemmas,e.g.,higher covertness leading to lower robustness.This paper concerns the problem of improving the covertness without sacrificing the robustness.This problem is important because of the following reasons:reducing the errors in recovered source message,improving the security,and ease of constructing a multi-factor authentication system.In this paper,we propose three covert PLA schemes to address the problem.In the first scheme,we improve the covertness by reducing the modification ratio on the source message based on an encoding mechanism.In the second scheme,we improve the covertness by optimizing the superimposing angle,which maximizes the minimum distance between the tagged symbols and the boundary line of the demodulation decision for the source message.In the third scheme,referred to as the hybrid scheme,we further improve the covertness by jointly using the advantages of both the above two schemes.Our experimental results show that when the SNR at a legitimate receiver is 25 dB,as compared with the prior scheme,the first scheme improves the covertness by 17:74%,the second scheme improves the covertness by 28:79%,and the third scheme improves the covertness by 32:09%,while they have similar robustness as Received:Aug.07,2020 Revised:Sep.08,2020 Editor:Nanrun Zhou that of the prior scheme.

关键词： physical-layer authentication encoding covertness superimposing angle security

混凝土绝热温升组合指数式参数计算方法的改进及应用

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水利水电技术（中英文） 2024年第S1期55卷 456-462页

作者：候天兴胡炜曹伟涛上海勘测设计研究院有限公司上海200434 长沙理工大学水利工程学院湖南长沙410114

在大体积混凝土施工温控方案研究中,绝热温升计算公式的选取是开展温度场及温度应力场计算的重要基础。目前工程界常用的混凝土绝热温升双曲线式及双指数式在后续水管冷却计算中较为复杂,而朱伯芳院士提出的组合指数式可极大的简化后续... 详细信息

在大体积混凝土施工温控方案研究中,绝热温升计算公式的选取是开展温度场及温度应力场计算的重要基础。目前工程界常用的混凝土绝热温升双曲线式及双指数式在后续水管冷却计算中较为复杂,而朱伯芳院士提出的组合指数式可极大的简化后续计算。以双曲线式为基础,利用数学回归分析对组合指数式中三个参数的计算方法进行改进,提出了确定组合指数式参数的幂函数计算式。通过对比分析表明采用改进的算法时,组合指数式与双曲线式计算结果吻合度更高,用于混凝土绝热温升计算及水管冷却计算更为合理。将该算法应用于望丰水库大坝施工期温控方案研究,采用有限元软件ANSYS计算不同温控方案下大坝温度场分布特征,研究成果及施工期监测数据表明该算法可有效运用于大坝混凝土温控计算,可为类似大体积混凝土工程温控防裂方案设计提供参考。

关键词：绝热温升水管冷却改进算法有限元温控仿真

胸部CT椎体hu值在2型糖尿病骨质疏松症机会性筛查中的价值

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中国组织工程研究 2024年第6期28卷 950-954页

作者：王力平连天星胡永荣杨红胜曾智谋刘浩屈波成都医学院第一附属医院骨科四川省成都市610500

背景:有研究表明基于腰椎CT的hu(hounsfield units)值可以筛查骨质疏松症,而目前因肺部感染就诊的患者增加,肺部感染合并2型糖尿病的患者也随之增加,增加了胸部CT的使用率。目的:探讨胸部CT检查中L_1椎体hu值在2型糖尿病骨质疏松症筛查... 详细信息

背景:有研究表明基于腰椎CT的hu(hounsfield units)值可以筛查骨质疏松症,而目前因肺部感染就诊的患者增加,肺部感染合并2型糖尿病的患者也随之增加,增加了胸部CT的使用率。目的:探讨胸部CT检查中L_1椎体hu值在2型糖尿病骨质疏松症筛查中的作用。方法:回顾性分析2020年6月至2022年6月成都医学院第一附属医院收治的244例2型糖尿病患者的临床资料。利用双能X射线骨密度仪获得骨密度T值,按WHO的骨质疏松症诊断标准,将研究对象分为非骨质疏松组(n=120)及骨质疏松组(n=124),比较两组患者一般情况、骨密度T值及胸部CT检查中L_(1)椎体的hu值,分析hu值与各部位T值的关系并评估2型糖尿病骨质疏松症的准确性。结果与结论:(1)两组患者性别、年龄、体质量指数、糖化血红蛋白、平均血糖、钙、磷、2型糖尿病患病时间、高血压病史、高脂血症病史之间对比差异无显著性意义(P>0.05);(2)hu值与最低T值呈正相关(r=0.619,Phu值取98时,其预测2型糖尿病骨质疏松症具有良好的准确性,敏感性为70.8%;(3)提示基于胸部CT检查的L_1椎体hu值对2型糖尿病患者的骨质疏松症筛查具有良好的价值,可作为2型糖尿病骨质疏松症一种机会性、无成本的补充筛查方法。

关键词：胸部CT检查 hu值 2型糖尿病骨质疏松症骨密度

肾透明细胞癌组织中NSUN2的表达及其与临床病理特征和预后的关系

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现代肿瘤医学 2024年第7期32卷 1295-1298页

作者：张媛胡文兵周蔷杜天幸武汉科技大学医学部医学院湖北武汉430081 黄石市中心医院(湖北理工学院附属医院)肿瘤内科肾脏疾病干预与发生湖北省重点实验室湖北黄石435000

目的:检测NSUN2在肾透明细胞癌(ccRCC)组织中的表达,分析其与临床病理特征、预后之间的关系。方法:收集ccRCC组织蜡块标本及对应的癌旁组织蜡块标本各95例,采用免疫组化法检测NSUN2在两组标本中的表达水平,分析NSUN2与ccRCC患者的临床... 详细信息

目的:检测NSUN2在肾透明细胞癌(ccRCC)组织中的表达,分析其与临床病理特征、预后之间的关系。方法:收集ccRCC组织蜡块标本及对应的癌旁组织蜡块标本各95例,采用免疫组化法检测NSUN2在两组标本中的表达水平,分析NSUN2与ccRCC患者的临床病理特征关系。采用Kaplan-Meier法绘制生存曲线,使用Log-rank检验进行单因素生存分析,Cox回归模型进行多因素生存分析,分析NSUN2表达与ccRCC患者预后之间的相关性。结果:NSUN2在癌组织的高表达率为69.5%,在癌旁组织中的高表达率为15.8%,两组差异有统计学意义(P<0.05)。NSUN2高表达与肿瘤大小(P<0.05)、组织学分级(P<0.05)、淋巴转移(P<0.05)及临床分期有关(P<0.05)。Kaplan-Meier分析显示,NSUN2表达水平与ccRCC患者预后相关(P<0.05)。Cox回归模型显示,NSUN2表达是预测ccRCC预后的独立危险因素。结论:NSUN2在ccRCC组织中高表达,且与ccRCC的临床病理特征、预后相关,可作为ccRCC预后判断的指标。

关键词：肾透明细胞癌 NSUN2 免疫组织化学表达预后

基于深度学习的图像识别技术在选矿中的应用进展

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矿冶 2024年第1期33卷 131-140页

作者：胡雅祺孔静李宇恒陈天星西安建筑科技大学资源工程学院西安710055

基于我国开展“矿山智慧化”的战略部署,未来矿产资源开发利用实现机械化、自动化、信息化、智能化已经成为行业发展的必然趋势。近年来,随着计算机图像处理技术的飞速发展,机器视觉在工业中得到广泛应用,基于深度学习的图像识别技术也... 详细信息

基于我国开展“矿山智慧化”的战略部署,未来矿产资源开发利用实现机械化、自动化、信息化、智能化已经成为行业发展的必然趋势。近年来,随着计算机图像处理技术的飞速发展,机器视觉在工业中得到广泛应用,基于深度学习的图像识别技术也将成为选矿厂智能化的重要工具。简述了图像识别的主要技术及方法,介绍了图像识别技术在重选、磁选、浮选中的研究现状,并对图像识别技术在选矿中的应用进行了展望,以期能够为相关学者提供参考。

关键词：图像识别深度学习选矿

Unveiling the Growth Mechanism of Faceted Primary Al_(2)Cu with Complex Morphologies During Solidification

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Acta Metallurgica Sinica(English Letters) 2022年第1期35卷 124-132页

作者： Zongye Ding Qiaodan hu Fan Yang Liao Yu tianxing Yang Naifang Zhang Wenquan Lu Jingwei Yang Jian Qiao Jianguo Li School of Mechatronic Engineering and Automation Foshan UniversityFoshan528225China Shanghai Key Laboratory of Materials Laser Processing and Modification School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China

The growth characteristic of primary faceted Al_(2)Cu intermetallic compounds(IMCs)during solidification was observed directly by synchrotron radiography.The formation and transition mechanisms of Al_(2)Cu IMCs with diverse morphologies were elucidated by first-principle calculations combined with electron backscatter diffraction analysis.The Al_(2)Cu crystals preferred to grow along the[001]direction and were bounded by{110}planes with the lowest surface energy.The faceted Al_(2)Cu rod-like clusters consisted of multiple crystals with complete rod,hollowness and partial sides,which was attributed to the increase in strain energy and solute redistribution during solidification.The faceted Al_(2)Cu with branches was characteristic with the perpendicular relationship between the main branches and side steps and partial coalescence at the junction,which was ascribed to the continuous propagation and growth of newly formed crystals along the diagonal direction.

关键词： Solidification Synchrotron radiography Internetallic compounds Crystal growth Morphology

Characteristics of alveolar macrophages in bronchioalveolar lavage fluids from active tuberculosis patients identified by single-cell RNA sequencing

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The Journal of Biomedical Research 2022年第3期36卷 167-180,I0001,I0002页

作者： Qianqian Chen Chunmei hu Wei Lu tianxing Hang Yan Shao Cheng Chen Yanli Wang Nan Li Linling Jin Wei Wu Hong Wang Xiaoning Zeng Weiping Xie Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Tuberculosis the Second Hospital of NanjingNanjingJiangsu 210029China Jiangsu Provincial Center for Disease Control and Prevention NanjingJiangsu 210029China Department of Bioinformatics Nanjing Medical UniversityNanjingJiangsu 210029China School of Biological Science and Medical Engineering Southeast UniversityNanjingJiangsu 210029China

Tuberculosis(TB),is an infectious disease caused by Mycobacterium tuberculosis(M.tuberculosis),and presents with high morbidity and mortality.Alveolar macrophages play an important role in TB pathogenesis although there is heterogeneity and functional plasticity.This study aimed to show the characteristics of alveolar macrophages from bronchioalveolar lavage fluid(BALF)in active TB patients.Single-cell RNA sequencing(scRNA-seq)was performed on BALF cells from three patients with active TB and additional scRNA-seq data from three healthy adults were established as controls.Transcriptional profiles were analyzed and compared by differential gene expression and functional enrichment analysis.We applied pseudo-temporal trajectory analysis to investigate correlations and heterogeneity within alveolar macrophage subclusters.Alveolar macrophages from active TB patients at the single-cell resolution are described.We found that TB patients have higher cellular percentages in five macrophage subclusters.Alveolar macrophage subclusters with increased percentages were involved in inflammatory signaling pathways as well as the basic macrophage functions.The TB-increased alveolar macrophage subclusters might be derived from M1-like polarization state,before switching to an M2-like polarization state with the development of M.tuberculosis infection.Cell-cell communications of alveolar macrophages also increased and enhanced in active TB patients.Overall,our study demonstrated the characteristics of alveolar macrophages from BALF in active TB patients by using scRNA-seq.

关键词： tuberculosis macrophage bronchioalveolar lavage fluid single-cell RNA sequencing

A biosensing system employing nanowell microelectrode arrays to record the intracellular potential of a single cardiomyocyte

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Microsystems & Nanoengineering 2022年第3期8卷 185-198页

作者： Yuting Xiang Haitao Liu Wenjian Yang Zhongyuan xu Yue Wu Zhajian Tang Zhjing Zhu Zhiyong Zeng Depeng Wang tianxing Wang Ning hu Diming Zhang Department of Obstetrics and Gynecology Affiliated Dongguan People's HospitalSouthern Medical UniversityDongguan 523058China Research Center for Inelligent Sensing Systems Zhejiang LaboratoryHangzhou 311100China Research Center for humanoid Sensing Zhejiang LaboratoryHangzhou 311100China Key Laboratory of Novel Target and Drug Study for Neural Repair of Zhejiang Province School of MedicineSchool of Computer&Computing ScienceZhejiang University City CollegeHangzhou 310015China School of Brain Science and Brain Medicine Zhejiang UniversityHangzhou 310058China School of Automation Nanjing University of Science and TechnologyNanjing 210094China College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China E-Link Care Meditech Co. LtdHangzhou 310011China ZJU-Hangzhou Global Scientific and Technological Innovation Center Department of ChemitryZhejiang UniversityHangzhou 310058China

Electrophysiological recording is a widely used method to investigate cardiovascular pathology,pharmacology and developmental biology.Microelectrode arrays record the electrical potential of cells in a minimally invasive and highthroughput way.However,commonly used microelectrode arays primarily employ planar microelectrodes and cannot work in applications that require a recording of the intracellular action potential of a single cell.In this study,we proposed a novel measuring method that is able to record the intracellular action potential of a single cardiomyocyte by using a nanowell patterned microelectrode array(NWMEA).The NWMEA consists of five nanoscale wells at the center of each circular planar microelectrode.Biphasic pulse electroporation was applied to the NWMEA to penetrate the cardiomyocyte membrane,and the intracellular action potential was continuously recorded.The intracellular potential recording of cardiomyocytes by the NWMEA measured a potential signal with a higher quality(213.76±25.85%),reduced noise root-mean-square(~33%),and higher signal-to-noise ratio(254.36±12.61%)when compared to those of the extracellular recording.Compared to previously reported nanopillar microelectrodes,the NWMEA could ensure single cell electroporation and acquire high-quality action potential of cardiomyocytes with reduced fabrication processes.This NWMEA-based biosensing system is a promising tool to record the intracellular action potential of a single cell to broaden the usage of microelectrode arrays in electrophysiological investigation.

关键词： arrays potential record

In-situ study on hydrogen bubble evolution in the liquid Al/solid Ni interconnection by synchrotron radiation X-ray radiography

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Journal of Materials Science & Technology 2019年第7期35卷 1388-1392页

作者： Zongye Ding Qiaodan hu Wenquan Lu Xuan Ge Sheng Cao Siyu Sun tianxing Yang Mingxu Xia Jianguo Li Shanghai Key Laboratory of Materials Laser Processing Modification School of Materials Science and EngineeringShanghai Jiao Tong University200240ShanghaiChina Monash Centre for Additive Manufacturing (MCAM) Monash UniversityClaytonVIC3800Australia

Synchrotron X-ray radiography was used to carry out an in-situ observation of the hydrogen bubble evolution in the liquid Al/solid Ni interconnection. The individual bubble mainly grows in a stochastic way during heating. The size distribution for groups of bubbles follows a Gaussian distribution in the early stage and Lifshitz-Slyozov-Wagner(LSW) diffusion controlled distribution in the final stage. The intermetallic compounds(IMCs) first form during solidification, following by the hydrogen bubbles. The bubbles between two adjacent Al3Ni grains grow unidirectionally along the liquid channel, with the bottom being impeded by the Al3Ni phase and the radius of the growth front being smaller. For the bubbles at triple junctions, they grow along the liquid channel and the crack with morphology transition.

关键词： Synchrotron radiation Liquid Al/solid Ni interconnection Hydrogen bubble Intermetallic compounds Growth behavior