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Decreased expression of the lncRNA CASC2 predicts advanced clinicopathological features and serves as an unfavorable risk factor for cancer patient survival

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Decreased expression of the lncRNA CASC2 predicts advanced c...

Prognostic value of the long noncoding RNA AFAP1-AS1 in cancers

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： tianrui xu Guoqiang xu Lixiu Zhu Department of Radiotherapy Yunnan Cancer Hospitalthe Third Affiliated Hospital of Kunming Medical University

Background:Cancer susceptibility candidate gene 2(CASC2) exhibits low expression in different carcinomas and is involved in cancer *** aimed of this study was to assess the value of CASC2 as a prognostic marker for ***:Two authors independently searched five databases for eligible studies from inception to June 2,*** hazard ratios(HRs),odds ratios(ORs),and 95% confidence intervals(CIs) were calculated using Review Manager *** MP 16.0 was utilized to perform the publication bias and sensitivity *** validated the results by Gene Expression Profiling Interaction Analysis 2(GEPIA2).Results:Twenty studies involving 1414 people encompassing 11 malignancies across five systems,were ***2 downregulation was markedly correlated with shorter overall survival(OS) in cancer patients(HR= 0.49;95% CI,0.41–0.60;P<0.00001).Furthermore,CASC2 downregulation was associated with advanced TNM stage(OR= 0.32;95% CI,0.25–0.42;P<0.00001),larger tumor size(OR= 0.48;95% CI,0.31–0.75;P= 0.001),and poor tumor differentiation(OR= 0.39;95% CI,0.27–0.56;P<0.00001) but not with age,sex,or distant ***2 downregulation was directly related to poor differentiation in digestive system cancers(OR= 0.53;95% CI,0.31–0.91;P= 0.02).Low CASC2 expression was related to negative lymph node metastasis in digestive system(OR= 1.96;95% CI,1.08–3.55;P= 0.03) and female reproductive system cancers(OR= 2.11;95% CI,1.16–3.85;P= 0.01).Conclusions:CASC2 expression is directly correlated with prognostic and clinicopathological characteristics in tumor patients,indicating that CASC2 might be a viable therapeutic target and a predictor of poor prognosis.

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Oncology and Translational Medicine 2023年第3期9卷 133-146页

作者： Lixiu Zhu Jiawen Yan Guoqiang xu Qiaoli Wang tianrui xu Ruixue Cao Chuanzheng Sun Yan Xi Wei Xiong Department of Radiotherapy Yunnan Cancer HospitalThe Third Affiliated Hospital of Kunming Medical UniversityKunming 650000China Department of Radiotherapy People's Hospital of Yuxi CityThe Sixth Affiliated Hospital of Kunming Medical UniversityYuxi 653100China Department of Head and Neck Surgery Yunnan Cancer HospitalThe Third Affiliated Hospital of Kunming Medical UniversityKunming 650000China

Objective This meta-analysis explored whether the expression of actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1)is related to the prognosis and clinicopathological features of patients with *** PubMed,EMBASE,and Cochrane Library were systematically *** ratios(HRs)with 95%confidence intervals(CIs)were used to assess the prognostic value based on overall survival(OS),disease-free survival(DFS),and progression-free survival(PFS).Odds ratios(ORs)with 95%CIs were used to determine the relationships between AFAP1-AS1 and clinicopathological features,such as large tumor size(LTS),high tumor stage(HTS),poor histological grade(PHG),lymph node metastasis(LNM),and distant metastasis(DM).Results Thirty-five eligible articles and 3433 cases were *** AFAP1-AS1 expression,compared to low AFAP1-AS1 expression,correlated with significantly shorter OS(HR=2.15,95%CI=1.97-2.34,P<0.001),DFS(HR=1.37,95%CI=1.19-1.57,P<0.001),and PFS(HR=1.97,95%CI=1.56-2.50,P<0.001)in patients with *** various cancers,elevated AFAP1-AS1 expression was significantly associated with LTS(OR=2.76,95%CI=2.16-3.53,P<0.001),HTS(OR=2.23,95%CI=1.83-2.71,P<0.001),and PHG(OR=1.39,95%CI=1.08-1.79,P=0.01)but not LNM(OR=1.59,95%CI=0.88-2.85,P=0.12)or DM(OR=1.81,95%CI=0.90-3.66,P=0.10).Conclusion High AFAP1-AS1 expression was associated with prognostic and clinicopathological features,suggesting that AFAP1-AS1 is a prognostic biomarker for human cancers.

关键词： long noncoding RNA(lncRNA) actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1) prognostic meta-analysis

适应三相不平衡主动配电网无功优化的二阶锥松弛模型

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电力系统自动化 2021年第24期45卷 81-88页

作者：徐添锐丁涛李立王康迟方德高虎成西安交通大学电气工程学院陕西省西安市710049 国网陕西省电力公司陕西省西安市710048

三相不平衡主动配电网无功优化的非凸非线性给全局优化求解带来一定挑战。传统方法采用二阶锥松弛方法来凸化原始非凸优化模型,从而实现全局最优解的有效搜索。然而,传统所提方法忽略了三相配电网相间耦合关系,从而导致三相不平衡场景... 详细信息

三相不平衡主动配电网无功优化的非凸非线性给全局优化求解带来一定挑战。传统方法采用二阶锥松弛方法来凸化原始非凸优化模型,从而实现全局最优解的有效搜索。然而,传统所提方法忽略了三相配电网相间耦合关系,从而导致三相不平衡场景下与全局最优解之间存在误差。为此,文中提出适应三相不平衡主动配电网无功优化的二阶锥松弛模型,通过将原始优化模型映射到高维空间,松弛秩约束,并采用Sylvester准则形成相间二阶锥约束。最后,通过IEEE 33节点、IEEE 123节点和906节点算例仿真分析验证了所提方法的有效性。

关键词：主动配电网三相不平衡配电系统二阶锥松弛无功优化分布式电源

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胃肠激素对肥胖的影响及抗肥胖药物研究进展

昆明理工大学学报（自然科学版） 2024年第3期49卷 218-228页

作者：安输白娅徐天瑞昆明理工大学生命科学与技术学院云南昆明650500 云南省高校靶点药物筛选与利用重点实验室云南昆明650500

在过去30年中,肥胖已成为全球关注的主要公共卫生问题,其发病率显著上升,全球患病人数已达10.38亿.肥胖不仅增加了2型糖尿病、心血管疾病及某些恶性肿瘤的患病风险,还带来了严重的经济和社会负担.作为一种异质性疾病,肥胖的发生与多种... 详细信息

在过去30年中,肥胖已成为全球关注的主要公共卫生问题,其发病率显著上升,全球患病人数已达10.38亿.肥胖不仅增加了2型糖尿病、心血管疾病及某些恶性肿瘤的患病风险,还带来了严重的经济和社会负担.作为一种异质性疾病,肥胖的发生与多种因素相关,其中摄食过多和能量消耗过少是主要原因.近年来,研究发现胃肠激素在调节进食和能量代谢中起着关键作用.综述了多种胃肠激素如胰高血糖素样肽-1(GLP-1)、葡萄糖依赖性促胰岛素多肽(GIP)和饥饿素(Ghrelin)等在肥胖中的作用机制,并重点介绍了基于这些激素抗肥胖药物的研发进展,特别是GLP-1受体激动剂已显示出显著的临床疗效,成为治疗肥胖的重要药物.通过总结当前的研究成果和临床试验数据,旨在为未来的肥胖治疗提供新的思路和方向.

关键词：胃肠激素肥胖抗肥胖药物胰高血糖素样肽-1受体胰高血糖素受体

A Generalized Rough Set Approach to Attribute Generalization in Data Mining

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Journal of Modern Transportation 2000年第1期17卷 69-75页

作者：李天瑞徐扬 Department of Applied Mathematics Southwest Jiaotong University Chengdu 610031 China

This paper presents a generalized method for updating approximations of a concept incrementally, which can be used as an effective tool to deal with dynamic attribute generalization. By combining this method and the LERS inductive learning algorithm, it also introduces a generalized quasi incremental algorithm for learning classification rules from data bases.

关键词： rough set data mining inductive learning

Relatively rapid evolution rates of SARS-CoV-2 spike gene at the primary stage of massive vaccination

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Biosafety and Health 2022年第4期4卷 228-233页

作者： Jing Yang Min Han Liang Wang Likui Wang tianrui xu Linhuan Wu Juncai Ma Gary Wong Wenjun Liu George F.Gao Yuhai Bi CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Anatomy and Cell Biology McGill UniversityMontreal H3A0G4Canada Microbial Resource and Big Data Center Chinese National Microbiology Data Center(NMDC)Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai 200031China

A series of stringent non-pharmacological and pharmacological interventions were implemented to contain the pandemic but the pandemic ***,vaccination breakthrough infection and reinfection in convalescent coronavirus disease 2019(COVID-19)cases have been ***,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants emerged with mutations in spike(S)gene,the target of most current ***,the mutations exhibit a trend of immune escape from the *** the scientific question that if the vaccination drives genetic or antigenic drifts of SARS-CoV-2 remains *** performed correlation analyses to uncover the impacts of wide vaccination on epidemiological characteristics of *** addition,we investigated the evolutionary dynamics and genetic diversity of SARS-CoV-2 under immune pressure by utilizing the Bayesian phylodynamic inferences and the lineage entropy calculation *** found that vaccination coverage was negatively related to the infections,severe cases,and deaths of COVID-19 *** the increasing vaccination coverage,the lineage diversity of SARS-CoV-2 dampened,but the rapid mutation rates of the S gene were identified,and the vaccination could be one of the explanations for driving mutations in S ***,new epidemics resurged in several countries with high vaccination coverage,questioning their current pandemic control ***,integrated vaccination and non-pharmacological interventions are critical to control the ***,novel vaccine preparation should enhance its capabilities to curb both disease severity and infection possibility.

关键词： SARS-CoV-2 Vaccine Genetic evolution Genetic drift Antigenic drift Lineage divergence Epidemiological characteristics

PC 12细胞定性及定量测定神经生长因子活性的新方法

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华西药学杂志 1999年第5期14卷 311-314页

作者：董跃伟徐天瑞熊郁良徐康森云南省药品检验所昆明650011

对用ＰＣ１２细胞培养测定神经生长因子活性的方法进行了探索，通过对几种培养条件的比较，找出了较为理想的能定性及定量测定神经生长因子的两种方法，为神经生长因子作为新药检测手段提供了一条新途径。

关键词： PC12细胞神经生长因子活性测定

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普洱熟茶化学成分研究进展

食品与发酵工业 2019年第12期45卷 285-290页

作者：孟宪钰付亚轩李明超徐天瑞郝倩昆明理工大学生命科学与技术学院云南省高校靶点药物筛选与利用重点实验室

普洱熟茶是一种独特的微生物发酵茶,由中国云南省的大叶种茶的晒干叶制成,为中国特有名茶。近年来,普洱熟茶由于其降血脂、抗氧化、减肥、抗菌等多重保健功效而备受欢迎,目前已从普洱熟茶中分离出多种功能性成分并进行了验证。该文综述... 详细信息

普洱熟茶是一种独特的微生物发酵茶,由中国云南省的大叶种茶的晒干叶制成,为中国特有名茶。近年来,普洱熟茶由于其降血脂、抗氧化、减肥、抗菌等多重保健功效而备受欢迎,目前已从普洱熟茶中分离出多种功能性成分并进行了验证。该文综述了近年来国内外对普洱熟茶化学成分及主要化学成分转化的研究,特别是普洱茶中特有的加成儿茶素类成分,为进一步研究普洱熟茶的生物活性物质及其形成机制提供了一定的理论基础。

关键词：普洱茶化学成分转化

补阳还五汤调控脊髓损伤后NLRP3炎症体介导炎症反应的机制

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国际中医中药杂志 2020年第6期42卷 552-556页

作者：丁洁徐天睿范筱中国人民解放军陆军第73集团军医院中医康复理疗科厦门361003 中国人民解放军陆军第73集团军医院骨科中心一区厦门361003 山东省青岛市市立医院中医科 266011 海洋生物医药资源福建省高校应用技术工程中心厦门361023

目的研究补阳还五汤对脊髓损伤后NOD样受体家族3(NOD-like receptors,NLRP3)炎症体介导炎症的作用机制。方法将48只大鼠按随机数字表分为假手术组、模型组、补阳还五汤组,每组16只。模型组和补阳还五汤组采用脊髓打击器击打脊髓,建立脊... 详细信息

目的研究补阳还五汤对脊髓损伤后NOD样受体家族3(NOD-like receptors,NLRP3)炎症体介导炎症的作用机制。方法将48只大鼠按随机数字表分为假手术组、模型组、补阳还五汤组,每组16只。模型组和补阳还五汤组采用脊髓打击器击打脊髓,建立脊髓损伤模型。补阳还五汤组灌胃补阳还五汤12.6 g/(kg·d),假手术组与模型组灌胃等体积无菌生理盐水,1次/d,连续给药3 d。采用尼氏染色法观察各组脊髓组织神经细胞形态,免疫组化染色法检测脊髓组织NLRP3表达,ELISA法检测血清IL-1β、IL-18水平,Western Blot检测脊髓组织活化型半胱氨酸天冬氨酸蛋白酶1(cleaved Systeinyl aspartate-specific protease,cleaved-Caspase1)表达。结果与模型组比较,补阳还五汤组脊髓组织NLRP3阳性表达平均光密度值[(0.54±0.04)比(0.78±0.06)]降低(P<0.05),血清IL-1β[(43.66±1.21)pg/ml比(67.64±2.43)pg/ml]、IL-18[(49.43±3.88)pg/ml比(65.87±2.53)pg/ml]水平降低(P<0.05),脊髓组织cleaved-Caspase1蛋白[(0.63±0.02)比(0.79±0.07)]表达降低(P<0.05)。结论补阳还五汤通过抑制脊髓损伤后NLRP3炎症体表达,减少Caspase1活化,从而减轻炎症反应。

关键词：补阳还五汤脊髓损伤炎症半胱氨酸天冬氨酸蛋白酶1 大鼠