Prognostic value of the long noncoding RNA AFAP1-AS1 in cancers

作     者：Lixiu Zhu Jiawen Yan Guoqiang Xu Qiaoli Wang Tianrui Xu Ruixue Cao Chuanzheng Sun Yan Xi Wei Xiong Lixiu Zhu;Jiawen Yan;Guoqiang Xu;Qiaoli Wang;Tianrui Xu;Ruixue Cao;Chuanzheng Sun;Yan Xi;Wei Xiong

作者机构：Department of RadiotherapyYunnan Cancer HospitalThe Third Affiliated Hospital of Kunming Medical UniversityKunming 650000China Department of RadiotherapyPeople's Hospital of Yuxi CityThe Sixth Affiliated Hospital of Kunming Medical UniversityYuxi 653100China Department of Head and Neck SurgeryYunnan Cancer HospitalThe Third Affiliated Hospital of Kunming Medical UniversityKunming 650000China 

出 版 物：《Oncology and Translational Medicine》 (肿瘤学与转化医学（英文版）)

年 卷 期：2023年第9卷第3期

页      面：133-146页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by a grant from the“Ten Thousand Plan”Youth Talent Project in Yunnan Province(no grant number is applicable). 

主　　题：long noncoding RNA(lncRNA) actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1) prognostic meta-analysis 

摘      要：Objective This meta-analysis explored whether the expression of actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1)is related to the prognosis and clinicopathological features of patients with cancer.Methods PubMed,EMBASE,and Cochrane Library were systematically searched.Hazard ratios(HRs)with 95%confidence intervals(CIs)were used to assess the prognostic value based on overall survival(OS),disease-free survival(DFS),and progression-free survival(PFS).Odds ratios(ORs)with 95%CIs were used to determine the relationships between AFAP1-AS1 and clinicopathological features,such as large tumor size(LTS),high tumor stage(HTS),poor histological grade(PHG),lymph node metastasis(LNM),and distant metastasis(DM).Results Thirty-five eligible articles and 3433 cases were analyzed.High AFAP1-AS1 expression,compared to low AFAP1-AS1 expression,correlated with significantly shorter OS(HR=2.15,95%CI=1.97-2.34,P0.001),DFS(HR=1.37,95%CI=1.19-1.57,P0.001),and PFS(HR=1.97,95%CI=1.56-2.50,P0.001)in patients with cancer.In various cancers,elevated AFAP1-AS1 expression was significantly associated with LTS(OR=2.76,95%CI=2.16-3.53,P0.001),HTS(OR=2.23,95%CI=1.83-2.71,P0.001),and PHG(OR=1.39,95%CI=1.08-1.79,P=0.01)but not LNM(OR=1.59,95%CI=0.88-2.85,P=0.12)or DM(OR=1.81,95%CI=0.90-3.66,P=0.10).Conclusion High AFAP1-AS1 expression was associated with prognostic and clinicopathological features,suggesting that AFAP1-AS1 is a prognostic biomarker for human cancers.