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Relatively rapid evolution rates of SARS-CoV-2 spike gene at the primary stage of massive vaccination

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Biosafety and Health 2022年第4期4卷 228-233页

作者： Jing Yang Min Han Liang Wang Likui Wang tianrui xu Linhuan Wu Juncai Ma Gary Wong Wenjun Liu George F.Gao Yuhai Bi CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Anatomy and Cell Biology McGill UniversityMontreal H3A0G4Canada Microbial Resource and Big Data Center Chinese National Microbiology Data Center(NMDC)Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai 200031China

A series of stringent non-pharmacological and pharmacological interventions were implemented to contain the pandemic but the pandemic continues.Moreover,vaccination breakthrough infection and reinfection in convalescent coronavirus disease 2019(COVID-19)cases have been reported.Further,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants emerged with mutations in spike(S)gene,the target of most current vaccines.Importantly,the mutations exhibit a trend of immune escape from the vaccination.Herein the scientific question that if the vaccination drives genetic or antigenic drifts of SARS-CoV-2 remains elusive.We performed correlation analyses to uncover the impacts of wide vaccination on epidemiological characteristics of COVID-19.In addition,we investigated the evolutionary dynamics and genetic diversity of SARS-CoV-2 under immune pressure by utilizing the Bayesian phylodynamic inferences and the lineage entropy calculation respectively.We found that vaccination coverage was negatively related to the infections,severe cases,and deaths of COVID-19 respectively.With the increasing vaccination coverage,the lineage diversity of SARS-CoV-2 dampened,but the rapid mutation rates of the S gene were identified,and the vaccination could be one of the explanations for driving mutations in S gene.Moreover,new epidemics resurged in several countries with high vaccination coverage,questioning their current pandemic control strategies.Hence,integrated vaccination and non-pharmacological interventions are critical to control the pandemic.Furthermore,novel vaccine preparation should enhance its capabilities to curb both disease severity and infection possibility.

关键词： SARS-CoV-2 Vaccine Genetic evolution Genetic drift Antigenic drift Lineage divergence Epidemiological characteristics

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胃肠激素对肥胖的影响及抗肥胖药物研究进展

昆明理工大学学报（自然科学版） 2024年第3期49卷 218-228页

作者：安输白娅徐天瑞昆明理工大学生命科学与技术学院云南昆明650500 云南省高校靶点药物筛选与利用重点实验室云南昆明650500

在过去30年中,肥胖已成为全球关注的主要公共卫生问题,其发病率显著上升,全球患病人数已达10.38亿.肥胖不仅增加了2型糖尿病、心血管疾病及某些恶性肿瘤的患病风险,还带来了严重的经济和社会负担.作为一种异质性疾病,肥胖的发生与多种... 详细信息

在过去30年中,肥胖已成为全球关注的主要公共卫生问题,其发病率显著上升,全球患病人数已达10.38亿.肥胖不仅增加了2型糖尿病、心血管疾病及某些恶性肿瘤的患病风险,还带来了严重的经济和社会负担.作为一种异质性疾病,肥胖的发生与多种因素相关,其中摄食过多和能量消耗过少是主要原因.近年来,研究发现胃肠激素在调节进食和能量代谢中起着关键作用.综述了多种胃肠激素如胰高血糖素样肽-1(GLP-1)、葡萄糖依赖性促胰岛素多肽(GIP)和饥饿素(Ghrelin)等在肥胖中的作用机制,并重点介绍了基于这些激素抗肥胖药物的研发进展,特别是GLP-1受体激动剂已显示出显著的临床疗效,成为治疗肥胖的重要药物.通过总结当前的研究成果和临床试验数据,旨在为未来的肥胖治疗提供新的思路和方向.

关键词：胃肠激素肥胖抗肥胖药物胰高血糖素样肽-1受体胰高血糖素受体

Prognostic value of the long noncoding RNA AFAP1-AS1 in cancers

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Oncology and Translational Medicine 2023年第3期9卷 133-146页

作者： Lixiu Zhu Jiawen Yan Guoqiang xu Qiaoli Wang tianrui xu Ruixue Cao Chuanzheng Sun Yan Xi Wei Xiong Department of Radiotherapy Yunnan Cancer HospitalThe Third Affiliated Hospital of Kunming Medical UniversityKunming 650000China Department of Radiotherapy People's Hospital of Yuxi CityThe Sixth Affiliated Hospital of Kunming Medical UniversityYuxi 653100China Department of Head and Neck Surgery Yunnan Cancer HospitalThe Third Affiliated Hospital of Kunming Medical UniversityKunming 650000China

Objective This meta-analysis explored whether the expression of actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1)is related to the prognosis and clinicopathological features of patients with cancer.Methods PubMed,EMBASE,and Cochrane Library were systematically searched.Hazard ratios(HRs)with 95%confidence intervals(CIs)were used to assess the prognostic value based on overall survival(OS),disease-free survival(DFS),and progression-free survival(PFS).Odds ratios(ORs)with 95%CIs were used to determine the relationships between AFAP1-AS1 and clinicopathological features,such as large tumor size(LTS),high tumor stage(HTS),poor histological grade(PHG),lymph node metastasis(LNM),and distant metastasis(DM).Results Thirty-five eligible articles and 3433 cases were analyzed.High AFAP1-AS1 expression,compared to low AFAP1-AS1 expression,correlated with significantly shorter OS(HR=2.15,95%CI=1.97-2.34,P<0.001),DFS(HR=1.37,95%CI=1.19-1.57,P<0.001),and PFS(HR=1.97,95%CI=1.56-2.50,P<0.001)in patients with cancer.In various cancers,elevated AFAP1-AS1 expression was significantly associated with LTS(OR=2.76,95%CI=2.16-3.53,P<0.001),HTS(OR=2.23,95%CI=1.83-2.71,P<0.001),and PHG(OR=1.39,95%CI=1.08-1.79,P=0.01)but not LNM(OR=1.59,95%CI=0.88-2.85,P=0.12)or DM(OR=1.81,95%CI=0.90-3.66,P=0.10).Conclusion High AFAP1-AS1 expression was associated with prognostic and clinicopathological features,suggesting that AFAP1-AS1 is a prognostic biomarker for human cancers.

关键词： long noncoding RNA(lncRNA) actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1) prognostic meta-analysis

Decreased expression of the lncRNA CASC2 predicts advanced clinicopathological features and serves as an unfavorable risk factor for cancer patient survival

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Decreased expression of the lncRNA CASC2 predicts advanced c...

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学...

作者： tianrui xu Guoqiang xu Lixiu Zhu Department of Radiotherapy Yunnan Cancer Hospitalthe Third Affiliated Hospital of Kunming Medical University

Background:Cancer susceptibility candidate gene 2(CASC2) exhibits low expression in different carcinomas and is involved in cancer progression.The aimed of this study was to assess the value of CASC2 as a prognostic marker for cancers.Methods:Two authors independently searched five databases for eligible studies from inception to June 2,2022.Combined hazard ratios(HRs),odds ratios(ORs),and 95% confidence intervals(CIs) were calculated using Review Manager 5.4.Stata MP 16.0 was utilized to perform the publication bias and sensitivity analyses.We validated the results by Gene Expression Profiling Interaction Analysis 2(GEPIA2).Results:Twenty studies involving 1414 people encompassing 11 malignancies across five systems,were considered.CASC2 downregulation was markedly correlated with shorter overall survival(OS) in cancer patients(HR= 0.49;95% CI,0.41–0.60;P<0.00001).Furthermore,CASC2 downregulation was associated with advanced TNM stage(OR= 0.32;95% CI,0.25–0.42;P<0.00001),larger tumor size(OR= 0.48;95% CI,0.31–0.75;P= 0.001),and poor tumor differentiation(OR= 0.39;95% CI,0.27–0.56;P<0.00001) but not with age,sex,or distant metastasis.CASC2 downregulation was directly related to poor differentiation in digestive system cancers(OR= 0.53;95% CI,0.31–0.91;P= 0.02).Low CASC2 expression was related to negative lymph node metastasis in digestive system(OR= 1.96;95% CI,1.08–3.55;P= 0.03) and female reproductive system cancers(OR= 2.11;95% CI,1.16–3.85;P= 0.01).Conclusions:CASC2 expression is directly correlated with prognostic and clinicopathological characteristics in tumor patients,indicating that CASC2 might be a viable therapeutic target and a predictor of poor prognosis.

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基于文献计量的天麻道地性形成原因分析

昆明理工大学学报（自然科学版） 2022年第6期47卷 93-107页

作者：杜倩倩杨烨浩徐天瑞王忠巧向诚昆明理工大学生命科学与技术学院云南昆明650500 云南省高校靶点药物筛选与利用重点实验室云南昆明650500 彝良县天麻产业开发中心云南昭通657600

以天麻的有效成分含量为品质评价指标,结合中医药理论和文献计量学方法对天麻道地性形成的原因进行分析,以期为天麻品质评价提供参考.统计分析发现,加工炮制为影响天麻品质的最主要因素,煮制块能提高天麻品质;各个产地中,云南产天麻综... 详细信息

以天麻的有效成分含量为品质评价指标,结合中医药理论和文献计量学方法对天麻道地性形成的原因进行分析,以期为天麻品质评价提供参考.统计分析发现,加工炮制为影响天麻品质的最主要因素,煮制块能提高天麻品质;各个产地中,云南产天麻综合品质较优;多个天麻品种中,乌天麻品种最优.天麻的种植采收因素较多,各地可因地制宜,开发优良菌株及天麻种用于天麻种植生产,以期提高天麻品质.

关键词：天麻道地性文献计量天麻品质天麻的有效成分

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南极光学天文望远镜控制软件关键技术

极地研究 2024年第1期36卷 99-111页

作者：李晓燕李运孙天瑞杨世海杜福嘉徐灵哲中国科学院南京天文光学技术研究所江苏南京210042 中国科学院天文光学技术重点实验室(南京天文光学技术研究所) 江苏南京210042 中国科学院紫金山天文台江苏南京210023

南极天文望远镜控制软件是望远镜软件系统的重要组成部分,是控制计算机在望远镜用户层和设备层之间运行的关键技术。对于用户层,控制软件需具备全自动观测的交互接口、卫星通信条件下的远程访问和故障诊断等功能;对于设备层,控制软件不... 详细信息

南极天文望远镜控制软件是望远镜软件系统的重要组成部分,是控制计算机在望远镜用户层和设备层之间运行的关键技术。对于用户层,控制软件需具备全自动观测的交互接口、卫星通信条件下的远程访问和故障诊断等功能;对于设备层,控制软件不但要完成对天体目标的精确指向和精密跟踪、计算并补偿系统误差和控制关键部件以达到目标像质,而且需实现对电源分配系统、除霜及加热系统的控制、设备及环境信息的采集和监测等。相比于普通台址,在南极大陆运行的光学天文望远镜有其独特的特点,控制软件需进行特殊设计。本文重点从操作系统选择、远程建立望远镜指向误差修正模型方法、全自动观测软件接口、卫星通信及远程运维、望远镜实时状态监测和故障诊断等方面探讨了南极天文光学望远镜控制软件的关键技术和设计原则,并展望未来技术的发展,为南极天文望远镜的研制和控制系统研发提供技术储备。

关键词：光学天文望远镜控制软件无人值守运行全自动观测指向误差修正故障诊断南极洲

V和B元素对Ti-44Al-5Nb-1Mo合金显微组织及热变形机制的影响

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金属学报 2024年第5期60卷 650-660页

作者：李天瑞许瑜倩吴文平甘文萱杨永刘国怀王昭东安徽工业大学冶金工程学院马鞍山243000 东北大学轧制技术与连轧自动化国家重点实验室沈阳110819

为了探究V和B元素复合添加对β型γ-TiAl合金的显微组织和变形机制产生的影响,本工作针对Ti-44Al-5Nb-1Mo合金和Ti-44Al-5Nb-1Mo-2V-0.2B合金,进行了不同温度和应变速率条件下的高温热压缩实验,利用SEM-BSE和TEM对组织进行表征,对比分... 详细信息

为了探究V和B元素复合添加对β型γ-TiAl合金的显微组织和变形机制产生的影响,本工作针对Ti-44Al-5Nb-1Mo合金和Ti-44Al-5Nb-1Mo-2V-0.2B合金,进行了不同温度和应变速率条件下的高温热压缩实验,利用SEM-BSE和TEM对组织进行表征,对比分析了其变形后的显微组织,研究了添加V和B对Ti-44Al-5Nb-1Mo合金的显微组织及热变形机制的影响。结果表明,2种TiAl合金的显微组织差异较大,添加V和B可以显著改变TiAl合金对热变形的敏感性。Ti-44Al-5Nb-1Mo-2V-0.2B合金高温变形能力明显优于Ti-44Al-5Nb-1Mo合金。Ti-44Al-5Nb-1Mo合金的高温热变形以难变形片层团的偏转、变形带的产生为主,温度为1250℃时,其变形组织表现出较高的温度和应变速率敏感性,极易形成尺寸不均匀的近片层组织;对于Ti-44Al-5Nb-1Mo-2V-0.2B合金而言,升高变形温度或降低应变速率,既可以促进片层团内部的变形诱导L(α/γ)→α+γ+β/B2和γ→α相变,又可以促进α和β/B2相的球化/动态再结晶,从而大幅提高该合金的组织均匀性。基于变形参数对组织的影响规律,确定了控制Ti-44Al-5Nb-1Mo和Ti-44Al-5Nb-1Mo-2V-0.2B合金中近全片层、近双态显微组织的方法。

关键词： TiAl合金 (V,B)合金化热变形显微组织

适应三相不平衡主动配电网无功优化的二阶锥松弛模型

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电力系统自动化 2021年第24期45卷 81-88页

作者：徐添锐丁涛李立王康迟方德高虎成西安交通大学电气工程学院陕西省西安市710049 国网陕西省电力公司陕西省西安市710048

三相不平衡主动配电网无功优化的非凸非线性给全局优化求解带来一定挑战。传统方法采用二阶锥松弛方法来凸化原始非凸优化模型,从而实现全局最优解的有效搜索。然而,传统所提方法忽略了三相配电网相间耦合关系,从而导致三相不平衡场景... 详细信息

三相不平衡主动配电网无功优化的非凸非线性给全局优化求解带来一定挑战。传统方法采用二阶锥松弛方法来凸化原始非凸优化模型,从而实现全局最优解的有效搜索。然而,传统所提方法忽略了三相配电网相间耦合关系,从而导致三相不平衡场景下与全局最优解之间存在误差。为此,文中提出适应三相不平衡主动配电网无功优化的二阶锥松弛模型,通过将原始优化模型映射到高维空间,松弛秩约束,并采用Sylvester准则形成相间二阶锥约束。最后,通过IEEE 33节点、IEEE 123节点和906节点算例仿真分析验证了所提方法的有效性。

关键词：主动配电网三相不平衡配电系统二阶锥松弛无功优化分布式电源

A Generalized Rough Set Approach to Attribute Generalization in Data Mining

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Journal of Modern Transportation 2000年第1期17卷 69-75页

作者：李天瑞徐扬 Department of Applied Mathematics Southwest Jiaotong University Chengdu 610031 China

This paper presents a generalized method for updating approximations of a concept incrementally, which can be used as an effective tool to deal with dynamic attribute generalization. By combining this method and the LERS inductive learning algorithm, it also introduces a generalized quasi incremental algorithm for learning classification rules from data bases.

关键词： rough set data mining inductive learning