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Research on the Orientated Effective Components of Huangqi in Huangqi Jianzhong Tang Against Chronic Atrophic Gastritis Based on Multi-Spectrum–Effect Correlation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 244-253页

作者： Guo-Hong Wang Long-Fei Yang Shi-Wei Wang Yue-Tao liu Department of Pharmacy Shanxi Traditional Chinese Medicine HospitalTaiyuanShanxi ProvinceChina Department of Pharmacy Shijazhuang Hospital of Traditional Chinese MedicineShijiazhuangHebeiChina Modern Research Center for Traditional Chinese Medicine Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of EducationTaiyuanShanxi ProvinceChina Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province Shanxi UniversityTaiyuanShanxi ProvinceChina

Objective: This study aimed to investigate the orientated effective components of Astragali Radix Huangqi(HQ) in HQ Jianzhong Tang(HQJZ), a classical formula of traditional Chinese medicine(TCM) used for treating chronic atrophic gastritis(CAG), using HQ as a monarch medicine. Materials and Methods: The spectra of HQJZ containing different polar parts of HQ were obtained using ultra-high-performance liquid chromatography-Q-Exactive mass spectrometry. Furthermore, the efficacy of HQJZ, which contains different polar parts of HQ, in treating rats with CAG was evaluated using traditional pharmacodynamic and nuclear magnetic resonance-based metabonomics. Grey relation analysis and partial least squares analysis were applied to analyze the spectrum–effect relationship and to screen out the orientated effective components related to HQ in the treatment of CAG. Results: Spectrum–effect relationship analysis showed that 24 compounds identified from the fingerprint spectrum were strongly correlated with efficacy. Compounds 8(calycosin-7-O-glc-6”-O-acetate), 9(3-hydroxy-9, 10-dimethoxyptercarpan), and 22(astragaloside II) were ranked among the top three. Conclusions: This study showed that integrating metabolomics and spectrum–effect relationship analysis is a powerful tool for obtaining orientated effective components of Chinese medicine in a given TCM formula.

关键词： Astragali radix chronic atrophic gastritis Huangqi Jianzhong Tang metabonomics spectrum–effect relationship

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A transfer learning enhanced physics-informed neural network for parameter identification in soft materials

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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1685-1704页

作者： Jing'ang ZHU Yiheng XUE Zishun liu International Center for Applied Mechanics State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi'an Jiaotong University

Soft materials, with the sensitivity to various external stimuli, exhibit high flexibility and stretchability. Accurate prediction of their mechanical behaviors requires advanced hyperelastic constitutive models incorporating multiple parameters. However,identifying multiple parameters under complex deformations remains a challenge, especially with limited observed data. In this study, we develop a physics-informed neural network(PINN) framework to identify material parameters and predict mechanical fields,focusing on compressible Neo-Hookean materials and hydrogels. To improve accuracy, we utilize scaling techniques to normalize network outputs and material parameters. This framework effectively solves forward and inverse problems, extrapolating continuous mechanical fields from sparse boundary data and identifying unknown mechanical *** explore different approaches for imposing boundary conditions(BCs) to assess their impacts on accuracy. To enhance efficiency and generalization, we propose a transfer learning enhanced PINN(TL-PINN), allowing pre-trained networks to quickly adapt to new scenarios. The TL-PINN significantly reduces computational costs while maintaining accuracy. This work holds promise in addressing practical challenges in soft material science, and provides insights into soft material mechanics with state-of-the-art experimental methods.

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Key progresses of MOE key laboratory of macromolecular synthesis and functionalization in 2022

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Chinese Chemical Letters 2024年第3期35卷 114-126页

作者： Xumeng Deng Kaihao Chen Kai Pang Xiaoting liu Minsong Gao Jie Ren Guanwen Yang Guangpeng Wu Chengjian Zhang Xufeng Ni Peng Zhang Jian Ji Jianzhao liu Zhengwei Mao Ziliang Wu Zhen Xu Haoke Zhang Hanying Li MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X PolymersDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

In 2022,The MOE Key Laboratory of Macromolecular Synthesis and Functionalization in Zhejiang University had achieved several important ***,a series of well-defined dinuclear organoboron catalysts were developed to precisely control the enchainment of ether and carbonate segments during the copolymerization of CO_(2)and ***,polyester had been synthesized through cationic copolymerization of cyclic ***,ring-opening polymerization of carbon dioxide based valerolactone had been achieved,revealing the prospect of 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one(EVL)in utilizing CO_(2)and synthesizing functional ***,machine learning methods have been applied to biomaterial research,enabling high-throughput screening of functional biomaterial surfaces for implantable devices,and searching for potent antimicrobial peptides in whole combinatorial peptide ***,methods of characterization of biomacromolecule RNA transcription and manipulation of nucleoside modification were ***,artificial enzymes-armed Bifidobacterium Longum probiotics were established to tune down gut ***,three-dimensional(3D)printing technologies were used to engineer tough supramolecular ***,hydroplastic foaming graphene frameworks for acoustic and conductive polymer composites were provided for ***,aggregate photophysics about the nature of through-space interactions(TSIs)and manipulating their strength in small molecules with non-conjugated structure had been ***,the forming mechanism of a newfound nested texture in poly(L-lactic acid)(PLLA)spherulitic films had been ***,the isotropically dyeing mechanism of KDP single crystals grown from hydrogels have been *** related works are reviewed in this paper.

关键词： Polymer Catalyst Biomaterial research mRNA Hydrogel Graphene Crystal

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Heparin-induced thrombocytopenia thrombosis after pancreaticoduodenectomy without definitive prophylactic or therapeutic use of heparin: a case report

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胰腺病学杂志(英文) 2024年第2期07卷 164-166页

作者： Wang Mengyi Huang Nan liu Qiaofei Liao Quan Department of General Surgery Key Laboratory of Research in Pancreatic Tumor State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College# Shuaifuyuan Dongcheng District Beijing China

Heparin-induced thrombocytopenia thrombosis (HITT) is a rare and potentially life-threatening complication after abdominal surgery, and it always occurs after the prophylactic or therapeutic use of heparin. HITT after pancreaticoduodenectomy (PD) has not been reported before. Herein, we reported a case of HITT after PD without prophylactic or therapeutic use of heparin. A 74-year-old female patient who suffered resectable pancreatic head cancer was transferred to our center for surgery. An open PD procedure was performed, and the operation was smooth. No heparin was used after surgery. Nine days after surgery, the platelet sharply declined to 48 × 109/L (100-350), and the D-dimer soared up to 33.56 mg/L (0-0.55). Ultrasound examination showed vein thrombosis in both the lower limb and the right upper limb. HIT-antibody was 6.3 U/mL (0-0.6). The diagnosis of HITT was confirmed. Fondaparinux was used. On postoperative day (POD) 23, the platelet recovered to the normal range. On POD 27, she was discharged without thromboembolism or active bleeding, and oral rivaroxaban was prescribed. One month after discharge, the platelet remained normal, and she did not complain of discomfort.

关键词： Heparin-induced thrombocytopenia Pancreatic cancer Pancreaticoduodenectomy Perioperative anticoagulation

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Enemies atpeace:Recentprogressin Agrobacterium-mediated cereal transformation

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The Crop Journal 2024年第2期12卷 321-329页

作者： Shaoshuai liu Ke Wang Shuaifeng Geng Moammar Hossain Xingguo Ye Aili Li Long Mao Karl-Heinz Kogel State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Institute of Phytopathology Centre for BioSystemsLand Use and NutritionJustus Liebig UniversityHeinrich Buff-Ring 26-32D-35392GiessenGermany

Agrobacterium tumefaciens mediated plant transformation is a versatile tool for plant genetic engineering following its discovery nearly half a century *** modifications were made in its application to increase efficiency,especially in the recalcitrant major cereals *** breakthroughs in transformation efficiency continue its role as a mainstream technique in CRISPR/Cas-based genome editing and gene *** modifications led to higher transformation frequency and lower but more stable transgene copies with the capability to revolutionize modern *** this review,we provide a brief overview of the history of Agrobacterium-mediated plant transformation and focus on the most recent progress to improve the system in both the Agrobacterium and the host recipient.A promising future for transformation in biotechnology and agriculture is predicted.

关键词： Agrobacterium tumefaciens Cereal species Genome editing Genetic engineering Plant breeding

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Divergent responses of growth rate and antioxidative system of ten Bacillus strains to acid stresses

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Soil Ecology Letters 2024年第1期6卷 107-118页

作者： Xiaoran Shan Jiayi Chen Jiaen Zhang Ziqiang liu Shufang Chen Hui Wei Key Laboratory of Agro-Environment in the Tropics of Ministry of Agriculture and Rural Affairs Guangdong Laboratory for Lingnan Modern AgricultureCollege of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China Guangdong Engineering Research Center for Modern Eco-agriculture and Circular Agriculture South China Agricultural UniversityGuangzhou 510642China

Response of growth rate and antioxidative system of ten Bacillus strains to acid stresses was *** acid treatment significantly decreased the growth rate of the *** stresses increased the GPX activity and GSSG content of the tested *** changes occurred in ROS and antioxidative system(SOD,CAT,GR,MDA and GSH).Environmental changes including soil acidification exert obvi-ous stresses on soil ecosystems and influence soil *** this study,ten microbial strains were incubated under different acid treatments to investigate responses of microbial growth and antioxidative system to acid *** the strains belong to Bacillus genus,but exhibit distinct ecological *** observed that these microbial strains had obviously different pH tolerance threshold,in spite of the close phylogenetic classification among *** stresses exerted significant effects on microbial antiox-idative system,including superoxide dismutase(SOD),cata-lase(CAT)and glutathione transferring enzymes(GPX and GR)and reactants(GSH and GSSH),but the effects were strain ***,we found acid stress effects on total variances of the investigated microbial antioxidative system along the first two principal components(PCs).Activities of CAT and SOD contributed substantially to PC1 that reflected obvious acid effects on NC7 and ZC4,and closely related to intracellular malondialdehyde *** GSSG activities and GSH/GSSG contributed greatly to PC2 that unveiled acid stress effects on most of the microbial *** results highlight substantially heterogeneous responses of microbial strains to acid stress and support that phylogenetic closeness does not imply functional similarity of soil microorganisms under environmental changes.

关键词： soil acidification microbial strain acid tolerance capacity microbial growth oxidative stress antioxidative system

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Influence of muscle activation on lumbar injury under a specific+Gz load

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Chinese Journal of Traumatology 2024年第4期27卷 218-225页

作者： Kang Lei Chen-Zhu Zhao Fan Li Shu-Lin liu Peng Yang State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha410082China Naval Medical Center The Secondary Military Medical UniversityShanghai200433China Department of Orthopedics Naval Medical Center of PLAShanghai200433China

Purpose:The present study aimed to analyze the influence of muscle activation on lumbar injury under aspecific+Gz ***:A hybrid finite element human body model with detailed lumbar anatomy and lumbar muscleactivation capabilities was *** the specific+Gz loading acceleration as input,the kinematicand biomechanical responses of the occupant's lower back were studied for both activated and deactivated states of the lumbar ***:The results indicated that activating the major lumbar muscles enhanced the stability of theoccupant's torso,which delayed the contact between the occupant's head and the *** activation led to higher strain and stress output in the lumbar spine under+Gz load,such as themaximum Von Mises stress of the vertebrae and intervertebral discs increased by 177.9%and 161.8%,respectively,and the damage response index increased by 84.5%.Conclusion:In both simulations,the occupant's risk of lumbar injury does not exceed 10%***,the activation of muscles could provide good protection for maintaining the lumbar spine andreduce the effect of acceleration in vehicle travel direction.

关键词： Lumbar muscles Finite element analysis Biomechanics +Gz load Injury mechanisms

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Association of TRMT2B gene variants with juvenile amyotrophic lateral sclerosis

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Frontiers of Medicine 2024年第1期18卷 68-80页

作者： Yanling liu Xi He Yanchun Yuan Bin Li Zhen liu Wanzhen Li Kaixuan Li Shuo Tan Quan Zhu Zhengyan Tang Feng Han Ziqiang Wu Lu Shen Hong Jiang Beisha Tang Jian Qiu Zhengmao Hu Junling Wang Department of Neurology Xiangya HospitalCentral South UniversityJiangxiNational Regional Center for Neurological DiseasesNanchang330038China Provincial Laboratory for Diagnosis and Treatment of Genitourinary System Disease Department of UrologyXiangya HospitalCentral South UniversityChangsha410078China Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhou310002China Department of Neurology Xiangya HospitalCentral South UniversityChangsha410078China National Clinical Research Center for Geriatric Diseases Xiangya HospitalCentral South UniversityChangsha410008China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha410008China Center for Medical Genetics School of Life SciencesCentral South UniversityChangsha410008China Engineering Research Center of Hunan Province in Cognitive Impairment Disorders Central South UniversityChangsha410078China Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases Changsha410078China Hunan Key Laboratory of Molecular Precision Medicine Xiangya HospitalCentral South UniversityChangsha410078China

Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons,and it demonstrates high clinical heterogeneity and complex genetic architecture.A variation within TRMT2B(c.1356G>T;p.K452N)was identified to be associated with ALS in a family comprising two patients with juvenile ALS(JALS).Two missense variations and one splicing variation were identified in 10 patients with ALS in a cohort with 910 patients with ALS,and three more variants were identified in a public ALS database including 3317 patients with ALS.A decreased number of mitochondria,swollen mitochondria,lower expression of ND1,decreased mitochondrial complex I activities,lower mitochondrial aerobic respiration,and a high level of ROS were observed functionally in patient-originated lymphoblastoid cell lines and TRMT2B interfering HEK293 ***,TRMT2B variations overexpression cells also displayed decreased *** conclusion,a novel JALS-associated gene called TRMT2B was identified,thus broadening the clinical and genetic spectrum of ALS.

关键词： TRMT2B amyotrophic lateral sclerosis mitochondrial complex I tRNA methylation reactive oxygen species

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Arginine promotes seed energy metabolism,increasing wheat seed germination at low temperature

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The Crop Journal 2024年第4期12卷 1185-1195页

作者： Jiayu Li Zhiyuan Li Yangyang Tang Jianke Xiao Vinay Nangia Yang liu College of Agronomy Northwest A&F UniversityYangling 712100ShaanxiChina International Center for Agricultural Research in the Dry Areas Rabat 999055Morocco

Low temperatures during germination inhibit seed growth,lead to small and weak seedlings,and significantly reduce the wheat *** the adverse effects of low temperature on wheat seed germination is highly important for achieving high and stable wheat *** this study,Tongmai 6(insensitive)and Zhengmai 113(sensitive),which have different low-temperature sensitivities during germination were treated with low temperature during *** transcriptome,metabolome and physiological data revealed that low temperature decreased the germination rate,downregulated the expression of a large number of genes involved in regulating glycometabolism,and inhibited carbon,nitrogen(especially amino acids)and energy metabolism in the *** content increased at low temperature,and its increase in the low-temperature-tolerant variety was significantly greater than that in the sensitive *** priming experiment showed that treatment with an appropriate concentration of arginine improved the seed germination *** conversion of starch to soluble sugar significantly increased under exogenous arginine conditions,the content of key metabolites in energy metabolism increased,and the utilization of ATP in the seeds *** together,arginine priming increased seed germination at low temperature by relieving inhibition of seed carbon and nitrogen metabolism and improving seed energy metabolism.

关键词： Low temperature Seed germination Arginine Energy metabolism Wheat

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Understanding the factors influencing cloud-core vertical accelerations during deep convection formation in the WRF model

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Atmospheric and Oceanic Science Letters 2024年第3期17卷 1-7页

作者： Na Li Jin Wang Lingkun Ran Lei Yin Xiba Tang Yuchen liu Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Guizhou Meteorological Bureau GuiyangChina University of Chinese Academy of Sciences BeijingChina Nanjing University of Posts and Telecommunications NanjingChina Yunnan Key Laboratory of Meteorological Disasters and Climate Resources in the Great Mekong Subregion Yunnan UniversityKunmingChina

本文将扰动气压利用一个线性诊断关系代替,重新推导了WRF模式框架地形追随坐标系下的垂直动量方程,建立了垂直加速与对流触发(DCI)影响因子(如温度,水汽等)的直接联系.研究发现,DCI过程与对流核垂直加速相关,三维副散,扰动位势在垂直方... 详细信息

本文将扰动气压利用一个线性诊断关系代替,重新推导了WRF模式框架地形追随坐标系下的垂直动量方程,建立了垂直加速与对流触发(DCI)影响因子(如温度,水汽等)的直接联系.研究发现,DCI过程与对流核垂直加速相关,三维副散,扰动位势在垂直方向的二阶非均匀性,扰动位温垂直梯度,比湿及其垂直梯度,水凝物拖曳,均是能够直接影响垂直加速和对流触发的物理因子,这些量与模式基本预报量相关,通过解析基本预报量对对流发展的直接影响,可能有助于理解模式对DCI过程预测失败的原因.

关键词：垂直加速深对流垂直速度冰雹

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