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MicroRNA-7-5p Inhibits Migration,Invasion and Metastasis of Intrahepatic Cholangiocarcinoma by Inhibiting MyD88

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 809-817页

作者： Yi Tang Zhenyong Tang Jianrong Yang tianqi liu Yuntian Tang Department of Hepatobiliary Surgery People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxiChina

Background and Aims:Intrahepatic cholangiocarcinoma(ICC)is a malignant tumor derived from intrahepatic bile duct epithelial *** studies report that microRNAs are widely involved in tumor migration and metastasis by regulation of target ***-7-5p has been confirmed to inhibit tumor metastasis and to be related to prognosis for several malignant *** study investigated the underlying functions of miR-7-5p in ***:The expression of miR-7-5p in ICC tissues but also in ICC cell lines was analyzed by real-time *** analyzing the relationship between the clinicopathological parameters of 60 ICC patients and the expression level of miR-7-5p,the effect of miR-7-5p on the prognosis was *** transfected with miR-7-5p mimics or miR-7-5p inhibitor,cell counting kit-8 assay was applied to evaluate the cells proliferation,flow cytometry was applied to analyze the cells apoptosis,wound healing assay and transwell chamber assay were applied to analyze the cell invasion and migration.A luciferase reporter assay was identified the relationship of miR-7-5p and myeloid differentiation factor 88(MyD88).Western blotting was used to analyze the proteins *** immunochemistry was performed to determine the expression of MYD88 in ICC ***:Our data showed the expression of miR-7-5p was down-regulated not only in ICC tissues but also in ICC cell lines compared with normal *** expression of miR-7-5p was notably associated with poor prognosis in ICC ***-7-5p negatively regulated cell proliferation,migration,invasion and apoptosis in ICC *** further verified that MyD88 was a novel target of miR-7-5p and was significantly overexpressed in ICC *** of MyD88 counteracted the effects of miR-7-5p in ICC ***:The present findings suggest that miR-7-5p plays a pivotal role in ICC invasion by regulating *** insight into the key factors of ICC invasion may result in the deve

关键词： Intrahepatic cholangiocarcinoma miR-7-5p MyD88

Oxidative cyclization of allyl compounds and isocyanide: A facile entry to polysubstituted 2-cyanopyrroles

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Chinese Chemical Letters 2024年第4期35卷 330-335页

作者： Yaping Zhang Wei Zhou Mingchun Gao tianqi liu Bingxin liu Chang-Hua Ding Bin Xu Department of Chemistry Affiliated Nantong Hospital of Shanghai University(The Sixth People's Hospital of Nantong)Shanghai Engineering Research Center of Organ RepairInnovative Drug Research CenterSchool of MedicineShanghai UniversityShanghai 200444China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

A facile Tf OH-catalyzed oxidative cyclization of allyl compounds and isocyanide has been developed with the assistance of DDQ, where isocyanide is used as the crucial "N" and "CN" sources. Highly functionalized 2-cyanopyrroles are constructed efficiently through a new formal [3 + 2] mode, demonstrating diverse reactivity and synthetic utility in organic chemistry. 2-Cyanopyrrole is converted into a nucleobase analogue of Remdesivir and 5H-pyrrolo[2,1-a]isoindole through a three-step or a two-step sequence, respectively. This protocol features broad substrate scope, operational simplicity and good functional group tolerance.

关键词： Isocyanide Cyanopyrrole Insertion Allyl compound Bronsted acid catalysis

Joint Limiting Control Strategy Based on Virtual Impedance Shaping for Suppressing DC Fault Current and Arm Current in MMC-HVDC Systems

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Journal of Modern Power Systems and Clean Energy 2023年第6期11卷 2003-2014页

作者： Qin Jiang Yan Tao Baohong Li tianqi liu Zhe Chen Frede Blaabjerg Peng Wang IEEE College of Electrical Engineering Sichuan UniversityChengdu 610065China Smart Grid Key Laboratory of Sichuan Province Chengdu610065China State Grid Jiangsu Electric Power Company Research Institute Nanjing 211103China Department of Energy Technology Aalborg UniversityAalborg 9920Denmark School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

This paper proposes a joint limiting control strategy for suppressing DC fault current and arm current in modular multilevel converter-based high-voltage direct current(MMC-HVDC) systems, which includes two target-oriented current limiting controls. To limit the DC fault current in the early fault stage, an equivalent modular multilevel converter(MMC) impedance is obtained, and its high-frequency part is reshaped by introducing virtual impedance, which is realized by adjusting the inserted submodules adaptively. Following the analysis of MMC control characteristics, the arm current limiting strategy is investigated, with results showing that the inner-loop control has significant effects on arm current and that a simple low-pass filter can reduce the arm current in the fault period. Finally, by combining the virtual impedance shaping and innerloop control, the fault currents of DC lines and MMC arms can be suppressed simultaneously, which can not only alleviate the interrupting pressure of the DC circuit breaker, but also prevent the MMC from being blocked by the arm overcurrent. Theoretical analysis conclusions and the proposed strategy are verified offline by a digital time-domain simulation on Power Systems Computer Aided Design/Electromagnetic Transients including DC platform, and experiment on a real-time digital simulator platform.

关键词： Modular multilevel converter(MMC) highvoltage direct current(HVDC)transmission direct current fault fault current limitation arm current suppression virtual impedance direct current circuit breaker

Impedance Model for Instability Analysis of LCC-HVDCs Considering Transformer Saturation

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1309-1319页

作者： Qin Jiang Ruiting Xu Baohong Li Xiang Chen Yue Yin tianqi liu Frede Blaabjerg College of Electrical Engineering Sichuan UniversityChengdu 610065China Smart Grid Key Laboratory of Sichuan Province Chengdu 610065China Department of Energy Technology Aalborg UniversityAalborg 9920Denmark

In line commutated converter based high-voltage direct current(LCC-HVDC)transmission systems,the transformer saturation can induce harmonic instability,which poses a serious threat to the safe operation of the power ***,the nonlinear characteristics of the power grids introduced by the transformer saturation considerably limit the application of the conventional analysis *** address the issue,this paper derives a linear model for the transformer saturation caused by the DC current due to the converter ***,the nonlinear characteristics of power grids with the transformer saturation is described by a complex valued impedance *** on the derived impedance matrix,the system harmonic stability is analyzed and the mechanism of the transformer saturation induced harmonic instability is ***,the sensitivity analysis is conducted to find the key factors that influence the system core saturation *** proposed impedance model is verified by the electromagnetic transient simulation,and the simulation results corroborate the effectiveness of the proposed impedance *** TermsLine commutated converter based high voltage direct current(LCC-HVDC),transformer saturation,harmonic instability,impedance model.

关键词： Line commutated converter based high voltage direct current(LCC-HVDC) transformer saturation harmonic instability impedance model

Time-delay Correction Control Strategy for HVDC Frequency Regulation Services

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CSEE Journal of Power and Energy Systems 2024年第5期10卷 2027-2037页

作者： Yuqing Dong Kaiqi Sun Jinning Wang Shunliang Wang He Huang tianqi liu Yilu liu School of Electrical Engineering Shandong UniversityJinan 250061China School of Electrical Engineering Shandong UniversityJinan 250061China. Department of Electrical Engineering and Computer Science University of TennesseeKnoxville 37996USA.

With the advancements in voltage source converter(VSC)technology,VSC based high voltage direct current(VSCHVDC)systems provide system operators with a prospective approach to enhance system operating stability and *** addition to long-distance transmission,the VSC-HVDC system can also provide multiple ancillary services,such as frequency regulation,due to its power ***,if a time delay exists in the control signal,the VSC-HVDC system may bring destabilizing influences to the system,which will decrease the system resilience under the *** order to reduce control deviation caused by time delay,in this paper,a small signal model is first conducted to analyze the impact of time delay on system *** a time-delay correction control strategy for HVDC frequency regulation control is developed to reduce the influence of the time *** control performance of the proposed time-delay correction control is verified both in the established small signal model and the runtime simulation in a modified IEEE 39 bus *** results indicate that the proposed time-delay correction control strategy shows significant improvement in system stability.

关键词： Frequency regulation control HVDC small signal analysis time delay time-delay correction control strategy

A novel evolving model for power grids

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Science China(Technological Sciences) 2010年第10期53卷 2862-2866页

作者： liu Xuan, liu tianqi & LI XingYuan School of Electrical Engineering and Automation, Sichuan University, Chengdu 610065, China School of Electrical Engineering and Automation Sichuan University Chengdu China

In this paper,a novel power grid evolving model,which can well describe the evolving property of power grids,is presented. Based on the BA model,motivated by the fact that in real power grids,connectivity of node not only depends on its degree,but also is influenced by many uncertain factors,so we introduce the subconnection factor K for each node. Using the mean-field theory,we get the analytical expression of power-law degree distribution with the exponent γ∈ (3,∞ ). Finally,simulation results show that the new model can provide a satisfactory description for empirical characteristics of power network,and power network falls somewhere in between scale-free network and uncertain network.

关键词： power grid evolving model scale-free

Impact of Grid Topology on Pole-to-ground Fault Current in Bipolar DC Grids:Mechanism and Evaluation

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 434-445页

作者： Yingmin Zhang Wenxin Zhang Qiao Peng Baohong Li Yan Tao Min Zhang tianqi liu Frede Blaabjerg College of Electrical Engineering Sichuan UniversityChengdu 610065China Electric Power Research Institute State Grid Shanxi Electric Power CompanyTaiyuan 030001China AAU Energy Aalborg UniversityAalborg 9920Denmark

The fault current level analysis is important for bipolar direct current(DC)grids,which determines the operation and protection *** DC grid topology significantly impacts the current path and then the fault current level of the grid,which makes it possible to limit the fault current by optimizing the grid ***,the corresponding discussion in the literature is *** at this point,the impact of grid topology,i.e.,the connecting scheme of converters,on the pole-to-ground fault current in bipolar DC grids,is investigated in this paper,and the ground-return-based and metallic-return-based grounding schemes are considered,***,the decoupled equivalent model in frequency domain for fault current analysis is ***,the impacts of converters with different distances to the fault point on the fault current can be analyzed according to the high-frequency impedance *** on the analysis results,a simplified fault current index(SFCI)is proposed to realize the fast evaluation of impact of grid topology on the fault current *** SFCI is then applied to evaluate the relative fault current ***,the simulation results validate the model,the analysis method,and the SFCI,which can effectively evaluate the relative fault current level in a direct and fast manner.

关键词： Bipolar DC grid pole-to-ground fault grid topology fault current evaluation simplified fault current index

Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats

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Bio-Design and Manufacturing 2021年第4期4卷 902-911页

作者： Zhiyong Zeng Guohua Jiang tianqi liu Gao Song Yanfang Sun Xueya Zhang Yanting Jing Mingjia Feng Yufei Shi School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China Institute of Smart Biomedical Materials Zhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China

Injection therapy for diabetes has poor patient compliance,and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic *** this work,to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues,methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic *** methacryloyl microneedles(GelMA-MNs)with different degrees of substitution were successfully prepared by a micro-molding *** resultant GelMA-MNs exhibited excellent mechanical properties and moisture ***,an anti-diabetic drug,was further encapsulated into the GelMA-MNs,and its release rate could be controlled by the three-dimensional cross-linked network of microneedles,thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic effect compared with that of subcutaneous injection in diabetic *** drug release period could be significantly prolonged by improving the cross-link density of *** results of hypoglycemic effect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefits for diabetes treatment.

关键词： Microneedles Metformin Transdermal delivery Biodegradable Gelatin Hypoglycemic effect

Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application

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Bioactive Materials 2024年第2期32卷 502-513页

作者： tianqi liu Ying liu Xiaoyu Zhao Liguo Zhang Wei Wang De Bai Ya Liao Zhenyuan Wang Mi Wang Jiaheng Zhang State Key Laboratory of Advanced Welding and Joining School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen518055China Research Center of Printed Flexible Electronics School of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen518055China Shenzhen Shinehigh Innovation Technology Co. Ltd.Shenzhen518055China Harbin Voolga Technology Co. Ltd.Harbin150070China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Department of Chemistry College of SciencesNortheastern UniversityShenyang110819China

Copper peptides(GHK-Cu)are a powerful hair growth promoter with minimal side effects when compared with minoxidil and finasteride;however,challenges in delivering GHK-Cu topically limits their non-invasive *** theoretical calculations and pseudo-ternary phase diagrams,we designed and constructed a thermodynamically stable ionic liquid(IL)-based microemulsion(IL-M),which integrates the high drug solubility of ILs and high skin permeability of microemulsions,thus improving the local delivery of copper peptides by approximately three-fold while retaining their biological *** in mice validated the effectiveness of our proposed IL-M ***,the exact effects of the IL-M system on the expression of growth factors,such as vascular endothelial growth factor,were revealed,and it was found that microemulsion increased the activation of the Wnt/β-catenin signaling pathway,which includes factors involved in hair growth ***,the safe and non-invasive IL microemulsion system developed in this study has great potential for the clinical treatment of hair loss.

关键词： Bio-based ionic liquids Copper peptides Microemulsion Hair regeneration Transdermal delivery