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Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients

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Neuroscience Bulletin 2016年第6期32卷 547-549页

作者： Weifeng Mi Feihu Liu Yongqiao Liu Bo Du Weidong Xiao Lingzhi Li Lan Huang tianlan lu Jia He Le Shi Weihua Yue Hongyan Zhang Peking University Sixth Hospital Peking University Instituteof Mental Health Key Laboratory of Mental Health Ministry of Health (Peking University) National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) Beijing 100191 China The Mental Health Center of Xi'an Xi'an 710061 China The Sixth People's Hospital of Hebei Province Baoding 07100 China The People's Hospital of Hubei Province Wuhan 430060China National Institute on Drug Dependence and Beijing KeyLaboratory of Drug Dependence Peking UniversityBeijing 100191 China Department of Pharmacology School of Basic Medical Sciences Peking University Health Science CenterBeijing 100191 China

Dear editor, P-glycoprotein （P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1） is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are abundant [ 1, 2], and ABCB1 is a well-conserved gene, there is increasing evi- dence that its polymorphisms affect substrate specificity [3]. A previous study reported that the synonymous single nucleotide polymorphism （SNP） C3435T （rs1045642） affects the timing of co-translational folding and insertionof P-gp into the membrane,

关键词： PANSS Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients

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一款荷叶碱果冻的研制

农产品加工 2024年第8期 14-17页

作者：董碧莲梅婷王德智罗旭莲鲁天兰遵义医科大学医学与科技学院贵州遵义563000

优化荷叶碱果冻的制作配方及工艺,确定最优工艺配方。以果冻的感官评价为指标,通过单因素试验依次考查魔芋胶-卡拉胶的配比、魔芋胶-卡拉胶添加量、荷叶碱添加量、甘露醇添加量对果冻品质的影响,得出荷叶碱果冻的最优工艺配方,并对其微... 详细信息

优化荷叶碱果冻的制作配方及工艺,确定最优工艺配方。以果冻的感官评价为指标,通过单因素试验依次考查魔芋胶-卡拉胶的配比、魔芋胶-卡拉胶添加量、荷叶碱添加量、甘露醇添加量对果冻品质的影响,得出荷叶碱果冻的最优工艺配方,并对其微生物指标进行检测。结果表明,荷叶碱果冻的最优工艺配方为魔芋胶-卡拉胶复配比1∶1,魔芋胶-卡拉胶复配凝胶剂添加量4.5%,荷叶碱添加量1.0%,甘露醇添加量5.0%,该工艺配方生产的荷叶碱果冻未检出大肠杆菌。采用最优配方制备的荷叶碱果冻为浅褐色,有淡淡的茶香,表面透亮有光滑,硬度适宜,荷叶碱的苦涩味被掩盖,滋味协调口感爽滑。

关键词：荷叶碱魔芋胶卡拉胶果冻工艺

STON2风险变异通过影响Syt1转运和突触功能导致精神分裂症样行为

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Science Bulletin 2024年第10期69卷 1458-1471页

作者：马远林高凯孙晓璇王金鑫杨扬武建荧柴安平姚立刘楠郁昊苏怡卢天兰王力芳岳伟华章晓辉徐林张岱李俊 Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Key Laboratory of Mental HealthChinese Academy of Medical SciencesBeijing 100191China The First Affiliated Hospital Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqing 400016China Changping Laboratory Beijing 102206China d Chinese Institute for Brain Research Beijing 102206China Laboratory of Learning and Memory Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China Shenzhen Key Laboratory of Translational Research for Brain Diseases The Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China State Key Laboratory of Cognitive Neuroscience and Learning IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China

Synaptic dysfunction is a core component of the pathophysiology of schizophrenia.However,the genetic risk factors and molecular mechanisms related to synaptic dysfunction are still not fully understood.The Stonin 2(STON2)gene encodes a major adaptor for clathrin-mediated endocytosis(CME)of synaptic vesicles.In this study,we showed that the C-C(307Pro-851Ala)haplotype of STON2 increases the susceptibility to schizophrenia and examined whether STON2 variations cause schizophrenia-like behaviors through the regulation of CME.We found that schizophrenia-related STON2 variations led to protein dephosphorylation,which affected its interaction with synaptotagmin 1(Syt1),a calcium sensor protein located in the presynaptic membrane that is critical for CME.STON2307Pro851Ala knockin mice exhibited deficits in synaptic transmission,short-term plasticity,and schizophrenia-like behaviors.Moreover,among seven antipsychotic drugs,patients with the C-C(307Pro-851Ala)haplotype responded better to haloperidol than did the T-A(307Ser-851Ser)carriers.The recovery of deficits in Syt1 sorting and synaptic transmission by acute administration of haloperidol effectively improved schizophrenia-like behaviors in STON2307Pro851Ala knockin mice.Our findings demonstrated the effect of schizophreniarelated STON2 variations on synaptic dysfunction through the regulation of CME,which might be attractive therapeutic targets for treating schizophrenia-like phenotypes.

关键词： STON2 variations Schizophrenia Synaptic dysfunction Syt1 Haloperidol

微针导入重组Ⅲ型人源化胶原蛋白在皮肤屏障功能修复中的应用效果

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临床医学研究与实践 2024年第7期9卷 102-105页

作者：于文渊耿栋芸庄卉如陆蒋惠文邱丹丹赵天兰苏州大学附属第二医院整形美容外科江苏苏州215000

目的探究微针导入重组Ⅲ型人源化胶原蛋白治疗因皮肤炎性衰老导致的皮肤屏障功能下降的有效性及安全性。方法选取2020年6月至2021年5月在本院接受面部皮肤治疗的30例患者作为研究对象,采用随机数字表法将其分为对照组(重组Ⅲ型人源化胶... 详细信息

目的探究微针导入重组Ⅲ型人源化胶原蛋白治疗因皮肤炎性衰老导致的皮肤屏障功能下降的有效性及安全性。方法选取2020年6月至2021年5月在本院接受面部皮肤治疗的30例患者作为研究对象,采用随机数字表法将其分为对照组(重组Ⅲ型人源化胶原蛋白)与治疗组(微针导入重组Ⅲ型人源化胶原蛋白),各15例。治疗后定期对患者进行随访,分别进行主观疗效评价及客观疗效评价。结果治疗后4、8、12周,治疗组的满意度显著高于对照组(P<0.05)。治疗后,治疗组的皮肤皱纹、纹理、红区、毛孔、弹性、皮肤经皮失水及皮肤含水量改善明显(P<0.05);对照组治疗后油脂改善明显(P<0.05)。治疗后12周,治疗组的总症状评分显著低于对照组(P<0.05)。结论微针导入重组Ⅲ型人源化胶原蛋白对皮肤修复有较好的疗效,可增强皮肤屏障功能,为改善皮肤屏障功能、治疗因皮肤屏障受损引起的炎性衰老提供了新选择。

关键词：微针重组Ⅲ型人源化胶原蛋白炎性衰老皮肤屏障功能

Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance

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Science China(Life Sciences) 2019年第4期62卷 535-543页

作者： Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang tianlan lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium Mental Health Center and Psychiatric Laboratory the State Key Laboratory of BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China Tianjin Medical University General Hospital Tianjin Medical UniversityTianjin 300070China Hebei Mental Health Center Baoding 71000China Second Affiliated Hospital of Xinxiang Medical University Xinxiang 453002China Department of Psychiatry Xijing HospitalFourth Military Medical UniversityXi'an 710032China Huaxi Biobank West China Hospital of Sichuan UniversityChengdu 610041China West China Brain Research Center West China Hospital of Sichuan UniversityChengdu 610041China Peking University Sixth Hospital(Institute of Mental Health) Beijing 100191China National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100191China 5Second Xiangya Hospital Central South UniversityChangsha 410011China Beijing Andi ng Hospital Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100088China Beijing HuiLongGuan Hospital Beijing 100096China Wuxi Mental Health Center Nanjing Medical UniversityWuxi 214151China Institute of Mental Health Tianjin Anding HospitalTianjin 300070China 不详

Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way.

关键词： MC4R antipsychotics metabolic disturbance

Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia

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Neuroscience Bulletin 2019年第6期35卷 1102-1105页

作者： Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang tianlan lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium Psychiatric Laboratory and Mental Health Center the State Key Laboratory of BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China West China Brain Research Center West China Hospital of Sichuan UniversityChengdu 610041China The National Engineering Research Center for Miniaturized Detection Systems College of Life ScienceNorthwest UniversityXi'an 710069China Shaanxi Lifegen Co. LtdXi'an 712000China Biomolecular Science Research Centre Sheffield Hallam UniversitySheffield S11WBUK Peking University Sixth Hospital(Institute of Mental Health) Beijing 100083China National Clinical Research Center for Mental Disorders and Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100871China Second Xiangya Hospital Central South UniversityChangsha 410011China Beijing Anding Hospital Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100088China Beijing HuiLongGuan Hospital Beijing 102200China Wuxi Mental Health Center Nanjing Medical UniversityWuxi 214121China Institute of Mental Health Tianjin Anding HospitalTianjin 300222China Tianjin Medical University General Hospital Tianjin Medical UniversityTianjin 300052China Hebei Mental Health Center Baoding 071000China Second Affiliated Hospital of Xinxiang Medical University Xinxiang 453003China Department of Psychiatry Xijing HospitalFourth Military Medical UniversityXi'an 710032China Huaxi Biobank West China Hospital of Sichuan UniversityChengdu 610041China 不详

Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia.

关键词： drugs Dopamine Schizophrenia

多次微波消融对原发性肝癌患者术后肝功能的影响

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解放军医学院学报 2023年第7期44卷 733-738,799页

作者：张天澜路营雷进董政千年松解放军医学院北京100853 解放军总医院第五医学中心肝病医学部肝病科北京100039 贵州医科大学临床医学院贵州贵阳550004 解放军总医院第八医学中心呼吸与危重症医学部胸部肿瘤科北京100091

背景微波消融(microwave ablation,MWA)是原发性肝癌的主要治疗手段之一,但对于复发患者,多次MWA是否会增加术后肝功能恶化的风险,目前尚不明确。目的探讨原发性肝癌患者行多次MWA对肝功能的影响。方法回顾性分析2016年6月-2021年7... 详细信息

背景微波消融(microwave ablation,MWA)是原发性肝癌的主要治疗手段之一,但对于复发患者,多次MWA是否会增加术后肝功能恶化的风险,目前尚不明确。目的探讨原发性肝癌患者行多次MWA对肝功能的影响。方法回顾性分析2016年6月-2021年7月因原发性肝癌在解放军总医院第五医学中心行经皮微波消融的患者,根据MWA总次数分为单次消融组和多次消融组。收集患者消融前、消融后24 h及消融后5~7 d的肝功能指标和术后并发症。应用白蛋白-胆红素分级(albumin-bilirubin,ALBI)评估患者术后肝功能。比较两组术后肝功能和并发症发生情况。结果共纳入223例原发性肝癌行经皮微波消融治疗患者,男性183例,女性40例,平均年龄(58.99±9.17)岁。单次消融组142例,多次消融组81例。两组一般资料和临床特点的差异无统计学意义(P>0.05)。天冬氨酸氨基转移酶(aspartate aminotransferase,AST)在术前、术后5~7 d的组间差异无统计学意义,但术后24 h多次消融组显著低于单次消融组[Md(IQR):247(148~370) U/L vs287(205~406) U/L,P=0.037]。两组间术前、术后24 h及术后5~7 d的凝血酶原活动度(prothrombin activity,PA)、白蛋白(albumin,ALB)、总胆红素(total bilirubin,TBIL)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、胆碱酯酶(cholinesterase,ChE)指标差异无统计学意义(P>0.05)。消融术后24 h,多次消融组ALB及两组ChE均较术前轻微下降,差异无统计学意义(P>0.05)。两组其余各肝功能指标不同时间点比较,术后24 h及术后5~7 d均较术前略差(P0.05)。MWA术后发热、肝区疼痛及严重并发症(严重感染、胸腔积液和腹水、术后出血、肝衰竭)的发生率,两组差异无统计学意义(P>0.05)。结论 MWA是一项安全有效、可重复性强的治疗手段,多次MWA不会增加原发性肝癌患者术后肝功能不全及并发症的发生率。

关键词：肝细胞癌微波消融肝功能白蛋白-胆红素分级术后并发症

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面向方面级别情感分析的端到端多跳记忆网络

计算机应用研究 2021年第5期38卷 1409-1415,1427页

作者：卢天兰陈荔上海理工大学管理学院上海200093

方面情感分析是指分析语句中目标方面项的情感极性,但目前较少研究语句中邻近方面项间依赖关系对情感分类的影响。基于此,针对方面情感分析提出一个结合基于注意力机制的双向LSTM和多跳端到端记忆网络的方面情感分类模型。首先利用Bi-L... 详细信息

方面情感分析是指分析语句中目标方面项的情感极性,但目前较少研究语句中邻近方面项间依赖关系对情感分类的影响。基于此,针对方面情感分析提出一个结合基于注意力机制的双向LSTM和多跳端到端记忆网络的方面情感分类模型。首先利用Bi-LSTM的序列学习能力,并引入注意力机制来得到语义向量表示;然后用多跳记忆网络来对目标方面项和语句中其余方面项间相关性进行建模构建深层的情感分类特征向量,输入到softmax函数得到最终的情感极性分类结果。该模型在SemEval 2014任务中的restaurant和laptop两个数据集和一组公开的Twitter数据集上进行实验,在三个数据集上的分类准确率都有所提高。实验结果表明,该模型对方面级别情感分类的有效性和考虑方面间依赖关系对于情感分类是有益的。

关键词：方面情感分析依赖关系注意力机制双向LSTM 端到端记忆网络

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多感官的风味感知-“味型金字塔”概念

现代食品科技 2023年第5期39卷 401-409页

作者：邓天野卢云浩施卫峰王晓昀陈俊文覃蕾李军吕舰李天兰何强四川豪吉食品有限公司四川成都610041 四川大学轻工科学与工程学院四川成都610065 雀巢产品技术中心德国巴登-符腾堡州辛根78224

风味是食物重要的品质之一,而消费者对食物或菜肴的风味感知是一个综合性的体验过程,涉及了嗅觉、味觉和三叉神经等多感知系统,那这些复杂的感知是如何在人体中形成的?不同的“香”和“味”又是如何影响人类的整体风味感知的?基于此,该... 详细信息

风味是食物重要的品质之一,而消费者对食物或菜肴的风味感知是一个综合性的体验过程,涉及了嗅觉、味觉和三叉神经等多感知系统,那这些复杂的感知是如何在人体中形成的?不同的“香”和“味”又是如何影响人类的整体风味感知的?基于此,该研究提出了“味型金字塔”概念,认为食物整体风味的完美呈现涉及基础味(金字塔之底)、主体风味(金字塔之腰)和挥发性香味(金字塔之顶)的三层结构搭建,三者互为支撑,循序演替,交相融合,协调统一,最终实现了整体风味的完美呈现。综述剖析了食品和菜肴风味呈现的内在规律,揭示了人类对于食品或菜肴的风味感知是一个重点突出、主次分明、层次清晰、平衡协调的过程,综述可对复合调味的科学优化提供参考。

关键词：味道味型金字塔感官复合调味香味