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Modulating a Local Shape Descriptor through Biologically Inspired Color Feature

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Journal of Bionic Engineering 2014年第2期11卷 311-321页

作者： Hongwei zhao Baoyu Zhou Pingping Liu tianjiao zhao School of Computer Science and Technology Jilin University Changchun 130012 P. R. China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun 130012 P. R. China

This paper presents a biologically inspired local image descriptor that combines color and shape features. Compared with previous descriptors, red-cyan cells associated with L, M, and S cones （L for long, M for medium, and S for short） are used to indicate one of the opponent color channels. Stepping forward from state-of-the-art color feature extraction, we exploit a new approach to compute the color orientation and magnitudes of three opponent color channels, namely, red-green, blue-yellow, and red-cyan, in two-dimensional space. Color orientation is calculated in histograms with magnitude weighting. We linearly concatenate the four-color-opponent-channel histogram and scale-invariant-feamre-transform histogram in the final step. We apply our biologically inspired descriptor to describe the local image feature. Quantitative comparisons with state-of-the-art descriptors demonstrate the significant advantages of maintaining invariance to photometric and geometric changes in image matching, particularly in cases, such as illumination variation and image blurring, where more color contrast information is observed.

关键词： local image descriptor color opponent color scale-invariant feature transform image matching

Nanomedicine-based treatment:An emerging therapeutical strategy for pulmonary hypertension

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Nano Research 2023年第5期16卷 7007-7029页

作者： Shuya Wang Qiaohui Chen tianjiao zhao Kelong Ai Changping Hu Department of Pharmacology Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410078China Hunan Provincial Key Laboratory of Cardiovascular Research Changsha 410078China

Pulmonary hypertension(PH)can cause breathing difficulty,a rapid decline of exercise capacity,heart failure,eventually death of the *** latest epidemiological study demonstrates that PH has a much higher incidence than previously *** is still a highly fatal disease due to the many disadvantages of the current drugs,such as short half-life,lack of targeting,potent side *** PH pathological features offer great opportunities for nanomedicines for ***,emerging nanomedicines demonstrated great advantages in the therapeutic effect of PH by enhancing the accumulation of drugs in PH lesion,optimizing drug efficacy,minimizing drug side ***,this promising field of cross-cutting research is far from being widely explored due to the huge professional *** solve this problem,we provide a comprehensive review for the latest progresses of nanomedicines in the treatment of ***,we systematical summarized the PH pathological features and the current clinical drug treatment of *** advantages of nanomedicines are also deeply discussed in the treatment of ***,we focused on the research progresses of nanomedicines in PH through three aspects:advanced nano-drug delivery system for traditional drugs and new target drugs,gene therapy-based nanomedicines,other nanomedicines for the treatment of ***,we also discussed the prospects and challenges for the clinical application of nanomedicines in PH,provided directions for the research and development of nanomedicines for PH treatment in the future.

关键词： pulmonary hypertension nanomedicines enhanced penetration and retention effects polymer liposome

长链脂肪酸钠/芳基酰胺脂肪酸钠复配成核剂对聚丙烯性能影响研究

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中国塑料 2024年第6期38卷 60-65页

作者：董亚鹏赵恬娇王美珍崔文举林福华王波太原科技大学化学工程与技术学院太原030024 太原科技大学环境与资源学院太原030024 山西工程科技职业大学交通工程学院山西晋中030619

使用长链脂肪酸钠盐与芳基酰胺脂肪酸钠(SCAB)复配作为聚丙烯(PP)成核剂,研究了复配前后SCAB对PP结晶及力学性能的影响。结果表明,长碳链脂肪酸钠盐在复配过程和PP加工温度下均未改变SCAB的分子结构且复配可以明显改善SCAB分子间聚集状... 详细信息

使用长链脂肪酸钠盐与芳基酰胺脂肪酸钠(SCAB)复配作为聚丙烯(PP)成核剂,研究了复配前后SCAB对PP结晶及力学性能的影响。结果表明,长碳链脂肪酸钠盐在复配过程和PP加工温度下均未改变SCAB的分子结构且复配可以明显改善SCAB分子间聚集状态;PP的结晶速率、缺口冲击强度和拉伸强度随着长链脂肪酸钠盐的碳链长度延长大幅提高且复配物未影响PP的晶体生长方式;硬脂酸钠复配的SCAB由于在PP基体中优异的分散性,能够更有效细化PP球晶,完善晶体结构,使其结晶速率提高6.3倍,缺口冲击强度提升27.3%,拉伸强度增长8.2 MPa。

关键词：聚丙烯长链脂肪酸钠盐芳基酰胺脂肪酸钠复配结晶性能力学性能

聚对苯二甲酸乙二醇酯结晶行为改性的研究进展

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塑料工业 2024年第7期52卷 31-38页

作者：王美珍赵恬娇董亚鹏崔文举宁丁怡郝新宇曾思梦林福华王波太原科技大学化学工程与技术学院山西太原030024 太原科技大学环境与资源学院山西太原030024 山西工程科技职业大学交通工程学院山西晋中030619

本文从聚对苯二甲酸乙二醇酯(PET)分子链结构带来的结晶行为特性出发,介绍了目前国内外在PET结晶行为改性领域的研究进展,主要涉及共聚改性、共混改性、扩链反应改性、加工条件改性、多种协同作用改性等方面。其中,共聚改性可通过柔性... 详细信息

本文从聚对苯二甲酸乙二醇酯(PET)分子链结构带来的结晶行为特性出发,介绍了目前国内外在PET结晶行为改性领域的研究进展,主要涉及共聚改性、共混改性、扩链反应改性、加工条件改性、多种协同作用改性等方面。其中,共聚改性可通过柔性链段的引入改变PET分子链的规整性,使其聚集态结构更加稳定,但其制备流程的复杂性限制了其在实际生产中的应用。共混改性可通过异相成核的方式改善PET的结晶行为,但其与PET界面相容性较差的问题仍对改性具有一定的局限性。扩链反应改性后的PET具有优异的结晶性能,但其对力学性能可能造成不利影响。加工条件改性虽没有额外化学品的添加,但其宏观性能的改变限制了PET的应用范围。多种协同作用改性通过优势互补使得PET的结晶性能得到了一定的提高,但其复杂的作用机理仍有待明确。最后,指出目前PET改性方法和改性剂应用和发展存在的问题,并对优化改性PET专用助剂的发展方向进行了展望。

关键词：聚对苯二甲酸乙二醇酯改性结晶行为研究进展

Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries

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Bioactive Materials 2022年第1期7卷 47-72页

作者： tianjiao zhao Wei Wu Lihua Sui Qiong Huang Yayun Nan Jianhua Liu Kelong Ai Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha410087China Department of Geriatric Surgery Xiangya HospitalCentral South UniversityChangsha410087China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410087China Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha410008China Geriatric Medical Center Ningxia People’s HospitalYinchuan750003China Department of Radiology The Second Hospital of Jilin UniversityChangchun130041China

Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction,but morbidity and mortality of acute myocardial infarction are still *** injuries are inevitable due to the generation of reactive oxygen species(ROS)and apoptosis of cardiac muscle ***,many antioxidant and anti-inflammatory drugs are largely limited by pharmacokinetics and route of administration,such as short half-life,low stability,low bioavailability,and side effects for treatment myocardial ischemia reperfusion ***,it is necessary to develop effective drugs and technologies to address this ***,nanotherapies have demonstrated great opportunities for treating myocardial ischemia reperfusion *** with traditional drugs,nanodrugs can effectively increase the therapeutic effect and reduces side effects by improving pharmacokinetic and pharmacodynamic properties due to nanodrugs’size,shape,and material *** this review,the biology of ROS and molecular mechanisms of myocardial ischemia reperfusion injury are ***,we summarized the applications of ROS-based nanoparticles,highlighting the latest achievements of nanotechnology researches for the treatment of myocardial ischemia reperfusion injury.

关键词： Reactive oxygen species Myocardial ischemia reperfusion injury Nano-enzyme Nanocarrier Antioxidant therapy

Passively-targeted mitochondrial tungsten-based nanodots for efficient acute kidney injury treatment

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Bioactive Materials 2023年第3期21卷 381-393页

作者： Qiong Huang Yuqi Yang tianjiao zhao Qiaohui Chen Min Liu Shuting Ji Yan Zhu Yunrong Yang Jinping Zhang Haixin zhao Yayun Nan Kelong Ai Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha410078China Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha410078China Geriatric Medical Center People’s Hospital of Ningxia Hui Autonomous RegionYinchuan750002China

Acute kidney injury(AKI)can lead to loss of kidney function and a substantial increase in *** burst of reactive oxygen species(ROS)plays a key role in the pathological progression of ***-targeted antioxidant therapy is very promising because mitochondria are the main source of ROS in *** nanodrugs with actively targeted mitochondria have achieved encouraging success in many oxidative stress-induced ***,most strategies to actively target mitochondria make the size of nanodrugs too large to pass through the glomerular system to reach the renal tubules,the main damage site of ***,an ultra-small Tungsten-based nanodots(TWNDs)with strong ROS scavenging can be very effective for treatment of *** can reach the tubular site after crossing the glomerular barrier,and enter the mitochondria of the renal tubule without resorting to complex active targeting *** our knowledge,this is the first time that ultra-small negatively charged nanodots can be used to passively target mitochondrial therapy for *** in-depth study of the therapeutic mechanism,such passive mitochondria-targeted TWNDs are highly effective in protecting mitochondria by reducing mitochondrial ROS and increasing *** addition,TWNDs can also reduce the infiltration of inflammatory *** work provides a new way to passively target mitochondria for AKI,and give inspiration for the treatment of many major diseases closely related to mitochondria,such as myocardial infarction and cerebral infarction.

关键词： ROS-scavenging Anti-inflammatory Acute kidney injury Passively-targeted mitochondrial Tungsten-Based Nanodots

Coupled interactive effects of ammonia and hydrogen additions on ethylene diffusion flames: A detailed kinetic study

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Science China(Technological Sciences) 2024年第3期67卷 930-948页

作者： XIAO JiaYi XU TingTing SHU ZhiMei DENG QiGe zhao Xuan YING YaoYao LI tianjiao LIU Dong MIIT Key Laboratory of Thermal Control of Electronic Equipment School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing 210094China Advanced Combustion Laboratory School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing210094China

In order to create effective combustion technologies and fuels with low or no carbon emissions,the research was conducted to assess the coupled interactive effects of NH_(3) and H_(2) additions on ethylene counterflow diffusion flames from a kinetic *** effects of the NH_(3)/H_(2) combination on flame temperatures,major species,key radicals,important intermediate species,representative oxygenated species and NO_xwere *** results of the study utilizing fictitious inert NH_(3) and/or H_(2) revealed the chemical effects of the two *** was found that the NH_(3)/H_(2) coupled effects had a more effective inhibitory effect on soot precursors than the effects of corresponding sum of single NH_(3) or H_(2) *** production of soot precursors was promoted by the coupled chemical effects of NH_(3) and H_(2),but the coupled dilution and thermal effects were observed to have a greater impact,resulting in a decrease of the mole fractions of soot *** for the interaction of NH_(3) and H_(2) effects,the presence of H_(2) decreased the chemical effects of NH_(3) on the augmentation of C_(2)H_(2),A1,A2,and CH_(3)CHO mole *** NH_(3) addition alleviated the H_(2) chemical effects on increasing C_(2)H_(2),C_(3)H_(3),A1 and A2 ***,the NH_(3)chemical effects on C_(3)H_(3),OH and CH_(3)CHO were enhanced when H_(2) was *** presence of NH_(3) augmented the chemical effects of H_(2) on the growth of OH mole ***,the H_(2) chemical effects hindered the production of NO and NO_(2) in the presence of NH_(3).

关键词： NH_(3)/H_(2)addition kinetic analysis coupled interactive effects chemical effects

Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

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Bioactive Materials 2023年第4期22卷 141-167页

作者： Qiaohui Chen Yayun Nan Yuqi Yang Zuoxiu Xiao Min Liu Jia Huang Yuting Xiang Xingyu Long tianjiao zhao Xiaoyuan Wang Qiong Huang Kelong Ai Xiangya School of Pharmaceutical Sciences Central South UniversityChangshaHunan410078PR China Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha410078PR China Department of Pharmacy Xiangya HospitalCentral South UniversityChangshaHunan410008PR China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan410008PR China Geriatric Medical Center People’s Hospital of Ningxia Hui Autonomous RegionYinchuanNingxia750002PR China

Currently,there are no clinical drugs available to treat acute kidney injury(AKI).Given the high prevalence and high mortality rate of AKI,the development of drugs to effectively treat AKI is a huge unmet medical need and a research *** existing evidence fully demonstrates that reactive oxygen and nitrogen species(RONS)burst at the AKI site is a major contributor to AKI progression,the heterogeneity,complexity,and unique physiological structure of the kidney make most antioxidant and anti-inflammatory small molecule drugs ineffective because of the lack of kidney targeting and side ***,nanodrugs with intrinsic kidney targeting through the control of size,shape,and surface properties have opened exciting prospects for the treatment of *** antioxidant nanodrugs have emerged to address the limitations of current AKI *** this review,we systematically summarized for the first time about the emerging nanodrugs that exploit the pathological and physiological features of the kidney to overcome the limitations of traditional small-molecule drugs to achieve high AKI ***,we analyzed the pathological structural characteristics of AKI and the main pathological mechanism of AKI:hypoxia,harmful substance accumulation-induced RONS burst at the renal site despite the multifactorial initiation and heterogeneity of ***,we introduced the strategies used to improve renal targeting and reviewed advances of nanodrugs for AKI:nano-RONS-sacrificial agents,antioxidant nanozymes,and nanocarriers for antioxidants and anti-inflammatory *** nanodrugs have demonstrated excellent therapeutic effects,such as greatly reducing oxidative stress damage,restoring renal function,and low side ***,we discussed the challenges and future directions for translating nanodrugs into clinical AKI treatment.

关键词： Reactive oxygen and nitrogen species Acute kidney injury Nanomaterials Antioxidant therapy Renal physiology

Heterogeneous integration of 2D materials on Si charge-coupled devices as optical memory

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Science China(Information Sciences) 2024年第6期67卷 190-197页

作者： Zheng BIAN Feng TIAN Zongwen LI Xiangwei SU tianjiao ZHANG Jialei MIAO Bin YU Yang XU Yuda zhao College of Integrated Circuits Hangzhou Global Scientific and Technological Innovation CentreZhejiang University

Optical memory integrates the function of optical sensing in memory devices, remarkably promoting the interconnection between sensory and memory terminals. Silicon charge-coupled photodetectors and floating gate memory have been widely used in imaging and storage technologies, respectively. However,the heterogeneous integration of the two devices requires technological innovation and complex electrical connections. In this work, we adopt a three-dimensional layer stacking method to design a novel optical memory device. On the top of Si charge-coupled photodetectors, we successively deposit two-dimensional graphene,hexagonal boron nitride, and molybdenum disulfide as a floating gate layer, a tunneling layer, and a readout layer, respectively. By applying a gate bias on lightly doped Si, a deep depletion layer is formed with a high voltage potential drop. Under dark conditions, the depletion layer cannot be filled, and the electric field across the h-BN tunnel barrier is relatively small. Under light irradiation, the deep depletion layer is gradually filled, and the h-BN tunneling layer withstands the increasing electric field, resulting in charge storage in the floating gate layer. Based on this mechanism, the device exhibits a gate voltage-dependent operation mode, including an integrated optical sensing-memory mode and an electrically driven storage mode. Under moderate gate voltage, the device can effectively detect the optical information with varied intensity and store the optical information in the floating gate, displaying optically controlled memory characteristics. Our work demonstrates a compact device structure for optical memory and displays excellent optically controlled memory performance, which can be applied in artificial vision systems.

关键词： heterogeneous integration charge-coupled device floating gate optical memory molybdenum disulfide lightly doped silicon