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Defects Engineering with Multiple Dimensions in Thermoelectric Materials

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Research 2020年第1期2020卷 1898-1920页

作者： Chenxi Zhao Zhou Li tianjiao fan Chong Xiao Yi Xie Hefei National Laboratory for Physical Sciences at Microscale CAS Center for Excellence in NanoscienceUniversity of Science&Technology of ChinaHefeiAnhui 230026China Institute of Energy Hefei Comprehensive National Science CenterHefeiAnhui 230031China

Going through decades of development,great progress in both theory and experiment has been achieved in thermoelectric materials.With the growing enhancement in thermoelectric performance,it is also companied with the complexation of defects induced in the materials.0D point defects,1D linear defects,2D planar defects,and 3D bulk defects have all been induced in thermoelectric materials for the optimization of thermoelectric performance.Considering the distinct characteristics of each type of defects,in-depth understanding of their roles in the thermoelectric transport process is of vital importance.In this paper,we classify and summarize the defect-related physical effects on both band structure and transport behavior of carriers and phonons when inducing different types of defects.Recent achievements in experimental characterization and theoretical simulation of defects are also summarized for accurately determining the type of defects serving for the design of thermoelectric materials.Finally,based on the current theoretical and experimental achievements,strategies engaged with multiple dimensional defects are reviewed for thermoelectric performance optimization.

关键词： materials defects Defects

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制氧纯化系统污氮预热效果及节能分析

冶金能源 2024年第2期43卷 43-46页

作者：孔庆国范天骄杜蒙宋玥儒王等虎中钢集团鞍山热能研究院有限公司石河子大学经济管理学院天津钢管制造有限公司

根据某钢铁企业生产实际情况和工艺要求,回收4万m~3/h制氧机组压缩空气余热用于预热分子筛纯化过程加热用污氮,降低电加热器电耗,同时压缩空气温度降低,可减少空气预冷系统中冷水机组电耗,达到节能降耗减排增效的目的。

关键词：纯化系统污氮预热余热回收节能

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基于人体工学的手动轮椅助力装置研究

机械制造与自动化 2024年第3期53卷 74-78页

作者：肖天骄蒋凡魏晨婧北京社会管理职业学院(民政部培训中心) 北京102627 北京工业大学北京100124

针对我国失能、半失能老人使用非电动轮椅推行费力的现状,综合考虑使用者功能需求、使用环境与可行技术支撑三方面的要素,从动力系统可靠性理论计算、人体工学设计以及智能控制设计等方面开展研究,研发一款新型助力装置。该装置通过基... 详细信息

针对我国失能、半失能老人使用非电动轮椅推行费力的现状,综合考虑使用者功能需求、使用环境与可行技术支撑三方面的要素,从动力系统可靠性理论计算、人体工学设计以及智能控制设计等方面开展研究,研发一款新型助力装置。该装置通过基于人体工学的集成优化设计实现了轻量化(≤5 kg)、小型化(390 mm×130 mm×140 mm)结构设计要求;创新地采用基于单手操作的快速挂接结构,实现了面向市面大部分手动轮椅的高适配要求和5 s内快速装卸的易操作要求;基于使用环境的动力学分析与设计实现了室内外行进20 km的续航里程要求;通过手环控制器和摇杆控制器的多元控制方式开发,实现了不同驱动人员对助力装置启停控制和速度控制的简易化操作要求。

关键词：人体工学助力装置手动轮椅快速挂接结构

Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting

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Science China(Life Sciences) 2022年第2期65卷 328-340页

作者： Bing Jiang Xiaohua Jia tianjiao Ji Meng Zhou Jiuyang He Kun Wang Jie Tian Xiyun Yan Kelong fan Nanozyme Medical Center School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Key Laboratory of Molecular Imaging of Chinese Academy of Sciences Institute of AutomationChinese Academy of SciencesBeijing 100190China CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of MedicineBeihang UniversityBeijing 100191China

Engineered nanocarriers have been widely developed for tumor theranostics.However,the delivery of imaging probes or therapeutic drugs to the tumor pre-formation site for early and accurate detection and therapy remains a major challenge.Here,by using tailor-functionalized human H-ferritin(HFn),we developed a triple-modality nanoprobe IRdye800-M-HFn and achieved the early imaging of tumor cells before the formation of solid tumor tissues.Then,we developed an HFn-doxorubicin(Dox)drug delivery system by loading Dox into the HFn protein cage and achieved early-stage tumor therapy.The intravenous injection of HFn nanoprobes enabled the imaging of tumor cells as early as two days after tumor implantation,and the triple-modality imaging techniques,namely,near-infrared fluorescence molecular imaging(NIR-FMI),magnetic resonance imaging(MRI),and photoacoustic imaging(PAI),ensured the accuracy of detection.Further exploration indicated that HFn could specifically penetrate into pre-solid tumor sites by tumor-associated inflammation-mediated blood vessel leakage,followed by effective accumulation in tumor cells by the specific targeting property of HFn to transferrin receptor 1.Thus,the HFn-Dox drug delivery system delivered Dox into the tumor pre-formation site and effectively killed tumor cells at early stage.IRDye800-M-HFn nanoprobes and HFn-Dox provide promising strategies for early-stage tumor diagnosis and constructive implications for early-stage tumor treatment.

关键词： ferritin nanocage early theranostics tumor-associated inflammation multimodality tumor imaging drug delivery

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绿色肟化反应的综合实验设计

实验科学与技术 2024年第2期22卷 76-80页

作者：范士明余伟李傲齐董思凡韩天佼河北科技大学省部共建国家重点实验室培育基地-河北省药用分子化学实验室石家庄050018 河北远大九孚生物科技有限公司研发中心保定072150 华北制药股份有限公司新制剂分厂石家庄050000

根据科研成果,针对传统肟化反应中存在的问题设计了一种绿色肟化反应的综合实验,对所用的碱和反应装置进行了改进。首先利用湿法研磨制备可循环利用的高活性纳米碳酸钾,通过激光粒径分布仪,扫描电子显微镜(SEM),CO_(2)-程序升温实验(CO_... 详细信息

根据科研成果,针对传统肟化反应中存在的问题设计了一种绿色肟化反应的综合实验,对所用的碱和反应装置进行了改进。首先利用湿法研磨制备可循环利用的高活性纳米碳酸钾,通过激光粒径分布仪,扫描电子显微镜(SEM),CO_(2)-程序升温实验(CO_(2)-TPD)进行表征;然后利用纳米碳酸钾为碱合成α-羟亚胺芳基丙酸酯,通过串联装置实现亚硝酸酯的制备与苄基丙二酸二乙酯的肟化反应同步进行。实验避免了醇钠不能回收、腐蚀设备的缺点,解决了亚硝酸酯易挥发造成的贮存、转运困难、容易污染环境的问题。该综合实验利于学生建立环境友好的绿色化学的理念,提高学生综合能力和素质,培养科研创新思维能力。

关键词：纳米颗粒绿色化学肟化反应碳酸钾综合实验

绿原酸对高游离脂肪酸处理犊牛肝细胞胆固醇和胆汁酸代谢的影响

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中国畜牧兽医 2024年第7期51卷 2766-2775页

作者：田艳刘佳晨王爽范文文常雅奇杨天娇张泽鑫张冰冰徐闯杨威黑龙江八一农垦大学动物科技学院大庆163319 黑龙江八一农垦大学生命科学技术学院大庆163319 中国农业大学动物医学院北京100193

【目的】探究绿原酸(CGA)对高游离脂肪酸(FFA)处理的犊牛肝细胞胆固醇和胆汁酸代谢的影响。【方法】采用两步胶原酶灌注法分离犊牛原代肝细胞,利用免疫荧光鉴定细胞后将其分为4组,对照组细胞用含2%BSA的RPMI-1640培养基培养;FFA组细胞在... 详细信息

【目的】探究绿原酸(CGA)对高游离脂肪酸(FFA)处理的犊牛肝细胞胆固醇和胆汁酸代谢的影响。【方法】采用两步胶原酶灌注法分离犊牛原代肝细胞,利用免疫荧光鉴定细胞后将其分为4组,对照组细胞用含2%BSA的RPMI-1640培养基培养;FFA组细胞在含2%BSA的RPMI-1640培养基中添加1.2 mmol/L FFA后培养;CGA组细胞在含2%BSA的RPMI-1640培养基中添加20μg/mL CGA后培养;CGA+FFA组细胞在含2%BSA的RPMI-1640培养基中添加1.2 mmol/L FFA和20μg/mL CGA后培养。培养12 h后收集细胞,通过试剂盒检测细胞中甘油三酯(TAG)和总胆固醇(TC)含量;利用实时荧光定量PCR、Western blotting分别检测肝细胞中胆固醇合成相关因子甾醇调节元件结合转录因子2(SREBF2)、3-羟基-3-甲基戊二酰辅酶A还原酶(HMGCR),胆固醇外排相关因子乙酰辅酶A乙酰转移酶2(ACAT2)、ATP结合盒亚家族A成员1(ABCA1)、ATP结合盒亚家族G成员5(ABCG5)以及胆汁酸代谢相关因子胆固醇7α-羟化酶(CYP7A1)、胆固醇12α-羟化酶(CYP8B1)、胆固醇27α-羟化酶(CYP27A1)、法尼醇X受体(FXR)、成纤维细胞生长因子受体4(FGFR4)等因子的mRNA和蛋白表达水平。【结果】犊牛肝细胞经过不同处理后,与对照组相比,FFA组犊牛肝细胞中TC含量极显著降低(P<0.01),TAG含量极显著升高(P<0.01),HMGCR、ABCA1、ABCG5、ABCG8、APOA1、ACAT1、NPC1L1、FXR、FGFR4基因mRNA表达量和SREBF2、ACAT2、ABCA1、ABCG5蛋白表达量均极显著或显著降低(P<0.01;P<0.05),CYP8B1基因mRNA表达量和CYP7A1、CYP8B1蛋白表达量均极显著或显著升高(P<0.01;P<0.05);CGA组犊牛肝细胞中TC含量极显著升高(P<0.01),SREBF2、ABCA1、CYP27A1、FXR、FGFR4蛋白表达量均极显著升高(P<0.01),CYP7A1蛋白表达量极显著降低(P<0.01)。与FFA组相比,CGA+FFA组犊牛肝细胞中TC含量显著升高(P<0.05),TAG含量显著降低(P<0.05),HMGCR、ACAT2、ABCA1、ABCG5、APOA1基因mRNA表达量和SREBF2、ACAT2、ABCA1、ABCG5、FXR、FGFR4蛋白表达量均极显著或显著升高(P<0.01;P<0.05),CYP7A1、CYP8B1蛋白表达量均极显著降低(P<0.01)。【结论】CGA能参与调节犊牛肝细胞内胆固醇稳态,同时激活FXR和FGFR4,进而缓解高FFA处理的犊牛肝细胞胆汁酸蓄积。

关键词：绿原酸游离脂肪酸(FFA) 犊牛原代肝细胞胆固醇胆汁酸

Mechanism of total glucosides from Chishao(Radix Paeoniae Rubra)on proliferation and apoptosis of hepatocellular carcinoma cells via phosphatase and tensin homolog deleted on chromosome ten/phosphatidylinositol 3-kinase/protein kinase B signaling pathway

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Journal of Traditional Chinese Medicine 2021年第5期41卷 677-683页

作者： fan Bingbing LI tianjiao MENG Xiansheng WANG Shuai BAO Yongrui WANG Fei College of Pharmacy Liaoning University of Traditional Chinese MedicineDalian 116600China College of Graduate Studies Liaoning University of Traditional Chinese MedicineShenyang 110847China

OBJECTIVE:To investigate the possible molecular mechanism of total glycosides of Chishao(Radix Paeoniae Rubra)(TG-RPR)on proliferation and apoptosis of hepatocellular carcinoma cells.METHODS:The proliferation of TG-RPR on Hep G2 cells was detected using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay.The apoptosis of Hep G2 cells was measured by annexin V-FITC/double staining.The phosphatase and tensin homolog deleted on chromosome ten(PTEN)/phosphatidylinositol 3-kinase(PI3 K)/protein kinase B(Akt)signaling pathway was evaluated by Western Blot and reverse transcription-polymerase chain reaction(RT-PCR).RESULTS:TG-RPR can up-regulation the expression of pro-apoptotic factors such as PTEN and BCL2-Associated X(Bax),down-regulation the expression of anti-apoptotic factors including B-cell lymphoma-2(Bcl-2),PI3 K,and Akt.CONCLUSION:TG-RPR significantly inhibits the proliferation of Hep G2 cells in a dose-dependent manner and promotes apoptosis.These results demonstrated TG-RPR has significant inhibitory effect on Hep G2 cells.These results identify a critical role of TG-RPR in proliferation and apoptosis of Hep G2 cells via modulating PTEN/PI3 K/Akt signaling pathway.TG-RPR may offer a promise as a potential pharmaceutical therapy for hepatocellular carcinoma.

关键词： carcinoma,hepatocellular glycosides PTEN phosphohydrolase phosphatidylinositol 3-kinase proto-oncogene proteins c-akt Chishao(Radix Paeoniae Rubra)

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某特种水泥熟料生产线脱硝工艺选择的探讨

水泥工程 2024年第3期 25-29页

作者：任勇折鹏飞吴振山陈天佼陈海周新桥赵樊方鹏陶东光吴朋朋枣庄市工程建设监理有限公司合肥华创碧蓝科技有限公司北京东方国信科技股份有限公司

某特种水泥熟料生产线在“窑头低氮燃烧+分解炉分级燃烧”同时作用下的单位熟料NOx产量为5.52 kg/t，理论推算即使“LNB+SCC+SNCR+SCR”的组合脱硝也不能同时满足NOx超净排放且单位熟料氨耗≤4 kg/t的刚性指标。本文遴选出“LNB+SCC+热... 详细信息

某特种水泥熟料生产线在“窑头低氮燃烧+分解炉分级燃烧”同时作用下的单位熟料NOx产量为5.52 kg/t，理论推算即使“LNB+SCC+SNCR+SCR”的组合脱硝也不能同时满足NOx超净排放且单位熟料氨耗≤4 kg/t的刚性指标。本文遴选出“LNB+SCC+热碳还原+高效SNCR+高温低尘SCR”的组合脱硝工艺可满足政策要求。实施后NOx排放浓度能够精准调控到45±5 mg/m3，单位熟料NOx消减5.38 kg/t，是常规水泥窑脱硝过程单位熟料NOx消减量的3.64倍，预期单位熟料氨耗2.69 kg/t，单位熟料煤耗增加1.36 kg/t，单位熟料电耗增加2.68 kWh/t，单位熟料脱硝综合运行成本由当前的9.31元/t降至7.27元/t，年脱硝运营费用节约113万元。

关键词： SCR脱硝精准脱硝气化炉热碳还原特种水泥氨氮比

Active knee joint exoskeleton for stair ascent augmentation

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Science China(Information Sciences) 2021年第3期64卷 243-245页

作者： Zongwei ZHANG Jizhuang fan Hongzhe JIN tianjiao ZHENG Sikai ZHAO Shun MA Jie ZHAO Yanhe ZHU State Key Laboratory of Robotics and Systems

Dear editor,Stair climbing is a strenuous daily movement that is challenging for older adults and those with lower limb weakness.In this study, we describe a novel stairclimbing exoskeleton that was designed to help w... 详细信息

关键词： exoskeleton stair climbing hybrid control zero-force tracking switching controller