检索结果-南通市图书馆

Intelligent gold nanocluster for effective treatment of malignant tumor via tumor-specific photothermal–chemodynamic therapy with AIE guidance

引用

National Science Review 2024年第5期11卷 326-342页

作者： Feng Liu tianfeng yang Xiaowei Chang Li Chen Cheng Cheng Xiuhong Peng Haihu Liu Yanmin Zhang Xin Chen School of Energy and Power Engineering Xi'an Jiaotong University Department of Chemical Engineering Shaanxi Key Laboratory of Energy Chemical Process IntensificationInstitute of Polymer Science in Chemical Engineering School of Chemical Engineering and Technology Xi'an Jiaotong University School of Pharmacy Health Science Center Xi'an Jiaotong University

Precise and efficient therapy of malignant tumors is always a challenge. Herein, gold nanoclusters co-modified by aggregation-induced-emission（AIE） molecules, copper ion chelator（acylthiourea） and tumor-targeting agent（folic acid） were fabricated to perform AIE-guided and tumor-specific synergistic therapy with great spatio-temporal controllability for the targeted elimination and metastasis inhibition of malignant tumors. During therapy, the functional gold nanoclusters（Au NTF） would rapidly accumulate in the tumor tissue due to the enhanced permeability and retention effect as well as folic acid-mediated tumor targeting, which was followed by endocytosis by tumor cells. After that, the overexpressed copper ions in the tumor cells would trigger the aggregation of these intracellular Au NTF via a chelation process that not only generated the photothermal agent in situ to perform the tumor-specific photothermal therapy damaging the primary tumor, but also led to the copper deficiency of tumor cells to inhibit its ***, the copper ions were reduced to cuprous ions along with the chelation, which further catalysed the excess H2O2in the tumor cells to produce cytotoxic reactive oxygen species, resulting in additional chemodynamic therapy for enhanced antitumor efficiency. The aggregation of Au NTF also activated the AIE molecules to present fluorescence, which not only imaged the therapeutic area for real-time monitoring of this tumor-specific synergistic therapy, but also allowed us to perform near-infrared radiation at the correct time point and location to achieve optimal photothermal therapy. Both in vitro and in vivo results revealed the strong tumor elimination, effective metastasis inhibition and high survival rate of tumor-bearing mice after treatment using the Au NTF nanoclusters, indicating that this AIE-guided and tumor-specific synergistic strategy could offer a promising approach for tumor therapy.

关键词： AIE-guided precise tumor treatment copper-dependent photothermal therapy copper-triggered chemodynamic therapy primary tumor elimination copper-plunder-induced metastasis inhibition

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Enhancing the Photosensitivity of Hypocrellin A by Perylene Diimide Metallacage‑Based Host–Guest Complexation for Photodynamic Therapy

引用

Nano-Micro Letters 2024年第11期16卷 71-87页

作者： Rongrong Li tianfeng yang Xiuhong Peng Qian Feng Yali Hou Jiao Zhu Dake Chu Xianglong Duan Yanming Zhang Mingming Zhang State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China School of Pharmacy Health Science CenterXi’an Jiaotong UniversityXi’an 710061People’s Republic of China Department of Rehabilitation Medicine Shaanxi Provincial People’s HospitalXi’an 710068ShaanxiPeople’s Republic of China Department of Gastroenterology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061People’s Republic of China

The development of supramolecular hosts which can efficiently encapsulate photosensitizers to improve the photodynamic efficacy holds great promise for cancer ***,we report two perylene diimide-based metallacages that can form stable host–guest complexes with planar conjugated molecules including polycyclic aromatic hydrocarbons and photosensitizers(hypocrellin A).Such host–guest complexation not only prevents the aggregation of photosensitizers in aqueous environments,but also offers fluorescence resonance energy transfer(FRET)from the metallacage to the photosensitizers to further improve the singlet oxygen generation(Φ_(Δ)=0.66).The complexes are further assembled with amphiphilic polymers,forming nanoparticles with improved stability for anticancer *** in vitro and in vivo studies indicate that the nanoparticles display excellent anticancer activities upon light irradiation,showing great potential for cancer photodynamic *** study provides a straightforward and effective approach for enhancing the photosensitivity of conventional photosensitizers via host–guest complexation-based FRET,which will open a new avenue for host–guest chemistry-based supramolecular theranostics.

关键词： Metallacages Host-guest interactions Fluorescence resonance energy transfer Singlet oxygen Photodynamic therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

被子植物花粉颜色多样性及应用研究进展

引用

生物多样性 2024年第1期32卷 116-129页

作者：张飞飞杨天凤陈莉荣刘冬梅杨柳园杨杜宇鞠鹏陆露昆明医科大学药学院暨云南省天然药物药理重点实验室昆明650500 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室昆明650201

花粉虽微小似尘埃,其形态特征的肉眼辨识度低,但花粉作为植物遗传信息携带和传播的重要结构,蕴含着被子植物生物多样性成因的关键密码,可为探索“达尔文恼人之谜”提供一个微形态学的视角。花粉形态具有遗传性和高度多样性,一直被用于... 详细信息

花粉虽微小似尘埃,其形态特征的肉眼辨识度低,但花粉作为植物遗传信息携带和传播的重要结构,蕴含着被子植物生物多样性成因的关键密码,可为探索“达尔文恼人之谜”提供一个微形态学的视角。花粉形态具有遗传性和高度多样性,一直被用于植物分类、演化、生态、生物地理等方面的研究。然而,已有工作主要聚焦于花粉形状、大小、萌发孔、外壁纹饰和小孢子发生发育等性状,忽略了在整个被子植物范围内对花粉颜色开展系统性研究。本文阐述了花粉颜色形成的化学和遗传物质基础、花粉颜色多样性的生物驱动因子(传粉者偏好、视觉隐匿、二态性选择等)和非生物驱动因子(紫外线、温度、湿度、经纬度等),并介绍了花粉颜色在蜂学、植物组培、食品、园艺学等领域的应用现状,以及目前花粉颜色常见的测量方法。同时,基于近百年已报道的花粉颜色数据,利用Fitch简约法重建了被子植物47科71属花粉颜色的演化式样。最后,结合近年来材料科学、光谱学、人工智能、进化生态学、多组学的发展,对未来开展花粉颜色物理结构基础、人工智能测量、系统性演化分析、颜色形成分子机制等方面的研究提出了思考和建议。

关键词：被子植物生物多样性驱动因子物质基础测量与量化花粉颜色

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

注射用头孢西丁钠有关物质测定方法的改进

引用

中国抗生素杂志 2024年第3期49卷 341-347页

作者：王强韩彬王韵杨天风李聪颖高燕霞河北省药品医疗器械检验研究院石家庄050020 河北科技大学石家庄050018

目的改进注射用头孢西丁钠有关物质的测定方法。方法采用苯基硅烷键合硅胶为填充剂(Inertsil Ph-3色谱柱4.6 mm×250 mm,3μm);以甲酸铵缓冲液(取甲酸铵1.0 g,加水1000 mL使溶解,用甲酸调节pH值至2.7)为流动相A,乙腈为流动相B,按线性梯... 详细信息

目的改进注射用头孢西丁钠有关物质的测定方法。方法采用苯基硅烷键合硅胶为填充剂(Inertsil Ph-3色谱柱4.6 mm×250 mm,3μm);以甲酸铵缓冲液(取甲酸铵1.0 g,加水1000 mL使溶解,用甲酸调节pH值至2.7)为流动相A,乙腈为流动相B,按线性梯度洗脱,流速为1.0 mL/min,柱温为35℃,检测波长为254 nm。结果头孢西丁峰与各杂质峰分离良好,头孢西丁在0.0446~13.3692μg/mL范围内线性良好,检出限为0.89 ng,精密度与重复性均符合规定。结论本方法灵敏度高,分离效果好,可现实对头孢西丁钠已知杂质和聚合物杂质进行同时检测。

关键词：注射用头孢西丁钠有关物质聚合物方法优化质量控制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于光学显微及电镜分析技术的土霉素片溶出行为解析

引用

河北医药 2024年第13期46卷 2055-2060页

作者：张少萌张冬杨天风丁维靖河北省药品审评中心石家庄市050090 河北省药品医疗器械检验研究院河北省儿童医院

目的建立土霉素片溶出度测定方法,考察不同企业产品体外溶出行为的差异;利用光学显微、电镜分析技术追溯引发溶出行为差异的根本原因。方法采用桨法-HPLC法测定溶出度,采用光学显微及电镜分析技术对片芯中土霉素与辅料形态与溶出行为... 详细信息

目的建立土霉素片溶出度测定方法,考察不同企业产品体外溶出行为的差异;利用光学显微、电镜分析技术追溯引发溶出行为差异的根本原因。方法采用桨法-HPLC法测定溶出度,采用光学显微及电镜分析技术对片芯中土霉素与辅料形态与溶出行为进行分析。结果土霉素在18.5~92.6μg/mL浓度范围内线性关系良好,平均回收率为98.4%,RSD为0.7%(n=9),方法准确可靠。偏光显微镜法和扫描电镜法的分析结果显示制剂中原、辅料的晶体形态与存在状态与药物的溶出行为存在一定的相关性。结论对于多晶型药物,利用光学显微及电镜分析与溶出度相结合的方法可更有效、全面地评价其口服固体制剂的质量。

关键词：土霉素片溶出行为光学显微电镜分析药物评价

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

心理压力对精子质量影响的机制研究

引用

预防医学 2024年第8期36卷 683-686页

作者：杨天峰(综述) 沈云芸(综述) 徐方忠(审校) 浙江理工大学心理学系浙江杭州310018 浙江省立同德医院浙江杭州310012

心理压力是男性精子质量下降的重要影响因素之一。在心理机制层面,心理压力导致精子质量下降与压力知觉增加及不同应对方式相关,外界压力源可能导致压力知觉增加进而影响精子质量,而不同应对方式又可能调节压力知觉对精子质量的影响。... 详细信息

心理压力是男性精子质量下降的重要影响因素之一。在心理机制层面,心理压力导致精子质量下降与压力知觉增加及不同应对方式相关,外界压力源可能导致压力知觉增加进而影响精子质量,而不同应对方式又可能调节压力知觉对精子质量的影响。在生理机制层面,心理压力会影响交感肾上腺系统、下丘脑-垂体-肾上腺轴和下丘脑-垂体-睾丸轴的正常功能,导致精子发生的内分泌环境紊乱,进而影响精子质量。本文对心理压力影响男性精子质量的心理和生理机制进行综述,为男性不育症防治提供依据。

关键词：心理压力精子质量压力知觉压力源内分泌

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

土霉素原料及片剂中有关物质测定

引用

中国药业 2024年第5期33卷 68-72页

作者：杨天风张少萌高燕霞张冬河北省药品医疗器械检验研究院河北石家庄050200 河北省药品审评中心河北石家庄050011

目的建立测定土霉素原料及片剂中有关物质含量的高效液相色谱法。方法色谱柱为Thermo Hypersil GOLD Sino Chrom C_(18)柱(250 mm×4.6 mm,5μm),流动相A为醋酸铵溶液[0.25 mol/L醋酸铵-0.05 mol/L乙二胺四乙酸二钠溶液-三乙胺(100∶10... 详细信息

目的建立测定土霉素原料及片剂中有关物质含量的高效液相色谱法。方法色谱柱为Thermo Hypersil GOLD Sino Chrom C_(18)柱(250 mm×4.6 mm,5μm),流动相A为醋酸铵溶液[0.25 mol/L醋酸铵-0.05 mol/L乙二胺四乙酸二钠溶液-三乙胺(100∶10∶1,V/V/V),用醋酸调pH至7.5]-乙腈(88∶12,V/V),流动相B为乙腈进行梯度洗脱,流速为1.0 mL/min,检测波长为254 nm,柱温为30℃,进样量为10μL。结果土霉素的质量浓度在0.5~20μg/mL范围内与峰面积线性关系良好(r=0.9998,n=6);检测限为1.4 ng,定量限为5.0 ng;精密度和稳定性试验结果的RSD均小于2.0%;专属性试验与强力破坏试验中,土霉素与强制破坏的降解产物及与其他8种已知杂质对照品均可实现有效分离。土霉素片中2-乙酰-2-去酰胺土霉素检出量为1.62%~2.73%,其他杂质总含量为1.20%~1.84%。结论该方法操作简便、专属性好、灵敏度高,可用于土霉素原料及片剂中有关物质的测定。拟订土霉素片中有关物质2-乙酰-2-去酰胺土霉素的限度为不得过对照溶液主峰面积的3.5%,其他各杂质峰面积之和不得过对照溶液主峰面积的2.0%。

关键词：土霉素高效液相色谱法有关物质 2-乙酰-2-去酰胺土霉素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Designing macrophage membrane-engineered ruthenium/selenium nanoparticles to block bone metastasis of breast cancer

引用

Nano Research 2024年第8期17卷 7504-7512页

作者： Meijin yang Zhiying Tang Xiaoying Li Yanzi Yu Lizhen He tianfeng Chen College of Chemistry and Materials Science Department of Oncology of The First Affiliated HospitalJinan UniversityGuangzhou 510632China

Bone metastasis along with osteolysis is a common complication of advanced breast cancer,which directly destroys bone function and becomes one of the major causes of cancer-related *** is crucial to develop a new strategy to achieve effective cancer therapy and inhibition of osteolytic bone *** ruthenium(Ru)complexes exhibit therapeutic potential in cancer ***,the clinical applications of Ru complexes were limited by poor bioavailability,lacking targeting,nonspecific ***,in this study,engineering of cell membrane biomimetic modification was used to construct a highly biocompatible nanoplatform with carrying Ru metal complex of RuPOP and Se nanoparticles(SeNPs).Strikingly,the obtained RPSR nanoparticles can efficiently inhibit the proliferation,invasion and migration of breast cancer cells(MDA-MB-231 cells)in *** importantly,RPSR nanoparticles can induce cycle arrest,apoptosis by generating excessive intracellular(reactive oxygen species,ROS)to disrupt the normal redox balance and induce DNA damage in tumor ***,RPSR nanoparticles can also reshape bone microenvironment by regulating selenoproteins to inhibit osteoclasts and avoid osteolytic bone metastasis induced by tumor *** together,this study not only provides an effective cell membrane biomimetic strategy to enhance the shortcomings of metal complexes,but also demonstrates potential clinical significance for the combined treatment of anti-cancer and bone metastasis inhibition.

关键词： cell membrane nanoparticles biomimetic modification ruthenium complexes selenium nanoparticles tumor bone metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cyanostilbene-based near-infrared emissive platinum(Ⅱ) metallacycles for cancer theranostics

引用

Chinese Chemical Letters 2019年第11期30卷 1942-1946页

作者： Lingzhi Ma tianfeng yang Zeyuan Zhang Siping Yin Zhongxiao Song Wen Shi Dake Chu Yanmin Zhang Mingming Zhang State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong UniversityXi'an 710049China School of Pharmacy Health Science CenterXi'an Jiaotong UniversityXi'an 710061China Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

In this work,a near-infrared emissive dipyridyl ligand was synthesized and used to prepare three platinum(II)metallacycles with different shapes via metal-coordination-driven self-assembly with different platinum(II)*** metallacycles were further used for both cell imaging and cancer therapy,offering a new type of theranostic agents towards cancer treatment.

关键词： Near-infrared emission Self-assembly Metallacycles Cancer therapy Cell imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multistimuli-Responsive Fluorescent Organometallic Assemblies Based on Mesoionic Carbene-Decorated Tetraphenylethene Ligands and Their Applications in Cell Imaging

引用

CCS Chemistry 2022年第2期4卷 732-743页

作者： yang Li tianfeng yang Nan Li Sha Bai Xin Li Li-Li Ma Kai Wang Yanmin Zhang Ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127 School of Pharmacy Health Science CenterXi’an Jiaotong UniversityXi’an 710061 State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012

The controllable construction of light-emitting organometallic supramolecular materials integrating stimulus responses and biological applications is still a major challenge *** this work,emissive organometallic assemblies based on AgI/AuI and mesoionic carbene-decorated tetraphenylethene(MIC-TPE)ligands have been synthesized and *** studies showed that these organometallic assemblies[M_(4)(2)_(2)](OTf)_(4) not only fluoresce in various dilute solutions,resulting from the rigidification of MIC-TPE ligands upon complexation,but also show tunable fluorescence wavelengths and intensity behaviors in mixed solvent systems and at varying temperatures while in solution,and mechanical pressure stimulus-responsive fluorescent features in the solid ***,the organometallic cages[M_(4)(2)_(2)](OTf)_(4)(M=Ag and Au)were successfully employed for cell imaging and showed the potential of anticancer activity,making them promising candidates for cancer *** work provides a simple and efficient method to prepare highly emissive and stimulus-responsive organometallic materials and paves the way for related biological applications such as cancer cell imaging and targeted therapy.

关键词： light-emitting materials mesoionic carbene organometallic chemistry mechanochromic properties cell imaging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：