Multistimuli-Responsive Fluorescent Organometallic Assemblies Based on Mesoionic Carbene-Decorated Tetraphenylethene Ligands and Their Applications in Cell Imaging

作     者：Yang Li Tianfeng Yang Nan Li Sha Bai Xin Li Li-Li Ma Kai Wang Yanmin Zhang Ying-Feng Han 

作者机构：Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of EducationCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127 School of PharmacyHealth Science CenterXi’an Jiaotong UniversityXi’an 710061 State Key Laboratory of Superhard MaterialsCollege of PhysicsJilin UniversityChangchun 130012 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2022年第4卷第2期

页      面：732-743页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：The authors gratefully acknowledge financial support from the National Natural Science Foundation(NSFC)(grant nos.22025107,21722105,and 21771146) the National Youth Top-notch Talent Support Program of China,the Key Science and Technology Innovation Team of Shaanxi Province(nos.2019TD-007 and 2019JLZ-02) the FM&EM International Joint Laboratory of Northwest University 

主　　题：light-emitting materials mesoionic carbene organometallic chemistry mechanochromic properties cell imaging 

摘      要：The controllable construction of light-emitting organometallic supramolecular materials integrating stimulus responses and biological applications is still a major challenge *** this work,emissive organometallic assemblies based on AgI/AuI and mesoionic carbene-decorated tetraphenylethene(MIC-TPE)ligands have been synthesized and *** studies showed that these organometallic assemblies[M_(4)(2)_(2)](OTf)_(4) not only fluoresce in various dilute solutions,resulting from the rigidification of MIC-TPE ligands upon complexation,but also show tunable fluorescence wavelengths and intensity behaviors in mixed solvent systems and at varying temperatures while in solution,and mechanical pressure stimulus-responsive fluorescent features in the solid ***,the organometallic cages[M_(4)(2)_(2)](OTf)_(4)(M=Ag and Au)were successfully employed for cell imaging and showed the potential of anticancer activity,making them promising candidates for cancer *** work provides a simple and efficient method to prepare highly emissive and stimulus-responsive organometallic materials and paves the way for related biological applications such as cancer cell imaging and targeted therapy.