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Prevention of urinary tract infection using a silver alloy hydrogel-coated catheter in critically ill patients: A single-center prospective randomized controlled study

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Journal of Intensive Medicine 2024年第1期4卷 118-124页

作者： Menglong Zhao Shike Geng Lei Zhang Xiaoqin Fan Fei Tong Xianlin Meng tianfeng wang Xiaowei Fang Qing Mei Aijun Pan Department of Intensive Care Unit The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001AnhuiChina

Background:A new type of silver alloy hydrogel-coated(SAH)catheter has been shown to prevent bacterial adhesion and colonization by generating a microcurrent,and to block the retrograde infection ***,these have only been confirmed in ordinary *** study aims to evaluate the effectiveness of a SAH catheter for preventing urinary tract infections in critically ill ***:This was a prospective single-center,single-blind,randomized,controlled study.A total of 132 patients requiring indwelling catheterization in the intensive care unit(ICU)of the First Affiliated Hospital of the University of Science and Technology of China between October 2022 and February 2023 and who met the study inclusion/exclusion criteria were randomly divided into two *** in the SAH catheter group received a SAH catheter,while patients in the conventional catheter group received a conventional siliconized latex Foley *** main outcome measure was the incidence of catheter-associated urinary tract infections(CAUTIs).Secondary outcome indicators included urine positivity for white blood cells and positive urine cultures on 3 days,7 days,10 days,and 14 days after catheterization,number of viable bacteria in the catheter biofilm on day 14,pathogenic characteristics of positive urine cultures,length of ICU stay,overall hospital stay,ICU mortality,and 28-day *** the data were compared between the two ***:A total of 68 patients in the conventional catheter group and 64 patients in the SAH catheter group were included in the *** day 7 after catheter placement,the positivity rate for urinary white blood cells was significantly higher in the conventional catheter group than in the SAH catheter group(33.8%vs.15.6%,P=0.016).On day 10,the rates of positive urine cultures(27.9%vs.10.9%,P=0.014)and CAUTIs(22.1%vs.7.8%,P=0.023)were significantly higher in the conventional catheter group than in the SAH catheter *** day 14,the numb

关键词： Catheter coating Effectiveness evaluation Biofilm Catheter-associated urinary tract infection Outcome

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品种保护法律制度与农户自留种权的冲突分析

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分子植物育种 2024年第10期22卷 3451-3457页

作者：王天凤吕梁学院吕梁033001

品种保护法律制度为农业创新提供了法律框架和经济激励,从而促进了农业的可持续发展,保障了育种者的权益,提高了农产品的质量和市场竞争力。但其实施也引发了一系列关于农户自留种权的问题。市场垄断、法规执行和农民对新品种需求的制... 详细信息

品种保护法律制度为农业创新提供了法律框架和经济激励,从而促进了农业的可持续发展,保障了育种者的权益,提高了农产品的质量和市场竞争力。但其实施也引发了一系列关于农户自留种权的问题。市场垄断、法规执行和农民对新品种需求的制约成了当前亟待解决的难题。本研究深入探讨了在品种保护法律制度下涌现的农户自留种权问题,对品种保护法律制度的定义、范围、法规体系以及国际比较进行了详细阐述,着眼于农户自留种权,深刻剖析了其内涵、法律依据以及特殊性。本研究深入分析当前农户自留种权问题存在的挑战与争议,提出可能的解决方案与改进建议,旨在推动农业法制的进步,确保农业可持续发展与农民权益的平衡。

关键词：品种保护法律制度农户自留种权生态多样性市场垄断农业创新

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宋代册页书画的文化解析与复制技术创新——以《夏卉骈芳图》为例

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印刷文化（中英文） 2024年第2期 122-131页

作者：王天凤故宫博物院

宋代见证了中国古代印刷装帧、绘画及科学的辉煌成就,其中团扇绘画以其精湛的“格物”精神和独特的审美价值,备受文人雅士钟爱。团扇绘画不仅在艺术表现上独树一帜,更因其便于保存和携带的册页装裱形式,成为宋代文化的重要组成部分。册... 详细信息

宋代见证了中国古代印刷装帧、绘画及科学的辉煌成就,其中团扇绘画以其精湛的“格物”精神和独特的审美价值,备受文人雅士钟爱。团扇绘画不仅在艺术表现上独树一帜,更因其便于保存和携带的册页装裱形式,成为宋代文化的重要组成部分。册页通常一侧为书法,另一侧为绘画,这种相得益彰的图文形式印证了宋人诗书画一体的观念。绘画的内容可为花卉、花鸟、山水等题材,对题的书法以创作、誊录诗句为主。本文以宋代花卉册页《夏卉骈芳图》为研究对象,深入探讨了册页类书画复制的可行性,并通过人工摹绘与数字技术相结合的方法,对册页类文物复制方法进行了创新性探究。研究结果表明,这种综合复制技术不仅能够有效地恢复文物原貌,还能为文物保护和文化传播提供新的视角和方法。

关键词：宋代团扇册页装裱艺术复制人工摹绘数字技术

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纳米气泡的特性及其在有机固体废物厌氧消化中的应用

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环境监测管理与技术 2024年第2期36卷 7-11页

作者：吴若愚李万华张庆芳王天烽兰州理工大学石油化工学院甘肃兰州730050 兰州华星高科技开发有限公司研发设计部甘肃兰州730050

基于国内外研究现状,分析了纳米气泡(NBs)的基本性质和产生方式,以及改善厌氧消化性能的作用机理,综述了NBs在有机固体废物厌氧消化中的研究进展,以及在增强厌氧消化稳定性、加快水解速率、提高甲烷产量等3个方面的应用,提出了加强不同... 详细信息

基于国内外研究现状,分析了纳米气泡(NBs)的基本性质和产生方式,以及改善厌氧消化性能的作用机理,综述了NBs在有机固体废物厌氧消化中的研究进展,以及在增强厌氧消化稳定性、加快水解速率、提高甲烷产量等3个方面的应用,提出了加强不同气体NBs理化性质研究、开发多种气源、提升检测能力、降低能耗和成本等后续研究展望。

关键词：纳米气泡厌氧消化有机固体废物稳定性水解速率甲烷产量

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Breast-conserving therapy and modified radical mastectomy for primary breast carcinoma:a matched comparative study

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Chinese Journal of Cancer Research 2015年第6期27卷 545-552页

作者： Lize wang Tao Ouyang tianfeng wang Yuntao Xie Zhaoqing Fan Benyao Lin Jinfeng Li Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Breast Cancer Center Peking University Cancer Hospital & Institute

Background- To compare two types of therapy for primary breast carcinoma, breast-conserving therapy （BCT） and modified radical mastectomy （MRM）, in a matched cohort study. Methods： A series of 1,746 patients with primary breast cancer treated with BCT or MRM in a single Chinese institute between January 2000 and February 2009 were analyzed retrospectively to compare their outcomes with respect to the incidence of local recurrence （LR）, distant metastasis, and survival. The patients were matched with regard to age at diagnosis, spreading to axillary lymph nodes, hormone receptor status, the use of neoadjuvant chemotherapy and maximal tumor diameter. The match ratio was 1：1, and each arm included 873 patients. Results： The median follow-up period was 71 months. The 6-year disease-free survival （DFS） and 6-year distant disease-free survival （DDFS） rates differed significantly between two groups. The 6-year local recurrence-free survival （LRFS） rates were 98.2% [95% confidence interval （CI）： 0.973-0.989] in the BCT group and 98.7% （95% CI： 0.980-0.994） in the MRM group （P=0.182）, respectively. DFS rates in BCT and MRM groups were 91.3% （95% CI： 0.894-0.932） and 86.3% （95% CI： 0.840-0.886）（P〈0.001）, respectively, whereas the DDFS rates in BCT and MRM groups were 93.6% （95% CI： 0.922-0.950） and 87.7% （95% CI： 0.854-0.900）（P〈0.001）, respectively. Conclusions： BCT in eligible patients is as effective as MRM with respect to local tumor control, DFS and DDFS, and may result in a better outcome than MRM in Chinese primary breast cancer patients.

关键词： Breast carcinoma breast-conserving therapy (BCT) mastectomy recurrence survival

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Early prediction of pathological outcomes to neoadjuvant chemotherapy in breast cancer patients using automated breast ultrasound

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Chinese Journal of Cancer Research 2016年第5期28卷 478-485页

作者： Xinguang wang Ling Huo Yingjian He Zhaoqing Fan tianfeng wang Yuntao Xie Jinfeng Li Tao Ouyang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Breast Center Peking University Cancer Hospital & Institute Beijing 100142 China

Objective： Early assessment of response to neoadjuvant chemotherapy （NAC） for breast cancer allows therapy to be individualized. The optimal assessment method has not been established. We investigated the accuracy of automated breast ultrasound （ABUS） to predict pathological outcomes after NAC. Methods： A total of 290 breast cancer patients were eligible for this study. Tumor response after 2 cycles of chemotherapy was assessed using the product change of two largest perpendicular diameters （PC） or the longest diameter change （LDC）. PC and LDC were analyzed on the axial and the coronal planes respectively. Receiver operating characteristic （ROC） curves were used to evaluate overall performance of the prediction methods. Youden＇s indexes were calculated to select the optimal cut-off value for each method. Sensitivity, specificity, positive and negative predictive values （PPV and NPV） and the area under the ROC curve （AUC） were calculated ***： ypT0/is was achieved in 42 patients （14.5%） while ypT0 was achieved in 30 patients （10.3%） after NAC. All four prediction methods （PC on axial planes, LDC on axial planes, PC on coronal planes and LDC on coronal planes） displayed high AUCs （all〉0.82）, with the highest of 0.89 [95% confidence interval （95% CI）, 0.83-0.95] when mid-treatment ＆BUS was used to predict final pathological complete remission （pCR）. High sensitivities （85.7%-88.1%） were observed across all four prediction methods while high specificities （81.5%-85.1%） were observed in two methods used PC. The optimal cut-off values defined by our data replicate the WHO and the RECIST criteria. Lower AUCs were observed when mid-treatment ABUS was used to predict poor pathological outcomes. Conclusions：ABUS is a useful tool in early evaluation of pCR after NAC while less reliable when predicting poor pathological outcomes.

关键词： Automated breast ultrasound breast neoplasms drug monitoring neoadjuvant therapy pathologicalcomplete remission ultrasonography

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Rockburst mechanism and the law of energy accumulation and release in mining roadway: a case study

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International Journal of Coal Science & Technology 2022年第5期9卷 96-112页

作者： Feng Du Ji Ma Xiaofei Guo tianfeng wang Xiaohang Dong Jiashuo Li Shulei He Dilinaer Nuerjuma Beijing Key Laboratory for Precise Mining of Intergrown Energy and Resources China University of Mining and Technology(Beijing)100083 BeijingChina State and Local Joint Engineering Laboratory for Gas Drainage&Ground Control of Deep Mines Henan Polytechnic University454003 JiaozuoHenanChina School of Safety Science and Engineering Henan Polytechnic University454003 JiaozuoHenanChina

The rockburst dynamic disasters in the process of deep coal mining become more and more *** the rockburst occurred in the 23130 working face of Yuejin Coal Mine as the engineering background,we study the characteristics of mining stress feld around roadway,the plastic failure morphological characteristics of surrounding rock and the accumulation/release law of elastic energy before and after *** analysis model quantitatively describing the physical process of rockburst in the mining roadway is established,and the calculation method of dynamic release of elastic energy in the physical process of rockburst is *** mechanism of rockburst in mining roadway is *** results show that an“L-shaped”stress concentration zone is formed within 100 m of the 23130 working face,and the principal stress ratio of the surrounding rock of the transportation roadway is 2.59–*** change of the direction of the maximum principal stress has a signifcant efect on the burst appearance *** failure strength of diferent sections of the mining roadway is characterized by the elastic energy release *** the increase of the working face distance,the elastic energy released by burst failure and the expansion variation of failure boundary radius show a nonlinear variation law that tends to decrease steadily after sharp *** closer to the working face,the higher the burst *** a distance of 10 m from the working surface,the maximum principal stress reaches its maximum *** butterfy-shaped failure system generated by the surrounding rock of the roadway has energy self-sustainability,and the elastic energy released by the sudden expansion of the butterfy leaf is enough to cause a burst damage of 1.9 *** work could provide theoretical support for the prediction and prevention of rockburst.

关键词： Coal Rockburst Mining roadway Plastic failure Dynamic and static load Elastic energy

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Metal complex catalysts broaden bioorthogonal reactions

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Science China Chemistry 2024年第2期67卷 428-449页

作者： Hanjie Zhang Xiaoyu Qin Junping wang Li Ma tianfeng Chen Department of Chemistry Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou510632China

Bioorthogonal reactions involving transition metals have diversified applications in imaging,drug development,chemical catalysis and other *** metals used to catalyze the bioorthogonal reaction mainly include ruthenium,palladium,copper,and ***,the great potential for translational applications of bioorthogonal reaction needs to be further expanded and their reaction efficiency should be ***,it is an urgent need for the development of this field to find more suitable catalysts to efficiently catalyze existing biological orthogonal reactions and expand the types of biological orthogonal ***,this review not only summarizes those transition metal complexes-based catalysts participating in bioorthogonal reaction and some bioorthogonal reactions involving transition metals inside the cells,but also sheds light into the discovery of new transition metal complexes and their future development in applications.

关键词： transition metal complexes bioorthogonal reactions biological applications

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Regulation effect of the grille spacing of a funnel-type grating water–sediment separation structure on the debris flow performance

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Journal of Mountain Science 2024年第7期21卷 2283-2304页

作者： LI Shuai GU tianfeng wang Jiading wang Fei LI Pu State Key Laboratory of Continental Dynamics/Department of Geology Northwest UniversityXi’an 710069China Chengdu Institute of Mountain Hazards and Environment Ministry of Water Resources&Chinese Academy of SciencesChengdu 610299China

The size of pores or the grille spacing of water–sediment separation structures directly affects their regulation effect on the debris flow performance.A suitable pore size or grille spacing can effectively improve the water–sediment separation ability of the *** new funnel-type grating water–sediment separation structure(FGWSS)combines vertical and horizontal structures and provides a satisfactory water–sediment separation ***,the regulation effect of the grille spacing of the structure on the debris flow performance has not been *** regulation effect of the structure grille spacing on the debris flow performance is studied through a flume test,and the optimal structure grille spacing is *** empirical equation of the relationship between the relative grille spacing of the structure and the sediment separation rate is ***,the influence of the water–sediment separation structure on the regulation effect of debris flows is examined from two aspects:external factors(properties of debris flows)and internal factors(structural factors).The experimental results show that the gradation characteristics of solid particles in debris flows constitute a key factor affecting the regulation effect of the structure on the debris flow *** optimum grille spacing of the FGWSS matches the particle size corresponding to the material distribution curves d85~d90 of the debris *** total separation rate of debris flow particles is related to the grille spacing of the structure and the content of coarse and fine particles in the debris flow.

关键词： Debris flow Water–sediment separation structure Grille spacing Performance regulation effect

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RNA2Immune:A Database of Experimentally Supported Data Linking Non-coding RNA Regulation to The Immune System

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Genomics, Proteomics & Bioinformatics 2023年第2期21卷 283-291页

作者： Jianjian wang Shuang Li tianfeng wang Si Xu Xu wang Xiaotong Kong Xiaoyu Lu Huixue Zhang Lifang Li Meng Feng Shangwei Ning Lihua wang Department of Neurology The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China College of Bioinformatics Science and Technology Harbin Medical UniversityHarbin 150081China

Non-coding RNAs(ncRNAs),such as microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs),have emerged as important regulators of the immune system and are involved in the control of immune cell biology,disease pathogenesis,as well as vaccine responses.A repository of ncRNA-immune associations will facilitate our understanding of ncRNA-dependent mechanisms in the immune system and advance the development of therapeutics and prevention for immune ***,we describe a comprehensive database,RNA2Immune,which aims to provide a high-quality resource of experimentally supported database linking ncRNA regulatory mechanisms to immune cell function,immune disease,cancer immunology,and *** current version of RNA2Immune documents 50,433 immune-ncRNA associations in 42 host species,including(1)6690 ncRNA associations with immune functions involving 31 immune cell types;(2)38,672 ncRNA associations with 348 immune diseases;(3)4833 ncRNA associations with cancer immunology;and(4)238 ncRNA associations with vaccine responses involving 26 vaccine types targeting 22 ***2Immune provides a user-friendly interface for browsing,searching,and downloading ncRNA-immune system ***,RNA2Immune provides important information about how ncRNAs influence immune cell function,how dysregulation of these ncRNAs leads to pathological consequences(immune diseases and cancers),and how ncRNAs affect immune responses to vaccines.

关键词： ncRNA Immune cell Immune disease Cancer immunology Vaccine

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