RNA2Immune:A Database of Experimentally Supported Data Linking Non-coding RNA Regulation to The Immune System

作     者：Jianjian Wang Shuang Li Tianfeng Wang Si Xu Xu Wang Xiaotong Kong Xiaoyu Lu Huixue Zhang Lifang Li Meng Feng Shangwei Ning Lihua Wang 

作者机构：Department of NeurologyThe Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China College of Bioinformatics Science and TechnologyHarbin Medical UniversityHarbin 150081China 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2023年第21卷第2期

页      面：283-291页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.81820108014,82071407,81771361,32070672,and 81901277) the National Key R&D Project of China(Grant No.2018YFE0114400) the Postdoctoral Foundation of Heilongjiang Province,China(Grant No.LBH-TZ1019) 

主　　题：ncRNA Immune cell Immune disease Cancer immunology Vaccine 

摘      要：Non-coding RNAs(ncRNAs),such as microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs),have emerged as important regulators of the immune system and are involved in the control of immune cell biology,disease pathogenesis,as well as vaccine responses.A repository of ncRNA-immune associations will facilitate our understanding of ncRNA-dependent mechanisms in the immune system and advance the development of therapeutics and prevention for immune ***,we describe a comprehensive database,RNA2Immune,which aims to provide a high-quality resource of experimentally supported database linking ncRNA regulatory mechanisms to immune cell function,immune disease,cancer immunology,and *** current version of RNA2Immune documents 50,433 immune-ncRNA associations in 42 host species,including(1)6690 ncRNA associations with immune functions involving 31 immune cell types;(2)38,672 ncRNA associations with 348 immune diseases;(3)4833 ncRNA associations with cancer immunology;and(4)238 ncRNA associations with vaccine responses involving 26 vaccine types targeting 22 ***2Immune provides a user-friendly interface for browsing,searching,and downloading ncRNA-immune system ***,RNA2Immune provides important information about how ncRNAs influence immune cell function,how dysregulation of these ncRNAs leads to pathological consequences(immune diseases and cancers),and how ncRNAs affect immune responses to vaccines.