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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue Ren Ying Tang Qi Yang tian-tian meng Song Li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

Lineal DNA logic gate for microRNA diagnostics with strand displacement and fluorescence resonance energy transfer

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Chinese Chemical Letters 2015年第9期26卷 1179-1182页

作者： tian-tian meng Ying-Xin Liu meng-Tan Liu Jiao-Bao Long Qing-Feng Cao Shu-Ya Yan Xiang-Xian meng College of Biology The High School Attach to Hunan University Hunan University School of Life Science Xiamen University

Designing molecular logic gates to operate programmably for molecular diagnostics in molecular computing still remains ***,we designed a novel linear DNA logic gates for microRNA analysis based on strand displacement and fluorescence resonance energy transfer（FRET）.Two labeled strands closed each other produce to FRET through hybridization with a complementary strand to form a basic work unit of logic *** indicators of heart failure（microRNA-195 and microRNA-21） were selected as the logic inputs and the fluorescence mode was used as the logic *** have demonstrated that the molecular logic gate mechanism worked well with the construction of YES and AND gates.

关键词： Molecular logic gate Strand displacement Fluorescence resonance energy transfer

Chinese herbal medicine Ginkgo biloba *** for ischemic stroke:An overview of systematic reviews and meta-analyses

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Journal of Integrative Medicine 2024年第2期22卷 163-179页

作者： tian-tian meng Ya-ping You Min Li Jian-bo Guo Xin-bin Song Jing-yi Ding Xiao-long Xie An-qi Li Shang-jin Li Xiang-jun Yin Peng Wang Zhe Wang Bao-liang Wang Qing-yong He Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100032China Department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing 100071China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chinese Medicine the University of Hong KongHong KongChina Graduate School Henan University of Chinese MedicineZhengzhou 450008Henan ProvinceChina Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesZhengzhou 450008Henan ProvinceChina School of Integrated Traditional Chinese and Western Medicine Southwest Medical UniversityHangzhou 310053Zhejiang ProvinceChina School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhu 310053Zhejang ProvinceChina Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450003Henan ProvinceChina

Background:Ginkgo biloba ***(GBLPs)are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke(IS).Recently,several systematic reviews(SRs)and meta-analyses(MAs)of GBLPs for IS have been ***:This overview aims to assess the quality of related SRs and *** strategy:Pub Med,Embase,Cochrane Library,Web of Science,Chinese Biological Medicine,China National Knowledge Infrastructure,Wanfang,and Chinese Science and Technology Journals databases were searched from their inception to December 31,*** criteria:SRs and MAs of randomized controlled trials(RCTs)that explored the efficacy of GBLPs for patients with IS were *** extraction and analysis:Two independent reviewers extracted data and assessed the methodological quality,risk of bias(ROB),reporting quality,and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),***,descriptive analysis and data synthesis were ***:Twenty-nine SRs/MAs involving 119 outcomes were included in this *** overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2,and 28 had a high ROB based on the *** to the PRISMA statement,the reporting items of the included SRs/MAs are relatively *** results based on GRADE showed that of the 119 outcomes,8 were rated as moderate quality,24 as low quality,and 87 as very low *** on the data synthesis,GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function ***:GBLPs can be considered a beneficial supplemental therapy for ***,because of the low quality of the existing eviden

关键词： statement synthesis alone

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai meng tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

“Slope-adsorption & plateau-pore filling” mechanism unlocking the potential of hard carbon anodes for “fast-charging & large-sized”batteries

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Science China Materials 2025年第1期 309-311页

作者： tian Liang Xiaoming Zhu Hubei Key Laboratory of Radiation Chemistry and Functional Materials School of Nuclear Technology and Chemistry & Biology Hubei University of Science and Technology

To date, there has been no report on fast-charging and Ahlevel sodium-ion batteries (SIBs) by utilizing thick hard carbon anodes that demonstrate prolonged cycling life and high areal capacity at high rates. Further, the relationship among the complex structure of hard carbon, storage mechanism, and fastcharging performance in alkali-metal ion batteries has been a subject of ongoing debate [1,2].

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Identification of Developmentally Regulated Genes by Transposon-mediated Gene Trap Approach in Zebrafish

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Identification of Developmentally Regulated Genes by Transpo...

以ZnO为模板和催化剂将PVC转化为分级多孔碳材料

中国遗传学会“发育、遗传和疾病”研讨会

作者： ZHAO Xin-Yi tian tian ZHAO Long meng An-Ming Department of Bioscience and Technology,Molecular and Developmental Biology Laboratory,Tsinghua University,Beijing,100084

Zebrafish is an excellent animal model to study vertebrate development by genetic approaches. To identify some key genes in the process of development,we have used the Tol2 transposable element to design and perform gene trapping in ***,we constructed a transposon-based gene trap vector containing a EF1αor vasa splice accepter,a EF1α polyA,and a GFP report gene to performed a pilot screen for gene *** Tol2 transposon vector and the transposase mRNA were coinjected into one-cell stage *** date,we have isolated about 150 transgenic lines expressing GFP in temporally and spatially restricted *** mutants with different phenotypes have also been *** the gene cloning and functional assay are being carried *** propose our gene trap approach should facilitate studies of zebrafish development.

关键词： Tol2 gene trap transposon development

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中国科学：化学 2022年第3期52卷 482-493页

作者：孟甜甜章骅吕凡邵立明何品晶同济大学环境科学与工程学院上海200092 上海污染控制与生态安全研究院上海200092

聚氯乙烯(PVC)在250~310℃时发生脱氯反应,碳原子由sp^(3)杂化转变为sp^(2)杂化,随着温度的升高,这些sp^(2)杂化的碳原子进一步组装形成芳香烃类型的碳,热解碳产物往往具有一定石墨化程度,具有较高的导电性,是制作电容器电极的优良前驱... 详细信息

聚氯乙烯(PVC)在250~310℃时发生脱氯反应,碳原子由sp^(3)杂化转变为sp^(2)杂化,随着温度的升高,这些sp^(2)杂化的碳原子进一步组装形成芳香烃类型的碳,热解碳产物往往具有一定石墨化程度,具有较高的导电性,是制作电容器电极的优良前驱物.本研究在没有活化剂的情况下,以纳米ZnO作为模板和催化剂,热解PVC成功制备了高产率的分级多孔碳材料(HPC),比电容(1 A/g)达到226 F/g.通过比较ZnO和PVC的混合方式,以及高温碳化前是否去除ZnCl_(2),发现ZnO会降低碳材料的石墨化程度,同时在材料表面引入含氧官能团,而ZnCl_(2)的作用与之相反.后续可通过控制催化剂的种类与尺寸,改善HPC的孔结构和石墨化性质等增强其电容性能,该研究为PVC基HPC的设计提供了参考.

关键词：聚氯乙烯纳米氧化锌模板碳化催化电容

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Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu Xin Ma Shaojie tian Qinghe Cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

Smart Gas Sensors: Recent Developments and Future Prospective

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NANO-MICRO LETTERS 2025年第1期17卷 1-32页

作者： Zong, Boyang Wu, Shufang Yang, Yuehong Li, Qiuju Tao, tian Mao, Shun Tongji Univ Biomed Multidisciplinary Innovat Res Inst Coll Environm Sci & Engn Shanghai East HospState Key Lab Pollut Control & 1239 Siping Rd Shanghai 200092 Peoples R China Shanghai Inst Pollut Control & Ecol Secur Shanghai 200092 Peoples R China Southern Med Univ Zhujiang Hosp Microbiome Med Ctr Dept Lab Med Guangzhou 510280 Peoples R China

Recent developments of advanced electronic and optoelectronic gas sensors are *** array with artificial intelligence algorithms and smart gas sensors in "Internet of Things" paradigm are *** of smart gas sensors in environmental monitoring, medical and healthcare applications, food quality control, and public safety are described. Gas sensor is an indispensable part of modern society with wide applications in environmental monitoring, healthcare, food industry, public safety, etc. With the development of sensor technology, wireless communication, smart monitoring terminal, cloud storage/computing technology, and artificial intelligence, smart gas sensors represent the future of gas sensing due to their merits of real-time multifunctional monitoring, early warning function, and intelligent and automated feature. Various electronic and optoelectronic gas sensors have been developed for high-performance smart gas analysis. With the development of smart terminals and the maturity of integrated technology, flexible and wearable gas sensors play an increasing role in gas analysis. This review highlights recent advances of smart gas sensors in diverse applications. The structural components and fundamental principles of electronic and optoelectronic gas sensors are described, and flexible and wearable gas sensor devices are highlighted. Moreover, sensor array with artificial intelligence algorithms and smart gas sensors in "Internet of Things" paradigm are introduced. Finally, the challenges and perspectives of smart gas sensors are discussed regarding the future need of gas sensors for smart city and healthy living.

关键词： Smart gas sensor Electronic sensor Optoelectronic sensor Flexible and wearable sensor Artificial intelligence