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A Single-Cell RNA Sequencing Profiles the Developmental Landscape of Arabidopsis Root

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Molecular Plant 2019年第5期12卷 648-660页

作者： tian-qi zhang Zhou-Geng Xu Guan-Dong Shang Jia-Wei Wang National Key Laboratory of Plant Molecular Genetics(NKLPMG) CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and Ecology(SIPPE)Shanghai 200032P.R.China University of Chinese Academy of Sciences Shanghai 200032P.R.China ShanghaiTech University Shanghai 200031P.R.China

Cells of eukaryotic multicellular organisms have inherent *** advances in single-cell gene expression studies enable us to explore transcriptional regulation in dynamic development processes and highly heterogeneous cell *** this study,using a high-throughput single-cell RNA-sequencing assay,we found that the cells in Arabidopsis root are highly heterogeneous in their transcriptomes.A total of 24 putative cell clusters and the cluster-specific marker genes were *** spatial distribution and temporal ordering of the individual cells at different developmental stages illustrate their hierarchical structures and enable the reconstruction of continuous differentiation trajectory of root ***,we found that each root cell cluster exhibits distinct patterns of ion assimilation and hormonal ***,our study reveals a high degree of heterogeneity of root cells and identifies the expression signatures of intermediate states during root cell differentiation at single-cell *** also established a web server(http://***/rootatlas/)to facilitate the use of the datasets generated in this study.

关键词： Arabidopsis root scRNA-seq cell atlas differentiation trajectory meristem

Hydrochloric acid-enhanced radiofrequency ablation for treating a large hepatocellular carcinoma with spontaneous rapture:a case report

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Chinese Journal of Cancer 2017年第1期36卷 44-49页

作者： Ru-Hai Zou Yang-Kui Gu Fei Gao tian-qi zhang Wang Yao Xiong-Ying Jiang Yan-Yang zhang Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine Department of Oncologic Interventional Therapy The First Affiliated Hospital Sun Yat-sen University Department of Radiology Intervention Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Intervention The Third Affiliated Hospital Sun Yat-sen University

Background:A ruptured hepatocellular carcinoma(HCC)is often *** addition to surgery and transarterial embo?lization,radiofrequency ablation(RFA)might be another option for treating a ruptured ***,conven?tional RFA has a limited ablation zone;as such,it is rarely used to treat ruptured *** presentation:This case was a 60?year?old man who had a large,ruptured HCC in which hydrochloric acid(HCl)?enhanced RFA successfully controlled the bleeding and made the tumor completely ***:Considering the effectiveness of HCl?enhanced RFA in achieving hemostasis and tumor ablation,it might be a new option for treating large,ruptured HCCs.

关键词： Hydrochloric acid Radiofrequency ablation Spontaneous rupture Hepatocellular carcinoma

Quantitative study of peripapillary retinal nerve fiber layer thickness and peripapillary vessel density in patients with different stages of Parkinson's disease

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International Journal of Ophthalmology(English edition) 2023年第5期16卷 762-769页

作者： Ting-Yu Yang tian-qi zhang Lai-qing Xie Ying zhang Shi-Mei Liu Xin-Wei Zeng Wei-Feng Luo Guo-Xu Xu Department of Ophthalmology the Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of Neurology the Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina

AIM: To observe the changes in the thickness of peripapillary retinal nerve fiber layer(p RNFL) and peripapillary vessel density(pVD) in patients with different stages of Parkinson's disease(PD).METHODS: Totally 47 patients(47 eyes) with primary PD were divided into the mild group and the moderateto-severe group according to Hoehn & Yahr(H&Y) stage. Among them, there were 27 cases(27 eyes) in mild group and 20 cases(20 eyes) in moderate-to-severe group. And 20 cases(20 eyes) who were included in the control group were healthy people who came to our hospital for health screening at the same time. All participants underwent optical coherence tomography angiography(OCTA) examinations. The pRNFL thickness, total vessel density(tVD) and capillary vessel density(cVD) of the optic disc in average, superior half, inferior half, superior nasal(SN), nasal superior(NS), nasal inferior(NI), inferior nasal(IN), inferior temporal(IT), temporal inferior(TI), temporal superior(TS), and superior temporal(ST) were measured. One-way ANOVA was used to compare the differences of optic disc parameters among the three groups, and Pearson and Spearman correlations were used to analyze the correlation between pRNFL, pVD and the disease duration, H&Y stage and UPDRS-Ⅲ score in patients with PD, ***: There were significant differences in p RNFL thickness in average, superior half, inferior half, SN, NS, IN, IT and ST quadrants among the three groups(P<0.05). In PD group, the pRNFL thickness in average, superior half, inferior half, NS and IT quadrants were negatively correlated with H&Y stage and UPDRS-Ⅲ score, respectively(P<0.05). There were statistically significant differences in the cVD of whole image, inferior half, NI and TS quadrants, the tVD of the whole image, inferior half, and peripapillary among the three groups(P<0.05). In PD group, the tVD of whole image and the c VD of NI and TS quadrants were negatively correlated with the H&Y stage, respectively(P<0.05);the

关键词： Parkinson's disease optic disc nerve fiber vascular density

Camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and hepatic artery infusion chemotherapy for hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (TRIPLET): a phase Ⅱ study

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5556-5562页

作者： tian-qi zhang Zhi-Jun Geng Meng-Xuan Zuo Ji-Bin Li Jin-Hua Huang Zi-Lin Huang Pei-Hong Wu Yang-Kui Gu Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhouP.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangzhouP.R.China Department of Radiology Sun Yat-sen University Cancer CenterGuangzhouP.R.China Department of Clinical Research Sun Yat-sen University Cancer CenterGuangzhouP.R.China

Hepatic arterial infusion chemotherapy(HAIC)using a combination of oxaliplatin,fluorouracil,and leucovorin(FOLFOX)has shown promise for hepatocellular carcinoma(HCC)patients classified under Barcelona Clinic Liver Cancer(BCLC)stage *** China,the combined therapy of camrelizumab and apatinib is now an approved first-line approach for inoperable *** study(NCT04191889)evaluated the benefit of combining camrelizumab and apatinib with HAIC-FOLFOX for HCC patients in BCLC stage *** patients were given a maximum of six cycles of HAIC-FOLFOX,along with camrelizumab and apatinib,until either disease progression or intolerable toxicities *** primary outcome measured was the objective response rate(ORR)based on the Response Evaluation Criteria in Solid Tumors(RECIST)***-five patients were *** on RECIST v1.1 criteria,the confirmed ORR stood at 77.1%(95%CI:59.9%to 89.6%),with a disease control rate of 97.1%(95%CI:85.1%to 99.9%).The median progression-free survival was 10.38 months(95%CI:7.79 to 12.45).Patient quality of life had a transient deterioration within four cycles of treatment,and generally recovered *** most frequent grade≥3 or above treatment-related adverse events included reduced lymphocyte count(37.1%)and diminished neutrophil count(34.3%).The combination of camrelizumab,apatinib,and HAIC demonstrated encouraging results and manageable safety concerns for HCC at BCLC stage C.

关键词： infusion transient Barcelona

Hepatic arterial infusion chemotherapy with anti-angiogenesis agents and immune checkpoint inhibitors for unresectable hepatocellular carcinoma and meta-analysis

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World Journal of Gastroenterology 2024年第4期30卷 318-331页

作者： Yu-Zhe Cao Guang-Lei Zheng tian-qi zhang Hong-Yan Shao Jia-Yu Pan Zi-Lin Huang Meng-Xuan Zuo Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy State Key Laboratory of Oncology in South ChinaGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy Guangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatic arterial infusion chemotherapy(HAIC)has been proven to be an ideal choice for treating unresectable hepatocellular carcinoma(uHCC).HAIC-based treatment showed great potential for treating ***,large-scale studies on HAIC-based treatments and meta-analyses of first-line treatments for uHCC are *** To investigate better first-line treatment options for uHCC and to assess the safety and efficacy of HAIC combined with angiogenesis inhibitors,programmed cell death of protein 1(PD-1)and its ligand(PD-L1)blockers(triple therapy)under real-world *** Several electronic databases were searched to identify eligible randomized controlled trials for this ***-level pooled analyses of hazard ratios(HRs)and odds ratios(ORs)were *** was a retrospective single-center study involving 442 patients with uHCC who received triple therapy or angiogenesis inhibitors plus PD-1/PD-L1 blockades(AIPB)at Sun Yat-sen University Cancer Center from January 2018 to April *** score matching(PSM)was performed to balance the bias between the *** Kaplan-Meier method and cox regression were used to analyse the survival data,and the log-rank test was used to compare the suvival time between the *** A total of 13 randomized controlled trials were *** alone and in combination with sorafenib were found to be effective treatments(P values for ORs:HAIC,0.95;for HRs:HAIC+sorafenib,0.04).After PSM,176 HCC patients were included in the *** triple therapy group(n=88)had a longer median overall survival than the AIPB group(n=88)(31.6 months vs 14.6 months,P<0.001)and a greater incidence of adverse events(94.3%vs 75.4%,P<0.001).CONCLUSION This meta-analysis suggests that HAIC-based treatments are likely to be the best choice for *** findings confirm that triple therapy is more effective for uHCC patients than AIPB.

关键词： Unresectable hepatocellular carcinoma Hepatic arterial infusion chemotherapy Angiogenesis inhibitors Programmed cell death protein 1 Programmed death ligand 1

Centrifuge model testing to ascertain vertical displacements of a pile under cyclic lateral loads

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2021年第9期22卷 760-766页

作者： Gang ZHENG Ji-bin SUN tian-qi zhang Yang JIAO Yu DIAO School of Civil Engineering Tianjin UniversityTianjin 300072China

Piles,as the basic components that support superstructures,are inevitably subjected to cyclic lateral *** lateral response(deformation and capacity)of a pile under a cyclic lateral load has been well ***,little attention has been given to its vertical *** this study,centrifuge model tests were conducted to study the vertical displacements of a pile under cyclic lateral *** was found that a pile may settle during cyclic lateral ***,the ultimate settlement of the pile was larger when the vertical load or the amplitude of the horizontal displacement was *** the observations can be explained by the loss of mobilized shaft friction and the transmission of the unbalanced force to the pile tip.

关键词： testing friction load

水泥搅拌桩复合地基的承载力与破坏模式研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第4期19卷 266-276页

作者： Hai-zuo ZHOU Gang ZHENG Xiao-xuan YU tian-qi zhang Jing-jin LIU School of Civil Engineering Tianjin University Key Laboratory of Coastal Civil Engineering Structure and Safety of Ministry of Education Tianjin University State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University

目的:工程规范中采取保守设计方法导致含有埋深的复合地基的承载力被严重低估。本文基于设计表格的方法展示水泥搅拌站复合地基的承载力系数(N_c、N_q和N_γ),分析埋深存在时的3种破坏模式,探讨承载力系数N_q和破坏模式随着各类因素(桩... 详细信息

目的:工程规范中采取保守设计方法导致含有埋深的复合地基的承载力被严重低估。本文基于设计表格的方法展示水泥搅拌站复合地基的承载力系数(N_c、N_q和N_γ),分析埋深存在时的3种破坏模式,探讨承载力系数N_q和破坏模式随着各类因素(桩长、置换率和埋置深度)变化的原因。创新点:1.确定简化的均质化水泥搅拌桩加固地基模型;2.建立非连续布局优化法(DLO)模型,计算工程实用设计表格;3.分析极限承载力系数N_q、破坏模式和各类影响因素的内在关联。方法:1.通过等效强度法确定合理的均质化数值计算模型,并与群桩模型和前人研究进行对比验证(图4和表1);2.通过极限分析上限解结合非连续布局优化法,进行大量计算,建立极限承载力系数的设计表格(图6~8)。结论:1.对于无埋深工况,承载力系数N_c随着置换率的增长而增大,直到某一临界值,此时发生实体基础破坏。2.在置换率较低时,承载力系数N_γ随着置换率的增长而减小,因为此时加固区内的等效内摩擦角减小。3.埋置深度对承载力和破坏模式产生复杂影响;当破坏模式从实体基础转化为复合型破坏时,N_q增长;随着桩长进一步增加,破坏面通过加固区内部时,N_q在减小之后保持不变。

关键词：承载力水泥搅拌桩埋置深度破坏模式

Hydrochloric acid enhanced radiofrequency ablation for treatment of large hepatocellular carcinoma in the caudate lobe:Report of three cases

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World Journal of Clinical Cases 2019年第4期7卷 508-515页

作者： Han-Xia Deng Jin-Hua Huang Wan Yee Lau Fei Ai Min-Shan Chen Zhi-Mei Huang tian-qi zhang Meng-Xuan Zuo Department of Minimally Invasive Interventional Therapy Cancer Centre of Sun Yat-sen University State Key Laboratory of Oncology in Southern China Department of Hepatobiliary Surgery Cancer Centre of Sun Yat-sen University Faculty of Medicine The Chinese University of Hong Kong Prince of Wales Hospital

BACKGROUND To report on the use of percutaneous hydrochloric acid(HCl) enhanced radiofrequency ablation(HRFA) for the treatment of large(maximum diameter ≥5 cm) hepatocellular carcinoma(HCC) in the caudate *** SUMMARY Between August 2013 and June 2016, three patients with a large HCC(maximum diameter: 5.0, 5.7, and 8.1 cm) in the caudate lobe were treated by transarterial chemoembolization followed by computer tomography(CT) guided RFA using a monopolar perfusion RF electrode, which was enhanced by local infusion of 10%HCl at 0.2 mL/min(total volume, 3 to 12 mL). The output power of HRFA reached 100 W, and the average ablation time was 39 min(range, 15 to 60 min).Two patients each underwent one session of HRFA and one patient two *** treatment, CT/magnetic resonance imaging showed that all the three lesions were completely ablated. There was no major complication. Two patients had asymptomatic bile duct dilatation. One patient died of tongue cancer 24 mo after ablation. The remaining two patients were alive and no area of enhancement is detected in the caudate lobe at 28 and 60 mo after ablation, *** Percutaneous CT-guided HRFA is safe and efficacious in treating large HCC in the caudate lobe.

关键词： Hydrochloric acid Radiofrequency ablation Hydrochloric acid enhanced radiofrequency ablation Caudate lobe Large hepatocellular carcinoma Case report

Visualizing the dynamic progression of backward erosion piping in a Hele-Shaw cell

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第11期23卷 945-954页

作者： Gang ZHENG Jing-bo TONG tian-qi zhang Zi-wu WANG Xun LI Ji-qing zhang Chun-yu qi Hai-zuo ZHOU Yu DIAO MOE Key Laboratory of Coast Civil Structure Safety Tianjin UniversityTianjin 300072China School of Science Tianjin UniversityTianjin 300072China China Railway Design Corporation Tianjin 300308China National Engineering Laboratory for Digital Construction and Evaluation Technology of Urban Rail Transit Tianjin 300308China

With the utilization of underground space,backward erosion piping(BEP)has been observed in many underground structures(e.g.,shield tunnels)founded on sandy ***,due to invisibility,the geometry of the eroded pipe and its spatial evolution with time during the piping process was still not *** this study,we developed a Hele-Shaw cell to visualize the dynamic progression of *** imaging process technology,we obtained a typical process of BEP(the erosion process can be divided into a piping progression phase and a piping stabilization phase),quantitatively characterized the formation of erosion pipes,and compared the patterns of erosion(e.g.,the erosion area A and the maximum erosion radius R)that spontaneously develop under different fluxes of *** most interesting finding is that the sand grains in a thicker Hele-Shaw model are easier to dislodge,which is possibly due to the granular system in a thicker model having more degrees of freedom,reducing the stability of the sand grains.

关键词： Backward erosion piping(BEP) Dynamic progression Hele-Shaw cell Visualize Imaging processing technology