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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia Xiu-jun Zhan Charity Ngina Qing-Rui Zhang Xiao-Ge Li Qi-Bao Jiang Shi bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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干细胞的趋电性迁移及机制

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中国组织工程研究 2025年第23期29卷 4984-4992页

作者：韩芳舒晴贾绍辉田峻武汉体育学院运动医学院湖北省武汉市430079 武汉大学中南医院骨科康复科湖北省武汉市430071

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,... 详细信息

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,同时综述可能的作用机制。方法:通过检索Pub Med和中国知网数据库,收集截至2024年3月的相关文献,英文检索词:“stem cells,direct current electric field,pulsed electric field,migration,electric field device,mechanism”;中文检索词:“干细胞,直流电场,脉冲电场,迁移,电场装置,机制”。排除不能获取全文和与主题无关的文献。结果与结论:根据筛选要求共纳入58篇文献,包括中文文献15篇及英文文献43篇。文献以脂肪间充质干细胞、骨髓间充质干细胞、神经干细胞、表皮干细胞、人胚胎干细胞和人诱导性多功能干细胞为研究对象,在迁移装置中研究电场的不同参数对上述干细胞迁移的影响及其机制。(1)电场作为一种简单、无创且稳定的干预方式在指导干细胞定向迁移的过程中起着积极作用;(2)不同类型的干细胞发生趋电性迁移的方向不同,同时大部分干细胞的迁移速度和定向性是随着电场强度增加而增加的;(3)不同的电场装置在观测干细胞迁移时的侧重点不同,可根据实验目的而择优选择相关装置;(4)不同干细胞趋电性迁移的机制不完全相同,多数干细胞迁移过程中有MAPK通路、ROCK活化以及PI3K功能的参与,同时还有其他蛋白质复合物与信号通路参与调控该过程;(5)除电场参数不同之外,细胞本身的衰老情况和培养环境也会对趋电性迁移的结果产生影响。总而言之,电场作为一种影响干细胞迁移特性的重要信号,与其他新兴材料结合在组织工程应用中展现出了一定的潜力,有望在指导干细胞归巢方面发挥更加重要的作用,促进骨组织再生和修复以及神经系统、自身免疫系统以及肿瘤等疾病的研究取得更大的突破。

关键词：干细胞电场趋电性迁移机制归巢效应物理因子电场装置细胞衰老培养环境

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Penile metastasis from rectal carcinoma: A case report

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World Journal of Clinical Cases 2022年第19期10卷 6609-6616页

作者： jun-Jie Sun Shi-Yu Zhang jun-Jie tian bai-Ye Jin Department of Urology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 311000Zhejiang ProvinceChina

BACKGROUND Metastasis to the penis is an unusual event,and penile metastasis from rectal carcinoma(PMRC)is extremely rare and associated with a dismal *** far,approximately 80 cases have been *** SUMMARY Herein,we report the case of a 49-year-old man with *** patient presented to the urology clinic with a complaint of penile pain during *** patient underwent the Dixon operation for rectal carcinoma 2 mo before the *** hospitalisation,abdominal computed tomography revealed a nodular lesion on the left *** postoperative pathological examination revealed a typical intestinal-type *** cases of PMRC were retrieved from PubMed to characterise the clinicopathological features and identify the prognostic factors of *** The analysis suggested that approximately 24 mo is the median time to metastasis occurrence and 150 d is the survival time after ***,poor pathological differentiation,lymph node involvement of the primary RC,metastasis time1 cm,and treatment abandonment are negative predictors of survival *** follow-up,surgical resection,chemotherapy,and radiotherapy may potentially improve the prognosis of patients.

关键词： Rectal carcinoma Penile metastasis Risk factors Prognosis Case report

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One-Pot Synthesis of Bismuth Basic Nitrate-Bi_(2)MoO_(6) Photocatalyst for Selective Oxidation of Toluene

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Chinese Journal of Structural Chemistry 2022年第12期41卷 25-32页

作者： tian-Qin Zeng Lang Chen Bing-Hao Wang Sheng tian Zhang-jun bai Xiong Wang jun-Kang Guo Shuang-Feng Yin Advanced Catalytic Engineering Research Center of the Ministry of Education College of Chemistry and Chemical EngineeringState Key Laboratory of Chemo/Biosensing and ChemometricsHunan UniversityChangsha 410082China College of Chemistry and Chemical Engineering Jishou UniversityJishou 416000China

The key issues to improve the performance of photocatalysts for selective oxidation of toluene are promoting the migration and separation of charge carrier,and enhancing the generation of active oxygen *** is known that the construction of compact heterojunction is an efficient protocol to inhibit photogenerated electron-hole *** this work,a 2D-2D[Bi_(6)O_(6)(OH)_(3)](NO_(3))3·1.5H2O-Bi_(2)MoO_(6)(denoted as BBN-BMO)composite heterojunction has been prepared by one-step hydrothermal method for the first *** tetragonal phase BBN in the composite plays the role of transferring electrons from the visible light activated orthorhombic phase BMO and promoting the generation of active·O_(2)^(-),the holes left in BMO are used to activate toluene and produce benzyl radical,thus greatly improving the photocatalytic performance for selective oxidation of *** toluene conversion rate of BBN-BMO is 3466μmol·g^(-1)·h^(-1),which is three times that of pure *** selectivity to benzalde-hyde is 94.2%.In addition,reasonable mechanism has been speculated based on a series of control experiments.

关键词： Bi_(2)MoO_(6) basic bismuth nitrate heterojunction photocatalysis selective oxidation of toluene

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Mechanism-inspired Design of Heterodinuclear Catalysts for Copolymerization of Epoxide and Lactone

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Chinese Journal of Polymer Science 2020年第9期38卷 950-957,I0006页

作者： Wei-Min Ren Rui-Jing Wang bai-Hao Ren Ge-Ge Gu tian-jun Yue State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

Polyesters,as a class of high-performance and versatile polymer materials,often suffer from some drawbacks,such as hydrophobicity and brittleness due to their single structure ***,modifications have attracted much attention for enhancing their desirable properties,of which one efficient way is incorporating the aliphatic polyether segment into the main chain of the ***,this approach is of much challenge because the obtained polyesters are problematic in either low alternating degree or low molecular ***,we describe an efficient strategy to incorporate polyether fragment into polyester by developing a novel Co-Al based heterodinuclear complex for mediating the copolymerization of propylene oxide(PO)withε-caprolactone(CL).The tracking experiments reveal that PO and CL convert into the polymer chain throughout the polymerization ***,the linear increase in the molecular weight with conversion of CL indicates the controllable nature of the *** competition polymerization,offering the monomer reactivity ratios of rCL=0.96 and rPO=1.04,suggests that the tendency of self-propagation or incorporation of monomers is nearly ***,the obtained polymers with different ether contents exhibit tunable thermal properties with enhanced decomposition temperature for the polymer with higher ether *** newly developed heterodinuclear complex for new polymerization provides an idea to synthesize new functional polymeric materials.

关键词： Heterodinuclear catalysis Polyester-polyether copolymer Lactone Epoxide Copolymerization

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Thermal hydraulic characteristics of helical coil once-through steam generator under ocean conditions

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Nuclear Science and Techniques 2022年第10期33卷 139-150页

作者： tian-Ze bai Chang-Hong Peng School of Nuclear Science and Technology University of Science and Technology of ChinaNo.96Jinzhai RoadBaohe DistrictHefei 230026China

Owing to its advantages of high heat transfer efficiency and compactness, the helical coil once-through steam generator(HCOTSG) can be used in floating nuclear power plants and has been widely used in the design of small modular reactors. The helical tubular geometric structure of the HCOTSG allows heat transfer and local flow changes to occur under complex ocean conditions. In this study, theoretical models of ocean conditions are added to the RELAP5/MOD3.3 code and verified. Using the modified RELAP5 code, the thermal–hydraulic characteristics of the HCOTSG under ocean conditions are simulated. The results show that under rolling conditions, the flow oscillation amplitudes of the single liquid-phase, twophase flow, and single gas-phase regions are different. A circular change in the horizontal position of the helical tube causes the fluctuation of the parameters to change periodically. A phase difference of approximately 3.9 s at a flow rate of 23 kg/s is observed in the flow fluctuation along the axial direction. The driving force, period, and amplitude of rolling significantly affect the flow fluctuation in the HCOTSG. In natural circulation, the flow in the HCOTSG is complex, and the primary-side flow fluctuation can reduce the trough of the flow oscillation at the helical tube by approximately 24.3%.

关键词： RELAP5 HCOTSG Ocean conditions Thermal–hydraulic analysis Flow oscillation

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An algorithm based on evidence theory and fuzzy entropy to defend against SSDF

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Journal of Systems Engineering and Electronics 2020年第2期31卷 243-251页

作者： YE Fang bai Ping tian Yuan College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China

In cognitive radio networks, spectrum sensing is one of the most important functions to identify available spectrum for improving the spectrum utilization. Due to the open characteristic of the wireless electromagnetic environment, the wireless network is vulnerable to be attacked by malicious users(MUs), and spectrum sensing data falsification(SSDF) attack is one of the most harmful attacks on spectrum sensing performance. In this article,an algorithm based on the evidence theory and fuzzy entropy is proposed to resist SSDF attacks. In this algorithm, secondary users(SUs) obtain the corresponding degree of membership function and basic probability assignment function based on the local energy detection result. The new conflicting coefficient is calculated based on the evidence distance and classical conflicting coefficient, and the conflicting weight of the evidence is *** fuzzy weight is calculated by the fuzzy entropy. The credibility weight is obtained by updating the credibility. On this basis, the probability assignment function of the evidence is corrected, and the final result is obtained by using the fusion formula. Simulation results show that the proposed algorithm has a higher detection probability and lower false alarm probability than other *** can effectively defend against SSDF attacks and improve the performance of spectrum sensing.

关键词： cooperative spectrum sensing evidence theory fuzzy entropy spectrum sensing data falsification(SSDF)

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Thermal-flow-electric coupling performance analysis of a liquid-immersed battery thermal management system

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Science China Technological Sciences 2025年第1期 157-176页

作者： Qiang GAO jun tian Chujin BAO Yangfan ZHONG Chengbin ZHANG Yongping CHEN School of Energy and Environment Southeast University Battery Testing Center China North Vehicle Research Institute Zhejiang Immertech Co. Ltd. Alibaba Cloud Computing Co. Ltd.

Ensuring the safety and performance of lithium-ion batteries(LIBs) is a significant challenge for electric *** tackle this issue, an innovative liquid-immersed battery thermal management system(LIBTMS) using bionic baffles with fish-like perforations is developed. The thermal-flow-electric coupling characteristics of LIBTMSs with different baffle structures(no baffle, conventional baffle, baffle with circular perforations and baffle with fish-like perforations) are systematically investigated using experimental and numerical methods. The results indicate that the forced flow scheme exhibits better thermal management performance and voltage equalization than static flow. Moreover, the LIB temperatures and voltage deviations of different LIBTMSs increase quickly with increasing discharge rates. More importantly, the innovative LIBTMS exhibits the best thermoelectric performance due to its excellent thermoelectric equilibrium behavior caused by high electrical and temperature consistency, as well as the best overall performance involving the balance between the pressure loss and heat transfer capacity of the system. Compared with other structures, the innovative LIBTMS using baffles with fish-like perforations exhibits a maximum reduction of 10.1%, 15.2%, 25.8% and 9.0% in LIB maximum temperature, maximum temperature difference, system pressure drop and voltage deviation, respectively, under the same operating ***, for the LIBTMS using baffles with fish-like perforations, the bottom inlet and top outlet configuration and coolant precooling are suggested to enhance cooling performance.

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Total Glucosides of Paeony Regulate Immune Imbalance Mediated by Dermal Mesenchymal Stem Cellsin Psoriasis Mice

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Chinese Journal of Integrative Medicine 2023年第6期29卷 517-525页

作者： LEI Ming-jun bai Fan ZHANG Qing-yun YANG Qing-qing tian Zan Department of Dermatology Hebei Province Hospital of Chinese MedicineShijazhuang(050011)China

Objective To investigate the therapeutic effects of total glucosides of paeony(TGP)on psoriasis based on the immunomodulatory effect of dermal mesenchymal stem cells(DMSCs).Methods A total of 30 male BALB/c mice were divided into 6 groups(n=5 in each)by a random number table method,including control,psoriasis model(model,5%imiquimod cream 42 mg/d),low-,medium-and high-dose TGP(50,100,and 200 mg/kg,L,M-,and H-TGP,respectively),and positive control group(2.5 mg/kg acitretin).After 14 days of continuous administration,the skin’s histopathological changes,apoptosis,secretion of inflammatory cytokines,and proportion of regulatory T cells(Treg)and T helper cell 17(Th17)were evaluated using hematoxylin-eosin(HE)staining,TdT-mediated dUTP nick end labeling staining,enzyme-linked immunosorbent assay,and flow cytometry,*** were further isolated from the skin tissues of normal and psoriatic mice,and the cell morphology,phenotype,and cycle were ***,TGP was used to treat psoriatic DMSCs to analyze the effects on the DMSCs immune *** TGP alleviated skin pathological injury,reduced epidermis layer thickness,inhibited apoptosis,and regulated the secretion of inflammatory cytokines and the proportion of Treg and Th17 in the skin tissues of psoriatic mice(P0.05),however,more psoriatic DMSCs remained in G0/G1 phase compared with the normal DMSCs(P<0.01).TGP treatment of psoriatic DMSCs significantly increased cell viability,decreased apoptosis,relieved inflammatory response,and inhibited the expression of toll-like receptor 4 and P65(P<0.05 or P<0.01).Conclusion TGP may exert a good therapeutic effect on psoriasis by regulating the immune imbalance of DMSCs.

关键词： total glucosides of paeony psoriasis dermal mesenchymal stem cells inflammatory response immuneimbalance

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Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

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Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： JIANG Xiao-ying SHI Li-ping ZHU jun-long bai Ren-ren XIE tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification

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