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Interspecies transmission and evolution of the emerging coronaviruses: perspectives from bat physiology and protein spatial structure

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Frontiers of Agricultural Science and Engineering 2020年第2期7卷 218-226页

作者： Baicheng huang Kegong tian National Research Center for Veterinary Medicine Luoyang 471003China College of Animal Science and Veterinary Medicine Henan Agricultural UniversityZhengzhou 450046China

Emergent coronaviruses(CoVs)such as SARS-CoV and MERS-CoV have posed great threats to public health worldwide over the past two ***,the emergence of SARS-CoV-2 as a pandemic causes greater public health *** diversity is due to the large size and replication mechanisms of the genomes together with having bats as their optimum natural *** ecological behavior and unique immune characteristics of bats are optimal for the homologous recombination of *** relationship of spatial structural characteristics of the spike protein,a protein that is critical for recognition by host receptors,in different CoVs may provide evidence in explaining the coevolution of CoVs and their *** information may help to enhance our understanding of CoV evolution and thus provide part of the basis of preparations for any future outbreaks.

关键词： bat coronavirus evolution host receptor spike protein transmission

地舒单抗与唑来膦酸治疗新诊断多发性骨髓瘤骨病的疗效及安全性

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中华血液学杂志 2024年第4期45卷 345-350页

作者：马艺肖秀斌刘耀升陈喜林袁顺宗赵世华鲁云殷华陈俊丽王玥琦程娜娜封盼黄文荣解放军总医院第五医学中心血液病医学部淋巴瘤-浆细胞疾病专科北京100071 解放军总医院第四医学中心骨科医学部北京100048

目的探讨地舒单抗(DENOS)与唑来膦酸(ZOL)治疗新诊断多发性骨髓瘤骨病(MBD)的疗效及安全性。方法回顾性分析2021年3月1日至2023年6月30日解放军总医院第五医学中心血液病医学部收治的80例新诊断MBD患者的临床资料。18例伴重度肾损害(SRI... 详细信息

目的探讨地舒单抗(DENOS)与唑来膦酸(ZOL)治疗新诊断多发性骨髓瘤骨病(MBD)的疗效及安全性。方法回顾性分析2021年3月1日至2023年6月30日解放军总医院第五医学中心血液病医学部收治的80例新诊断MBD患者的临床资料。18例伴重度肾损害(SRI)患者[内生肌酐清除率(CrCl)0.05),中位无进展生存及总生存时间均未达到。结论DENOS治疗MBD具有较强的抗骨吸收作用和低肾毒性,低钙血症是常见不良反应,多为轻中度且可控。

关键词：多发性骨髓瘤骨疾病低钙血症地舒单抗

Comparison of the predictive value of anthropometric indicators for the risk of benign prostatic hyperplasia in southern China

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Asian Journal of Andrology 2023年第2期25卷 265-270页

作者： Meng-Jun huang Yan-yi Yang Can Chen Rui-Xiang Luo Chu-Qi Wen Yang Li Ling-Peng Zeng Xiang-Yang Li Zhuo yin Department of Urology The Second Xiangya Hospital of Central South UniversityChangsha 410011China Health Management Center The Second Xiangya Hospital of Central South UniversityChangsha 410011China

This study aimed to compare the predictive value of six selected anthropometric indicators for benign prostatic hyperplasia(BPH).Males over 50 years of age who underwent health examinations at the Health Management Center of the Second Xiangya Hospital,Central South University(Changsha,China)from June to December 2020 were enrolled in this *** characteristic data were collected,including basic anthropometric indices,lipid parameters,six anthropometric indicators,prostate-specific antigen,and total prostate *** odds ratios(ORs)with 95%confidence intervals(95%CIs)for all anthropometric parameters and BPH were calculated using binary logistic *** assess the diagnostic capability of each indicator for BPH and identify the appropriate cutoff values,receiver operating characteristic(ROC)curves and the related areas under the curves(AUCs)were *** six indicators had diagnostic value for BPH(all P≤0.001).The visceral adiposity index(VAI;AUC:0.797,95%CI:0.759–0.834)had the highest AUC and therefore the highest diagnostic *** was followed by the cardiometabolic index(CMI;AUC:0.792,95%CI:0.753–0.831),lipid accumulation product(LAP;AUC:0.766,95%CI:0.723–0.809),waist-to-hip ratio(WHR;AUC:0.660,95%CI:0.609–0.712),waist-to-height ratio(WHtR;AUC:0.639,95%CI:0.587–0.691),and body mass index(BMI;AUC:0.592,95%CI:0.540–0.643).The sensitivity of CMI was the highest(92.1%),and WHtR had the highest specificity of 94.1%.CMI consistently showed the highest OR in the binary logistic regression ***,WHtR,WHR,VAI,CMI,and LAP all influence the occurrence of BPH in middle-aged and older men(all P≤0.001),and CMI is the best predictor of BPH.

关键词： benign prostate hyperplasia obesity index predictive value risk prediction

基于MaxEnt模型和ArcGIS软件的湖南省林麝生境适宜性评价

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湖南林业科技 2024年第1期51卷 43-49页

作者：王安文东新周芸芸于桂清陈军彭德永黄太福田书荣肖芬中南林业科技大学湖南长沙410004 湖南省林业科学院湖南长沙410004 湖南壶瓶山国家级自然保护区管理局湖南常德415319 湖南莽山国家级自然保护区管理处湖南宜章424221 湖南金童山国家级自然保护区管理处湖南城步422510

林麝是国家一级重点保护野生动物,近年来种群数量极速下降。本研究对林麝在湖南省的生境适宜性进行评价,为有效保护和管理林麝种群与生境提供科学指导与基础数据。本文采用ArcGIS软件和MaxEnt模型分析了影响湖南林麝分布的主要因素,获... 详细信息

林麝是国家一级重点保护野生动物,近年来种群数量极速下降。本研究对林麝在湖南省的生境适宜性进行评价,为有效保护和管理林麝种群与生境提供科学指导与基础数据。本文采用ArcGIS软件和MaxEnt模型分析了影响湖南林麝分布的主要因素,获得了其生境分布区。研究结果表明:影响林麝生境适宜性的重要生态因子是最冷季平均温度、最冷季降水量和海拔。湖南省林麝适宜生境2690.57 km^(2),主要于湘西北、湘西南呈现非连续的斑块化分布;次适宜生境3053.64 km^(2),主要分布在适宜生境的外围区域,适宜生境仅占研究区域面积的1.27%。最冷季平均温度2.5℃、最冷季降水量90~100 mm以及海拔1500~1900 m区间对应的模型响应结果最好。建议进一步加强林麝非连续适宜生境的廊道建设,提升适宜生境的保护与管理水平。

关键词：林麝湖南省最大熵模型生境适宜性

四川省甘孜州部分地区藏猪消化道寄生虫感染情况调查

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动物医学进展 2024年第3期45卷 129-132页

作者：杨丹娇张敏王俊伟张敏刘怡雯且华敏田维赵光辉叶忠明宋军科甘孜藏族自治州畜牧业科学研究所四川康定626000 西北农林科技大学动物医学院陕西杨陵712100 焦作市动物疫病预防控制中心河南焦作454003

为了解四川省甘孜州部分地区藏猪消化道寄生虫感染情况,通过饱和盐水漂浮法结合形态学对采自该地区7个养殖场的176份藏猪新鲜粪便样品中的寄生虫虫卵和卵囊进行鉴定。结果显示,检测样品中猪蛔虫虫卵、猪毛尾线虫虫卵、食道口线虫虫卵以... 详细信息

为了解四川省甘孜州部分地区藏猪消化道寄生虫感染情况,通过饱和盐水漂浮法结合形态学对采自该地区7个养殖场的176份藏猪新鲜粪便样品中的寄生虫虫卵和卵囊进行鉴定。结果显示,检测样品中猪蛔虫虫卵、猪毛尾线虫虫卵、食道口线虫虫卵以及猪囊等孢球虫卵囊的阳性率分别为42.04%(74/176)、25.57%(45/176)、5.11%(9/176)和43.18%(76/176),总感染率达75%(132/176);腹泻粪便样本寄生虫感染率80.88%(55/68),显著高于非腹泻粪便样本71.29%(77/108)(P<0.05);放牧藏猪寄生虫感染率85.06%(74/87),显著高于圈养藏猪65.17%(58/89)(P<0.05)。表明四川省甘孜州部分地区藏猪消化道寄生虫的感染较为严重,为该地区藏猪消化道寄生虫病的防控提供了依据。

关键词：藏猪消化道寄生虫感染率

Electrochemical Rhodium-Catalyzed Enantioselective C–H Annulation with Alkynes

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CCS Chemistry 2022年第9期4卷 3181-3189页

作者： Yuan-Qiong huang Zhi-Jie Wu Li Zhu Qing Gu Xiaojie Lu Shu-Li You tian-Sheng Mei State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032 State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesPudongShanghai 201203

The synergistic use of transition metal catalysis and electrochemistry is an attractive strategy for oxidative site-selective C–H functionalization since the use of stoichiometric chemical oxidants can be avoided and novel reactivity can be ***,metalcatalyzed electrochemical C–H functionalization is mainly limited to arene C(sp^(2))–Hfunctionalization,and enantioselective C–H functionalization is uncommon and remains challenging.

关键词： organic electrochemistry enantioselective C–H annulation rhodium catalysis chiral spiropyrazolones C–H functionalization

基于孔裂隙理论的岩石物理实验研究与理论应用

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地质论评 2024年第S1期70卷 151-153页

作者：陈剑铭涂运中张波尹浩王晓赛王文赵明吴纪修高鹏举田倩媛徐梦龙黄威张家声哈利法科技大学阿拉伯联合酋长国阿布扎比127788 中国地质科学院勘探技术研究所中国廊坊065000 中国地质科学院地球物理地球化学勘查研究所中国廊坊065000 深圳市勘察测绘院有限公司中国深圳518028

地下地质构造中含有一系列不同尺度的孔隙和裂缝,相比于裂隙,孔隙不易发生形变而裂隙在压力作用下易于变形闭合,这一特性显著影响着岩石中弹性波的传播。在此背景下,提出的新理论模型,就裂隙对弹性介质的影响进行了分析,引入了“挤喷流... 详细信息

地下地质构造中含有一系列不同尺度的孔隙和裂缝,相比于裂隙,孔隙不易发生形变而裂隙在压力作用下易于变形闭合,这一特性显著影响着岩石中弹性波的传播。在此背景下,提出的新理论模型,就裂隙对弹性介质的影响进行了分析,引入了“挤喷流”(squirt flow)效应的贡献.

关键词：岩石物理实验孔裂隙理论理论应用

Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin

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Genes & Diseases 2022年第4期9卷 1024-1037页

作者： Chunyun Pu Shaorong tian Sanxiu He Weihong Chen Yuanyuan He Hongyan Ren Jing Zhu Jun Tang Xiaolan huang ying Xiang yixiao Fu Tingxiu Xiang Key Laboratory of Molecular Oncology and Epigenetics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Department of Urinary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Department of Oncology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Ph.D Research Center for Medical and Social Development Chongqing Medical UniversityChongqing 400016PR China Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China

Recent studies suggest that Hypocretin (HCRT, Orexin) are involved in stress regulation of depression through the hypothalamic-pituitary-adrenal (HPA) axis. However, the molecular mechanism by which Hypocretin regulate neurobiological responses is unknown. Herein, the effects of chronic stress on the epigenetic modification of HCRT and its association with depression were explored with regard to a potential role in cancer progression. In the study, Sprague Dawley (SD) rats were used to establish an animal model of cancer with depression by administrating n-nitrosodiethylamine (DEN) and chronic unpredictable mild stress (CUMS). RNA-sequencing was used to detect differentially expressed genes in the hippocampus of rats and quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the results of RNA-sequencing. The status of HCRT promoter methylation was assessed by methylation specific polymerase chain reaction. Behavioral tests showed that rats exposed to CUMS had significant depressive-like behaviors. The number of liver tumors and tumor load in depressed rats exposed to CUMS was higher than in SD rats without CUMS. RNA-sequencing revealed that HCRT was one of the most siginificantly downregulated gene in the hippocampus of SD rats with CUMS compared to non-stressed group, which was validated by qRT-PCR. HCRT mRNA expression was downregulated and the promoter for HCRT was hyper-methylated in those with depression. These results identified a critical role for chronic psychological stressors in tumorigenesis and cancer progression, via epigenetic HCRT downregulation. Such epigenetic downregulation may be the molecular basis for the association of cancer with depression.

关键词： Cancer Chronic unpredictability mild stress CpG methylation Depressi on Hypocretin

综合性大学临床医学专业教学质量同质化管理模式的探索——以中山大学为例

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医学教育管理 2024年第4期10卷 389-394页

作者：李晶黄玲娟青永红朱琳梁立阳田琦硕莫承强王淑珍中山大学医学教育处广州510080 中山大学孙逸仙纪念医院教学科广州510120 中山大学孙逸仙纪念医院儿科广州510120 中山大学附属第一医院外科广州510080

医学教育是卫生健康事业发展的重要基石,临床教学是医学生获取临床技能和经验的重要途径,是培养医学人才的重要环节。本文梳理了临床教学同质化的难点和原因,并以中山大学为例,阐述了学校在构建临床教学统筹管理体系、推进全链条管理模... 详细信息

医学教育是卫生健康事业发展的重要基石,临床教学是医学生获取临床技能和经验的重要途径,是培养医学人才的重要环节。本文梳理了临床教学同质化的难点和原因,并以中山大学为例,阐述了学校在构建临床教学统筹管理体系、推进全链条管理模式、激发教师队伍活力方面实践探索的过程和成效,为建立科学、合理的临床教学质量同质化保障体系,提高医学生的临床实践能力和培养质量提供参考。

关键词：临床教学质量教学同质化管理模式医学人才培养