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Axonotmesis-evoked plantar vasodilatation as a novel assessment of C-fiber afferent function after sciatic nerve injury in rats

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Neural Regeneration Research 2019年第12期14卷 2164-2172页

作者： Xue-Song Wang Xue Chen Tian-Wen Gu Ya-Xian Wang Da-guo Mi wen Hu Department of Orthopedics The Affiliated Hospital of Jiangnan University (The Third People’s Hospital of Wuxi City) Wuxi Jiangsu Province China Wuxi School of Medicine Jiangnan University Wuxi Jiangsu Province China Key Laboratory for Neuroregeneration of Ministry of Education and Co-innovation Center for Neuroregeneration of Jiangsu Province Nantong University Nantong Jiangsu Province China Department of Orthopedics Nantong Hospital of Traditional Chinese Medicine Nantong Jiangsu Province China

Quantitative assessment of the recovery of nerve function, especially sensory and autonomic nerve function, remains a challenge in the field of nerve regeneration research. We previously found that neural control of vasomotor activity could be potentially harnessed to evaluate nerve function. In the present study, five different models of left sciatic nerve injury in rats were established: nerve crush injury, nerve transection/ suturing, nerve defect/autografting, nerve defect/conduit repair, and nerve defect/non-regeneration. Laser Doppler perfusion imaging was used to analyze blood perfusion of the hind feet. The toe pinch test and walking track analysis were used to assess sensory and motor functions of the rat hind limb, respectively. Transmission electron microscopy was used to observe the density of unmyelinated axons in the injured sciatic nerve. Our results showed that axonotmesis-evoked vasodilatation in the foot 6 months after nerve injury/repair recovered to normal levels in the nerve crush injury group and partially in the other three repair groups;whereas the nerve defect/non-regeneration group exhibited no recovery in vasodilatation. Furthermore, the recovery index of axonotmesis-evoked vasodilatation was positively correlated with toe pinch reflex scores and the density of unmyelinated nerve fibers in the regenerated nerve. As C-fiber afferents are predominantly responsible for dilatation of the superficial vasculature in the glabrous skin in rats, the present findings indicate that axonotmesis-evoked vasodilatation can be used as a novel way to assess C-afferent function recovery after peripheral nerve injury. This study was approved by the Ethics Committee for Laboratory Animals of Nantong University of China (approval No. 20130410-006) on April 10, 2013.

关键词： nerve regeneration axonotmesis-evoked vasodilatation laser Doppler perfusion imaging nerve function autonomic nerve C-fiber afferent function peripheral nerve injury unmyelinated afferent fiber regeneration neural regeneration

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The weeping characteristic of submerged multi-orifice plate

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Chinese Journal of Chemical Engineering 2020年第4期28卷 955-968页

作者： Jiming wen Ruifeng tian Sichao Tan Qiunan Sun Haifeng gu Fundamental Science on Nuclear Safety and Simulation Technology Laboratory Harbin Engineering UniversityHarbin 150001China

Weeping is an adverse phenomenon which results in higher pressure drop and poorer aeration performance.Visual experiments have been conducted to study the mechanism by which weeping impairs the work performance of multi-orifice plate.A theoretical model is improved to analyze the weeping phenomenon of multiorifice plate based on potential flow theory.The relations of different bubbling conditions and weeping rate are analyzed.Weeping condition and average weeping rate have relation with the driven pressure differential and dynamic variation of gas chamber pressure.In addition,a set of experiments are designed to study the influence of various factors on weeping rate.The bubble coalescence during bubble formation is a fatal factor determining weeping rate,so the relation between weeping rate and gas flow rate is concerned with the pitch of orifices and orifice diameter.There is a critical plate thickness which is in favor of weeping.

关键词： Weeping Multi-orifice plate Wave pressure Gas chamber pressure

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Classification of weed seeds based on visual images and deep learning

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农业信息处理(英文) 2023年第1期10卷 40-51页

作者： Tongyun Luo Jianye Zhao Yujuan gu Shuo Zhang Xi Qiao wen tian Yangchun Han College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100PR China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120PR China Qingdao China-Agri IOT Science&Technology Co.Ltd. Qingdao 266106PR China guangzhou Customs Districk Technology Center Guangzhou 510623PR China Jiangyin Customs Jiangyin 214400PR China

Weeds are mainly spread by weed seeds being mixed with agricultural and forestry crop seeds,grain,animal hair,and other plant products,and disturb the growing environment of target plants such as crops and wild native plants.The accurate and efficient classification of weed seeds is important for the effective management and control of weeds.However,classification remains mainly dependent on destructive sampling-based manual inspection,which has a high cost and rather low flux.We considered that this problem could be solved using a nondestructive intelligent image recognition method.First,on the basis of the establishment of the image acquisition system for weed seeds,images of single weed seeds were rapidly and completely segmented,and a total of 47696 samples of 140 species of weed seeds and foreign materials remained.Then,six popular and novel deep Convolutional Neural Network(CNN)models are compared to identify the best method for intelligently identifying 140 species of weed seeds.Of these samples,33600 samples are randomly selected as the training dataset for model training,and the remaining 14096 samples are used as the testing dataset for model *** and GoogLeNet emerged from the quantitative evaluation as the best *** has strong classification accuracy and efficiency(low time consumption),and GoogLeNet has the best classification accuracy.A suitable CNN model for weed seed classification could be selected according to specific identification accuracy requirements and time costs of applications.This research is beneficial for developing a detection system for weed seeds in various applications.The resolution of taxonomic issues and problems associated with the identi-fication of these weed seeds may allow for more effective management and control.

关键词： Seed identification Image acquisition system Multi-object classification Convolutional neural network Computer vision

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Monitoring and Prediction of the Vibration Intensity of Seismic Waves Induced in Underwater Rock by Underwater Drilling and Blasting

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Defence Technology（防务技术） 2022年第1期18卷 109-118页

作者： Zhen-xiong Wang wen-bin gu Ting Liang Shou-tian Zhao Peng Chen Liu-fang Yu Research Institute of Chemical Defence 102205 China Armry Engineering University 210007China Archives Department of Space System100094China

All underwater drilling and blasting operations generate seismic waves.However,due to a lack of suitable vibration sensing instruments,most studies on the propagation of seismic waves have been limited to shorelines near construction areas or wharfs,whereas comparatively few studies have beerconducted on the larger seafloor itself.To address this gap,a seafloor vibration sensor system was developed and applied in this study that consists of an autonomous acquisition storage terminal,soft-ware platform,and hole-plugging device that was designed to record the blasting vibration intensities received through submarine rocks at a given measurement point.Additionally,dimensional analyses were used to derive a predictive equation for the strength of blast vibrations that considered the in fluence of the water depth.By combining reliable vibration data obtained using the sensor system in submarine rock and the developed predictive equation,it was determined that the water depth was ar important factor influencing the measured vibration strength.The results using the newly derivedequation were compared to those determined using the Sadowski equation,which is commonly used on land,and it was found that predictions using the derived equation were closer to the experimental values with an average error of less than 10%,representing a significant improvement.Based on these results the developed sensor system and preliminary theoretical basis was deemed suitable for studying the propagation behavior of submarine seismic waves generated by underwater drilling and blasting operations.

关键词： Seismic wave Underwater drilling and blasting Blasting vibration Dimensional analysis Induced seismicity

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Weighted gene co-expression network analysis identiffes potential regulators in response to Salmonella Enteritidis challenge in the reproductive tract of laying ducks

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Journal of Integrative Agriculture 2022年第8期21卷 2384-2398页

作者： ZHANG Yu LUO Shu-wen HOU Li-e gu tian-tian ZHU guo-qiang Wanwipa VONGSANGNAK XU Qi CHEN guo-hong Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education Yangzhou UniversityYangzhou 225009P.R.China Jiangsu Key Laboratory of Zoonosis Yangzhou UniversityYangzhou 225009P.R.China Department of Zoology Faculty of ScienceKasetsart UniversityBangkok 10900Thailand

Salmonella Enteritidis(SE)is a zoonotic and vertically transmitted pathogen,often colonized in the reproductive tract of adult poultry,which can result in direct contamination of eggs and threaten human health.Previous studies have revealed that some pattern recognition receptors and resistance genes were involved in regulating immune responses to SE invasion in birds.However,the role of these immune response genes was not independent,and the interactions among the genes remained to be further investigated.In this study,SE burden and colonization were determined in reproductive tissue after the ducks were SE-infected,and RNA-sequencing was performed to construct co-expression networks by weighted gene co-expression network analysis(WGCNA).The result showed that SE could be isolated from 22% of infected-birds in any segment of the reproductive tract and the SE was readily colonized in the stroma,small follicle,isthmus,and vagina of the reproductive tracts in morbid ducks.The top central,highly connected genes were subsequently identified three specific modules in the above four tissues at the defined cut-offs(Pgulators and 125 transcription factors.Moreover,those 185 differentially expressed genes(DEGs)in these modules were co-expressed.Moreover,the hub genes(TRAF3,CXCR4 and IL13RA1)were identified to act with many other genes through immune response pathways including NF-kappaB,Toll-like receptor,steroid biosynthesis,and p53signaling pathways.These data provide references that will understand the immune regulatory relationships during SE infection,but also assist in the breeding of SE-resistant lines through potential biomarkers.

关键词： duck Salmonella Enteritidis reproductive tract infection-related genes WGCNA

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Contralateral C7 Nerve Root Transfer for Function Recovery in Adults： A Meta-analysis

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Chinese Medical Journal 2017年第24期130卷 2960-2968页

作者： wen-Jun Li Li-Yue He Shan-Lin Chen Yan-Wei Lyu Shu-Feng Wang Yang Yong wen tian guang-Lei tian Yu-Dong gu Department of Hand Surgery Beijing Jishuitan Hospital Beijing 100035 China Department of Health Policy and Management School of Public Health Peking University Health Science Center Beijing 100191 China Department of Hand surgery Huashan Hospital Fudan University Shanghai 200040 China

Background：Root avulsion to all 5 roots of the brachial plexus is a common presentation and keeps a major reconstructive challenge.The contralateral C7 （CC7） nerve transfer has been used in treating brachial plexus avulsion injury （BPAI） since 1986.However,the effectiveness of the procedure remains a subject of controversy.The aim of this meta-analysis was to study surgical outcomes regarding motor and sensory recovery after CC7 nerve transfer.Methods：Chinese or English （i.e.,＂contralateral c-7＂,＂contralateral c7＂,＂c7 nerve root＂,and ＂seventh cervical nerve root＂） keywords were used for a literature search for articles related to CC7 nerve transfer in several databases （i.e.,PubMed,Cochrane,Embase,CNKI,CQVIP,and Wanfang Data）.Clinical research articles were screened,and animal studies as well as duplicate publications were excluded.Muscle strength and sensory recovery were considered to be effective only when the scores on the United Kingdom Medical Research Council scale were equal to or higher than M3 and S3,respectively.Results：The overall ipsilateral recipient nerve recovery rates were as follows：the efficiency rate for muscle strength recovery after CC7 nerve transfer was 0.57 （95% confidence interval [CI]：0.48-0.66） and for sensory recovery was 0.52 （95% CI：0.46-0.58）.When the recipient nerve was the median nerve,the efficiency rate for muscle strength recovery was 0.50 （95% CI：0.39-0.61） and for sensory was 0.56 （95% CI：0.50-0.63）.When the recipient nerve was the musculocutaneous nerve and the radial nerve,the efficiency rate for muscle strength recovery was 0.74 （95% CI：0.65-0.82） and 0.50 （95% CI：0.31-0.70）,respectively.Conclusions：Transfer of CC7 nerves to musculocutaneous nerves leads to the best results.CC7 is a reliable donor nerve,which can be safely used for upper limb function reconstruction,especially for entirely BPAI.When modifying procedures,musculocutaneous nerves and median nerve can be combined as recipient nerves.

关键词： Contralateral C7 Functional Recovery Meta-analysis Nerve Transfer

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Creep damage properties of sandstone under dry-wet cycles

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Journal of Mountain Science 2020年第12期17卷 3112-3122页

作者： WANG Xin-gang LIAN Bao-qin WANG Jia-ding FENG wen-kai gu tian-Feng State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China guangxi Key Laboratory of Disaster Prevention and Engineering Safety Guangxi UniversityNanning 530004China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China

Rock creep properties can be used to predict the long-term stability in rock engineering.In reservoir bank slopes,sandstones which are frequently used in the bank slope undergoing longterm effects of dry-wet(DW) cycles due to periodic water inundation and drainage may gradually accumulate creep deformation,resulting in rock structure’s damage or even geological hazards such as landslides.To fully investigate the effect of DW cycles on the creep damage properties of sandstone,triaxial creep tests were conducted on saturated sandstone with different DW cycles by using a triaxial rheometer apparatus.The experimental results show that both the instantaneous strain and the stabilized strain increase with the DW cycles.In addition,using the Burgers model,four kinds of functions including an exponentially decreasing function,a linearly decreasing function,a linearly increasing function and an exponentially increasing function were proposed to express the relationships between the shear modulus,viscoelastic parameters of the Burgers model and the deviatoric stress under different DW cycles.Through comparative analysis,it is found that the theoretical curves generated using proposed four kinds of functions are in good agreement with the experimental data.Furthermore,macromorphological and microstructural observations were performed on specimens after various triaxial rheological tests.For samples with small number of DW cycles,approximately X-shaped fracture surfaces were observed in shear failure zones,whereas several shear fractures including obvious axial and horizontal tensile cracks,and flaws were found for samples with relatively large DW cycles due to long-term propagation and evolution of micro-fissures and micro-pores.Furthermore,as the DW cycles increases,the variation in micro-structure of samples after creep failure was summarized into three stages,namely,a stage with good and dense structure,a stage with pore and fissure propagation,and a stage with extensive increase of pores,fissures and loose particles.It

关键词： Creep damage property Sandstone Drywet cycles Triaxial rheological test Microstructure

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Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein Trafficking in Oligodendrocytes

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Neuroscience Bulletin 2016年第4期32卷 331-340页

作者： Yun-tian Shen Yun gu wen-Feng Su Jing-fei Zhong Zi-Han Jin Xiao-Song gu Gang Chen Jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationNantong University Xinglin College Nantong University

Myelination by oligodendrocytes in the central nervous system requires coordinated exocytosis and endocytosis of the major myelin protein, proteolipid protein （PLP）. Here, we demonstrated that a small GTPase, Rab27b, is involved in PLP trafficking in oligodendrocytes. We showed that PLP co-localized with Rab27b in late endosomes/lysosomes in oligodendrocytes. Short hairpin- mediated knockdown of Rab27b not only reduced lysosomal exocytosis but also greatly diminished the surface expression of PLP in oligodendrocytes. In addition, knockdown of Rab27b reduced the myelin-like membranes induced by co-culture of oligodendrocytes and neurons. Our data suggest that Rab27b is involved in myelin biogenesis by regulating PLP transport from late endosomes/ lysosomes to the cell membrane in oligodendrocytes.

关键词： Myelination Neuron-glial interaction Oligodendrocyte Lysosome Rab27b

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Rab27a/Slp2-a complex is involved in Schwann cell myelination

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Neural Regeneration Research 2016年第11期11卷 1830-1838页

作者： wen-feng Su Yun gu Zhong-ya Wei Yun-tian Shen Zi-han Jin Ying Yuan Xiao-song gu Gang Chen Jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationNantong University Affiliated Hospital of Nantong University

Myelination of Schwann cells in the peripheral nervous system is an intricate process involving myelin protein trafficking. Recently, the role and mechanism of the endosomal/lysosomal system in myelin formation were emphasized. Our previous results demonstrated that a small GTPase Rab27a regulates lysosomal exocytosis and myelin protein trafficking in Schwann cells. In this present study, we established a dorsal root ganglion （DRG） neuron and Schwann cell co-culture model to identify the signals associated with Rab27a during myelination. First, Slp2-a, as the Rab27a effector, was endogenously expressed in Schwann cells. Second, Rab27a expression significantly increased during Schwann cell myelination. Finally, Rab27a and Slp2-a silencing in Schwann cells not only reduced myelin protein expression, but also impaired formation of myelin-like membranes in DRG neuron and Schwann cell co-cultures. Our findings suggest that the Rab27a/ Slp2-a complex affects Schwann cell myelination in vitro.

关键词： nerve regeneration Schwann cells dorsal root ganglion neurons co-culture myelin proteins myelination Rab27 effectors Rab27a Slp2-a neural regeneration

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Leukoaraiosis is associated with clinical symptom severity,poor neurological function prognosis and stroke recurrence in mild intracerebral hemorrhage:a prospective multi-center cohort study

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Neural Regeneration Research 2022年第4期17卷 819-823页

作者： tian-Qi Xu Wei-Zhi Lin Yu-Lan Feng Fan-Xia Shen Jie Chen Wei-wen Wu Xiao-Dong Zhu Lin gu Yi Fu Department of Neurology Ruijin Hospital/Luwan BranchSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina The Third Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine FuzhouFujian ProvinceChina Department of Neurology Minhang HospitalFudan UniversityShanghaiChina Department of Neurology Ruijin North HospitalShanghaiChina Department of Neurology Zhongshan Hospital Qingpu BranchFudan UniversityShanghaiChina Department of Neurology The First Hospital of JiaxingJiaxingZhejiang ProvinceChina Department of Rehabilitation Shanghai Ruijin Rehabilitation HospitalShanghaiChina

Leukoaraiosis(LA)results from ischemic injury in small cerebral vessels,which may be attributable to decreased vascular density,reduced cerebrovascular angiogenesis,decreased cerebral blood flow,or microcirculatory dysfunction in the brain.In this study,we enrolled 357 patients with mild intracerebral hemorrhage(ICH)from five hospitals in China and analyzed the relationships between LA and clinical symptom severity at admission,neurological function prognosis at 3 months,and 1-year stroke recurrence.Patients were divided into groups based on Fazekas scale scores:no LA(n=83),mild LA(n=64),moderate LA(n=98)and severe LA(n=112).More severe LA,larger hematoma volume,and higher blood glucose level at admission were associated with more severe neurological deficit.More severe LA,older age and larger hematoma volume were associated with worse neurological function prognosis at 3 months.In addition,moderate-to-severe LA,admission glucose and symptom-free cerebral infarction were associated with 1-year stroke recurrence.These findings suggest that LA severity may be a potential marker of individual ICH vulnerability,which can be characterized by poor tolerance to intracerebral attack or poor recovery ability after ICH.Evaluating LA severity in patients with mild ICH may help neurologists to optimize treatment protocols.This study was approved by the Ethics Committee of Ruijin Hospital Affiliated to Shanghai Jiao Tong University(approval No.12)on March 10,2011.

关键词： clinical symptom severity functional dependence intracerebral hemorrhage leukoaraiosis modified Rankin scale National Institute Health of Stroke Scale prognosis stroke recurrence white matter hyperintensities

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